{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:12:54Z","timestamp":1760235174516,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Cardiac rehabilitation (CR) is a requisite component of care for patients with heart failure (HF). We aimed to evaluate the clinical outcomes in outpatients with HF with preserved ejection fraction (HFpEF) compared to those in patients with non-HFpEF who did and did not continue a 5-month CR program. Methods: 173 outpatients with HF who participated in a 5-month CR program were registered. We divided them into two groups: HFpEF (n = 84, EF 63 \u00b1 7%) and non-HFpEF (n = 89, EF 31 \u00b1 11%). We further divided the patients into those who continued the CR program (continued group) and those who did not (discontinued group) in the HFpEF and non-HFpEF groups. The clinical outcomes at 5 months were compared among the groups. Results: There were no significant differences in patient characteristics at baseline between the continued and discontinued groups in the HFpEF and non-HFpEF groups except for % diabetes mellitus in the non-HFpEF group. The rates of all-cause death and hospital admissions in the continued group in both the HFpEF and non-HFpEF groups were significantly lower than those in the discontinued group. The all-cause death and hospital admissions in each group were independently associated with the continuation of the CR program. Conclusions: The continuation of a 5-month CR program was associated with the prevention of all-cause death and hospital admissions in both the HFpEF and non-HFpEF groups.<\/jats:p>","DOI":"10.3390\/jcm10153306","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T12:18:31Z","timestamp":1627388311000},"page":"3306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Difference in Prognosis between Continuation and Discontinuation of A 5-Month Cardiac Rehabilitation Program in Outpatients with Heart Failure with Preserved Ejection Fraction"],"prefix":"10.3390","volume":"10","author":[{"given":"Hidetaka","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Suematsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuiko","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaya","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuro","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Kaino","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Teshima","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Ura","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaomi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Tazawa","sequence":"additional","affiliation":[{"name":"Division of Nutrition, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironari","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Postgraduate Clinical Training Center, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanta","family":"Fujimi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Department of Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichiro","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Center for Cardiac Rehabilitation, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-Ku, Fukuoka 814-0180, Japan"},{"name":"Department of Cardiology, Fukuoka University Nishijin Hospital, 15-4 Sohara Sawara-Ku, Fukuoka 814-8522, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the heart failure association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","article-title":"2017 ACC\/AHA\/HFSA Focused Update of the 2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America","volume":"136","author":"Yancy","year":"2017","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1161\/01.CIR.99.9.1173","article-title":"Randomized, controlled trial of long-term moderate exercise training in chronic heart failure","volume":"99","author":"Belardinelli","year":"1999","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/bmj.328.7441.711-b","article-title":"Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH)","volume":"328","author":"Piepoli","year":"2004","journal-title":"BMJ"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s11897-013-0155-7","article-title":"The emerging epidemic of heart failure with preserved ejection fraction","volume":"10","author":"Oktay","year":"2013","journal-title":"Curr. Heart Fail. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1056\/NEJMoa052256","article-title":"Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction","volume":"355","author":"Owan","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1093\/eurheartj\/ehl250","article-title":"The perindopril in elderly people with chronic heart failure (PEP-CHF) study","volume":"27","author":"Cleland","year":"2006","journal-title":"Eur. Heart J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(03)14282-1","article-title":"Effects of candesartan on mortality and morbidity in patients with chronic heart failure: The CHARM-Overall programme","volume":"362","author":"Pfeffer","year":"2003","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1056\/NEJMoa0805450","article-title":"Irbesartan in patients with heart failure and preserved ejection fraction","volume":"359","author":"Massie","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/eurjhf\/hfs141","article-title":"Effects of carvedilol on heart failure with preserved ejection fraction: The Japanese Diastolic Heart Failure Study (J-DHF)","volume":"15","author":"Yamamoto","year":"2013","journal-title":"Eur. J. Heart Fail."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1056\/NEJMoa1313731","article-title":"Spironolactone for heart failure with preserved ejection fraction","volume":"370","author":"Pitt","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijcha.2016.07.004","article-title":"Assessment of various parameters using simple non-invasive tests in patients with cardiovascular diseases with or without cardiac rehabilitation","volume":"12","author":"Ueda","year":"2016","journal-title":"IJC Heart Vasc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ijcha.2017.10.001","article-title":"Cardiac rehabilitation in patients with cardiovascular disease leads various hemodynamic parameters obtained using simple non-invasive tests to their appropriate levels","volume":"17","author":"Futami","year":"2017","journal-title":"IJC Heart Vasc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1536\/ihj.16-026","article-title":"Visit-to-visit variability and reduction in blood pressure after a 3-month cardiac rehabilitation program in patients with cardiovascular disease","volume":"57","author":"Ishida","year":"2016","journal-title":"Int. Heart J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.14740\/cr440e","article-title":"Influence of a cardiac rehabilitation program on renal function in patients with cardiovascular disease in a one-year follow-up","volume":"6","author":"Fujimi","year":"2015","journal-title":"Cardiol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.2169\/internalmedicine.2281-18","article-title":"Possibility of cardio-renal protection by long-term cardiac rehabilitation in elderly patients with cardiovascular diseases","volume":"58","author":"Kitajima","year":"2019","journal-title":"Intern. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ijcard.2019.06.017","article-title":"Differential prognostic impact between completion and non-completion of a 5-month cardiac rehabilitation program in outpatients with cardiovascular diseases","volume":"292","author":"Fujimi","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s10741-019-09774-5","article-title":"Effects of exercise training on cardiac function, exercise capacity, and quality of life in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials","volume":"24","author":"Fukuta","year":"2019","journal-title":"Heart Fail. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijcard.2012.05.070","article-title":"Effects of exercise training for heart failure with preserved ejection fraction: A systematic review and meta-analysis of comparative studies","volume":"162","author":"Taylor","year":"2012","journal-title":"Int. J. Cardiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4081\/monaldi.2016.759","article-title":"Exercise training in heart failure patients with preserved ejection fraction: A systematic review and meta-analysis","volume":"86","author":"Chan","year":"2016","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/CIRCHEARTFAILURE.119.006798","article-title":"Multidisciplinary cardiac rehabilitation and long-term prognosis in patients with heart failure","volume":"13","author":"Kamiya","year":"2020","journal-title":"Circ. Heart Fail."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1001\/jama.283.23.3095","article-title":"Effects of exercise training on left ventricular function and peripheral resistance in patients with chronic heart failure","volume":"283","author":"Hambrecht","year":"2000","journal-title":"JAMA"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1161\/01.CIR.98.24.2709","article-title":"Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure","volume":"98","author":"Hambrecht","year":"1998","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"European Heart Failure Training Group (1998). Experience from controlled trials of physical training in chronic heart failure. Protocol and patient factors in effectiveness in the improvement in exercise tolerance. Eur. Heart J., 19, 466\u2013475.","DOI":"10.1053\/euhj.1997.0736"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.amjmed.2004.01.009","article-title":"Exercise-based rehabilitation for patients with coronary heart disease: Systematic review and meta-analysis of randomized controlled trials","volume":"116","author":"Taylor","year":"2004","journal-title":"Am. J. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.jacc.2004.12.077","article-title":"The effects of physical activity on serum C-reactive protein and inflammatory markers: A systematic review","volume":"45","author":"Kasapis","year":"2005","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0735-1097(03)00848-9","article-title":"Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure","volume":"42","author":"Gielen","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0735-1097(97)00015-6","article-title":"Effects of endurance training on mitochondrial ultrastructure and fiber type distribution in skeletal muscle of patients with stable chronic heart failure","volume":"29","author":"Hambrecht","year":"1997","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2337\/diacare.15.11.1477","article-title":"Dropout and Relapse During Diabetes Care","volume":"15","author":"Graber","year":"1992","journal-title":"Diabetes Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/dme.12949","article-title":"A cluster randomized trial on the effect of a multifaceted intervention improved the technical quality of diabetes care by primary care physicians: The Japan Diabetes Outcome Intervention Trial-2 (J-DOIT 2)","volume":"33","author":"Hayashino","year":"2015","journal-title":"Diabet. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/15\/3306\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:35:33Z","timestamp":1760164533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/15\/3306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":30,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10153306"],"URL":"https:\/\/doi.org\/10.3390\/jcm10153306","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,7,27]]}}}