{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:06:09Z","timestamp":1790755569086,"version":"4.1.0"},"reference-count":128,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20K21672"],"award-info":[{"award-number":["20K21672"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["P20412"],"award-info":[{"award-number":["P20412"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The dental pulp is a soft connective tissue of ectomesenchymal origin that harbors distinct cell populations, capable of interacting with each other to maintain the vitality of the tooth. After tooth injuries, a sequence of complex biological events takes place in the pulpal tissue to restore its homeostasis. The pulpal response begins with establishing an inflammatory reaction that leads to the formation of a matrix of reactionary or reparative dentin, according to the nature of the exogenous stimuli. Using several in vivo designs, antigen-presenting cells, including macrophages and dendritic cells (DCs), are identified in the pulpal tissue before tertiary dentin deposition under the afflicted area. However, the precise nature of this phenomenon and its relationship to inherent pulp cells are not yet clarified. This literature review aims to discuss the role of pulpal DCs and their relationship to progenitor\/stem cells, odontoblasts or odontoblast-like cells, and other immunocompetent cells during physiological and pathological dentinogenesis. The concept of \u201cdentin-pulp immunology\u201d is proposed for understanding the crosstalk among these cell types after tooth injuries, and the possibility of immune-based therapies is introduced to accelerate pulpal healing after exogenous stimuli.<\/jats:p>","DOI":"10.3390\/jcm10153348","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T10:47:46Z","timestamp":1627555666000},"page":"3348","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Role of Dendritic Cells during Physiological and Pathological Dentinogenesis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4631","authenticated-orcid":false,"given":"Angela","family":"Quispe-Salcedo","sequence":"first","affiliation":[{"name":"Department of Tissue Regeneration and Reconstruction, Division of Anatomy and Cell Biology of the Hard Tissue, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan"},{"name":"Department of Stomatology, Faculty of Health Sciences, School of Stomatology, Universidad Cientifica del Sur, Lima 15067, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8571-9900","authenticated-orcid":false,"given":"Hayato","family":"Ohshima","sequence":"additional","affiliation":[{"name":"Department of Tissue Regeneration and Reconstruction, Division of Anatomy and Cell Biology of the Hard Tissue, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"ref_1","unstructured":"Nanci, A. (2018). Ten Cate\u2019s Oral Histology: Development, Structure, and Function, Elsevier. [9th ed.]."},{"key":"ref_2","unstructured":"Berkovitz, B.K.B., Holland, G.R., Moxham, B.J., and Berkovitz, B.K.B. (2018). Oral Anatomy, Histology and Embryology, Elsevier. [5th ed.]."},{"key":"ref_3","unstructured":"Chiego, D.J. (2018). Essentials of Oral Histology and Embryology: A Clinical Approach, Elsevier. [5th ed.]."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"104591","DOI":"10.1016\/j.archoralbio.2019.104591","article-title":"Post-mitotic odontoblasts in health, disease, and regeneration","volume":"109","author":"Rajan","year":"2020","journal-title":"Arch. Oral. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jdsr.2018.03.001","article-title":"The roles of odontoblasts in dental pulp innate immunity","volume":"54","author":"Yumoto","year":"2018","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1177\/0022034513495874","article-title":"The amazing odontoblast: Activity, autophagy, and aging","volume":"92","author":"Couve","year":"2013","journal-title":"J. Dent. Res."},{"key":"ref_7","unstructured":"Hargreaves, K.M., Goodis, H.E., and Tay, F.R. (2012). Seltzer and Bender\u2019s Dental Pulp, Quintessence Publishing. [2nd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.12968\/denu.2001.28.4.200","article-title":"An update on the physiology of the dentine-pulp complex","volume":"28","author":"Orchardson","year":"2001","journal-title":"Dent. Update"},{"key":"ref_9","first-page":"427","article-title":"Pulp-dentin biology in restorative dentistry. Part 1: Normal structure and physiology","volume":"32","author":"Mjor","year":"2001","journal-title":"Quintessence Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1600-0722.1997.tb00225.x","article-title":"Cell proliferation in developing human dental pulp. A combined flow cytometric and immunohistochemical study","volume":"105","author":"Casasco","year":"1997","journal-title":"Eur. J. Oral Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00004770-200004000-00007","article-title":"bcl-2, p53, and MIB-1 in human adult dental pulp","volume":"26","author":"Piattelli","year":"2000","journal-title":"J. Endod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1600-0722.1996.tb00140.x","article-title":"Apoptosis in human and rat dental pulp","volume":"104","author":"Vermelin","year":"1996","journal-title":"Eur. J. Oral Sci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1600-0722.1998.tb02202.x","article-title":"Immunocytochemical detection of apoptosis in human odontoblasts","volume":"106","author":"Franquin","year":"1998","journal-title":"Eur. J. Oral Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/002215549904700304","article-title":"Apoptosis of dental pulp cells and their elimination by macrophages and MHC class II-expressing dendritic cells","volume":"47","author":"Nishikawa","year":"1999","journal-title":"J. Histochem. Cytochem."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1046\/j.1365-2591.2003.00657.x","article-title":"Apoptosis: An introduction for the endodontist","volume":"36","author":"Satchell","year":"2003","journal-title":"Int. Endod. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00418-008-0438-3","article-title":"Cell dynamics in the pulpal healing process following cavity preparation in rat molars","volume":"130","author":"Harada","year":"2008","journal-title":"Histochem. Cell Biol."},{"key":"ref_17","first-page":"611","article-title":"Pulp-dentin biology in restorative dentistry. Part 3: Pulpal inflammation and its sequelae","volume":"32","author":"Heyeraas","year":"2001","journal-title":"Quintessence Int."},{"key":"ref_18","first-page":"717","article-title":"Pulp-dentin biology in restorative dentistry. Part 4: Dental caries--characteristics of lesions and pulpal reactions","volume":"32","author":"Bjorndal","year":"2001","journal-title":"Quintessence Int."},{"key":"ref_19","first-page":"537","article-title":"Pulp-dentin biology in restorative dentistry. Part 2: Initial reactions to preparation of teeth for restorative procedures","volume":"32","author":"Mjor","year":"2001","journal-title":"Quintessence Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jez.b.21259","article-title":"Odontoblasts in the dental pulp immune response","volume":"312B","author":"Farges","year":"2009","journal-title":"J. Exp. Zool. B Mol. Dev. Evol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fphys.2013.00326","article-title":"Odontoblast control of dental pulp inflammation triggered by cariogenic bacteria","volume":"4","author":"Farges","year":"2013","journal-title":"Front. Physiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230251","DOI":"10.1155\/2015\/230251","article-title":"Dental pulp defence and repair mechanisms in dental caries","volume":"2015","author":"Farges","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1365-2591.1994.tb00233.x","article-title":"Mechanisms controlling secondary initiation of dentinogenesis: A review","volume":"27","author":"Tziafas","year":"1994","journal-title":"Int. Endod. J."},{"key":"ref_24","first-page":"51","article-title":"Odontoblast differentiation","volume":"39","author":"Ruch","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"ref_25","first-page":"273","article-title":"Reactionary dentinogenesis","volume":"39","author":"Smith","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/08959374010150011201","article-title":"Molecular regulation of odontoblast activity under dentin injury","volume":"15","author":"Magloire","year":"2001","journal-title":"Adv. Dent. Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/10454411010120050501","article-title":"Induction and regulation of crown dentinogenesis: Embryonic events as a template for dental tissue repair?","volume":"12","author":"Smith","year":"2001","journal-title":"Crit. Rev. Oral Biol. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1747-4477.2002.tb00386.x","article-title":"The mechanism of pulpal wound healing","volume":"28","author":"Tjaderhane","year":"2002","journal-title":"Aust. Endod. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.biocel.2004.01.006","article-title":"Odontoblasts: The cells forming and maintaining dentine","volume":"36","author":"Massa","year":"2004","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1177\/0022034516645333","article-title":"Osteopontin is essential for type I collagen secretion in reparative dentin","volume":"95","author":"Saito","year":"2016","journal-title":"J. Dent. Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s40496-018-0196-9","article-title":"Tooth repair and regeneration","volume":"5","author":"Zaugg","year":"2018","journal-title":"Curr. Oral Health Rep."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1177\/0022034517743431","article-title":"Regulation of reactionary dentine formation","volume":"97","author":"Neves","year":"2018","journal-title":"J. Dent. Res."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.joen.2018.12.002","article-title":"Characterization of odontoblast-like cell phenotype and reparative dentin formation in vivo: A comprehensive literature review","volume":"45","author":"Tziafas","year":"2019","journal-title":"J. Endod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00784-010-0409-7","article-title":"Proliferation of rat molar pulp cells after direct pulp capping with dentine adhesive and calcium hydroxide","volume":"15","author":"Dammaschke","year":"2011","journal-title":"Clin. Oral Investig."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.job.2013.03.001","article-title":"Use of a triple antibiotic solution affects the healing process of intentionally delayed replanted teeth in mice","volume":"55","author":"Ohshima","year":"2013","journal-title":"J. Oral Biosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.joen.2014.05.005","article-title":"Effects of a triple antibiotic solution on pulpal dynamics after intentionally delayed tooth replantation in mice","volume":"40","author":"Ohshima","year":"2014","journal-title":"J. Endod."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.reth.2020.10.001","article-title":"Responses of oral-microflora-exposed dental pulp to capping with a triple antibiotic paste or calcium hydroxide cement in mouse molars","volume":"15","author":"Sato","year":"2020","journal-title":"Regen. Ther."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.joen.2013.06.017","article-title":"Dynamics of bromodeoxyuridine label-retaining dental pulp cells during pulpal healing after cavity preparation in mice","volume":"39","author":"Saito","year":"2013","journal-title":"J. Endod."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1679\/aohc.57.435","article-title":"The relationship between odontoblasts and immunocompetent cells during dentinogenesis in rat incisors: An immunohistochemical study using OX6-monoclonal antibody","volume":"57","author":"Ohshima","year":"1994","journal-title":"Arch. Histol. Cytol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"303","DOI":"10.3109\/03008209509013738","article-title":"Responses of immunocompetent cells to cavity preparation in rat molars: An immunohistochemical study using OX6-monoclonal antibody","volume":"32","author":"Ohshima","year":"1995","journal-title":"Connect. Tissue Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1679\/aohc.61.1","article-title":"Class II MHC antigen-expressing cells in the pulp tissue of human deciduous teeth prior to shedding","volume":"61","author":"Kannari","year":"1998","journal-title":"Arch. Histol. Cytol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0003-9969(98)00044-2","article-title":"Responses of macrophage-associated antigen-expressing cells in the dental pulp of rat molars to experimental tooth replantation","volume":"43","author":"Rungvechvuttivittaya","year":"1998","journal-title":"Arch. Oral Biol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s004410000263","article-title":"Responses of immunocompetent cells in the dental pulp to replantation during the regeneration process in rat molars","volume":"302","author":"Shimizu","year":"2000","journal-title":"Cell Tissue Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/jemt.10289","article-title":"Pulpal regeneration after cavity preparation, with special reference to close spatio-relationships between odontoblasts and immunocompetent cells","volume":"60","author":"Ohshima","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/jmicro\/52.6.581","article-title":"Possible role of immunocompetent cells and the expression of heat shock protein-25 in the process of pulpal regeneration after tooth injury in rat molars","volume":"52","author":"Watanabe","year":"2003","journal-title":"J. Electron. Microsc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00441-003-0840-z","article-title":"An immunocytochemical study of pulpal responses to cavity preparation by laser ablation in rat molars by using antibodies to heat shock protein (Hsp) 25 and class II MHC antigen","volume":"315","author":"Suzuki","year":"2004","journal-title":"Cell Tissue Res."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-006-0230-4","article-title":"Pulpal responses to cavity preparation in aged rat molars","volume":"326","author":"Kawagishi","year":"2006","journal-title":"Cell Tissue Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1679\/aohc.73.165","article-title":"Responses of infected dental pulp to \u03b1 TCP-containing antimicrobials in rat molars","volume":"73","author":"Sato","year":"2011","journal-title":"Arch. Histol. Cytol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1369\/0022155411403314","article-title":"The expression of GM-CSF and osteopontin in immunocompetent cells precedes the odontoblast differentiation following allogenic tooth transplantation in mice","volume":"59","author":"Saito","year":"2011","journal-title":"J. Histochem. Cytochem."},{"key":"ref_50","first-page":"8","article-title":"Acid phosphatase activity in the class II MHC antigen-expressing cells in the rat incisor pulp","volume":"33","author":"Ohshima","year":"1997","journal-title":"Dent. Jpn."},{"key":"ref_51","unstructured":"Ohshima, H., Takano, Y., Sato, O., Kawahara, I., and Maeda, T. (1996). Responses of class II MHC antigen-expressing cells to cavity preparation. Dentin\/Pulp Complex, Proceedings of the International Conference on Dentin Pulp Complex, Chiba, Japan, 1-4 July 1995, Quintessence Pub. Co."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"ix","DOI":"10.1016\/S1937-6448(19)30095-4","article-title":"Preface\u2014Dendritic cells: Master regulators of innate and adaptive immunity","volume":"348","author":"Lhuillier","year":"2019","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00281-016-0602-0","article-title":"The origin of DCs and capacity for immunologic tolerance in central and peripheral tissues","volume":"39","author":"Devi","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s00441-005-0138-4","article-title":"Histochemical and immunocytochemical study of hard tissue formation in dental pulp during the healing process in rat molars after tooth replantation","volume":"325","author":"Ikegame","year":"2006","journal-title":"Cell Tissue Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00441-006-0242-0","article-title":"Capacity of dental pulp differentiation after tooth transplantation","volume":"326","author":"Ogawa","year":"2006","journal-title":"Cell Tissue Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1369\/jhc.2008.951558","article-title":"Capacity of dental pulp differentiation in mouse molars as demonstrated by allogenic tooth transplantation","volume":"56","author":"Takamori","year":"2008","journal-title":"J. Histochem. Cytochem."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/ar.20831","article-title":"Pulpal regeneration following allogenic tooth transplantation into mouse maxilla","volume":"292","author":"Unno","year":"2009","journal-title":"Anat. Rec."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00418-011-0868-1","article-title":"Responses of BrdU label-retaining dental pulp cells to allogenic tooth transplantation into mouse maxilla","volume":"136","author":"Mutoh","year":"2011","journal-title":"Histochem. Cell Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.job.2015.01.003","article-title":"The effects of enzymatically synthesized glycogen on the pulpal healing process of extracted teeth following intentionally delayed replantation in mice","volume":"57","author":"Ohshima","year":"2015","journal-title":"J. Oral Biosci."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.joen.2008.03.021","article-title":"Immunohistochemical analysis of nestin, osteopontin, and proliferating cells in the reparative process of exposed dental pulp capped with mineral trioxide aggregate","volume":"34","author":"Kuratate","year":"2008","journal-title":"J. Endod."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s10266-012-0078-x","article-title":"Odontoblast response to cavity preparation with Er:YAG laser in rat molars: An immunohistochemical study","volume":"101","author":"Shigetani","year":"2013","journal-title":"Odontology"},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Nakakura-Ohshima, K., Quispe-Salcedo, A., Sano, H., Hayasaki, H., and Ohshima, H. (2021). The effects of reducing the root length by apicoectomy on dental pulp revascularization following tooth replantation in mice. Dent. Traumatol.","DOI":"10.1111\/edt.12679"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00441-012-1347-2","article-title":"The relationship between cell proliferation and differentiation and mapping of putative dental pulp stem\/progenitor cells during mouse molar development by chasing BrdU-labeling","volume":"348","author":"Ishikawa","year":"2012","journal-title":"Cell Tissue Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00418-010-0727-5","article-title":"Mapping of BrdU label-retaining dental pulp cells in growing teeth and their regenerative capacity after injuries","volume":"134","author":"Ishikawa","year":"2010","journal-title":"Histochem. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2220\/biomedres.32.247","article-title":"Differentiation capacity of BrdU label-retaining dental pulp cells during pulpal healing following allogenic transplantation in mice","volume":"32","author":"Saito","year":"2011","journal-title":"Biomed. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1258\/la.2009.008120","article-title":"Rat molar teeth as a study model for direct pulp capping research in dentistry","volume":"44","author":"Dammaschke","year":"2010","journal-title":"Lab. Anim."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-9657.2011.00983.x","article-title":"Critical considerations when planning experimental in vivo studies in dental traumatology","volume":"27","author":"Andreasen","year":"2011","journal-title":"Dent. Traumatol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"409347","DOI":"10.1155\/2015\/409347","article-title":"In vivo experiments with dental pulp stem cells for pulp-dentin complex regeneration","volume":"2015","author":"Kim","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.ircmb.2019.07.004","article-title":"Dendritic cell subsets and locations","volume":"348","author":"Balan","year":"2019","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1084\/jem.137.5.1142","article-title":"Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution","volume":"137","author":"Steinman","year":"1973","journal-title":"J. Exp. Med."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1136\/jim-2016-000072","article-title":"Identification and characterization of human dendritic cell subsets in the steady state: A review of our current knowledge","volume":"64","author":"Patel","year":"2016","journal-title":"J. Investig. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"891","DOI":"10.4049\/jimmunol.1002943","article-title":"Dendritic cells in distinct oral mucosal tissues engage different mechanisms to prime CD8+ T cells","volume":"186","author":"Nudel","year":"2011","journal-title":"J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fimmu.2015.00527","article-title":"Immunity to pathogens taught by specialized human dendritic cell subsets","volume":"6","author":"Geginat","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: An update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1007\/s12026-017-8931-1","article-title":"Dendritic cell-based immunotherapy: A basic review and recent advances","volume":"65","author":"Constantino","year":"2017","journal-title":"Immunol. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev-immunol-061020-053707","article-title":"Dendritic cells revisited","volume":"39","author":"Cardoso","year":"2021","journal-title":"Annu. Rev. Immunol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.smim.2017.04.002","article-title":"Dendritic cells in the host response to implanted materials","volume":"29","author":"Keselowsky","year":"2017","journal-title":"Semin. Immunol."},{"key":"ref_78","first-page":"690643","article-title":"Optimizing dendritic cell-based immunotherapy: Tackling the complexity of different arms of the immune system","volume":"2012","author":"Berneman","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1177\/00220345870660061101","article-title":"Immunocompetent cells in the normal dental pulp","volume":"66","author":"Jontell","year":"1987","journal-title":"J. Dent. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1046\/j.1365-201X.1997.584337000.x","article-title":"Perivascular dendritic cells of the human dental pulp","volume":"159","author":"Okiji","year":"1997","journal-title":"Acta Physiol. Scand."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1177\/00220345960750081001","article-title":"Immunohistochemical localization of HLA-DR-positive cells in unerupted and erupted normal and carious human teeth","volume":"75","author":"Yoshiba","year":"1996","journal-title":"J. Dent. Res."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s004410051221","article-title":"The distribution and ultrastructure of class II MHC-positive cells in human dental pulp","volume":"295","author":"Ohshima","year":"1999","journal-title":"Cell Tissue Res."},{"key":"ref_83","first-page":"249","article-title":"Immunohistochemical study on antigen-presenting cells in healthy and carious human teeth","volume":"119","author":"Georgiev","year":"2018","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.joen.2015.01.005","article-title":"Phenotypic analysis of immunocompetent cells in healthy human dental pulp","volume":"41","author":"Gaudin","year":"2015","journal-title":"J. Endod."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.archoralbio.2004.09.008","article-title":"The eternal tooth germ is formed at the apical end of continuously growing teeth","volume":"50","author":"Ohshima","year":"2005","journal-title":"Arch. Oral. Biol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0099-2399(96)80266-4","article-title":"Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: A quantitative immunohistochemical study","volume":"22","author":"Kawashima","year":"1996","journal-title":"J. Endod."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1093\/intimm\/dxl070","article-title":"The existence of CD11c+ sentinel and F4\/80+ interstitial dendritic cells in dental pulp and their dynamics and functional properties","volume":"18","author":"Zhang","year":"2006","journal-title":"Int. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1177\/00220345880670100301","article-title":"Dendritic cells and macrophages expressing class II antigens in the normal rat incisor pulp","volume":"67","author":"Jontell","year":"1988","journal-title":"J. Dent. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1177\/00220345920710051201","article-title":"An immunohistochemical study of the distribution of immunocompetent cells, especially macrophages and Ia antigen-expressing cells of heterogeneous populations, in normal rat molar pulp","volume":"71","author":"Okiji","year":"1992","journal-title":"J. Dent. Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s004180050407","article-title":"Appearance and distribution of dendritic cells and macrophages in dental pulp during early postnatal morphogenesis of mouse mandibular first molars","volume":"112","author":"Tsuruga","year":"1999","journal-title":"Histochem. Cell Biol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2591.1991.tb00864.x","article-title":"Class II antigen expressing cells in experimentally induced pulpitis","volume":"24","author":"Bergenholtz","year":"1991","journal-title":"Int. Endod. J."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1177\/43.9.7543913","article-title":"Recruitment of immunocompetent cells after dentinal injuries in innervated and denervated young rat molars: An immunohistochemical study","volume":"43","author":"Fristad","year":"1995","journal-title":"J. Histochem. Cytochem."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1177\/00220345010800061001","article-title":"Primary and secondary induction of apoptosis in odontoblasts after cavity preparation of rat molars","volume":"80","author":"Kitamura","year":"2001","journal-title":"J. Dent. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/03008200290000736","article-title":"Expression of heat-shock protein 25 immunoreactivity in the dental pulp and enamel organ during odontogenesis in the rat molar","volume":"43","author":"Ohshima","year":"2002","journal-title":"Connect. Tissue Res."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1067\/moe.2002.124577","article-title":"Age-related changes in the immunoreactivity of the monocyte\/macrophage system in rat molar pulp after cavity preparation. Oral Surg","volume":"94","author":"Izumi","year":"2002","journal-title":"Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joen.2007.01.002","article-title":"Update on the adaptive immune responses of the dental pulp","volume":"33","author":"Hahn","year":"2007","journal-title":"J. Endod."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Shah, D., Lynd, T., Ho, D., Chen, J., Vines, J., Jung, H.D., Kim, J.H., Zhang, P., Wu, H., and Jun, H.W. (2020). Pulp-dentin tissue healing response: A discussion of current biomedical approaches. J. Clin. Med., 9.","DOI":"10.3390\/jcm9020434"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0099-2399(97)80257-9","article-title":"Defense responses of dentin\/pulp complex to experimentally induced caries in rat molars: An immunohistochemical study on kinetics of pulpal Ia antigen-expressing cells and macrophages","volume":"23","author":"Kamal","year":"1997","journal-title":"J. Endod."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0003-9969(96)00075-1","article-title":"An immunohistochemical study of HLA-DR and alpha 1-antichymotrypsin-positive cells in the pulp of human non-carious and carious teeth","volume":"41","author":"Izumi","year":"1996","journal-title":"Arch. Oral Biol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1679\/aohc.61.343","article-title":"Immunohistochemical localizations of class II antigens and nerve fibers in human carious teeth: HLA-DR immunoreactivity in Schwann cells","volume":"61","author":"Yoshiba","year":"1998","journal-title":"Arch. Histol. Cytol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1177\/00220345990780100401","article-title":"Co-increase of nerve fibers and HLA-DR- and\/or factor-XIIIa-expressing dendritic cells in dentinal caries-affected regions of the human dental pulp: An immunohistochemical study","volume":"78","author":"Sakurai","year":"1999","journal-title":"J. Dent. Res."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1177\/154405910308200604","article-title":"Class II antigen-presenting dendritic cell and nerve fiber responses to cavities, caries, or caries treatment in human teeth","volume":"82","author":"Yoshiba","year":"2003","journal-title":"J. Dent. Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1034\/j.1600-0722.2002.21282.x","article-title":"Immunohistochemical study on pulpal response in rat molars after cavity preparation by Er:YAG laser","volume":"110","author":"Tanabe","year":"2002","journal-title":"Eur. J. Oral Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cytogfr.2019.05.004","article-title":"Role of osteopontin in dendritic cell shaping of immune responses","volume":"50","author":"Scutera","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Weber, G.F. (2018). The phylogeny of osteopontin-analysis of the protein sequence. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19092557"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3109\/03008208909002412","article-title":"The nature and significance of osteopontin","volume":"23","author":"Butler","year":"1989","journal-title":"Connect. Tissue Res."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1091\/mbc.3.10.1169","article-title":"Expression and distribution of osteopontin in human tissues: Widespread association with luminal epithelial surfaces","volume":"3","author":"Brown","year":"1992","journal-title":"Mol. Biol. Cell"},{"key":"ref_108","first-page":"169","article-title":"The nature and functional significance of dentin extracellular matrix proteins","volume":"39","author":"Butler","year":"1995","journal-title":"Int. J. Dev. Biol."},{"key":"ref_109","first-page":"206","article-title":"Differentiation, maturation, and survival of dendritic cells by osteopontin regulation","volume":"12","author":"Kawamura","year":"2005","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3389\/fimmu.2018.01207","article-title":"Adaptive regulation of osteopontin production by dendritic cells through the bidirectional interaction with mesenchymal stromal cells","volume":"9","author":"Scutera","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12026-010-8179-5","article-title":"Intracellular osteopontin (iOPN) and immunity","volume":"49","author":"Inoue","year":"2011","journal-title":"Immunol. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1177\/0022034515605270","article-title":"Osteopontin in immune-mediated diseases","volume":"94","author":"Rittling","year":"2015","journal-title":"J. Dent. Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1017\/S1462399411001839","article-title":"Osteopontin in macrophage function","volume":"13","author":"Rittling","year":"2011","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"78","DOI":"10.2302\/kjm.53.78","article-title":"Osteoclasts, mononuclear phagocytes, and c-Fos: New insight into osteoimmunology","volume":"53","author":"Matsuo","year":"2004","journal-title":"Keio J. Med."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.imbio.2012.02.002","article-title":"The hypoxic environment reprograms the cytokine\/chemokine expression profile of human mature dendritic cells","volume":"218","author":"Blengio","year":"2013","journal-title":"Immunobiology"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/nrm3049","article-title":"The elusive nature and function of mesenchymal stem cells","volume":"12","author":"Ritz","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1359\/jbmr.2003.18.4.696","article-title":"Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp","volume":"18","author":"Shi","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/jbmr.2717","article-title":"Perivascular stem cells at the tip of mouse incisors regulate tissue regeneration","volume":"31","author":"Pang","year":"2016","journal-title":"J. Bone Miner. Res."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/iej.12983","article-title":"Activation of alphaSMA expressing perivascular cells during reactionary dentinogenesis","volume":"52","author":"Vijaykumar","year":"2019","journal-title":"Int. Endod. J."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2174\/1574888X10666150904114035","article-title":"Cross-talk between mesenchymal stem\/stromal cells and dendritic cells","volume":"11","author":"Ethokic","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3389\/fendo.2020.00465","article-title":"Osteoimmunology: The regulatory roles of T lymphocytes in osteoporosis","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Negrescu, A.M., and Cimpean, A. (2021). The state of the art and prospects for osteoimmunomodulatory biomaterials. Materials, 14.","DOI":"10.3390\/ma14061357"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1152\/physrev.00036.2016","article-title":"Osteoimmunology: The conceptual framework unifying the immune and skeletal systems","volume":"97","author":"Okamoto","year":"2017","journal-title":"Physiol. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Okamoto, K., and Takayanagi, H. (2019). Osteoimmunology. Cold Spring Harb. Perspect. Med., 9.","DOI":"10.1101\/cshperspect.a031245"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature12984","article-title":"The bone marrow niche for haematopoietic stem cells","volume":"505","author":"Morrison","year":"2014","journal-title":"Nature"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1111\/iej.12043","article-title":"CpG ODN-induced matrix metalloproteinase-13 expression is mediated via activation of the ERK and NF-kappaB signalling pathways in odontoblast cells","volume":"46","author":"Zhang","year":"2013","journal-title":"Int. Endod. J."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1089\/nat.2018.0761","article-title":"G-quadruplex structure improves the immunostimulatory effects of CpG oligonucleotides","volume":"29","author":"Hoshi","year":"2019","journal-title":"Nucleic Acid Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/IJN.S114477","article-title":"CpG oligodeoxynucleotide nanomedicines for the prophylaxis or treatment of cancers, infectious diseases, and allergies","volume":"12","author":"Hanagata","year":"2017","journal-title":"Int. J. Nanomed."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/15\/3348\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:36:35Z","timestamp":1760164595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/15\/3348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":128,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10153348"],"URL":"https:\/\/doi.org\/10.3390\/jcm10153348","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]}}}