{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:26:53Z","timestamp":1790483213734,"version":"4.1.0"},"reference-count":49,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Measurement of cerebral oximetry by near-infrared spectroscopy provides continuous and non-invasive information about the oxygen saturation of haemoglobin in the central nervous system. This is especially important in the case of patients with traumatic brain injuries. Monitoring of cerebral oximetry in these patients could allow for the diagnosis of inadequate cerebral oxygenation caused by disturbances in cerebral blood flow. It could enable identification of episodes of hypoxia and cerebral ischemia. Continuous bedside measurement could facilitate the rapid diagnosis of intracranial bleeding or cerebrovascular autoregulation disorders and accelerate the implementation of treatment. However, it should be remembered that the method of monitoring cerebral oximetry by means of near-infrared spectroscopy also has its numerous limitations, resulting mainly from its physical properties. This paper summarizes the usefulness of monitoring cerebral oximetry by near-infrared spectroscopy in patients with traumatic brain injury, taking into account the advantages and the disadvantages of this technique.<\/jats:p>","DOI":"10.3390\/jcm10132938","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T10:03:19Z","timestamp":1625047399000},"page":"2938","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Usefulness of Cerebral Oximetry in TBI by NIRS"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-2421","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Barud","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0449-2375","authenticated-orcid":false,"given":"Wojciech","family":"Dabrowski","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1001-0080","authenticated-orcid":false,"given":"Dorota","family":"Siwicka-Gieroba","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, 20-954 Lublin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Robba","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Policlinico San Martino, 16100 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bielacz","sequence":"additional","affiliation":[{"name":"Institute of Tourism and Recreation, State Vocational College of Szymon Szymonowicz, 22-400 Zamosc, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7017-0150","authenticated-orcid":false,"given":"Rafael","family":"Badenes","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Intensive Care, Hospital Cl\u00ecnico Universitario de Valencia, University of Valencia, 46010 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition","volume":"80","author":"Carney","year":"2017","journal-title":"Neurosurgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1542\/peds.75.2.217","article-title":"Noninvasive monitoring of cerebral oxygenation in preterm infants: Preliminary observations","volume":"75","author":"Brazy","year":"1985","journal-title":"Pediatrics"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1213\/01.ane.0000246814.29362.f4","article-title":"Monitoring brain oxygen saturation during coronary bypass surgery: A randomized, prospective study","volume":"104","author":"Murkin","year":"2007","journal-title":"Anesth. Analg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1126\/science.929199","article-title":"Noninvasive infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters","volume":"23","author":"Jobsis","year":"1977","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.siny.2010.05.003","article-title":"Near-infrared spectroscopy: A methodology-focused review","volume":"16","author":"Pellicer","year":"2011","journal-title":"Semin. Fetal Neonatal Med."},{"key":"ref_6","first-page":"605","article-title":"New technology for noninvasive brain monitoring: Continuous cerebral oximetry","volume":"72","author":"Casati","year":"2006","journal-title":"Minerva Anestesiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/bja\/aep299","article-title":"Near-infrared spectroscopy as an index of brain and tissue oxygenation","volume":"103","author":"Murkin","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/bja\/82.3.418","article-title":"Near infrared spectroscopy","volume":"82","author":"Smith","year":"1999","journal-title":"Br. J. Anaesth."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0301-0082(98)00093-8","article-title":"Near-infrared oximetry of the brain","volume":"58","author":"Madsen","year":"1999","journal-title":"Prog. Neurobiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1089\/neu.2014.3748","article-title":"Near-Infrared Spectroscopy in the Monitoring of Adult Traumatic Brain Injury: A Review","volume":"32","author":"Davies","year":"2015","journal-title":"J. Neurotrauma"},{"key":"ref_11","first-page":"876","article-title":"Assessment of cerebral oxygenation in neurocritical care patients: Comparison of a new four wavelengths forehead regional saturation in oxygen sensor (EQUANOX\u00ae) with brain tissue oxygenation. A prospective observational study","volume":"81","author":"Esnault","year":"2015","journal-title":"Minerva Anestesiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00134-010-1920-7","article-title":"Invasive and noninvasive assessment of cerebral oxygenation in patients with severe traumatic brain injury","volume":"36","author":"Cayuela","year":"2010","journal-title":"Intensive Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00004647-200205000-00012","article-title":"Comparison of near-infrared spectroscopy and tissue P(O2) time series in patients after severe head injury and aneurysmal subarachnoid hemorrhage","volume":"22","author":"Brawanski","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/01616412.1997.11740807","article-title":"Dynamic changes of cerebral oxygenation measured by brain tissue oxygen pressure and near infrared spectroscopy","volume":"19","author":"Holzschuh","year":"1997","journal-title":"Neurol. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1460-9592.2007.02365.x","article-title":"Comparison of different near-infrared spectroscopic cerebral oxygenation indices with central venous and jugular venous oxygenation saturation in children","volume":"18","author":"Nagdyman","year":"2008","journal-title":"Paediatr. Anaesth."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jcrc.2016.11.006","article-title":"Can the cerebral regional oxygen saturation be a perfusion parameter in shock?","volume":"38","author":"Abouelela","year":"2017","journal-title":"J. Crit. Care"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Forcione, M., Ganau, M., Prisco, L., Chiarelli, A.M., Bellelli, A., Belli, A., and Davies, D.J. (2021). Mismatch between Tissue Partial Oxygen Pressure and Near-Infrared Spectroscopy Neuromonitoring of Tissue Respiration in Acute Brain Trauma: The Rationale for Implementing a Multimodal Monitoring Strategy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031122"},{"key":"ref_18","first-page":"549","article-title":"Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury","volume":"88","author":"Gupta","year":"1999","journal-title":"Anesth. Analg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"438","DOI":"10.3171\/jns.1997.86.3.0438","article-title":"Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury","volume":"86","author":"Lam","year":"1997","journal-title":"J. Neurosurg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/ALN.0000000000001625","article-title":"Cerebral Autoregulation-oriented Therapy at the Bedside: A Comprehensive Review","volume":"126","author":"Geocadin","year":"2017","journal-title":"Anesthesiology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/jcbfm.2012.189","article-title":"Cerebral autoregulation after subarachnoid hemorrhage: Comparison of three methods","volume":"33","author":"Budohoski","year":"2013","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1097\/CCM.0b013e3182514eb6","article-title":"Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury","volume":"40","author":"Aries","year":"2012","journal-title":"Crit. Care Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1213\/ANE.0b013e31823d292a","article-title":"Predicting the limits of cerebral autoregulation during cardiopulmonary bypass","volume":"114","author":"Joshi","year":"2012","journal-title":"Anesth. Analg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1161\/01.STR.26.12.2285","article-title":"Can cerebrovascular reactivity be measured with near-infrared spectroscopy?","volume":"26","author":"Smielewski","year":"1995","journal-title":"Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1161\/STROKEAHA.107.485706","article-title":"Continuous time-domain analysis of cerebrovascular autoregulation using near-infrared spectroscopy","volume":"38","author":"Brady","year":"2007","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/ANA.0000000000000607","article-title":"The Role of Near-infrared Spectroscopy in Cerebral Autoregulation Monitoring","volume":"31","author":"Bush","year":"2019","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12028-008-9140-5","article-title":"Near-infrared spectroscopy can monitor dynamic cerebral autoregulation in adults","volume":"10","author":"Steiner","year":"2009","journal-title":"Neurocrit. Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s12028-012-9721-1","article-title":"Continuous cerebral blood flow autoregulation monitoring in patients undergoing liver transplantation","volume":"17","author":"Zheng","year":"2012","journal-title":"Neurocrit. Care"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tsalach, A., Ratner, E., Lokshin, S., Silman, Z., Breskin, I., Budin, N., and Kamar, M. (2016). Cerebral Autoregulation Real-Time Monitoring. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0161907"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1097\/00008506-200207000-00008","article-title":"Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: A pilot study","volume":"14","author":"Gora","year":"2002","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1152\/jappl.1999.87.5.1981","article-title":"Measurement of cerebral blood volume using near-infrared spectroscopy and indocyanine green elimination","volume":"87","author":"Hopton","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/ANA.0000000000000084","article-title":"Intravenously administered indocyanine green may cause falsely high near-infrared cerebral oximetry readings","volume":"27","author":"Yoo","year":"2015","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1053-8119(03)00315-X","article-title":"Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dye dilution","volume":"20","author":"Keller","year":"2003","journal-title":"NeuroImage"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1177\/0271678X19872564","article-title":"Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI","volume":"40","author":"Milej","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1385\/NCC:4:1:008","article-title":"Impact of intracranial pressure and cerebral perfusion pressure on severe disability and mortality after head injury","volume":"4","author":"Balestreri","year":"2006","journal-title":"Neurocrit. Care"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/978-3-7091-6837-0_35","article-title":"Near infrared spectroscopy (NIRS) in patients with severe brain injury and elevated intracranial pressure. A pilot study","volume":"70","author":"Kampfl","year":"1997","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/978-3-319-22533-3_29","article-title":"Plateau Waves of Intracranial Pressure and Multimodal Brain Monitoring","volume":"122","author":"Dias","year":"2016","journal-title":"Acta Neurochir. Suppl."},{"key":"ref_38","first-page":"514","article-title":"Diagnosis influences response of cerebral near infrared spectroscopy to intracranial hypertension in children","volume":"11","author":"Zuluaga","year":"2010","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e034015","DOI":"10.1117\/1.3146814","article-title":"Diffuse optical monitoring of hemodynamic changes in piglet brain with closed head injury","volume":"14","author":"Zhou","year":"2009","journal-title":"J. Biomed. Opt."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1177\/0271678X19846657","article-title":"Continuous non-invasive optical monitoring of cerebral blood flow and oxidative metabolism after acute brain injury","volume":"39","author":"Baker","year":"2019","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_41","first-page":"4407","article-title":"Haemoglobin oxygen saturation as a biomarker: The problem and a solution","volume":"369","author":"Boas","year":"2011","journal-title":"Philos. Trans. A Math. Phys. Eng. Sci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.xjtc.2021.01.023","article-title":"The role of diffuse correlation spectroscopy and frequency-domain near-infrared spectroscopy in monitoring cerebral hemodynamics during hypothermic circulatory arrests","volume":"7","author":"Zavriyev","year":"2021","journal-title":"JTCVS Tech."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.jcrc.2013.05.004","article-title":"Dynamic evaluation of near-infrared peripheral oximetry in healthy volunteers: A comparison between INVOS and EQUANOX","volume":"28","author":"Fellahi","year":"2013","journal-title":"J. Crit. Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/00000542-200703000-00009","article-title":"Effects of hemoglobin concentration, skull thickness, and the area of the cerebrospinal fluid layer on near-infrared spectroscopy measurements","volume":"106","author":"Yoshitani","year":"2007","journal-title":"Anesthesiology"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10877-012-9348-y","article-title":"Monitoring tissue oxygenation by near infrared spectroscopy (NIRS): Background and current applications","volume":"26","author":"Scheeren","year":"2012","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/cpf.12156","article-title":"Influence of skin blood flow and source-detector distance on near-infrared spectroscopy-determined cerebral oxygenation in humans","volume":"35","author":"Hirasawa","year":"2015","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1046\/j.1365-2044.2002.02826.x","article-title":"A comparison of cerebral oxygenation as measured by the NIRO 300 and the INVOS 5100 Near-Infrared Spectrophotometers","volume":"57","author":"Thavasothy","year":"2002","journal-title":"Anaesthesia"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1179\/174313209X383286","article-title":"Near infrared technology in neuroscience: Past, present and future","volume":"31","author":"Alaraj","year":"2009","journal-title":"Neurol. Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1097\/00003246-199707000-00031","article-title":"Failure of the INVOS 3100 cerebral oximeter to detect complete absence of cerebral blood flow","volume":"25","author":"Gomersall","year":"1997","journal-title":"Crit. Care Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/13\/2938\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:23:52Z","timestamp":1760163832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/13\/2938"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":49,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["jcm10132938"],"URL":"https:\/\/doi.org\/10.3390\/jcm10132938","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}