{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T21:00:30Z","timestamp":1774990830310,"version":"3.50.1"},"reference-count":20,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Few data are available about brain natriuretic peptide (BNP) variation and left atrial remodeling after the left atrial appendage occlusion (LAAO) technique. Methods: Prospective study included all consecutive patients successfully implanted with an LAAO device. Contrast-enhanced cardiac computed tomography (CT) was performed before and 6 weeks after the procedure with reverse left atrial remodeling defined by an increase in LA volume &gt;10%, together with blood sampling obtained before, 48 h after device implantation and at the first visit after discharge (30\u201345 days) for BNP measurement. Results: Among the 43 patients implanted with a complete dataset, mean end-diastolic LA volume was 139 \u00b1 64 mL and 141 \u00b1 62 mL at baseline and during follow-up (45 \u00b1 15 days), respectively, showing no statistical difference (p = 0.45). No thrombus was seen on the atrial side of the device. Peridevice leaks (defined as presence of dye in the LAA beyond the device) were observed in 17 patients (40%) but were trivial or mild. Reverse atrial remodeling (RAR) at 6 weeks was observed in six patients (14%). Despite no difference in BNP levels on admission, median BNP levels at 48 h were slightly increased in RAR patients when compared with controls. During FU, BNP levels were strictly identical in both groups. These results were not modified even when each RAR case was matched with two controls on age, LVEF, creatinine levels and ACE inhibitors treatment to avoid potential confounders. Conclusion: Our study showed that despite the fact that the LAAO technique can induce left atrial remodeling measured by a CT scan, it does not seem to impact BNP levels on the follow-up. The results need to be transposed to clinical outcomes of this expanding population in future studies.<\/jats:p>","DOI":"10.3390\/jcm10153443","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T08:16:39Z","timestamp":1627978599000},"page":"3443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Left Atrial Remodeling and Brain Natriuretic Peptide Levels Variation after Left Atrial Appendage Occlusion"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1637-8855","authenticated-orcid":false,"given":"Thibaut","family":"Pommier","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"},{"name":"Laboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2), University of Burgundy, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9333-3896","authenticated-orcid":false,"given":"Thibault","family":"Leclercq","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3554-7714","authenticated-orcid":false,"given":"Charles","family":"Guenancia","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"},{"name":"Laboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2), University of Burgundy, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Richard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"},{"name":"Laboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2), University of Burgundy, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Porot","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Laurent","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Lorgis","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital, 21000 Dijon, France"},{"name":"Laboratory of Cerebro-Vascular Pathophysiology and Epidemiology (PEC2), University of Burgundy, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: National implications for rhythm management and stroke prevention: The AnTicoagulation and Risk Factors in Atrial Fi-brillation (ATRIA) Study","volume":"285","author":"Go","year":"2001","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/205013","article-title":"Left Atrial Appendage: Physiology, Pathology, and Role as a Therapeutic Target","volume":"2015","author":"Regazzoli","year":"2015","journal-title":"BioMed Res. 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