{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:50:03Z","timestamp":1790193003259,"version":"4.1.0"},"reference-count":147,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T00:00:00Z","timestamp":1626566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Despite the abundant literature on vasopressor therapy, few studies have focused on vasopressor-sparing strategies in patients with shock. We performed a scoping-review of the published studies evaluating vasopressor-sparing strategies by analyzing the results from randomized controlled trials conducted in patients with shock, with a focus on vasopressor doses and\/or duration reduction. We analyzed 143 studies, mainly performed in septic shock. Our analysis demonstrated that several pharmacological and non-pharmacological strategies are associated with a decrease in the duration of vasopressor therapy. These strategies are as follows: implementing a weaning strategy, vasopressin use, systemic glucocorticoid administration, beta-blockers, and normothermia. On the contrary, early goal directed therapies, including fluid therapy, oral vasopressors, vitamin C, and renal replacement therapy, are not associated with an increase in vasopressor-free days. Based on these results, we proposed an evidence-based vasopressor management strategy.<\/jats:p>","DOI":"10.3390\/jcm10143164","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T21:16:48Z","timestamp":1626643008000},"page":"3164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Vasopressor-Sparing Strategies in Patients with Shock: A Scoping-Review and an Evidence-Based Strategy Proposition"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7019-9727","authenticated-orcid":false,"given":"Pierre-Gr\u00e9goire","family":"Guinot","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"},{"name":"Lipness Team, INSERM Research Center LNC-UMR1231 and LabEx LipSTIC, University of Burgundy, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Berthoud","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Voizeux","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Bartamian","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erminio","family":"Santangelo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belaid","family":"Bouhemad","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"},{"name":"Lipness Team, INSERM Research Center LNC-UMR1231 and LabEx LipSTIC, University of Burgundy, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-1487","authenticated-orcid":false,"given":"Maxime","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, CHU Dijon, 21000 Dijon, France"},{"name":"Lipness Team, INSERM Research Center LNC-UMR1231 and LabEx LipSTIC, University of Burgundy, 21000 Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1056\/NEJMra002709","article-title":"The Pathogenesis of Vasodilatory Shock","volume":"345","author":"Landry","year":"2001","journal-title":"N. 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