{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:40:26Z","timestamp":1787960426808,"version":"build-2784847793"},"reference-count":19,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Japanese Ministry of Health, Labor and Welfare","award":["21FC1008"],"award-info":[{"award-number":["21FC1008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute cerebral infarction (ACI) includes cardiogenic ACI treated with anticoagulants and atherosclerotic ACI treated with antiplatelet agents. The differential diagnosis between cardiogenic and atherosclerotic ACI is still difficult. Materials and Methods: The plasma sCLEC-2 and D-dimer levels were measured using the STACIA system. Results: The plasma sCLEC-2 level was significantly high in patients with ACI, especially those in patients with atherosclerotic or lacunar ACI, and plasma D-dimer levels were significantly high in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2\/D-dimer ratios in patients with atherosclerotic or lacunar ACI were significantly higher than those in patients with cardioembolic ACI. The plasma D-dimer levels in patients with atherosclerotic or lacunar ACI were significantly lower than those in patients with cardioembolic ACI. The plasma levels of sCLEC-2 and the sCLEC-2\/D-dimer ratios were significantly higher in patients with atherosclerotic or lacunar ACI or acute myocardial infarction in comparison to patients with cardioembolic ACI or those with deep vein thrombosis. Conclusion: Using both the plasma sCLEC-2 and D-dimer levels may be useful for the diagnosis of ACI, and differentiating between atherosclerotic and cardioembolic ACI.<\/jats:p>","DOI":"10.3390\/jcm10153408","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T12:59:24Z","timestamp":1627649964000},"page":"3408","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Soluble C-Type Lectin-Like Receptor 2 Elevation in Patients with Acute Cerebral Infarction"],"prefix":"10.3390","volume":"10","author":[{"given":"Akisato","family":"Nishigaki","sequence":"first","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhuko","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Ezaki","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Emergency and Critical Care Center, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Tachibana","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshitaka","family":"Kamon","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutoshi","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Department of Laboratory and General Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Shimpo","sequence":"additional","affiliation":[{"name":"Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1930-3397","authenticated-orcid":false,"given":"Motomu","family":"Shimaoka","sequence":"additional","affiliation":[{"name":"Department of Molecular Pathobiology and Cell Adhesion Biology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsue","family":"Suzuki-Inoue","sequence":"additional","affiliation":[{"name":"Department of Clinical and Laboratory Medicine, University of Yamanashi, Yamanashi 409-3898, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9021-8633","authenticated-orcid":false,"given":"Hideo","family":"Wada","sequence":"additional","affiliation":[{"name":"Department of Laboratory and General Medicine, Mie Prefectural General Medical Center, Yokkaichi 510-8561, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"ref_1","first-page":"16983","article-title":"Management of acute ischemic stroke","volume":"368","author":"Phipps","year":"2020","journal-title":"BMJ"},{"key":"ref_2","unstructured":"World Stroke Organization (2021, January 05). 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