{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T21:17:59Z","timestamp":1788297479500,"version":"build-2803163510"},"reference-count":64,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Amyloid-beta (A\u03b2) deposition in the brain is the main pathological hallmark of Alzheimer disease. Peripheral clearance of A\u03b2 may possibly also lower brain levels. Recent evidence suggested that hepatic clearance of A\u03b242 is impaired in liver cirrhosis. To further test this hypothesis, serum A\u03b242 was measured by ELISA in portal venous serum (PVS), systemic venous serum (SVS), and hepatic venous serum (HVS) of 20 patients with liver cirrhosis. Mean A\u03b242 level was 24.7 \u00b1 20.4 pg\/mL in PVS, 21.2 \u00b1 16.7 pg\/mL in HVS, and 19.2 \u00b1 11.7 pg\/mL in SVS. Similar levels in the three blood compartments suggested that the cirrhotic liver does not clear A\u03b242. A\u03b242 was neither associated with the model of end-stage liver disease score nor the Child\u2013Pugh score. Patients with abnormal creatinine or bilirubin levels or prolonged prothrombin time did not display higher A\u03b242 levels. Patients with massive ascites and patients with large varices had serum A\u03b242 levels similar to patients without these complications. Serum A\u03b242 was negatively associated with connective tissue growth factor levels (r = \u22120.580, p = 0.007) and a protective role of A\u03b242 in fibrogenesis was already described. Diabetic patients with liver cirrhosis had higher A\u03b242 levels (p = 0.069 for PVS, p = 0.047 for HVS and p = 0.181 for SVS), which is in accordance with previous reports. Present analysis showed that the cirrhotic liver does not eliminate A\u03b242. Further studies are needed to explore the association of liver cirrhosis, A\u03b242 levels, and cognitive dysfunction.<\/jats:p>","DOI":"10.3390\/jcm10122669","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T11:20:26Z","timestamp":1623928826000},"page":"2669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum Amyloid Beta42 Is Not Eliminated by the Cirrhotic Liver: A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Reiner","family":"Wiest","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery and Medicine, University Inselspital, 3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0336-0581","authenticated-orcid":false,"given":"Thomas S.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Children\u2019s University Hospital (KUNO), Regensburg University Hospital, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4130-8477","authenticated-orcid":false,"given":"Lusine","family":"Danielyan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Institute of Clinical and Experimental Pharmacology and Toxicology, University Hospital of Tuebingen, 72074 Tuebingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-3994","authenticated-orcid":false,"given":"Christa","family":"Buechler","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, Regensburg University Hospital, 93053 Regensburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1590\/1980-57642016dn11-020002","article-title":"Type 2 diabetes mellitus in the pathophysiology of Alzheimer\u2019s disease","volume":"11","year":"2017","journal-title":"Dement. 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