{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T12:13:57Z","timestamp":1776082437014,"version":"3.50.1"},"reference-count":58,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>There is a lack of research regarding blood tests within individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS) and between patients and healthy controls. We aimed to compare results of routine blood tests between patients and healthy controls. Data from 149 patients diagnosed with ME\/CFS based on clinical and psychiatric evaluation as well as on the DePaul Symptom Questionnaire, and data from 264 healthy controls recruited from blood donors were compared. One-way ANCOVA was conducted to examine differences between ME\/CFS patients and healthy controls, adjusting for age and gender. Patients had higher sedimentation rate (mean difference: 1.38, 95% CI: 0.045 to 2.714), leukocytes (mean difference: 0.59, 95% CI: 0.248 to 0.932), lymphocytes (mean difference: 0.27, 95% CI: 0.145 to 0.395), neutrophils (mean difference: 0.34, 95% CI: 0.0 89 to 0.591), monocytes (mean difference: 0.34, 95% CI: 0.309 to 0.371), ferritin (mean difference: 28.13, 95% CI: \u22121.41 to 57.672), vitamin B12 (mean difference: 83.43, 95% CI: 62.89 to 124.211), calcium (mean difference: 0.02, 95% CI: \u22120.02 to 0.06), alanine transaminase (mean difference: 3.30, 95% CI: \u22121.37 to -7.971), low-density lipoproteins (mean difference: 0.45, 95% CI: 0.104 to 0.796), and total proteins (mean difference: 1.53, 95% CI: \u22120.945 to 4.005) than control subjects. The patients had lower potassium levels (mean difference: 0.11, 95% CI: 0.056 to 0.164), creatinine (mean difference: 2.60, 95% CI: 0.126 to 5.074) and creatine kinase (CK) (mean difference: 37.57, 95% CI: \u22120.282 to 75.422) compared to the healthy controls. Lower CK and creatinine levels may suggest muscle damage and metabolic abnormalities in ME\/CFS patients.<\/jats:p>","DOI":"10.3390\/jcm10143105","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T10:13:42Z","timestamp":1626257622000},"page":"3105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evaluating Routine Blood Tests According to Clinical Symptoms and Diagnostic Criteria in Individuals with Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome"],"prefix":"10.3390","volume":"10","author":[{"given":"Ingrid H.","family":"Baklund","sequence":"first","affiliation":[{"name":"Department of Behavioural Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toril","family":"Dammen","sequence":"additional","affiliation":[{"name":"Department of Behavioural Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn \u00c5ge","family":"Moum","sequence":"additional","affiliation":[{"name":"Department of Behavioural Medicine, Faculty of Medicine, University of Oslo, 0315 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenche","family":"Kristiansen","sequence":"additional","affiliation":[{"name":"CFS\/ME Center, Division of Medicine, Oslo University Hospital, 0318 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1767-9024","authenticated-orcid":false,"given":"Daysi Sosa","family":"Duarte","sequence":"additional","affiliation":[{"name":"CFS\/ME Center, Division of Medicine, Oslo University Hospital, 0318 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-3052","authenticated-orcid":false,"given":"Jesus","family":"Castro-Marrero","sequence":"additional","affiliation":[{"name":"CFS\/ME Unit, Division of Rheumatology, Vall d\u2019Hebron Research Institute, Universitat Aut\u00f2noma de Barcelona, 08035 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid Bergliot","family":"Helland","sequence":"additional","affiliation":[{"name":"National Advisory Unit for CFS\/ME, Rikshospitalet, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin Bolle","family":"Strand","sequence":"additional","affiliation":[{"name":"National Advisory Unit for CFS\/ME, Rikshospitalet, Oslo University Hospital, Rikshospitalet OUS, 0372 Oslo, Norway"},{"name":"Faculty of Health, VID Specialized University, 0370 Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1365-2796.2011.02428.x","article-title":"Myalgic encephalomyelitis: International consensus criteria","volume":"270","author":"Carruthers","year":"2011","journal-title":"J. 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