{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:27:01Z","timestamp":1789986421104,"version":"4.0.1"},"reference-count":167,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T00:00:00Z","timestamp":1623974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Therapeutic ultrasound has been studied for over seven decades for different medical applications. The versatility of ultrasound applications are highly dependent on the frequency, intensity, duration, duty cycle, power, wavelength, and form. In this review article, we will focus on low-intensity continuous ultrasound (LICUS). LICUS has been well-studied for numerous clinical disorders, including tissue regeneration, pain management, neuromodulation, thrombosis, and cancer treatment. PubMed and Google Scholar databases were used to conduct a comprehensive review of all research studying the application of LICUS in pre-clinical and clinical studies. The review includes articles that specify intensity and duty cycle (continuous). Any studies that did not identify these parameters or used high-intensity and pulsed ultrasound were not included in the review. The literature review shows the vast implication of LICUS in many medical fields at the pre-clinical and clinical levels. Its applications depend on variables such as frequency, intensity, duration, and type of medical disorder. Overall, these studies show that LICUS has significant promise, but conflicting data remain regarding the parameters used, and further studies are required to fully realize the potential benefits of LICUS.<\/jats:p>","DOI":"10.3390\/jcm10122698","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T11:19:20Z","timestamp":1624015160000},"page":"2698","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Low-Intensity Continuous Ultrasound Therapies\u2014A Systematic Review of Current State-of-the-Art and Future Perspectives"],"prefix":"10.3390","volume":"10","author":[{"given":"Sardar","family":"Uddin","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2618-9492","authenticated-orcid":false,"given":"David","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Motyka","sequence":"additional","affiliation":[{"name":"Department of Osteopathic Manipulative Medicine, Campbell University, Buies Creek, NC 27506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Petterson","sequence":"additional","affiliation":[{"name":"The Orthopedic Foundation, Stamford, CT 06905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ijsu.2015.11.030","article-title":"Shock wave as biological therapeutic tool: From mechanical stimulation to recovery and healing, through mechanotransduction","volume":"24","author":"Craig","year":"2015","journal-title":"Int. J. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0301-5629(90)90044-D","article-title":"The biomechanical effects of low-intensity ultrasound on healing tendons","volume":"16","author":"Enwemeka","year":"1990","journal-title":"Ultrasound Med. Biol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11926-011-0177-7","article-title":"Mechanical means to improve bone strength: Ultrasound and vibration","volume":"13","author":"Kasturi","year":"2011","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"952","DOI":"10.4252\/wjsc.v12.i9.952","article-title":"Mechanotransduction of stem cells for tendon repair","volume":"12","author":"Wang","year":"2020","journal-title":"World J. Stem Cells"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1042\/CS20190488","article-title":"The molecular mechanism of mechanotransduction in vascular homeostasis and disease","volume":"134","author":"Yamashiro","year":"2020","journal-title":"Clin. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.ultrasmedbio.2004.11.010","article-title":"The effects of low-intensity ultrasound on growing bone after sciatic neurectomy","volume":"31","author":"Yang","year":"2005","journal-title":"Ultrasound Med. Biol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ultrasmedbio.2012.06.002","article-title":"Integrin-mediated mechanotransduction pathway of low-intensity continuous ultrasound in human chondrocytes","volume":"38","author":"Whitney","year":"2012","journal-title":"Ultrasound Med. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Simpson, L.J., Reader, J.S., and Tzima, E. (2020). Mechanical Forces and Their Effect on the Ribosome and Protein Translation Machinery. Cells, 9.","DOI":"10.3390\/cells9030650"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"17693","DOI":"10.1074\/jbc.REV119.007963","article-title":"Control of cellular responses to mechanical cues through YAP\/TAZ regulation","volume":"294","author":"Dasgupta","year":"2019","journal-title":"J. Biol. Chem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1016\/j.cub.2018.02.003","article-title":"Tensile Forces and Mechanotransduction at Cell-Cell Junctions","volume":"28","author":"Charras","year":"2018","journal-title":"Curr. Biol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1093\/jas\/skz189","article-title":"Skeletal response to whole body vibration and dietary calcium and phosphorus in growing pigs","volume":"97","author":"Huseman","year":"2019","journal-title":"J. Anim. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jmpt.2019.12.003","article-title":"Effect of Whole-Body Vibration Exercise on Power Profile and Bone Mineral Density in Postmenopausal Women with Osteoporosis: A Randomized Controlled Trial","volume":"43","author":"ElDeeb","year":"2020","journal-title":"J. Manip. Physiol. Ther."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"151598","DOI":"10.1016\/j.acthis.2020.151598","article-title":"Short-term effects of whole-body vibration on the soleus of ooforectomized rats: Histomorphometric analysis and oxidative stress in an animal model","volume":"122","author":"Peretti","year":"2020","journal-title":"Acta Histochem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10433-019-00498-x","article-title":"Tai Chi and whole-body vibrating therapy in sarcopenic men in advanced old age: A clinical randomized controlled trial","volume":"16","author":"Zhu","year":"2019","journal-title":"Eur. J. Ageing"},{"key":"ref_15","unstructured":"Sapoval, J., Singh, V., and Carter, R.E. (2020). Ultrasound Biophysical Profile, StatPearls."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"623","DOI":"10.7863\/jum.2012.31.4.623","article-title":"Overview of therapeutic ultrasound applications and safety considerations","volume":"31","author":"Miller","year":"2012","journal-title":"J. Ultrasound Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5455\/aim.2011.19.168-171","article-title":"Application of ultrasound in medicine","volume":"19","author":"Carovac","year":"2011","journal-title":"Acta Inform. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.12968\/hmed.2017.78.9.492","article-title":"Point-of-care ultrasound: Its growing application in hospital medicine","volume":"78","author":"Kingwill","year":"2017","journal-title":"Br. J. Hosp. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1056\/NEJM197206152862411","article-title":"Application of ultrasound in medicine","volume":"286","author":"Lele","year":"1972","journal-title":"N. Engl. J. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bpobgyn.2017.09.002","article-title":"High-intensity focused ultrasound therapy","volume":"46","author":"Cheung","year":"2018","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.clon.2010.12.003","article-title":"High-intensity focussed ultrasound","volume":"23","author":"Popert","year":"2011","journal-title":"Clin. Oncol. R. Coll. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.3171\/2017.11.FOCUS17610","article-title":"High-intensity focused ultrasound: Past, present, and future in neurosurgery","volume":"44","author":"Quadri","year":"2018","journal-title":"Neurosurg. Focus"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jclinpath-2011-200460","article-title":"Prostatic needle biopsies following primary high intensity focused ultrasound (HIFU) therapy for prostatic adenocarcinoma: Histopathological features in tumour and non-tumour tissue","volume":"65","author":"Ryan","year":"2012","journal-title":"J. Clin. Pathol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1109\/TBME.2018.2889669","article-title":"A Review of Low-Intensity Pulsed Ultrasound for Therapeutic Applications","volume":"66","author":"Jiang","year":"2019","journal-title":"IEEE Trans. Biomed. Eng."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.ultsonch.2011.01.004","article-title":"Therapeutic ultrasound an overview","volume":"18","author":"Mason","year":"2011","journal-title":"Ultrason. Sonochem."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1177\/0269215519866494","article-title":"Effects of therapeutic ultrasound for knee osteoarthritis: A systematic review and meta-analysis","volume":"33","author":"Wu","year":"2019","journal-title":"Clin. Rehabil."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ultrasmedbio.2014.11.019","article-title":"A review of low-intensity ultrasound for cancer therapy","volume":"41","author":"Wood","year":"2015","journal-title":"Ultrasound Med. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7469197","DOI":"10.1155\/2018\/7469197","article-title":"Effects of Low-Intensity Pulsed Ultrasound on Knee Osteoarthritis: A Meta-Analysis of Randomized Clinical Trials","volume":"2018","author":"Zhou","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.psc.2018.04.010","article-title":"Noninvasive Focused Ultrasound for Neuromodulation: A Review","volume":"41","author":"Bowary","year":"2018","journal-title":"Psychiatr. Clin. N. Am."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1093\/rheumatology\/kei210","article-title":"Pulsed low-intensity ultrasound therapy for chronic lateral epicondylitis: A randomized controlled trial","volume":"45","author":"Ostor","year":"2006","journal-title":"Rheumatology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"197","DOI":"10.7863\/jum.2001.20.3.197","article-title":"Low-intensity pulsed ultrasound initiates bone healing in rat nonunion fracture model","volume":"20","author":"Takikawa","year":"2001","journal-title":"J. Ultrasound Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1046\/j.1540-8175.2001.00259.x","article-title":"Potential use of therapeutic ultrasound in ischemic stroke treatment","volume":"18","author":"Behrens","year":"2001","journal-title":"Echocardiography"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0929-8266(02)00049-6","article-title":"Therapeutic ultrasound in ischemic stroke treatment: Experimental evidence","volume":"16","author":"Daffertshofer","year":"2002","journal-title":"Eur. J. Ultrasound"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(02)00299-5","article-title":"Phonophoresis: Efficiency, mechanisms and skin tolerance","volume":"243","author":"Machet","year":"2002","journal-title":"Int. J. Pharm."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.pbiomolbio.2012.01.004","article-title":"Bio-effects and safety of low-intensity, low-frequency ultrasonic exposure","volume":"108","author":"Ahmadi","year":"2012","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s10396-008-0195-x","article-title":"Therapeutic potential of low-intensity ultrasound (part 2): Biomolecular effects, sonotransfection, and sonopermeabilization","volume":"35","author":"Feril","year":"2008","journal-title":"J. Med. Ultrason."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10396-008-0194-y","article-title":"Therapeutic potential of low-intensity ultrasound (part 1): Thermal and sonomechanical effects","volume":"35","author":"Feril","year":"2008","journal-title":"J. Med. Ultrason."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"De Lucas, B., Perez, L.M., Bernal, A., and Galvez, B.G. (2020). Ultrasound Therapy: Experiences and Perspectives for Regenerative Medicine. Genes, 11.","DOI":"10.3390\/genes11091086"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.ultrasmedbio.2019.12.007","article-title":"Therapeutic Potential Low-Intensity Pulsed Ultrasound for Osteoarthritis: Pre-clinical and Clinical Perspectives","volume":"46","author":"Uddin","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.21037\/tau.2016.02.04","article-title":"Clinical applications of low-intensity pulsed ultrasound and its potential role in urology","volume":"5","author":"Xin","year":"2016","journal-title":"Transl. Androl. Urol."},{"key":"ref_41","first-page":"52","article-title":"Ultrasound as a stimulus for musculoskeletal disorders","volume":"9","author":"Zhang","year":"2017","journal-title":"J. Orthop. Transl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00129334-200610000-00011","article-title":"Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds","volume":"19","author":"Ennis","year":"2006","journal-title":"Adv. Skin Wound Care"},{"key":"ref_43","first-page":"227","article-title":"Effect of ultrasound and dexpanthenol on collagen organization in tegumentary lesions","volume":"15","author":"Guimaraes","year":"2011","journal-title":"Rev. Bras. Fisioter."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"54463","DOI":"10.1074\/jbc.M404786200","article-title":"Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts","volume":"279","author":"Zhou","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_45","unstructured":"Collins, C. (2021, May 02). Wound Care and Healing. Available online: https:\/\/www.defensemedianetwork.com\/stories\/wound-care-and-healing\/."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.berh.2006.12.004","article-title":"Muscle injuries: Optimising recovery","volume":"21","author":"Jarvinen","year":"2007","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1538-7836.2004.00655.x","article-title":"Low-intensity ultrasound increases endothelial cell nitric oxide synthase activity and nitric oxide synthesis","volume":"2","author":"Altland","year":"2004","journal-title":"J. Thromb. Haemost."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Sahu, N., Viljoen, H.J., and Subramanian, A. (2019). Continuous low-intensity ultrasound attenuates IL-6 and TNFalpha-induced catabolic effects and repairs chondral fissures in bovine osteochondral explants. BMC Musculoskelet. Disord., 20.","DOI":"10.1186\/s12891-019-2566-4"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ultrasmedbio.2007.08.008","article-title":"Nitric oxide generation directly responds to ultrasound exposure","volume":"34","author":"Sugita","year":"2008","journal-title":"Ultrasound Med. Biol."},{"key":"ref_50","first-page":"1106","article-title":"Angiogenesis effect of therapeutic ultrasound on HUVECs through activation of the PI3K-Akt-eNOS signal pathway","volume":"7","author":"Huang","year":"2015","journal-title":"Am. J. Transl. Res."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/apmr.2002.26254","article-title":"Continuous therapeutic ultrasound accelerates repair of contraction-induced skeletal muscle damage in rats","volume":"83","author":"Karnes","year":"2002","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_52","first-page":"779","article-title":"Effect of pulsed and continuous therapeutic ultrasound on healthy skeletal muscle in rats","volume":"7","author":"Vasquez","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/00913847.2015.1095617","article-title":"Sustained acoustic medicine: Wearable, long duration ultrasonic therapy for the treatment of tendinopathy","volume":"43","author":"Best","year":"2015","journal-title":"Phys. Sportsmed."},{"key":"ref_54","first-page":"271","article-title":"Low Intensity Ultrasound for Promoting Soft Tissue Healing: A Systematic Review of the Literature and Medical Technology","volume":"2","author":"Best","year":"2016","journal-title":"Intern. Med. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0301-5629(94)00092-1","article-title":"Effect of therapeutic ultrasound on endochondral ossification","volume":"21","author":"Wiltink","year":"1995","journal-title":"Ultrasound Med. Biol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1089\/ten.2006.0130","article-title":"Intermittent applications of continuous ultrasound on the viability, proliferation, morphology, and matrix production of chondrocytes in 3D matrices","volume":"13","author":"Noriega","year":"2007","journal-title":"Tissue Eng."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1089\/ten.tea.2018.0355","article-title":"Continuous Low-Intensity Ultrasound Promotes Native-to-Native Cartilage Integration","volume":"25","author":"Sahu","year":"2019","journal-title":"Tissue Eng. Part A"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1177\/0363546504267356","article-title":"The effects of low-intensity ultrasound on medial collateral ligament healing in the rabbit model","volume":"33","author":"Sparrow","year":"2005","journal-title":"Am. J. Sports Med."},{"key":"ref_59","first-page":"545","article-title":"Efficacy of Sustained Acoustic Medicine as an Add-on to Traditional Therapy in Treating Sport-related Injuries: Case Reports","volume":"2","author":"Draper","year":"2020","journal-title":"Glob. J. Orthop. Res."},{"key":"ref_60","first-page":"24","article-title":"Ultrasound therapy for recalcitrant diabetic foot ulcers: Results of a randomized, double-blind, controlled, multicenter study","volume":"51","author":"Ennis","year":"2005","journal-title":"Ostomy Wound Manag."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2106\/00004623-200102000-00015","article-title":"The use of low-intensity ultrasound to accelerate the healing of fractures","volume":"83","author":"Rubin","year":"2001","journal-title":"J. Bone Jt. Surg. Am."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40258-014-0117-6","article-title":"EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: A NICE medical technology guidance","volume":"12","author":"Higgins","year":"2014","journal-title":"Appl. Health Econ. Health Policy"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/154405910808701018","article-title":"Effects of ultrasound modes on mandibular osteodistraction","volume":"87","author":"Elgazzar","year":"2008","journal-title":"J. Dent. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.1016\/j.bja.2019.03.023","article-title":"Chronic pain: A review of its epidemiology and associated factors in population-based studies","volume":"123","author":"Mills","year":"2019","journal-title":"Br. J. Anaesth."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"S295","DOI":"10.1016\/j.pmrj.2015.09.006","article-title":"Managing Chronic Pain in Children and Adolescents: A Clinical Review","volume":"7","author":"Landry","year":"2015","journal-title":"PM&R"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jpain.2012.03.009","article-title":"The economic costs of pain in the United States","volume":"13","author":"Gaskin","year":"2012","journal-title":"J. Pain"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00296-016-3481-8","article-title":"An overview of treatment approaches for chronic pain management","volume":"37","author":"Duarte","year":"2017","journal-title":"Rheumatol. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tvjl.2018.05.004","article-title":"The neurobiology of acute pain","volume":"237","author":"Bell","year":"2018","journal-title":"Vet. J."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/pm\/pnz102","article-title":"Therapeutic Ultrasound for Chronic Pain Management in Joints: A Systematic Review","volume":"21","author":"Aiyer","year":"2020","journal-title":"Pain Med."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00296-010-1419-0","article-title":"Comparison the efficacy of phonophoresis and ultrasound therapy in myofascial pain syndrome","volume":"31","author":"Ay","year":"2011","journal-title":"Rheumatol. Int."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/PHM.0b013e318174e467","article-title":"Comparing hot pack, short-wave diathermy, ultrasound, and TENS on isokinetic strength, pain, and functional status of women with osteoarthritic knees: A single-blind, randomized, controlled trial","volume":"87","author":"Cetin","year":"2008","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"808","DOI":"10.2522\/ptj.20140559","article-title":"Effect of Continuous-Wave Low-Intensity Ultrasound in Inflammatory Resolution of Arthritis-Associated Synovitis","volume":"96","author":"Chung","year":"2016","journal-title":"Phys. Ther."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/09593980903423079","article-title":"Thermal ultrasound decreases tissue stiffness of trigger points in upper trapezius muscles","volume":"26","author":"Draper","year":"2010","journal-title":"Physiother. Theory Pract."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Ebadi, S., Ansari, N.N., Henschke, N., Naghdi, S., and van Tulder, M.W. (2011). The effect of continuous ultrasound on chronic low back pain: Protocol of a randomized controlled trial. BMC Musculoskelet. Disord., 12.","DOI":"10.1186\/1471-2474-12-59"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Ebadi, S., Ansari, N.N., Naghdi, S., Jalaei, S., Sadat, M., Bagheri, H., Vantulder, M.W., Henschke, N., and Fallah, E. (2012). The effect of continuous ultrasound on chronic non-specific low back pain: A single blind placebo-controlled randomized trial. BMC Musculoskelet. Disord., 13.","DOI":"10.1186\/1471-2474-13-192"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1177\/0269215510367539","article-title":"Efficacy of exercise and ultrasound in patients with lumbar spinal stenosis: A prospective randomized controlled trial","volume":"24","author":"Goren","year":"2010","journal-title":"Clin. Rehabil."},{"key":"ref_77","first-page":"2","article-title":"Continuous versus pulsed ultrasound on myofascial pain syndrome: Randomized single blind controlled trial","volume":"17","author":"Ali","year":"2017","journal-title":"Int. J. Ther. Rehabil. Res."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/PHM.0000000000000210","article-title":"Efficacy of Pulsed and Continuous Therapeutic Ultrasound in Myofascial Pain Syndrome: A Randomized Controlled Study","volume":"94","author":"Ilter","year":"2015","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.2147\/JPR.S247463","article-title":"Low-Intensity Continuous Ultrasound for the Symptomatic Treatment of Upper Shoulder and Neck Pain: A Randomized, Double-Blind Placebo-Controlled Clinical Trial","volume":"13","author":"Petterson","year":"2020","journal-title":"J. Pain Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5539\/gjhs.v4n5p46","article-title":"Management of myofascial pain of upper trapezius: A three group comparison study","volume":"4","author":"Kannan","year":"2012","journal-title":"Glob. J. Health Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/j.jpain.2012.01.390","article-title":"Wearable long-duration ultrasound treatment of chronic trapezius myalgia","volume":"13","author":"Lewis","year":"2012","journal-title":"J. Pain"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.ultrasmedbio.2013.03.007","article-title":"Design and evaluation of a wearable self-applied therapeutic ultrasound device for chronic myofascial pain","volume":"39","author":"Lewis","year":"2013","journal-title":"Ultrasound Med. Biol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/pri.1580","article-title":"Ultrasound and laser as stand-alone therapies for myofascial trigger points: A randomized, double-blind, placebo-controlled study","volume":"19","author":"Manca","year":"2014","journal-title":"Physiother. Res. Int."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/pm\/pny287","article-title":"Therapeutic Ultrasound for Pain Management in Chronic Low Back Pain and Chronic Neck Pain: A Systematic Review","volume":"21","author":"Noori","year":"2020","journal-title":"Pain Med."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"418","DOI":"10.5606\/ArchRheumatol.2018.6538","article-title":"Effectiveness of Ultrasound Therapy on Myofascial Pain Syndrome of the Upper Trapezius: Randomized, Single-Blind, Placebo-Controlled Study","volume":"33","author":"Yildirim","year":"2018","journal-title":"Arch. Rheumatol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5455\/aim.2013.21.170-172","article-title":"Therapeutic ultrasound and pain in degenerative diseases of musculoskeletal system","volume":"21","author":"Muftic","year":"2013","journal-title":"Acta Inform. Med."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.pain.2008.04.009","article-title":"Stimulation of myofascial trigger points with ultrasound induces segmental antinociceptive effects: A randomized controlled study","volume":"139","author":"Srbely","year":"2008","journal-title":"Pain"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/rheumatology\/kem384","article-title":"Low-intensity pulsed ultrasound for chronic patellar tendinopathy: A randomized, double-blind, placebo-controlled trial","volume":"47","author":"Warden","year":"2008","journal-title":"Rheumatology"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S0003-9993(99)90144-2","article-title":"Delayed onset muscle soreness: Lack of effect of therapeutic ultrasound in humans","volume":"80","author":"Craig","year":"1999","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.apmr.2005.02.007","article-title":"Use of ultrasound to increase effectiveness of isokinetic exercise for knee osteoarthritis","volume":"86","author":"Huang","year":"2005","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/art.21590","article-title":"Preliminary results of integrated therapy for patients with knee osteoarthritis","volume":"53","author":"Huang","year":"2005","journal-title":"Arthritis Rheum."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Langer, M.D., Levine, V., Taggart, R., Lewis, G.K., Hernandez, L., and Ortiz, R. (2014, January 25\u201327). Pilot Clinical Studies of Long Duration, Low Intensity Therapeutic Ultrasound for Osteoarthritis. Proceedings of the 40th Annual Northeast Bioengineering Conference (NEBEC), Boston, MA, USA.","DOI":"10.1109\/NEBEC.2014.6972850"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.joca.2014.06.028","article-title":"Effectiveness of continuous and pulsed ultrasound for the management of knee osteoarthritis: A systematic review and network meta-analysis","volume":"22","author":"Zeng","year":"2014","journal-title":"Osteoarthr. Cartil."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/j.ultrasmedbio.2005.07.002","article-title":"The effect of sonication on simulated osteoarthritis. Part I: Effects of 1 MHz ultrasound on uptake of hyaluronan into the rabbit synovium","volume":"31","author":"Park","year":"2005","journal-title":"Ultrasound Med. Biol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.ultrasmedbio.2005.07.001","article-title":"The effect of sonication on simulated osteoarthritis. Part II: Alleviation of osteoarthritis pathogenesis by 1 MHz ultrasound with simultaneous hyaluronate injection","volume":"31","author":"Park","year":"2005","journal-title":"Ultrasound Med. Biol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.joca.2016.06.014","article-title":"Chondro-protective effects of low intensity pulsed ultrasound","volume":"24","author":"Uddin","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1177\/147323001003800404","article-title":"Short-term effectiveness of ultrasound therapy in knee osteoarthritis","volume":"38","author":"Tascioglu","year":"2010","journal-title":"J. Int. Med. Res."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s13018-018-0965-0","article-title":"Effect of low-intensity long-duration ultrasound on the symptomatic relief of knee osteoarthritis: A randomized, placebo-controlled double-blind study","volume":"13","author":"Draper","year":"2018","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.brs.2018.08.013","article-title":"Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications","volume":"11","author":"Fomenko","year":"2018","journal-title":"Brain Stimul."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"17250","DOI":"10.1038\/s41598-018-35486-1","article-title":"Effects of Low Intensity Focused Ultrasound on Liposomes Containing Channel proteins","volume":"8","author":"Babakhanian","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1016\/j.cub.2019.08.021","article-title":"Ultrasonic Neuromodulation via Astrocytic TRPA1","volume":"29","author":"Oh","year":"2019","journal-title":"Curr. Biol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/jnr.23845","article-title":"Prolonged stimulation with low-intensity ultrasound induces delayed increases in spontaneous hippocampal culture spiking activity","volume":"95","author":"Kim","year":"2017","journal-title":"J. Neurosci. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2019.04.002","article-title":"Seizure control by low-intensity ultrasound in mice with temporal lobe epilepsy","volume":"154","author":"Li","year":"2019","journal-title":"Epilepsy Res."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.ultrasmedbio.2018.12.015","article-title":"Ultrasound Neuromodulation: A Review of Results, Mechanisms and Safety","volume":"45","author":"Blackmore","year":"2019","journal-title":"Ultrasound Med. Biol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1016\/j.ultrasmedbio.2017.04.020","article-title":"Neuroprotective Effect of Low-Intensity Pulsed Ultrasound Against MPP(+)-Induced Neurotoxicity in PC12 Cells: Involvement of K2P Channels and Stretch-Activated Ion Channels","volume":"43","author":"Zhao","year":"2017","journal-title":"Ultrasound Med. Biol."},{"key":"ref_106","first-page":"3152","article-title":"Ultrasound Enhances the Expression of Brain-Derived Neurotrophic Factor in Astrocyte Through Activation of TrkB-Akt and Calcium-CaMK Signaling Pathways","volume":"27","author":"Liu","year":"2017","journal-title":"Cereb. Cortex"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ultrasmedbio.2012.09.009","article-title":"Effective parameters for ultrasound-induced in vivo neurostimulation","volume":"39","author":"King","year":"2013","journal-title":"Ultrasound Med. Biol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.brs.2014.06.011","article-title":"Focused ultrasound-mediated non-invasive brain stimulation: Examination of sonication parameters","volume":"7","author":"Kim","year":"2014","journal-title":"Brain Stimul."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"035011","DOI":"10.1088\/1361-6560\/aa9fc2","article-title":"Non-invasive peripheral nerve stimulation via focused ultrasound in vivo","volume":"63","author":"Downs","year":"2018","journal-title":"Phys. Med. Biol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ultrasmedbio.2016.09.017","article-title":"The Effect of Low-Intensity Ultrasound on Brain-Derived Neurotropic Factor Expression in a Rat Sciatic Nerve Crushed Injury Model","volume":"43","author":"Ni","year":"2017","journal-title":"Ultrasound Med. Biol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0041-624X(84)90008-8","article-title":"Use of focused ultrasound for stimulation of nerve structures","volume":"22","author":"Gavrilov","year":"1984","journal-title":"Ultrasonics"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"620863","DOI":"10.3389\/fnins.2021.620863","article-title":"Effect of Low Intensity Transcranial Ultrasound Stimulation on Neuromodulation in Animals and Humans: An Updated Systematic Review","volume":"15","author":"Kim","year":"2021","journal-title":"Front. Neurosci."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fnhum.2020.00052","article-title":"Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans","volume":"14","author":"Sanguinetti","year":"2020","journal-title":"Front. Hum. Neurosci."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/ima.22091","article-title":"Creation of various skin sensations using pulsed focused ultrasound: Evidence for functional neuromodulation","volume":"24","author":"Lee","year":"2014","journal-title":"Int. J. Imaging Syst. Technol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000092396","article-title":"Sonothrombolysis: Experimental evidence","volume":"21","author":"Daffertshofer","year":"2006","journal-title":"Front. Neurol. Neurosci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1540-8175.2001.00239.x","article-title":"Ultrasound-enhanced thrombolysis","volume":"18","author":"Francis","year":"2001","journal-title":"Echocardiography"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"649","DOI":"10.7863\/jum.2002.21.6.649","article-title":"Low-frequency ultrasound induces nonenzymatic thrombolysis in vitro","volume":"21","author":"Nedelmann","year":"2002","journal-title":"J. Ultrasound Med."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1161\/STROKEAHA.107.496117","article-title":"Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: Neurologic and histologic evaluation in a rat middle cerebral artery stroke model","volume":"39","author":"Saguchi","year":"2008","journal-title":"Stroke"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.ultrasmedbio.2014.01.015","article-title":"Improved sonothrombolysis from a modified diagnostic transducer delivering impulses containing a longer pulse duration","volume":"40","author":"Wu","year":"2014","journal-title":"Ultrasound Med. Biol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1182\/blood.V81.10.2636.2636","article-title":"Characterization of ultrasound-potentiated fibrinolysis in vitro","volume":"81","author":"Blinc","year":"1993","journal-title":"Blood"},{"key":"ref_121","first-page":"697s","article-title":"Thrombolysis by ultrasound","volume":"3","author":"Trubestein","year":"1976","journal-title":"Clin. Sci. Mol. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0967-2109(96)00093-2","article-title":"Ultrasound enhancement of rabbit femoral artery thrombolysis","volume":"5","author":"Riggs","year":"1997","journal-title":"Cardiovasc. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1161\/01.CIR.101.19.2296","article-title":"Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: Enhancement of thrombolysis and improvement in capillary muscle perfusion","volume":"101","author":"Suchkova","year":"2000","journal-title":"Circulation"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000086122","article-title":"Ultrasound-induced blood clot dissolution without a thrombolytic drug is more effective with lower frequencies","volume":"20","author":"Nedelmann","year":"2005","journal-title":"Cerebrovasc. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"765","DOI":"10.29271\/jcpsp.2020.07.765","article-title":"Transcranial Pulsed Ultrasound with Alteplase Intravenous Thrombolysis for Vascular Recanalisation in Acute Ischemic Stroke","volume":"30","author":"Chen","year":"2020","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"e009536","DOI":"10.1161\/CIRCIMAGING.119.009536","article-title":"Sonothrombolysis Improves Myocardial Dynamics and Microvascular Obstruction Preventing Left Ventricular Remodeling in Patients with ST Elevation Myocardial Infarction","volume":"13","author":"Aguiar","year":"2020","journal-title":"Circ. Cardiovasc. Imaging"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrd4363","article-title":"Overcoming the challenges in administering biopharmaceuticals: Formulation and delivery strategies","volume":"13","author":"Mitragotri","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/nbt.1504","article-title":"Transdermal drug delivery","volume":"26","author":"Prausnitz","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1088\/0031-9155\/60\/6\/2421","article-title":"Cavitation-enhanced delivery of insulin in agar and porcine models of human skin","volume":"60","author":"Feiszthuber","year":"2015","journal-title":"Phys. Med. Biol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.2147\/IJN.S174759","article-title":"Recent advances in ultrasound-based transdermal drug delivery","volume":"13","author":"Seah","year":"2018","journal-title":"Int. J. Nanomed."},{"key":"ref_131","first-page":"OL767","article-title":"Transdermal drug delivery using ultrasound-theory, understanding and critical analysis","volume":"51","author":"Sivakumar","year":"2005","journal-title":"Cell Mol. Biol."},{"key":"ref_132","first-page":"585","article-title":"Perspectives on transdermal ultrasound mediated drug delivery","volume":"2","author":"Smith","year":"2007","journal-title":"Int. J. Nanomed."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"75074","DOI":"10.1121\/1.4801417","article-title":"\u201cSonoBandage\u201d a transdermal ultrasound drug delivery system for peripheral neuropathy","volume":"19","author":"Langer","year":"2013","journal-title":"Proc. Meet. Acoust."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1248\/cpb.40.2826","article-title":"External control of drug release and penetration. VI. Enhancing effect of ultrasound on the transdermal absorption of indomethacin from an ointment in rats","volume":"40","author":"Miyazaki","year":"1992","journal-title":"Chem. Pharm. Bull."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1269\/jrr.45.479","article-title":"Biological effects of low intensity ultrasound: The mechanism involved, and its implications on therapy and on biosafety of ultrasound","volume":"45","author":"Feril","year":"2004","journal-title":"J. Radiat. Res."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1158\/1078-0432.CCR-06-2443","article-title":"Pulsed-high intensity focused ultrasound and low temperature-sensitive liposomes for enhanced targeted drug delivery and antitumor effect","volume":"13","author":"Dromi","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"343re2","DOI":"10.1126\/scitranslmed.aaf6086","article-title":"Clinical trial of blood-brain barrier disruption by pulsed ultrasound","volume":"8","author":"Carpentier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/14764170802524445","article-title":"Evaluation of histologic and electron microscopic changes after novel treatment using combined microdermabrasion and ultrasound-induced phonophoresis of human skin","volume":"10","author":"Dudelzak","year":"2008","journal-title":"J. Cosmet. Laser Ther."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/ptj\/83.8.707","article-title":"Phonophoresis versus topical application of ketoprofen: Comparison between tissue and plasma levels","volume":"83","author":"Cagnie","year":"2003","journal-title":"Phys. Ther."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.ultsonch.2014.02.017","article-title":"Investigating the sonophoresis effect on the permeation of diclofenac sodium using 3D skin equivalent","volume":"22","author":"Aldwaikat","year":"2015","journal-title":"Ultrason. Sonochem."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"363","DOI":"10.4155\/tde-2020-0009","article-title":"Sustained acoustic medicine; sonophoresis for nonsteroidal anti-inflammatory drug delivery in arthritis","volume":"11","author":"Masterson","year":"2020","journal-title":"Ther. Deliv."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2174\/1874325002014010176","article-title":"Sustained Acoustic Medicine Combined with A Diclofenac Ultrasound Coupling Patch for the Rapid Symptomatic Relief of Knee Osteoarthritis: Multi-Site Clinical Efficacy Study","volume":"14","author":"Madzia","year":"2020","journal-title":"Open Orthop. J."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jconrel.2012.08.019","article-title":"Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound","volume":"163","author":"Schoellhammer","year":"2012","journal-title":"J. Control. Release"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jconrel.2015.02.002","article-title":"Applicability and safety of dual-frequency ultrasonic treatment for the transdermal delivery of drugs","volume":"202","author":"Schoellhammer","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_145","first-page":"5","article-title":"Enhancing percutaneous permeability of sinomenine hydrochloride using dual-frequency sonophoresis","volume":"36","author":"Yin","year":"2016","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"ref_146","first-page":"5717","article-title":"Ultrasound-Enhanced Ciclopirox Delivery for Treatment of Onychomycosis","volume":"2018","author":"Le","year":"2018","journal-title":"Conf. Proc. IEEE Eng. Med. Biol. Soc."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.7863\/jum.2004.23.10.1349","article-title":"Drug delivery into the eye with the use of ultrasound","volume":"23","author":"Zderic","year":"2004","journal-title":"J. Ultrasound Med."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ultras.2006.07.021","article-title":"In vitro ultrasound-mediated leakage from phospholipid vesicles","volume":"45","author":"Pong","year":"2006","journal-title":"Ultrasonics"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pbiomolbio.2006.07.005","article-title":"Therapeutic applications of ultrasound","volume":"93","year":"2007","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1211\/jpp.61.06.0001","article-title":"Sonophoresis: Recent advancements and future trends","volume":"61","author":"Rao","year":"2009","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.ultrasmedbio.2005.06.008","article-title":"The antivascular action of physiotherapy ultrasound on murine tumors","volume":"31","author":"Wood","year":"2005","journal-title":"Ultrasound Med. Biol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3892\/or.2012.1816","article-title":"Effects of low-intensity pulsed ultrasound on osteosarcoma and cancer cells","volume":"28","author":"Sawai","year":"2012","journal-title":"Oncol. Rep."},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"111448","DOI":"10.1016\/j.yexcr.2019.05.029","article-title":"Regulation of exosomes secretion by low-intensity pulsed ultrasound in lung cancer cells","volume":"383","author":"Zeng","year":"2019","journal-title":"Exp. Cell Res."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ultsonch.2003.07.002","article-title":"Treatment of transplanted adriamycin-resistant ovarian cancers in mice by combination of adriamycin and ultrasound exposure","volume":"11","author":"Yu","year":"2004","journal-title":"Ultrason. Sonochem."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1346-8138.2000.tb02171.x","article-title":"Combination effect of photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H\/HeN mice","volume":"27","author":"Jin","year":"2000","journal-title":"J. Dermatol."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ultrasmedbio.2008.11.004","article-title":"Treatment of murine tumors using dual-frequency ultrasound in an experimental in vivo model","volume":"35","author":"Barati","year":"2009","journal-title":"Ultrasound Med. Biol."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.ultsonch.2006.12.016","article-title":"Effect of exposure parameters on cavitation induced by low-level dual-frequency ultrasound","volume":"14","author":"Barati","year":"2007","journal-title":"Ultrason. Sonochem."},{"key":"ref_158","first-page":"897","article-title":"Mechanism of photofrin-enhanced ultrasound-induced human glioma cell death","volume":"29","author":"Hayashi","year":"2009","journal-title":"Anticancer Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00330-014-3334-3","article-title":"Activation of microbubbles by low-level therapeutic ultrasound enhances the antitumor effects of doxorubicin","volume":"24","author":"Yang","year":"2014","journal-title":"Eur. Radiol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1002\/jps.22088","article-title":"Distribution of doxorubicin in rats undergoing ultrasonic drug delivery","volume":"99","author":"Staples","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13046-018-1018-6","article-title":"Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells","volume":"38","author":"Loria","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ultras.2011.08.002","article-title":"The targeted gene (KDRP-CD\/TK) therapy of breast cancer mediated by SonoVue and ultrasound irradiation in vitro","volume":"52","author":"Li","year":"2012","journal-title":"Ultrasonics"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.ultrasmedbio.2010.02.001","article-title":"Antivascular ultrasound therapy extends survival of mice with implanted melanomas","volume":"36","author":"Wood","year":"2010","journal-title":"Ultrasound Med. Biol."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1038\/srep16354","article-title":"Low-intensity continuous ultrasound triggers effective bisphosphonate anticancer activity in breast cancer","volume":"5","author":"Tardoski","year":"2015","journal-title":"Sci. Rep."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1109\/TBCAS.2019.2947395","article-title":"A Miniaturized Low-Intensity Ultrasound Device for Wearable Medical Therapeutic Applications","volume":"13","author":"Jiang","year":"2019","journal-title":"IEEE Trans. Biomed. Circuits Syst."},{"key":"ref_166","first-page":"94670I","article-title":"Sustained Acoustic Medicine: A Novel Long Duration Approach to Biomodulation Utilizing Low Intensity Therapeutic Ultrasound","volume":"9467","author":"Langer","year":"2015","journal-title":"Proc. SPIE Int. Soc. Opt. Eng."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s42358-019-0099-z","article-title":"Comparison of the effects of low-level laser and pulsed and continuous ultrasound on pain and physical disability in chronic non-specific low back pain: A randomized controlled clinical trial","volume":"59","author":"Rubira","year":"2019","journal-title":"Adv. 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