{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:09:52Z","timestamp":1785190192944,"version":"3.55.0"},"reference-count":130,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Through the years, the available psychopharmacological treatments have expanded with numerous new drugs. Besides weight gain, gastro-intestinal problems or Parkinson-like symptoms, ocular adverse effects of psychiatric drugs have been reported. These adverse effects are not common, but can be dangerous for the patient. This review summarises the current knowledge on the risk of raised intraocular pressure and glaucoma entailed by psychopharmacological treatment. Also, it provides updated data for clinicians involved in the treatment of patients with glaucoma or glaucoma risk factors. For this purpose, we performed an extensive literature search in the PubMed database using specific terms. Selective serotonin and noradrenaline reuptake inhibitors are the best evidenced as having no association with glaucoma. Antipsychotics, and especially first generation, seem to have no correlation with an increased intraocular pressure and therefore possibly with a risk of glaucoma, although a special attention should be paid when using ziprasidone. Tricyclic antidepressants, benzodiazepines and topiramate should be avoided in patients diagnosed with glaucoma or at risk. Clinicians should be aware of the possible psychotropic drug induced glaucoma and monitor at risk patients closely in order to prevent this condition. Irrespective of the psychopharmacological regimen taken into consideration, the glaucoma patient should be under the strict supervision of the ophthalmologist.<\/jats:p>","DOI":"10.3390\/jcm10132947","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T10:03:19Z","timestamp":1625047399000},"page":"2947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2520-5486","authenticated-orcid":false,"given":"Adela Magdalena","family":"Ciobanu","sequence":"first","affiliation":[{"name":"Neuroscience Department, Discipline of Psychiatry, Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0075-0050","authenticated-orcid":false,"given":"Vlad","family":"Dionisie","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"},{"name":"Department of Psychiatry and Psychology, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Neagu","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otilia Maria","family":"Bolog","sequence":"additional","affiliation":[{"name":"Service d\u2019Ophtalmologie, Centre Hospitalier \u2018Rene Dubos\u2019, 95300 Pontoise, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sorin","family":"Riga","sequence":"additional","affiliation":[{"name":"Department of Stress Research and Prophylaxis, \u2018Prof. Dr. Alexandru Obregia\u2019 Clinical Hospital of Psychiatry, 041914 Bucharest, Romania"},{"name":"Romanian Academy of Medical Sciences, 927180 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4112-083X","authenticated-orcid":false,"given":"Ovidiu","family":"Popa-Velea","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology, Faculty of Medicine, \u2018Carol Davila\u2019 University of Medicine and Pharmacy, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"596","DOI":"10.2174\/1381612822666161129151308","article-title":"Glaucoma: Hot Topics in Pharmacology","volume":"23","author":"Balendra","year":"2017","journal-title":"Curr. Pharm. Des."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1221","DOI":"10.1016\/S2214-109X(17)30393-5","article-title":"Global Causes of Blindness and Distance Vision Impairment 1990\u20132020: A Systematic Review and Meta-Analysis","volume":"5","author":"Flaxman","year":"2017","journal-title":"Lancet Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.revmed.2018.12.001","article-title":"Le glaucome primitif \u00e0 angle ouvert","volume":"40","author":"Bertaud","year":"2019","journal-title":"Rev. Med. Interne"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1442-9071.2012.02773.x","article-title":"Definition of Glaucoma: Clinical and Experimental Concepts: Definition of Glaucoma","volume":"40","author":"Casson","year":"2012","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_5","first-page":"887","article-title":"Glaucoma Is Second Leading Cause of Blindness Globally","volume":"82","author":"Kingman","year":"2004","journal-title":"Bull. World Health Organ."},{"key":"ref_6","first-page":"225","article-title":"The Diagnosis and Treatment of Glaucoma","volume":"117","author":"Schuster","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma: A Review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.optom.2016.02.003","article-title":"Glaucoma History and Risk Factors","volume":"10","author":"McMonnies","year":"2017","journal-title":"J. Optom."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.pop.2015.05.008","article-title":"Glaucoma","volume":"42","author":"Mantravadi","year":"2015","journal-title":"Prim. Care"},{"key":"ref_10","unstructured":"Salmon, J. (2019). Kanski\u2019s Clinical Ophthalmology: A Systematic Approach, Elsevier Health Sciences. [9th ed.]."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of People with Glaucoma Worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1001\/archopht.122.4.532","article-title":"Prevalence of Open-Angle Glaucoma among Adults in the United States","volume":"122","author":"Friedman","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"ref_13","first-page":"174","article-title":"Risk Factors and Long Term Progression in Open Angle Glaucoma Patients","volume":"60","author":"Pantalon","year":"2016","journal-title":"Rom. J. Ophthalmol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.ophtha.2015.11.004","article-title":"Prevalence, Awareness, and Risk Factors of Primary Open-Angle Glaucoma: Korea National Health and Nutrition Examination Survey 2008\u20132011","volume":"123","author":"Kim","year":"2016","journal-title":"Ophthalmology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ajo.2017.06.003","article-title":"Risk Factors for Rapid Glaucoma Disease Progression","volume":"180","author":"Chan","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5005\/jp-journals-10028-1226","article-title":"Steroid-Induced Glaucoma: An Avoidable Irreversible Blindness","volume":"11","author":"Phulke","year":"2017","journal-title":"J. Curr. Glaucoma Pract."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"C174","DOI":"10.12968\/hmed.2019.80.12.C174","article-title":"Acute Angle Closure Glaucoma","volume":"80","author":"Tatham","year":"2019","journal-title":"Br. J. Hosp. Med."},{"key":"ref_18","first-page":"S118","article-title":"Drug-Induced Secondary Glaucoma","volume":"93","author":"Boonyaleephan","year":"2010","journal-title":"J. Med. Assoc. Thai"},{"key":"ref_19","first-page":"1937","article-title":"Open-Angle Glaucoma","volume":"67","author":"Distelhorst","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"351","DOI":"10.24869\/psyd.2017.351","article-title":"Glaucoma, Depression and Quality of Life: Multiple Comorbidities, Multiple Assessments and Multidisciplinary Plan Treatment","volume":"29","author":"Biuk","year":"2017","journal-title":"Psychiatr. Danub."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"11671","DOI":"10.1038\/s41598-018-29489-1","article-title":"Illness Uncertainty, Anxiety and Depression in Chinese Patients with Glaucoma or Cataract","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_22","first-page":"41","article-title":"Associating Factors of Insomnia and Depression in Glaucoma: A Descriptive Analysis","volume":"4","author":"Akhilesh","year":"2018","journal-title":"Int. Multispec. J. Health IMJH"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/0706743716659417","article-title":"Canadian Network for Mood and Anxiety Treatments (CANMAT) 2016 Clinical Guidelines for the Management of Adults with Major Depressive Disorder: Section 3. Pharmacological Treatments: Section 3. Pharmacological Treatments","volume":"61","author":"Kennedy","year":"2016","journal-title":"Can. J. Psychiatry"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3109\/15622975.2013.804195","article-title":"Task Force on Unipolar Depressive Disorders. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Unipolar Depressive Disorders, Part 1: Update 2013 on the Acute and Continuation Treatment of Unipolar Depressive Disorders","volume":"14","author":"Bauer","year":"2013","journal-title":"World J. Biol. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.31887\/DCNS.2010.12.2\/mkellner","article-title":"Drug Treatment of Obsessive-Compulsive Disorder","volume":"12","author":"Kellner","year":"2010","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/14656566.2018.1491966","article-title":"Pharmacotherapy for Generalized Anxiety Disorder in Adult and Pediatric Patients: An Evidence-Based Treatment Review","volume":"19","author":"Strawn","year":"2018","journal-title":"Expert Opin. Pharmacother."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2165\/00003495-200464040-00004","article-title":"SSRIs versus Non-SSRIs in Post-Traumatic Stress Disorder: An Update with Recommendations","volume":"64","author":"Asnis","year":"2004","journal-title":"Drugs"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2165\/00023210-200418080-00001","article-title":"SSRIs and Intraocular Pressure Modifications: Evidence, Therapeutic Implications and Possible Mechanisms","volume":"18","author":"Costagliola","year":"2004","journal-title":"CNS Drugs"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.survophthal.2018.09.006","article-title":"Association between Serotonin-Norepinephrine Reuptake Inhibitors and Acute Angle Closure: What Is Known?","volume":"64","author":"Kaluzny","year":"2019","journal-title":"Surv. Ophthalmol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1080\/15569527.2017.1330270","article-title":"Effects of Selective Serotonin Reuptake Inhibitors on Intraocular Pressure and Anterior Segment Parameters in Open Angle Eyes","volume":"37","year":"2018","journal-title":"Cutan. Ocul. Toxicol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.optom.2017.08.002","article-title":"Beta2 Adrenergic Receptor Silencing Change Intraocular Pressure in New Zealand Rabbits","volume":"11","author":"Loma","year":"2018","journal-title":"J. Optom."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1089\/jop.2017.0133","article-title":"How Does Usage of Serotonin Noradrenaline Reuptake Inhibitors Affect Intraocular Pressure in Depression Patients?","volume":"34","year":"2018","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"358","DOI":"10.18071\/isz.70.0358","article-title":"Bilateral Acute Angle-Closure Glaucoma Induced by Duloxetine","volume":"70","author":"Mahmut","year":"2017","journal-title":"Ideggyogy. Sz."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Vall\u00e9e, A., Vall\u00e9e, J.-N., and Lecarpentier, Y. (2021). Lithium and Atypical Antipsychotics: The Possible WNT\/\u03b2 Pathway Target in Glaucoma. Biomedicines, 9.","DOI":"10.3390\/biomedicines9050473"},{"key":"ref_35","unstructured":"Stahl, S.M. (2008). Essential Psychopharmacology Series: Stahl\u2019s Essential Psychopharmacology: Neuroscientific Basis and Practical Applications, Cambridge University Press. [3rd ed.]."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1001\/jamaophthalmol.2015.2180","article-title":"Risk of Angle-Closure Glaucoma with Bupropion and Topiramate","volume":"133","author":"Symes","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Chen, V.C.-H., Ng, M.-H., Chiu, W.-C., McIntyre, R.S., Lee, Y., Lin, T.-Y., Weng, J.-C., Chen, P.-C., and Hsu, C.-Y. (2017). Effects of Selective Serotonin Reuptake Inhibitors on Glaucoma: A Nationwide Population-Based Study. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0173005"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4065\/76.5.511","article-title":"Pharmacology of antidepressants","volume":"76","author":"Richelson","year":"2001","journal-title":"Mayo Clin. Proc."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Stein, J.D., Talwar, N., Kang, J.H., Okereke, O.I., Wiggs, J.L., and Pasquale, L.R. (2015). Bupropion Use and Risk of Open-Angle Glaucoma among Enrollees in a Large U.S. Managed Care Network. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0123682"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"749","DOI":"10.2165\/00002018-200326110-00002","article-title":"Drug-Induced Glaucomas","volume":"26","author":"Tripathi","year":"2003","journal-title":"Drug Saf."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ophtha.2018.01.007","article-title":"Systemic Medication Associations with Presumed Advanced or Uncontrolled Primary Open-Angle Glaucoma","volume":"125","author":"Zheng","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/ceo.12769","article-title":"Venlafaxine-Induced Intraocular Pressure Rise in a Patient with Open Angle Glaucoma: Venlafaxine Induced Intraocular Pressure Rise","volume":"44","author":"Botha","year":"2016","journal-title":"Clin. Exp. Ophthalmol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/JCP.0b013e31825420a1","article-title":"Short-Term Exposure to Antidepressant Drugs and Risk of Acute Angle-Closure Glaucoma among Older Adults","volume":"32","author":"Seitz","year":"2012","journal-title":"J. Clin. Psychopharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e2041","DOI":"10.1097\/MD.0000000000002041","article-title":"Long-Term Use of Selective Serotonin Reuptake Inhibitors and Risk of Glaucoma in Depression Patients","volume":"94","author":"Chen","year":"2015","journal-title":"Medicine"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e692","DOI":"10.4088\/JCP.15m10038","article-title":"Association of Selective Serotonin Reuptake Inhibitor Use and Acute Angle\u2013Closure Glaucoma","volume":"77","author":"Chen","year":"2016","journal-title":"J. Clin. Psychiatry"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jad.2018.07.079","article-title":"The Risk of Glaucoma and Serotonergic Antidepressants: A Systematic Review and Meta-Analysis","volume":"241","author":"Wang","year":"2018","journal-title":"J. Affect. Disord."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Croos, R., Thirumalai, S., Hassan, S., and Davis, J.D.R. (2005). Citalopram Associated with Acute Angle-Closure Glaucoma: Case Report. BMC Ophthalmol., 5.","DOI":"10.1186\/1471-2415-5-23"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/bjo.2006.107185","article-title":"Bilateral Symptomatic Angle Closure Associated with a Regular Dose of Citalopram, an SSRI Antidepressant","volume":"91","author":"Massaoutis","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.ajo.2006.01.033","article-title":"Escitalopram-Induced Uveal Effusions and Bilateral Angle Closure Glaucoma","volume":"141","author":"Zelefsky","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/OAEM.S107551","article-title":"Bilateral Acute Closed Angle Glaucoma Associated with the Discontinuation of Escitalopram: A Case Report","volume":"8","author":"AlQuorain","year":"2016","journal-title":"Open Access Emerg. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1136\/bmj.314.7091.1387","article-title":"Acute Angle Closure Glaucoma Associated with Paroxetine","volume":"314","author":"Eke","year":"1997","journal-title":"BMJ"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1136\/bjo.81.3.252","article-title":"Bilateral Acute Angle Closure Glaucoma after Administration of Paroxetine","volume":"81","author":"Kirwan","year":"1997","journal-title":"Br. J. Ophthalmol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3109\/08820538.2013.771193","article-title":"Chronic Angle-Closure Glaucoma Related to Paroxetine Treatment","volume":"28","year":"2013","journal-title":"Semin. Ophthalmol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/eye.2000.106","article-title":"Acute Angle Closure Glaucoma Presenting in a Young Patient after Administration of Paroxetine","volume":"14","author":"Browning","year":"2000","journal-title":"EYE"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/S0008-4182(04)80074-7","article-title":"Late Bilateral Acute Angle-Closure Glaucoma after Administration of Paroxetine in a Patient with Plateau Iris Configuration","volume":"39","author":"Levy","year":"2004","journal-title":"Can. J. Ophthalmol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1345\/aph.1Z440","article-title":"Aggravation of Glaucoma with Fluvoxamine","volume":"35","author":"Zurdo","year":"2001","journal-title":"Ann. Pharmacother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.genhosppsych.2012.09.001","article-title":"Acute Angle Closure Glaucoma after Sertraline","volume":"35","author":"Ho","year":"2013","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1177\/1060028014529645","article-title":"Probable Association of an Attack of Bilateral Acute Angle-Closure Glaucoma with Duloxetine","volume":"48","author":"Shifera","year":"2014","journal-title":"Ann. Pharmacother."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"121","DOI":"10.5694\/j.1326-5377.2005.tb06613.x","article-title":"Bilateral Acute Angle Closure Caused by Supraciliary Effusions Associated with Venlafaxine Intake","volume":"182","author":"Thiagalingam","year":"2005","journal-title":"Med. J. Aust."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/sj.eye.6701815","article-title":"Simultaneous Bilateral Acute Angle Closure Glaucoma Following Venlafaxine Treatment","volume":"20","author":"Ezra","year":"2006","journal-title":"EYE"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"241","DOI":"10.5694\/j.1326-5377.2002.tb04386.x","article-title":"Venlafaxine and Bilateral Acute Angle Closure Glaucoma","volume":"176","author":"Ng","year":"2002","journal-title":"Med. J. Aust."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.4103\/0366-6999.233952","article-title":"Acute Angle-Closure Glaucoma Caused by Venlafaxine","volume":"131","author":"Zhou","year":"2018","journal-title":"Chin. Med. J. Engl."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"18","DOI":"10.2165\/00002018-199410010-00003","article-title":"Comparative Tolerability Profiles of the Newer versus Older Antidepressants","volume":"10","author":"Rudorfer","year":"1994","journal-title":"Drug Saf."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/bjophthalmol-2016-308846","article-title":"Association between Self-Reported Bupropion Use and Glaucoma: A Population-Based Study","volume":"101","author":"Kakigi","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1001\/archopht.130.1.120","article-title":"Bilateral Uveal Effusion and Angle-Closure Glaucoma Associated with Bupropion Use","volume":"130","author":"Takusagawa","year":"2012","journal-title":"Arch. Ophthalmol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2165\/11533180-000000000-00000","article-title":"Ocular Adverse Effects of Common Psychotropic Agents: A Review: A Review","volume":"24","author":"Richa","year":"2010","journal-title":"CNS Drugs"},{"key":"ref_67","first-page":"6","article-title":"A Review of Drug-Induced Acute Angle Closure Glaucoma for Non-Ophthalmologists","volume":"2015","author":"Egong","year":"2015","journal-title":"Qatar Med. J."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0033-3182(87)72555-9","article-title":"Use of Tricyclic Antidepressants in Patients with Glaucoma. Assessment and Appropriate Precautions","volume":"28","author":"Lieberman","year":"1987","journal-title":"Psychosomatics"},{"key":"ref_69","first-page":"144","article-title":"Psychotropic Drugs and Ocular Side Effects","volume":"44","author":"Aykan","year":"2014","journal-title":"Turk. J. Ophthalmol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.amjmed.2010.08.011","article-title":"Iatrogenic Glaucoma Secondary to Medications","volume":"124","author":"Razeghinejad","year":"2011","journal-title":"Am. J. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(96)90041-0","article-title":"Amaurosis Fugax on Standing and Angle-Closure Glaucoma with Clomipramine","volume":"347","author":"Schlingemann","year":"1996","journal-title":"Lancet"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"509","DOI":"10.5694\/j.1326-5377.1966.tb97299.x","article-title":"Amitriptyline and Glaucoma","volume":"2","author":"Lowe","year":"1966","journal-title":"Med. J. Aust."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1001\/archopht.1994.01090130077021","article-title":"Oral Imipramine and Acute Angle Closure Glaucoma","volume":"112","author":"Ritch","year":"1994","journal-title":"Arch. Ophthalmol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/archopht.1995.01100060020008","article-title":"Oral Imipramine and Acute Angle-Closure Glaucoma","volume":"113","author":"Epstein","year":"1995","journal-title":"Arch. Ophthalmol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s40264-020-00914-7","article-title":"Benzodiazepine Use and Risk of Acute Angle-Closure Glaucoma: A Population-Based Case-Crossover Study","volume":"43","author":"Kim","year":"2020","journal-title":"Drug Saf."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jpsychores.2019.04.013","article-title":"Association between Use of Benzodiazepines and Occurrence of Acute Angle-Closure Glaucoma in the Elderly: A Population-Based Study","volume":"122","author":"Park","year":"2019","journal-title":"J. Psychosom. Res."},{"key":"ref_77","first-page":"2273","article-title":"The Effect of Midazolam Maleate and Diazepam on Intraocular Pressure in Adults","volume":"31","author":"Fragen","year":"1981","journal-title":"Arzneimittelforschung"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/sj.mp.4002066","article-title":"Atypical Antipsychotic-Induced Metabolic Side Effects: Insights from Receptor-Binding Profiles","volume":"13","author":"Nasrallah","year":"2008","journal-title":"Mol. Psychiatry"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1590\/S0004-27492008000500009","article-title":"Intraocular Pressure in Schizophrenic Patients Treated with Psychiatric Medications","volume":"71","author":"Souza","year":"2008","journal-title":"Arq. Bras. Oftalmol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0033-3182(76)71149-6","article-title":"Outpatient Psychiatric Medications and Glaucoma","volume":"17","author":"Reid","year":"1976","journal-title":"Psychosomatics"},{"key":"ref_81","first-page":"580","article-title":"Evaluation of Haloperidol, a Dopamine Antagonist, on Intraocular Pressure in Experimental Glaucoma","volume":"34","author":"Khosla","year":"1996","journal-title":"Indian J. Exp. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archopht.1984.01040030121050","article-title":"Ocular Hypotensive Actions of Haloperidol, a Dopaminergic Antagonist","volume":"102","author":"Chiou","year":"1984","journal-title":"Arch. Ophthalmol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1089\/jop.1986.2.215","article-title":"Oral Haloperidol Lowers Human Intraocular Pressure","volume":"2","author":"Sheppard","year":"1986","journal-title":"J. Ocul. Pharmacol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"105173","DOI":"10.1016\/j.ejps.2019.105173","article-title":"Repurposing of Iloperidone: Antihypertensive and Ocular Hypotensive Activity in Animals","volume":"143","author":"Joshi","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"144","DOI":"10.9758\/cpn.2013.11.3.144","article-title":"Effects of Antipsychotics on the Inflammatory Response System of Patients with Schizophrenia in Peripheral Blood Mononuclear Cell Cultures","volume":"11","year":"2013","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Caruso, G., Grasso, M., Fidilio, A., Tascedda, F., Drago, F., and Caraci, F. (2020). Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia. Pharmaceuticals, 13.","DOI":"10.3390\/ph13120457"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pharmthera.2018.06.012","article-title":"Molecular Targets of Atypical Antipsychotics: From Mechanism of Action to Clinical Differences","volume":"192","author":"Aringhieri","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Carli, M., Aringhieri, S., Kolachalam, S., Longoni, B., Grenno, G., Rossi, M., Gemignani, A., Fornai, F., Maggio, R., and Scarselli, M. (2020). Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?. Curr. Neuropharmacol., 18.","DOI":"10.2174\/1570159X18666200818194948"},{"key":"ref_89","first-page":"3460","article-title":"Retrograde Axonal Transport of BDNF in Retinal Ganglion Cells Is Blocked by Acute IOP Elevation in Rats","volume":"41","author":"Quigley","year":"2000","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.schres.2006.07.011","article-title":"A Model of Anticholinergic Activity of Atypical Antipsychotic Medications","volume":"88","author":"Chew","year":"2006","journal-title":"Schizophr. Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.schres.2010.02.001","article-title":"Topiramate for Prevention of Olanzapine Associated Weight Gain and Metabolic Dysfunction in Schizophrenia: A Double-Blind, Placebo-Controlled Trial","volume":"118","author":"Narula","year":"2010","journal-title":"Schizophr. Res."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Rapoport, Y., Benegas, N., Kuchtey, R.W., and Joos, K.M. (2014). Acute Myopia and Angle Closure Glaucoma from Topiramate in a Seven-Year-Old: A Case Report and Review of the Literature. BMC Pediatr., 14.","DOI":"10.1186\/1471-2431-14-96"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ajo.2012.07.016","article-title":"Topiramate Use and the Risk of Glaucoma Development: A Population-Based Follow-up Study","volume":"155","author":"Ho","year":"2013","journal-title":"Am. J. Ophthalmol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ophtha.2003.04.004","article-title":"Topiramate-Associated Acute, Bilateral, Secondary Angle-Closure Glaucoma","volume":"111","author":"Fraunfelder","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.ajo.2011.10.018","article-title":"Use of Topiramate and Risk of Glaucoma: A Case-Control Study","volume":"153","author":"Etminan","year":"2012","journal-title":"Am. J. Ophthalmol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"202","DOI":"10.4103\/SJOPT.SJOPT_9_20","article-title":"Topiramate-Induced Angle Closure Glaucoma: Two Unique Case Reports","volume":"34","author":"Alzendi","year":"2020","journal-title":"Saudi J. Ophthalmol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.4103\/ijo.IJO_245_19","article-title":"Ciliochoroidal Effusion in Topiramate-Induced Bilateral Acute Angle Closure Glaucoma","volume":"67","author":"Agarwal","year":"2019","journal-title":"Indian J. Ophthalmol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.4103\/ijo.IJO_1192_17","article-title":"Topiramate-Induced Acute Angle Closure with Severe Panuveitis: A Challenging Case Report","volume":"66","author":"Mahendradas","year":"2018","journal-title":"Indian J. Ophthalmol."},{"key":"ref_99","first-page":"130","article-title":"Acute narrow-angle glaucoma induced by topiramate with acute myopia and macular striae: A case report","volume":"94","year":"2019","journal-title":"Arch. Soc. Esp. Oftalmol. Engl. Ed."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1007\/s10792-017-0740-y","article-title":"Bilateral Acute Angle Closure Glaucoma and Myopic Shift by Topiramate-Induced Ciliochoroidal Effusion: Case Report and Literature Review","volume":"38","author":"Lan","year":"2018","journal-title":"Int. Ophthalmol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/IJG.0b013e3182948491","article-title":"Delayed Topiramate-Induced Bilateral Angle-Closure Glaucoma","volume":"23","author":"Czyz","year":"2014","journal-title":"J. Glaucoma"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"bcr2014203787","DOI":"10.1136\/bcr-2014-203787","article-title":"Acute Bilateral Glaucoma and Panuveitis as a Side Effect of Topiramate for Weight Loss Treatment","volume":"2014","author":"Pikkel","year":"2014","journal-title":"BMJ Case Rep."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1055\/s-0034-1368282","article-title":"Bilateral Severe Anterior Uveitis and Acute Angle-Closure Glaucoma Following Topiramate Use for Migraine Crisis","volume":"231","author":"Katsimpris","year":"2014","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1590\/S0004-27492013000100014","article-title":"Topiramate-Associated Acute, Bilateral, Angle-Closure Glaucoma: Case Report","volume":"76","author":"Quagliato","year":"2013","journal-title":"Arq. Bras. Oftalmol."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1089\/jop.2011.0161","article-title":"Topiramate Induced Bilateral Angle-Closure Glaucoma: Low Dosage in a Short Time","volume":"28","author":"Caglar","year":"2012","journal-title":"J. Ocul. Pharmacol. Ther."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1016\/j.jemermed.2009.09.020","article-title":"Bilateral Acute Angle-Closure Glaucoma in a Migraine Patient Receiving Topiramate: A Case Report","volume":"43","author":"Cole","year":"2012","journal-title":"J. Emerg. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5301\/EJO.2010.5979","article-title":"Topiramate-Induced Acute Bilateral Angle Closure and Myopia: Pathophysiology and Treatment Controversies","volume":"21","author":"Mavrakanas","year":"2011","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1752-1947-5-33","article-title":"Refractory Topiramate-Induced Angle-Closure Glaucoma in a Man: A Case Report","volume":"5","author":"Willett","year":"2011","journal-title":"J. Med. Case Rep."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"26","DOI":"10.4103\/0974-620X.60018","article-title":"Topiramate-Induced Angle Closure with Acute Myopia, Macular Striae","volume":"3","author":"Natesh","year":"2010","journal-title":"Oman J. Ophthalmol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"557","DOI":"10.4103\/0301-4738.71700","article-title":"Topiramate-Associated Bilateral Anterior Uveitis and Angle Closure Glaucoma","volume":"58","author":"Acharya","year":"2010","journal-title":"Indian J. Ophthalmol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1757-1626-2-87","article-title":"Topiramate-Associated Acute Glaucoma in a Migraine Patient Receiving Concomitant Citalopram Therapy: A Case-Report","volume":"2","author":"Spaccapelo","year":"2009","journal-title":"Cases J."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/IJG.0b013e31818159e9","article-title":"Argon Laser Peripheral Iridoplasty for Topiramate-Induced Bilateral Acute Angle Closure","volume":"18","author":"Sbeity","year":"2009","journal-title":"J. Glaucoma"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1752-1947-2-1","article-title":"Acute Bilateral Simultaneous Angle Closure Glaucoma after Topiramate Administration: A Case Report","volume":"2","author":"Chalam","year":"2008","journal-title":"J. Med. Case Rep."},{"key":"ref_114","first-page":"1904","article-title":"Bilateral Acute Onset Myopia and Angle Closure Glaucoma after Oral Topiramate: A Case Report","volume":"91","author":"Boonyaleephan","year":"2008","journal-title":"J. Med. Assoc. Thai."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.2174\/1874364100802010046","article-title":"Topiramate Induced Acute Angle Closure Glaucoma","volume":"2","author":"Aminlari","year":"2008","journal-title":"Open Ophthalmol. J."},{"key":"ref_116","first-page":"234","article-title":"Topiramate Induced Bilateral Angle-Closure Glaucoma","volume":"5","author":"Singh","year":"2007","journal-title":"Kathmandu Univ. Med. J. KUMJ"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1097\/IJG.0b013e318098739b","article-title":"Choroidal Drainage in the Management of Acute Angle Closure after Topiramate Toxicity","volume":"16","author":"Parikh","year":"2007","journal-title":"J. Glaucoma"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-2006-926600","article-title":"Blood-Brain Barrier Disruption Associated with Topiramate-Induced Angle-Closure Glaucoma of Acute Onset","volume":"223","author":"Ravinet","year":"2006","journal-title":"Klin. Monbl. Augenheilkd."},{"key":"ref_119","first-page":"72","article-title":"Topiramate Induced Secondary Angle Closure Glaucoma","volume":"52","author":"Sachi","year":"2006","journal-title":"J. Postgrad. Med."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.ajo.2006.01.021","article-title":"Rapid Resolution of Topiramate-Induced Angle-Closure Glaucoma with Methylprednisolone and Mannitol","volume":"141","author":"Rhee","year":"2006","journal-title":"Am. J. Ophthalmol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1139\/I06-012","article-title":"Topiramate-Induced Bilateral Angle-Closure Glaucoma","volume":"41","author":"Levy","year":"2006","journal-title":"Can. J. Ophthalmol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0301-4738.27072","article-title":"Acute Myopia and Angle Closure Caused by Topiramate, a Drug Used for Prophylaxis of Migraine","volume":"54","author":"Desai","year":"2006","journal-title":"Indian J. Ophthalmol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1111\/j.1600-0420.2005.00534.x","article-title":"Bilateral Angle-Closure Glaucoma Following Oral Topiramate Therapy","volume":"83","author":"Mansoor","year":"2005","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0002-9394(03)00774-8","article-title":"Mechanism of Topiramate-Induced Acute-Onset Myopia and Angle Closure Glaucoma","volume":"137","author":"Craig","year":"2004","journal-title":"Am. J. Ophthalmol."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1212\/01.WNL.0000091425.43083.C1","article-title":"Acute Myopia and Angle-Closure Glaucoma Induced by Topiramate","volume":"61","author":"Boentert","year":"2003","journal-title":"Neurology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1001\/archopht.121.2.282","article-title":"Angle-Closure Glaucoma Associated with Ciliary Body Detachment in Patients Using Topiramate","volume":"12","author":"Medeiros","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/bjo.87.5.648","article-title":"Topiramate Induced Myopic Shift and Angle Closure Glaucoma","volume":"87","author":"Chen","year":"2003","journal-title":"Br. J. Ophthalmol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0002-9394(01)01013-3","article-title":"Presumed Topiramate-Induced Bilateral Acute Angle-Closure Glaucoma","volume":"132","author":"Banta","year":"2001","journal-title":"Am. J. Ophthalmol."},{"key":"ref_129","first-page":"1210","article-title":"Uveal Effusion and Secondary Angle-Closure Glaucoma Associated with Topiramate Use","volume":"119","author":"Sankar","year":"2001","journal-title":"Arch. Ophthalmol."},{"key":"ref_130","first-page":"1721","article-title":"Bilateral Angle-Closure Glaucoma and Ciliary Body Swelling from Topiramate","volume":"119","author":"Rhee","year":"2001","journal-title":"Arch. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/13\/2947\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:23:59Z","timestamp":1760163839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/13\/2947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,30]]},"references-count":130,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2021,7]]}},"alternative-id":["jcm10132947"],"URL":"https:\/\/doi.org\/10.3390\/jcm10132947","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,30]]}}}