{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:05:30Z","timestamp":1779314730690,"version":"3.51.4"},"reference-count":28,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The aim of this study was to determine whether the presence of disproportionate vertebral bodies is a risk factor for disc herniation (DH). Methods: Sixty-seven consecutive patients (m: 31 f: 36) who underwent lumbar discectomy for symptomatic DH at one level between L3 and S1 were retrospectively included. The last three motion segments (3 \u00d7 67 = 201) were assessed on sagittal MRI scans. A disproportionate motion segment was defined as the difference of more than 10% of the antero-posterior diameter of two adjacent endplates. Results: DH was present in 6\/67 (9%), 26\/67 (38.8%), and 35\/67 (52.2%) patients at L3\/4, L4\/5, and L5\/S1, respectively. A total of 14 of 67 patients demonstrated a disproportionate motion segment at the discectomy level (20.9%). A total of 23 of the 201 (11.4%) investigated motion segments met our criteria for a disproportionate motion segment. In our study population, when one of the 201 segments was disproportionate, the positive predictive value (PPV) for DH increased toward the lower segments: the PPV at the L5\/S1 level was 83.0%. The odds ratio of disproportion for DH was the highest at the L5\/S1 level, with 6.0 \u00b1 0.82 (p = 0.017). Conclusions: The presence of a disproportionate motion segment in the lower spine may lead to a significant higher risk for DH in patients undergoing discectomy.<\/jats:p>","DOI":"10.3390\/jcm10143174","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T10:07:37Z","timestamp":1626689257000},"page":"3174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Disproportionate Vertebral Bodies and Their Impact on Lumbar Disc Herniation"],"prefix":"10.3390","volume":"10","author":[{"given":"Ralph","family":"L\u00e4ubli","sequence":"first","affiliation":[{"name":"Orthopedic Surgery, Interlaken Hospital FMI, Weissenaustrasse 27, 3800 Unterseen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Brugger","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Interlaken Hospital FMI, Weissenaustrasse 27, 3800 Unterseen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Pirvu","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Interlaken Hospital FMI, Weissenaustrasse 27, 3800 Unterseen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Wirbels\u00e4ulenmedizin Bern, Hirslanden Salem-Spital, Sch\u00e4nzlistrasse 39, 3000 Bern, Switzerland"},{"name":"Orthopedic Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Siero\u0144","sequence":"additional","affiliation":[{"name":"Silesian Center for Heart Diseases, Division of Magnetic Resonance Imaging, 41-800 Zabrze, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karol","family":"Szyluk","sequence":"additional","affiliation":[{"name":"I Departament of Trauma and Orthopaedics, District Hospital of Orthopaedics and Trauma Surgery, Bytomska 62 str, 41-940 Piekary \u015al\u0105skie, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2751-3458","authenticated-orcid":false,"given":"Christoph E.","family":"Albers","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-2591","authenticated-orcid":false,"given":"Andreas","family":"Christe","sequence":"additional","affiliation":[{"name":"Department of Radiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010 Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0304-3959(99)00187-6","article-title":"The Economic Burden of Back Pain in the UK","volume":"84","author":"Maniadakis","year":"2000","journal-title":"Pain"},{"key":"ref_2","first-page":"646","article-title":"Burden of Major Musculoskeletal Conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull. 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