{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T08:13:15Z","timestamp":1766391195268,"version":"build-2065373602"},"reference-count":39,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T00:00:00Z","timestamp":1624320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CONSEJER\u00cdA DE SALUD Y FAMILIAS. JUNTA DE ANDALUC\u00cdA. PROYECTOS DE INNOVACI\u00d3N EN SALUD 2017","award":["PIN-0530-2017 \"."],"award-info":[{"award-number":["PIN-0530-2017 \"."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study sought to develop a diagnostic model with aberrometry and biomechanical variables for subclinical keratoconus. The design was a cross-sectional study. The topographic data were obtained with a rotating Scheimpflug camera (Pentacam HR), and biomechanical data were obtained with Corvis ST. The study included 81 eyes distributed in 61 healthy corneas and 20 subclinical keratoconus (SCKC), defined as eyes with suspicious topographic findings, normal slit-lamp examination, and a manifestation of keratoconus. Analyses of the topographic and biomechanical data were performed, and a classifying model of SCKC was elaborated. The model for the diagnosis of SCKC includes posterior coma to 90\u00b0, Ambr\u00f3sio\u2019s Relational Thickness in the horizontal profile (ARTh), and velocity when the air pulse is off (A2 velocity). The sensitivity was 89.5%, specificity 96.7%, accuracy 94.9%, and precision 89.5%. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the model was 0.951. Diagnosis of subclinical keratoconus depends on the aberrometry variable posterior coma to 90\u00b0 and the biomechanical variables A2 velocity and ARTh.<\/jats:p>","DOI":"10.3390\/jcm10132746","type":"journal-article","created":{"date-parts":[[2021,6,22]],"date-time":"2021-06-22T13:02:10Z","timestamp":1624366930000},"page":"2746","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Diagnosis of Subclinical Keratoconus with a Combined Model of Biomechanical and Topographic Parameters"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2104-2907","authenticated-orcid":false,"given":"Antonio","family":"P\u00e9rez-Rueda","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Torrec\u00e1rdenas University Hospital, 04009 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1169-0428","authenticated-orcid":false,"given":"Diana","family":"Jim\u00e9nez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-9728","authenticated-orcid":false,"given":"Gracia","family":"Castro-Luna","sequence":"additional","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine, University of Almer\u00eda, 04120 Almer\u00eda, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1097\/00003226-200210000-00008","article-title":"Between-Eye Asymmetry in Keratoconus","volume":"21","author":"Zadnik","year":"2002","journal-title":"Cornea"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1475-1313.1996.95000178.x","article-title":"An evaluation of the keratoconic cornea using computerised corneal mapping and ultrasonic measurements of corneal thickness","volume":"16","author":"Owens","year":"1996","journal-title":"Ophthalmic Physiol. 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