{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T05:18:34Z","timestamp":1785561514337,"version":"3.56.0"},"reference-count":29,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T00:00:00Z","timestamp":1623801600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We evaluated the spectrum of choriocapillaris (CC) abnormalities in the fellow eyes of unilateral exudative age-related macular degeneration (AMD) patients using swept-source optical coherence tomography angiography (SS-OCTA). Fellow eyes of unilateral exudative AMD patients were prospectively included between May 2018 and October 2018. Patients underwent a multimodal imaging including a SS-OCTA. Demographics and clinical findings were analyzed. The estimated prevalence of macular neovascularization (MNV) was computed. Number and size of flow deficits (FDs) and percentage of flow deficits (FD%) were computed on the compensated CC flow images with the Fiji software. We included 97 eyes of 97 patients (mean age was 80 \u00b1 7.66 years, 39 males, 58 females). The prevalence of MNV in the studied eyes was 8.25% (8\/97 eyes). In the 89 non-neovascular eyes, FD% averaged 45.84% \u00b1 11.63%, with a corresponding total area of FDs of 4.19 \u00b1 1.12 mm2. There was a higher prevalence of drusenoid pigment epithelial detachment in eyes with subclinical neovascularization (p = 0.021). Fellow eyes with unilateral exudative AMD encompassed a series of CC abnormalities, from FDs of the aging CC to subclinical non-exudative MNV.<\/jats:p>","DOI":"10.3390\/jcm10122658","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T10:27:07Z","timestamp":1623839227000},"page":"2658","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Spectrum of Central Choriocapillaris Abnormalities on Swept-Source Optical Coherence Tomography Angiography in the Fellow Eye of Unilateral Exudative Age-Related Macular Degeneration Patients: From Flow Deficits to Subclinical Non-Exudative Neovascularization"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7286-5984","authenticated-orcid":false,"given":"Alexis","family":"Khorrami Kashi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Souied","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Clinical Research Center, GRC Macula, and Biological Ressources Center, Centre Hospitalier Intercommunal de Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0159-2047","authenticated-orcid":false,"given":"Selim","family":"Fares","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Borrelli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Capuano","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8486-8939","authenticated-orcid":false,"given":"Camille","family":"Jung","sequence":"additional","affiliation":[{"name":"Clinical Research Center, GRC Macula, and Biological Ressources Center, Centre Hospitalier Intercommunal de Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-9581","authenticated-orcid":false,"given":"Giuseppe","family":"Querques","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, University Vita-Salute San Raffaele, Via Olgettina 60, 20132 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Mouallem","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-8210","authenticated-orcid":false,"given":"Alexandra","family":"Miere","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Centre Hospitalier Intercommunal de Cr\u00e9teil, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1001\/jama.291.15.1900","article-title":"Age-related macular degeneration is the leading cause of blindness","volume":"291","author":"Bressler","year":"2004","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ophtha.2018.08.017","article-title":"Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17","volume":"126","author":"Yu","year":"2019","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1167\/iovs.17-22360","article-title":"Alterations in the Choriocapillaris in Intermediate Age-Related Macular Degeneration","volume":"58","author":"Borrelli","year":"2017","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_4","first-page":"2857","article-title":"Morphometric analysis of Bruch\u2019s membrane, the choriocapillaris, and the choroid in aging","volume":"35","author":"Ramrattan","year":"1994","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1167\/iovs.04-1050","article-title":"Reduced foveolar choroidal blood flow in eyes with increasing AMD severity","volume":"46","author":"Grunwald","year":"2005","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.mam.2012.04.005","article-title":"Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor\/retinal pigment epithelium\/Bruch\u2019s membrane\/choriocapillaris complex","volume":"33","author":"Bhutto","year":"2012","journal-title":"Mol. Asp. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ajo.2016.07.023","article-title":"Choriocapillaris Flow Features Follow a Power Law Distribution: Implications for Characterization and Mechanisms of Disease Progression","volume":"170","author":"Spaide","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.preteyeres.2018.07.002","article-title":"OCT angiography and evaluation of the choroid and choroidal vascular disorders","volume":"67","author":"Borrelli","year":"2018","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ajo.2018.12.025","article-title":"Age-dependent Changes in the Macular Choriocapillaris of Normal Eyes Imaged with Swept-Source Optical Coherence Tomography Angiography","volume":"200","author":"Zheng","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.ajo.2018.08.014","article-title":"Topographic Analysis of the Choriocapillaris in Intermediate Age-related Macular Degeneration","volume":"196","author":"Borrelli","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","first-page":"180","article-title":"Senile macular degeneration: A histopathologic study","volume":"75","author":"Green","year":"1977","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/bjo.57.12.951","article-title":"New vessel formation beneath the retinal pigment epithelium in senile eyes","volume":"57","author":"Sarks","year":"1973","journal-title":"Br. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"6886","DOI":"10.1167\/iovs.13-11665","article-title":"Functional characterization and multimodal imaging of treatment-naive \u201cquiescent\u201d choroidal neovascularization","volume":"54","author":"Querques","year":"2013","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ajo.2016.06.042","article-title":"Optical Coherence Tomography Angiography: A Useful Tool for Diagnosis of Treatment-Na\u00efve Quiescent Choroidal Neovascularization","volume":"169","author":"Carnevali","year":"2016","journal-title":"Am. J. Ophthalmol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ophtha.2016.01.044","article-title":"Optical Coherence Tomography Angiography of Asymptomatic Neovascularization in Intermediate Age-Related Macular Degeneration","volume":"123","author":"Roisman","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2019.06.017","article-title":"Two-Year Risk of Exudation in Eyes with Nonexudative Age-Related Macular Degeneration and Subclinical Neovascularization Detected with Swept Source Optical Coherence Tomography Angiography","volume":"208","author":"Yang","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.2147\/CIA.S142685","article-title":"Early and intermediate age-related macular degeneration: Update and clinical review","volume":"12","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/IAE.0000000000001689","article-title":"Disease Expression in Nonexudative Age-Related Macular Degeneration Varies with Choroidal Thickness","volume":"38","author":"Spaide","year":"2018","journal-title":"Retina"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1167\/iovs.17-22953","article-title":"A Novel Strategy for Quantifying Choriocapillaris Flow Voids Using Swept-Source OCT Angiography","volume":"59","author":"Zhang","year":"2018","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ajo.2020.02.003","article-title":"Quantification of Choriocapillaris with Phansalkar Local Thresholding: Pitfalls to Avoid","volume":"213","author":"Chu","year":"2020","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1136\/bjophthalmol-2018-313004","article-title":"Quantitative changes in the ageing choriocapillaris as measured by swept source optical coherence tomography angiography","volume":"103","author":"Sacconi","year":"2019","journal-title":"Br. J. Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/IAE.0000000000001732","article-title":"Improving the Age-Related Macular Degeneration Construct: A New Classification System","volume":"38","author":"Spaide","year":"2018","journal-title":"Retina"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Nassisi, M., Baghdasaryan, E., Tepelus, T., Asanad, S., Borrelli, E., and Sadda, S.R. (2018). Topographic distribution of choriocapillaris flow deficits in healthy eyes. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0207638"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1001\/jamaophthalmol.2017.3904","article-title":"Choriocapillaris Imaging Using Multiple En Face Optical Coherence Tomography Angiography Image Averaging","volume":"135","author":"Uji","year":"2017","journal-title":"JAMA Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ajo.2019.08.026","article-title":"Impact of Slab Selection on Quantification of Choriocapillaris Flow Deficits by Optical Coherence Tomography Angiography","volume":"208","author":"Byon","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ajo.2019.07.003","article-title":"Quantification of Choriocapillaris with Optical Coherence Tomography Angiography: A Comparison Study","volume":"208","author":"Chu","year":"2019","journal-title":"Am. J. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Nassisi, M., Baghdasaryan, E., Borrelli, E., Ip, M., and Sadda, S.R. (2019). Choriocapillaris flow impairment surrounding geographic atrophy correlates with disease progression. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0212563"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/tvst.7.5.19","article-title":"Prevalence of Subclinical CNV and Choriocapillaris Nonperfusion in Fellow Eyes of Unilateral Exudative AMD on OCT Angiography","volume":"7","author":"Treister","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.ophtha.2017.08.030","article-title":"Natural History of Subclinical Neovascularization in Nonexudative Age-Related Macular Degeneration Using Swept-Source OCT Angiography","volume":"125","author":"Zhang","year":"2018","journal-title":"Ophthalmology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/12\/2658\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:17:07Z","timestamp":1760163427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/12\/2658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,16]]},"references-count":29,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["jcm10122658"],"URL":"https:\/\/doi.org\/10.3390\/jcm10122658","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,16]]}}}