{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T15:18:58Z","timestamp":1776352738324,"version":"3.51.2"},"reference-count":173,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project-ID251293561"],"award-info":[{"award-number":["Project-ID251293561"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Today it is well established that early life stress leads to cardiovascular programming that manifests in cardiovascular disease, but the mechanisms by which this occurs, are not fully understood. This perspective review examines the relevant literature that implicates the dysregulation of the gasomediator hydrogen sulfide and the neuroendocrine oxytocin systems in heart disease and their putative mechanistic role in the early life stress developmental origins of cardiovascular disease. Furthermore, interesting hints towards the mutual interaction of the hydrogen sulfide and OT systems are identified, especially with regards to the connection between the central nervous and the cardiovascular system, which support the role of the vagus nerve as a communication link between the brain and the heart in stress-mediated cardiovascular disease.<\/jats:p>","DOI":"10.3390\/jcm10163484","type":"journal-article","created":{"date-parts":[[2021,8,8]],"date-time":"2021-08-08T21:49:41Z","timestamp":1628459381000},"page":"3484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["H2S and Oxytocin Systems in Early Life Stress and Cardiovascular Disease"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7879-7695","authenticated-orcid":false,"given":"Oscar","family":"McCook","sequence":"first","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3655-6433","authenticated-orcid":false,"given":"Nicole","family":"Denoix","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"},{"name":"Clinic for Psychosomatic Medicine and Psychotherapy, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Radermacher","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Waller","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine and Psychotherapy, Nuremberg General Hospital, Paracelsus Medical University, 90471 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-9171","authenticated-orcid":false,"given":"Tamara","family":"Merz","sequence":"additional","affiliation":[{"name":"Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University Medical Center, 89081 Ulm, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00392-019-01488-w","article-title":"Significance of Psychosocial Factors in Cardiology: Update 2018: Position Paper of the German Cardiac Society","volume":"108","author":"Albus","year":"2019","journal-title":"Clin. Res. Cardiol."},{"key":"ref_2","first-page":"125","article-title":"Childhood Maltreatment and Health Impact: The Examples of Cardiovascular Disease and Type 2 Diabetes Mellitus in Adults","volume":"24","author":"Basu","year":"2017","journal-title":"Clin. Psychol. Sci. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/CIR.0000000000000536","article-title":"Childhood and Adolescent Adversity and Cardiometabolic Outcomes: A Scientific Statement from the American Heart Association","volume":"137","author":"Suglia","year":"2018","journal-title":"Circulation"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e015855","DOI":"10.1161\/JAHA.119.015855","article-title":"Increased Cardiometabolic and Mortality Risk Following Childhood Maltreatment in the United Kingdom","volume":"9","author":"Chandan","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Trautwein, B., Merz, T., Denoix, N., Szabo, C., Calzia, E., Radermacher, P., and McCook, O. (2021). \u0394MST and the Regulation of Cardiac CSE and OTR Expression in Trauma and Hemorrhage. Antioxidants, 10.","DOI":"10.3390\/antiox10020233"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.4103\/1673-5374.313018","article-title":"Localization of the Hydrogen Sulfide and Oxytocin Systems at the Depth of the Sulci in a Porcine Model of Acute Subdural Hematoma","volume":"16","author":"McCook","year":"2021","journal-title":"Neural Regen. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fneur.2020.00649","article-title":"Cerebral Immunohistochemical Characterization of the H2S and the Oxytocin Systems in a Porcine Model of Acute Subdural Hematoma","volume":"11","author":"Denoix","year":"2020","journal-title":"Front. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/4309605","article-title":"Maternal Separation Induces Long-Term Alterations in the Cardiac Oxytocin Receptor and Cystathionine \u03b3-Lyase Expression in Mice","volume":"2020","author":"Wigger","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40635-018-0207-0","article-title":"Interaction of the Hydrogen Sulfide System with the Oxytocin System in the Injured Mouse Heart","volume":"6","author":"Merz","year":"2018","journal-title":"Intensive Care Med. Exp."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3389\/fendo.2020.00299","article-title":"The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model with Underlying Atherosclerosis","volume":"11","author":"Merz","year":"2020","journal-title":"Front. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fpsyt.2019.00118","article-title":"Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation","volume":"10","author":"Agorastos","year":"2019","journal-title":"Front. Psychiatry"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Denoix, N., McCook, O., Ecker, S., Wang, R., Waller, C., Radermacher, P., and Merz, T. (2020). The Interaction of the Endogenous Hydrogen Sulfide and Oxytocin Systems in Fluid Regulation and the Cardiovascular System. Antioxidants, 9.","DOI":"10.3390\/antiox9080748"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.lpm.2017.12.006","article-title":"Post-Traumatic Psychiatric Disorders: PTSD Is Not the Only Diagnosis","volume":"47","year":"2018","journal-title":"Presse M\u00e9dicale"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yhbeh.2014.11.008","article-title":"Effects of Hydrogen Sulfide (H2S) on Water Intake and Vasopressin and Oxytocin Secretion Induced by Fluid Deprivation","volume":"67","author":"Coletti","year":"2015","journal-title":"Horm. Behav."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.psyneuen.2010.01.009","article-title":"Marital Behavior, Oxytocin, Vasopressin, and Wound Healing","volume":"35","author":"Gouin","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.psyneuen.2013.06.019","article-title":"The Role of Oxytocin in Social Bonding, Stress Regulation and Mental Health: An Update on the Moderating Effects of Context and Interindividual Differences","volume":"38","author":"Olff","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/768607","article-title":"The Cardioprotective Actions of Hydrogen Sulfide in Acute Myocardial Infarction and Heart Failure","volume":"2014","author":"Polhemus","year":"2014","journal-title":"Scientifica"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/pr.117.014050","article-title":"International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H2S Levels: H2S Donors and H2S Biosynthesis Inhibitors","volume":"69","author":"Szabo","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hsu, C.-N., and Tain, Y.-L. (2021). Preventing Developmental Origins of Cardiovascular Disease: Hydrogen Sulfide as a Potential Target?. Antioxidants, 10.","DOI":"10.3390\/antiox10020247"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Wang, Y.-Z., Ngowi, E.E., Wang, D., Qi, H.-W., Jing, M.-R., Zhang, Y.-X., Cai, C.-B., He, Q.-L., Khattak, S., and Khan, N.H. (2021). The Potential of Hydrogen Sulfide Donors in Treating Cardiovascular Diseases. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22042194"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hsu, C., Hou, C., Chang-Chien, G., Lin, S., and Tain, Y. (2021). Maternal Garlic Oil Supplementation Prevents High-Fat Diet-Induced Hypertension in Adult Rat Offspring: Implications of H2S-Generating Pathway in the Gut and Kidneys. Mol. Nutr. Food Res., 2001116.","DOI":"10.1002\/mnfr.202001116"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ijcha.2015.01.010","article-title":"A Cardioprotective Insight of the Cystathionine \u03b3-Lyase\/Hydrogen Sulfide Pathway","volume":"7","author":"Huang","year":"2015","journal-title":"IJC Heart Vasc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 Protects against Myocardial Ischemia and Reperfusion Injury by Attenuating Oxidative Stress and Apoptosis in Rats","volume":"29","author":"Meng","year":"2015","journal-title":"J. Biomed. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1111\/bph.12900","article-title":"Emerging Role of Hydrogen Sulfide in Hypertension and Related Cardiovascular Diseases: Hydrogen Sulfide and Hypertension","volume":"172","author":"Meng","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1582-4934.2009.00645.x","article-title":"Hydrogen Sulfide and the Vasculature: A Novel Vasculoprotective Entity and Regulator of Nitric Oxide Bioavailability?","volume":"13","author":"Whiteman","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.phrs.2014.06.006","article-title":"Statins Upregulate Cystathionine \u03b3-Lyase Transcription and H2S Generation via Activating Akt Signaling in Macrophage","volume":"87","author":"Xu","year":"2014","journal-title":"Pharmacol. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cca.2014.07.012","article-title":"Hydrogen Sulfide as a Potent Cardiovascular Protective Agent","volume":"437","author":"Yu","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.apsb.2015.06.004","article-title":"Hydrogen Sulfide Prodrugs\u2014A Review","volume":"5","author":"Zheng","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40635-017-0131-8","article-title":"Cardiovascular Disease and Resuscitated Septic Shock Lead to the Downregulation of the H2S-Producing Enzyme Cystathionine-\u03b3-Lyase in the Porcine Coronary Artery","volume":"5","author":"Merz","year":"2017","journal-title":"Intensive Care Med. Exp."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40635-016-0089-y","article-title":"Left Ventricular Function during Porcine-Resuscitated Septic Shock with Pre-Existing Atherosclerosis","volume":"4","author":"McCook","year":"2016","journal-title":"Intensive Care Med. Exp."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuroscience.2007.12.008","article-title":"Hydrogen Sulphide in the Hypothalamus Causes an ATP-Sensitive K+ Channel-Dependent Decrease in Blood Pressure in Freely Moving Rats","volume":"152","author":"Dawe","year":"2008","journal-title":"Neuroscience"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Liu, W.-Q., Chai, C., Li, X.-Y., Yuan, W.-J., Wang, W.-Z., and Lu, Y. (2011). The Cardiovascular Effects of Central Hydrogen Sulfide Are Related to KATP Channels Activation. Physiol. Res., 729\u2013738.","DOI":"10.33549\/physiolres.932092"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"34608","DOI":"10.1038\/srep34608","article-title":"Cystathionine \u03b3-Lyase Is Expressed in Human Atherosclerotic Plaque Microvessels and Is Involved in Micro-Angiogenesis","volume":"6","author":"Mencke","year":"2016","journal-title":"Sci. Rep."},{"key":"ref_35","first-page":"1145","article-title":"Plasma Hydrogen Sulfide and Homocysteine Levels in Hypertensive Patients with Different Blood Pressure Levels and Complications","volume":"35","author":"Sun","year":"2007","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/00029330-200703010-00008","article-title":"Imbalance of Endogenous Homocysteine and Hydrogen Sulfide Metabolic Pathway in Essential Hypertensive Children","volume":"120","author":"Chen","year":"2007","journal-title":"Chin. Med. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.niox.2014.03.163","article-title":"H2S during Circulatory Shock: Some Unresolved Questions","volume":"41","author":"McCook","year":"2014","journal-title":"Nitric Oxide"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/SHK.0000000000001603","article-title":"Reply to Radermacher et al. on \u201cSerum Hydrogen Sulfide and Outcome Association in Pneumonia by the SARS-CoV-2 Coronavirus\u201d","volume":"55","author":"Radermacher","year":"2021","journal-title":"Shock"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"R165","DOI":"10.1186\/cc9257","article-title":"Effects of Hydrogen Sulfide on Hemodynamics, Inflammatory Response and Oxidative Stress during Resuscitated Hemorrhagic Shock in Rats","volume":"14","author":"Ganster","year":"2010","journal-title":"Crit. Care"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.niox.2014.05.014","article-title":"Hydrogen Sulfide and Nitric Oxide Interactions in Inflammation","volume":"41","author":"Fox","year":"2014","journal-title":"Nitric Oxide"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.113.002208","article-title":"Decreased Endogenous Production of Hydrogen Sulfide Accelerates Atherosclerosis","volume":"127","author":"Mani","year":"2013","journal-title":"Circulation"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/FJC.0b013e3181bfac02","article-title":"Postinfarct Treatment with Oxytocin Improves Cardiac Function and Remodeling via Activating Cell-Survival Signals and Angiogenesis","volume":"54","author":"Kobayashi","year":"2009","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/FJC.0b013e3181c5e7d4","article-title":"Cardiovascular Effects of Oxytocin Infusion in a Porcine Model of Myocardial Infarct","volume":"55","author":"Authier","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"ref_44","first-page":"e58341","article-title":"Assessing Cellular Stress and Inflammation in Discrete Oxytocin-Secreting Brain Nuclei in the Neonatal Rat before and after First Colostrum Feeding","volume":"141","author":"Klein","year":"2018","journal-title":"J. Vis. Exp."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jss.2005.01.021","article-title":"Oxytocin Protects Against Sepsis-Induced Multiple Organ Damage: Role of Neutrophils","volume":"126","author":"Gedik","year":"2005","journal-title":"J. Surg. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1095\/biolreprod.116.139766","article-title":"N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers","volume":"95","author":"Tain","year":"2016","journal-title":"Biol. Reprod."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.niox.2015.12.006","article-title":"Maternal N-Acetylcysteine Therapy Regulates Hydrogen Sulfide-Generating Pathway and Prevents Programmed Hypertension in Male Offspring Exposed to Prenatal Dexamethasone and Postnatal High-Fat Diet","volume":"53","author":"Tai","year":"2016","journal-title":"Nitric Oxide"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-1838(97)00040-4","article-title":"Oxytocin Decreases Blood Pressure in Male but Not in Female Spontaneously Hypertensive Rats","volume":"66","author":"Petersson","year":"1997","journal-title":"J. Auton. Nerv. Syst."},{"key":"ref_49","first-page":"737","article-title":"Influence of sex hormones on DNA content and cystathionine-\u03b3-lyase expression in rat myocardium","volume":"19","author":"Melnik","year":"2017","journal-title":"Zaporozhye Med. J."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"4385","DOI":"10.1111\/bph.12776","article-title":"Overexpression of Oxytocin Receptors in the Hypothalamic PVN Increases Baroreceptor Reflex Sensitivity and Buffers BP Variability in Conscious Rats: Oxytocin Receptors in Autonomic Circulatory Control","volume":"171","author":"Greenwood","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1093\/cvr\/cvx084","article-title":"Chronic Activation of Hypothalamic Oxytocin Neurons Improves Cardiac Function during Left Ventricular Hypertrophy-Induced Heart Failure","volume":"113","author":"Garrott","year":"2017","journal-title":"Cardiovasc. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.psyneuen.2014.01.021","article-title":"Dose-Dependent Effects of Chronic Central Infusion of Oxytocin on Anxiety, Oxytocin Receptor Binding and Stress-Related Parameters in Mice","volume":"42","author":"Peters","year":"2014","journal-title":"Psychoneuroendocrinology"},{"key":"ref_53","first-page":"123","article-title":"Oxytocin in The Cardiovascular Responses to Stress","volume":"59","author":"Wsol","year":"2008","journal-title":"J. Physiol. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jpedsurg.2016.10.013","article-title":"Intestinal Epithelial Injury Induced by Maternal Separation Is Protected by Hydrogen Sulfide","volume":"52","author":"Li","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1093\/ijnp\/pyx030","article-title":"Hydrogen Sulfide Inhibits Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior by Upregulation of Sirt-1: Involvement in Suppression of Hippocampal Endoplasmic Reticulum Stress","volume":"20","author":"Liu","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/1755-5922.12128","article-title":"A Novel Hydrogen Sulfide Prodrug, SG 1002, Promotes Hydrogen Sulfide and Nitric Oxide Bioavailability in Heart Failure Patients","volume":"33","author":"Polhemus","year":"2015","journal-title":"Cardiovasc. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"R162","DOI":"10.1152\/ajpregu.00062.2020","article-title":"Intranasal Oxytocin Has Sympathoexcitatory Effects on Vascular Tone in Healthy Males","volume":"320","author":"Meusel","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.redox.2018.01.007","article-title":"Total Sulfane Sulfur Bioavailability Reflects Ethnic and Gender Disparities in Cardiovascular Disease","volume":"15","author":"Rajpal","year":"2018","journal-title":"Redox Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3389\/fnins.2019.00454","article-title":"Therapeutic Potential of Oxytocin in Atherosclerotic Cardiovascular Disease: Mechanisms and Signaling Pathways","volume":"13","author":"Wang","year":"2019","journal-title":"Front. Neurosci."},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Jankowski, M., Broderick, T.L., and Gutkowska, J. (2016). Oxytocin and Cardioprotection in Diabetes and Obesity. BMC Endocr. Disord., 16.","DOI":"10.1186\/s12902-016-0110-1"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1046\/j.1440-1681.2000.03264.x","article-title":"Centrally Produced Nitric Oxide and The Regulation of Body Fluid And Blood Pressure Homeostases","volume":"27","author":"Kadekaro","year":"2000","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e12686","DOI":"10.1111\/jne.12686","article-title":"Nitric Oxide Acutely Modulates Hypothalamic and Neurohypophyseal Carbon Monoxide and Hydrogen Sulphide Production to Control Vasopressin, Oxytocin and Atrial Natriuretic Peptide Release in Rats","volume":"31","author":"Coletti","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1590\/1414-431X20133309","article-title":"The Role of Oxytocin in Cardiovascular Regulation","volume":"47","author":"Gutkowska","year":"2014","journal-title":"Braz. J. Med. Biol. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"11704","DOI":"10.1073\/pnas.94.21.11704","article-title":"Oxytocin Releases Atrial Natriuretic Peptide by Combining with Oxytocin Receptors in the Heart","volume":"94","author":"Gutkowska","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fpsyg.2018.00173","article-title":"Child Maltreatment Is Associated with a Reduction of the Oxytocin Receptor in Peripheral Blood Mononuclear Cells","volume":"9","author":"Krause","year":"2018","journal-title":"Front. Psychol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"14558","DOI":"10.1073\/pnas.95.24.14558","article-title":"Rat Heart: A Site of Oxytocin Production and Action","volume":"95","author":"Jankowski","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1073\/pnas.110137497","article-title":"Oxytocin and Its Receptors Are Synthesized in the Rat Vasculature","volume":"97","author":"Jankowski","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"E183","DOI":"10.1152\/ajpendo.00346.2016","article-title":"Regulation of the Macrophage Oxytocin Receptor in Response to Inflammation","volume":"312","author":"Szeto","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"170089","DOI":"10.1016\/j.peptides.2019.05.001","article-title":"Oxytocin: Potential to Mitigate Cardiovascular Risk","volume":"117","author":"Reiss","year":"2019","journal-title":"Peptides"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.3389\/fpsyg.2020.02139","article-title":"The Role of Oxytocin in Cardiovascular Protection","volume":"11","author":"Jankowski","year":"2020","journal-title":"Front. Psychol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.peptides.2012.08.001","article-title":"The Role of Nitric Oxide, Reactive Oxygen Species, and Protein Kinase C in Oxytocin-Induced Cardioprotection in Ischemic Rat Heart","volume":"37","author":"Faghihi","year":"2012","journal-title":"Peptides"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/j.1365-2826.2011.02235.x","article-title":"Oxytocin Revisited: Its Role in Cardiovascular Regulation: Role of OT in Cardiovascular Regulation","volume":"24","author":"Gutkowska","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1161\/01.HYP.38.2.292","article-title":"Negative Inotropic and Chronotropic Effects of Oxytocin","volume":"38","author":"Yin","year":"2001","journal-title":"Hypertension"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1113\/expphysiol.2004.027714","article-title":"Stress-Induced Pressor and Corticosterone Responses in Oxytocin-Deficient Mice: Stress Reactivity in Oxytocin-Deficient Mice","volume":"89","author":"Bernatova","year":"2004","journal-title":"Exp. Physiol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1566-0702(02)00134-0","article-title":"Postnatal Oxytocin Treatment and Postnatal Stroking of Rats Reduce Blood Pressure in Adulthood","volume":"99","author":"Holst","year":"2002","journal-title":"Auton. Neurosci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neulet.2008.05.091","article-title":"Postnatal Oxytocin Treatment of Spontaneously Hypertensive Male Rats Decreases Blood Pressure and Body Weight in Adulthood","volume":"440","author":"Petersson","year":"2008","journal-title":"Neurosci. Lett."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.psyneuen.2012.08.009","article-title":"Oxytocin Administration Attenuates Atherosclerosis and Inflammation in Watanabe Heritable Hyperlipidemic Rabbits","volume":"38","author":"Szeto","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0950-351X(96)80314-4","article-title":"Vasopressin and Oxytocin Receptors","volume":"10","author":"Zingg","year":"1996","journal-title":"Baillieres Clin. Endocrinol. Metab."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuron.2012.09.025","article-title":"Neuromodulation by Oxytocin and Vasopressin","volume":"76","author":"Stoop","year":"2012","journal-title":"Neuron"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yfrne.2015.04.003","article-title":"Vasopressin and Oxytocin Receptor Systems in the Brain: Sex Differences and Sex-Specific Regulation of Social Behavior","volume":"40","author":"Dumais","year":"2016","journal-title":"Front. Neuroendocrinol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yfrne.2017.10.004","article-title":"Cross-Talk among Oxytocin and Arginine-Vasopressin Receptors: Relevance for Basic and Clinical Studies of the Brain and Periphery","volume":"51","author":"Song","year":"2018","journal-title":"Front. Neuroendocr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1111\/bph.12613","article-title":"Body Temperature and Cardiac Changes Induced by Peripherally Administered Oxytocin, Vasopressin and the Non-Peptide Oxytocin Receptor Agonist WAY 267,464: A Biotelemetry Study in Rats: Body Temperature and Cardiac Effects of Oxytocin","volume":"171","author":"Hicks","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"101985","DOI":"10.1016\/j.cpr.2021.101985","article-title":"Developmental Programming of Oxytocin through Variation in Early-Life Stress: Four Meta-Analyses and a Theoretical Reinterpretation","volume":"86","author":"Ellis","year":"2021","journal-title":"Clin. Psychol. Rev."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/pr.120.019398","article-title":"Is Oxytocin \u201cNature\u2019s Medicine\u201d?","volume":"72","author":"Carter","year":"2020","journal-title":"Pharmacol. Rev."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41572-019-0106-z","article-title":"Atherosclerosis","volume":"5","author":"Libby","year":"2019","journal-title":"Nat. Rev. Dis. Primer"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/cc11430","article-title":"Erythropoietin in the Critically Ill: Do We Ask the Right Questions?","volume":"16","author":"McCook","year":"2012","journal-title":"Crit. Care"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","article-title":"Hydrogen Sulfide and Cell Signaling","volume":"51","author":"Li","year":"2011","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/ki.2009.221","article-title":"Hydrogen Sulfide: A New EDRF","volume":"76","author":"Wang","year":"2009","journal-title":"Kidney Int."},{"key":"ref_89","first-page":"225","article-title":"Role of Oxytocin in Deceleration of Early Atherosclerotic Inflammatory Processes in Adult Male Rats","volume":"31","author":"Ahmed","year":"2011","journal-title":"Bull. Egypt. Soc. Physiol. Sci."},{"key":"ref_90","first-page":"B4161","article-title":"Human-like Atherosclerosis in Minipigs: A New Model for Detection and Treatment of Vulnerable Plaques","volume":"57","author":"Thim","year":"2010","journal-title":"Dan. Med. Bull."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1096-8628(19980413)76:5<379::AID-AJMG3>3.0.CO;2-I","article-title":"Identification of a Mutation in the Low Density Lipoprotein Receptor Gene Associated with Recessive Familial Hypercholesterolemia in Swine","volume":"76","author":"Ellegren","year":"1998","journal-title":"Am. J. Med. Genet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40635-018-0208-z","article-title":"Cystathionine-\u03b3-Lyase Expression Is Associated with Mitochondrial Respiration during Sepsis-Induced Acute Kidney Injury in Swine with Atherosclerosis","volume":"6","author":"Merz","year":"2018","journal-title":"Intensive Care Med. Exp."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1177\/1535370217732325","article-title":"Hydrogen Sulfide Ameliorated L-NAME-Induced Hypertensive Heart Disease by the Akt\/ENOS\/NO Pathway","volume":"242","author":"Jin","year":"2017","journal-title":"Exp. Biol. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","article-title":"The Oxytocin Receptor: From Intracellular Signaling to Behavior","volume":"98","author":"Jurek","year":"2018","journal-title":"Physiol. Rev."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"100794","DOI":"10.1016\/j.yfrne.2019.100794","article-title":"The Inflammatory Event of Birth: How Oxytocin Signaling May Guide the Development of the Brain and Gastrointestinal System","volume":"55","author":"Kingsbury","year":"2019","journal-title":"Front. Neuroendocrinol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"113833","DOI":"10.1016\/j.bcp.2020.113833","article-title":"Cardiovascular Phenotype of Mice Lacking 3-Mercaptopyruvate Sulfurtransferase","volume":"176","author":"Peleli","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1017\/S2040174415001300","article-title":"The Programming of Cardiovascular Disease","volume":"6","author":"Thornburg","year":"2015","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1161\/01.HYP.2.4.117","article-title":"Studies of Blood Pressure in Tecumseh, Michigan. II. Antecedents in Childhood of High Blood Pressure in Young Adults","volume":"2","author":"Higgins","year":"1980","journal-title":"Hypertension"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0140-6736(86)91340-1","article-title":"Infant Mortality, Childhood Nutrition, and Ischaemic Heart Disease in England and Wales","volume":"1","author":"Barker","year":"1986","journal-title":"Lancet"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1017\/S2040174415001129","article-title":"The Birth and Future Health of DOHaD","volume":"6","author":"Hanson","year":"2015","journal-title":"J. Dev. Orig. Health Dis."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.yjmcc.2014.12.006","article-title":"Programming of Cardiovascular Disease across the Life-Course","volume":"83","author":"Blackmore","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Tain, Y.-L., and Hsu, C.-N. (2017). Interplay between Oxidative Stress and Nutrient Sensing Signaling in the Developmental Origins of Cardiovascular Disease. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18040841"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12929-019-0514-0","article-title":"Effects of Oxytocin on Prosocial Behavior and the Associated Profiles of Oxytocinergic and Corticotropin-Releasing Hormone Receptors in a Rodent Model of Posttraumatic Stress Disorder","volume":"26","author":"Wang","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.genhosppsych.2015.10.002","article-title":"High Prevalence of Posttraumatic Stress in Patients with Primary Hypertension","volume":"38","author":"Balint","year":"2016","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/apha.12189","article-title":"A Mechanistic Look at the Effects of Adversity Early in Life on Cardiovascular Disease Risk during Adulthood","volume":"210","author":"Loria","year":"2014","journal-title":"Acta Physiol."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/gps.1723","article-title":"Depression and the Risk for Cardiovascular Diseases: Systematic Review and Meta Analysis","volume":"22","author":"Marwijk","year":"2007","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"9256","DOI":"10.1073\/pnas.1604285113","article-title":"Distinct Oxytocin Effects on Belief Updating in Response to Desirable and Undesirable Feedback","volume":"113","author":"Ma","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"15118","DOI":"10.1073\/pnas.1113137108","article-title":"Oxytocin Receptor Gene (OXTR) Is Related to Psychological Resources","volume":"108","author":"Way","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/10253890500456287","article-title":"Enhanced Involvement of Brain Vasopressin V1 Receptors in Cardiovascular Responses to Stress in Rats with Myocardial Infarction: Research Report","volume":"8","author":"Dobruch","year":"2005","journal-title":"Stress"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.amjcard.2005.06.035","article-title":"Myocardial Perfusion Study of Panic Attacks in Patients with Coronary Artery Disease","volume":"96","author":"Fleet","year":"2005","journal-title":"Am. J. Cardiol."},{"key":"ref_112","doi-asserted-by":"crossref","unstructured":"Hsu, C.-N., and Tain, Y.-L. (2018). Hydrogen Sulfide in Hypertension and Kidney Disease of Developmental Origins. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19051438"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1152\/physiol.00045.2013","article-title":"Sex Differences in the Developmental Origins of Cardiovascular Disease","volume":"29","author":"Intapad","year":"2014","journal-title":"Physiology"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1042\/CS20150611","article-title":"Gender Differences in Developmental Programming of Cardiovascular Diseases","volume":"130","author":"Dasinger","year":"2016","journal-title":"Clin. Sci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/heartjnl-2020-316991","article-title":"Does the Association of Child Maltreatment with Adult Cardiovascular Disease Differ by Gender?","volume":"106","author":"Li","year":"2020","journal-title":"Heart"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nrneph.2017.189","article-title":"Sex-Specific Differences in Hypertension and Associated Cardiovascular Disease","volume":"14","author":"Colafella","year":"2018","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41386-018-0129-2","article-title":"Sex-Dependent Regulation of Social Reward by Oxytocin: An Inverted U Hypothesis","volume":"44","author":"Borland","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1111\/cdev.12136","article-title":"Stress-Induced Elevation of Oxytocin in Maltreated Children: Evolution, Neurodevelopment, and Social Behavior","volume":"85","author":"Seltzer","year":"2014","journal-title":"Child Dev."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3389\/fphar.2018.00154","article-title":"The Associations between Oxytocin and Trauma in Humans: A Systematic Review","volume":"9","author":"Donadon","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.psyneuen.2018.08.037","article-title":"Early Nurture Epigenetically Tunes the Oxytocin Receptor","volume":"99","author":"Perkeybile","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/7854_2017_9","article-title":"Oxytocin and Steroid Actions","volume":"35","author":"Jirikowski","year":"2018","journal-title":"Curr. Top. Behav. Neurosci."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0145-2134(90)90077-7","article-title":"Sexual Abuse in a National Survey of Adult Men and Women: Prevalence, Characteristics, and Risk Factors","volume":"14","author":"Finkelhor","year":"1990","journal-title":"Child Abus. Negl."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1001\/jama.284.5.592","article-title":"Pituitary-Adrenal and Autonomic Responses to Stress in Women After Sexual and Physical Abuse in Childhood","volume":"284","author":"Heim","year":"2000","journal-title":"JAMA"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1037\/a0031467","article-title":"Complex Mental Health Sequelae of Psychological Trauma among Women in Prenatal Care","volume":"6","author":"Seng","year":"2014","journal-title":"Psychol. Trauma Theory Res. Pract. Policy"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s11682-014-9333-9","article-title":"Oxytocin and Vasopressin Effects on the Neural Response to Social Cooperation Are Modulated by Sex in Humans","volume":"9","author":"Feng","year":"2015","journal-title":"Brain Imaging Behav."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1038\/npp.2016.1","article-title":"Intranasal Oxytocin Normalizes Amygdala Functional Connectivity in Posttraumatic Stress Disorder","volume":"41","author":"Koch","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/npp.2015.299","article-title":"Intranasal Oxytocin Administration Dampens Amygdala Reactivity towards Emotional Faces in Male and Female PTSD Patients","volume":"41","author":"Koch","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.biopsych.2006.09.007","article-title":"Sensitivity to Intranasal Oxytocin in Adult Men with Early Parental Separation","volume":"61","author":"Meinlschmidt","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000382021","article-title":"Serum Oxytocin, Posttraumatic Coping and C-Reactive Protein in Motor Vehicle Accident Survivors by Gender","volume":"71","author":"Nishi","year":"2015","journal-title":"Neuropsychobiology"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"104482","DOI":"10.1016\/j.psyneuen.2019.104482","article-title":"Intranasal Oxytocin Enhances Stress-Protective Effects of Social Support in Women with Negative Childhood Experiences during a Virtual Trier Social Stress Test","volume":"111","author":"Riem","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1038\/tp.2013.34","article-title":"Sniffing around Oxytocin: Review and Meta-Analyses of Trials in Healthy and Clinical Groups with Implications for Pharmacotherapy","volume":"3","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1177\/1362361320902903","article-title":"An Association of Intrapartum Synthetic Oxytocin Dosing and the Odds of Developing Autism","volume":"24","author":"Soltys","year":"2020","journal-title":"Autism"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-8993(00)02464-1","article-title":"A Single Social Defeat Experience Selectively Stimulates the Release of Oxytocin, but Not Vasopressin, within the Septal Brain Area of Male Rats","volume":"872","author":"Ebner","year":"2000","journal-title":"Brain Res."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yhbeh.2008.02.013","article-title":"Maternal Influences on the Sexual Behavior and Reproductive Success of the Female Rat","volume":"54","author":"Cameron","year":"2008","journal-title":"Horm. Behav."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroscience.2005.05.025","article-title":"Sexually Dimorphic Expression of Oxytocin Binding Sites in Forebrain and Spinal Cord of the Rat","volume":"135","author":"Waltisperger","year":"2005","journal-title":"Neuroscience"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/hup.2402","article-title":"Gender Moderates the Effect of Oxytocin on Social Judgments: Oxytocin, Gender, and Person Perception","volume":"29","author":"Hoge","year":"2014","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.yhbeh.2013.08.012","article-title":"Sex Differences in Oxytocin Receptor Binding in Forebrain Regions: Correlations with Social Interest in Brain Region- and Sex-Specific Ways","volume":"64","author":"Dumais","year":"2013","journal-title":"Horm. Behav."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1097\/GME.0b013e3182874732","article-title":"Estrogens Increase Cystathionine-\u03b3-Lyase Expression and Decrease Inflammation and Oxidative Stress in the Myocardium of Ovariectomized Rats","volume":"20","author":"Zhu","year":"2013","journal-title":"Menopause"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/bph.12740","article-title":"Crucial Role of Androgen Receptor in Vascular H 2 S Biosynthesis Induced by Testosterone: Androgen Receptor Activation and H2S Biosynthesis","volume":"172","author":"Brancaleone","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0034-5687(97)00086-8","article-title":"Oxygen-Sensing Neurons in the Caudal Hypothalamus and Their Role in Cardiorespiratory Control","volume":"110","author":"Horn","year":"1997","journal-title":"Respir. Physiol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0006-8993(92)91499-5","article-title":"Excitotoxin Paraventricular Nucleus Lesions: Stress and Endocrine Reactivity and Oxytocin MRNA Levels","volume":"597","author":"Callahan","year":"1992","journal-title":"Brain Res."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jacbts.2020.03.007","article-title":"Activation of Oxytocin Neurons Improves Cardiac Function in a Pressure-Overload Model of Heart Failure","volume":"5","author":"Dyavanapalli","year":"2020","journal-title":"JACC Basic Transl. Sci."},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Khademullah, C.S., and Ferguson, A.V. (2013). Depolarizing Actions of Hydrogen Sulfide on Hypothalamic Paraventricular Nucleus Neurons. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0064495"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"311","DOI":"10.31887\/DCNS.2011.13.3\/lbrenner","article-title":"Neuropsychological and Neuroimaging Findings in Traumatic Brain Injury and Post-Traumatic Stress Disorder","volume":"13","author":"Brenner","year":"2011","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_145","unstructured":"Mauri, M.C., Paletta, S., Di Pace, C., Reggiori, A., Cirnigliaro, G., and Miserocchi, G. (2018). Depression and Post-Traumatic Brain Injury: Clinical and Neuropsychological Characteristics. Dual Diagn. Open Access, 2."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s40473-014-0010-5","article-title":"Vagus Nerve Stimulation","volume":"1","author":"Howland","year":"2014","journal-title":"Curr. Behav. Neurosci. Rep."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and Immunology of the Cholinergic Antiinflammatory Pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1097\/01.CCM.0000186762.05301.13","article-title":"Activation of an Efferent Cholinergic Pathway Produces Strong Protection against Myocardial Ischemia\/Reperfusion Injury in Rats","volume":"33","author":"Mioni","year":"2005","journal-title":"Crit. Care Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.3748\/wjg.v12.i20.3271","article-title":"Effects of Nuclei Ambiguus and Dorsal Motor Nuclei of Vagus on Gastric H+ and HCO3\u2212 Secretion in Rats","volume":"12","author":"Zhang","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.resp.2016.10.008","article-title":"Oxytocin\u2019s Role on the Cardiorespiratory Activity of Endotoxemic Rats","volume":"236","author":"Hadamitzky","year":"2017","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/CCM.0000000000003714","article-title":"Vagus Nerve Stimulation Attenuates Multiple Organ Dysfunction in Resuscitated Porcine Progressive Sepsis","volume":"47","author":"Kohoutova","year":"2019","journal-title":"Crit. Care Med."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.1073\/pnas.0600506103","article-title":"Central Muscarinic Cholinergic Regulation of the Systemic Inflammatory Response during Endotoxemia","volume":"103","author":"Pavlov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1161\/01.CIR.0000050627.90734.ED","article-title":"Efferent Vagal Fibre Stimulation Blunts Nuclear Factor-\u039aB Activation and Protects Against Hypovolemic Hemorrhagic Shock","volume":"107","author":"Guarini","year":"2003","journal-title":"Circulation"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1007\/BF03345142","article-title":"Changes of Autonomic Cardiac Profile after a 3-Week Integrated Body Weight Reduction Program in Severely Obese Patients","volume":"26","author":"Facchini","year":"2003","journal-title":"J. Endocrinol. Investig."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1177\/153537020122600508","article-title":"VLCD-Induced Weight Loss Improves Heart Rate Variability in Moderately Obese Japanese","volume":"226","author":"Akehi","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.3109\/10641969909070857","article-title":"Acute and Chronic Effects of a Hypocaloric Diet on 24-Hour Blood Pressure, Heart Rate and Heart-Rate Variability in Mildly-to-Moderately Obese Patients with Essential Hypertension","volume":"21","author":"Minami","year":"1999","journal-title":"Clin. Exp. Hypertens."},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/j.1550-8528.1996.tb00512.x","article-title":"Autonomic Activity Assessed by Heart Rate Spectral Analysis Varies with Fat Distribution in Obese Women","volume":"4","author":"Gao","year":"1996","journal-title":"Obes. Res."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-2006-924083","article-title":"Selective Contribution of Diabetes and Other Cardiovascular Risk Factors to Cardiac Autonomic Dysfunction in the General Population","volume":"114","author":"Ziegler","year":"2006","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.metabol.2006.02.010","article-title":"Effects of Lifestyle Modifications on C-Reactive Protein: Contribution of Weight Loss and Improved Aerobic Capacity","volume":"55","author":"Jae","year":"2006","journal-title":"Metabolism"},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijcard.2004.08.073","article-title":"Exercise Training Modulates Cytokines Activity in Coronary Heart Disease Patients","volume":"100","author":"Goldhammer","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1161\/01.ATV.0000140060.13203.22","article-title":"C-Reactive Protein Genotypes Affect Baseline, but Not Exercise Training\u2013Induced Changes, in C-Reactive Protein Levels","volume":"24","author":"Obisesan","year":"2004","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1067\/mpd.2002.127497","article-title":"Hemostatic and Inflammatory Markers in Obese Youths: Effects of Exercise and Adiposity","volume":"141","author":"Barbeau","year":"2002","journal-title":"J. Pediatr."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1055\/s-2000-8852","article-title":"Reduction of the Plasma Concentration of C-Reactive Protein Following Nine Months of Endurance Training","volume":"21","author":"Mattusch","year":"2000","journal-title":"Int. J. Sports Med."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1016\/j.amjcard.2006.01.029","article-title":"Relation of Heart Rate Variability to Serum Levels of C-Reactive Protein in Patients with Unstable Angina Pectoris","volume":"97","author":"Lanza","year":"2006","journal-title":"Am. J. Cardiol."},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The Anti-Inflammatory Effect of Exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_166","doi-asserted-by":"crossref","unstructured":"Erdman, S.E. (2021). Microbial Muses: Threads of Our Inner Wisdom. Challenges, 12.","DOI":"10.3390\/challe12010010"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/nmo.12530","article-title":"Role of Hydrogen Sulfide within the Dorsal Motor Nucleus of the Vagus in the Control of Gastric Function in Rats","volume":"27","author":"Sun","year":"2015","journal-title":"Neurogastroenterol. Motil."},{"key":"ref_168","doi-asserted-by":"crossref","unstructured":"Gan, X.-B., Liu, T.-Y., Xiong, X.-Q., Chen, W.-W., Zhou, Y.-B., and Zhu, G.-Q. (2012). Hydrogen Sulfide in Paraventricular Nucleus Enhances Sympathetic Activity and Cardiac Sympathetic Afferent Reflex in Chronic Heart Failure Rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050102"},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuroscience.2013.08.048","article-title":"Immunohistochemical Localization of Oxytocin Receptors in Human Brain","volume":"253","author":"Boccia","year":"2013","journal-title":"Neuroscience"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1152\/physiol.00040.2014","article-title":"Gaseous Modulators in the Control of the Hypothalamic Neurohypophyseal System","volume":"30","author":"Ruginsk","year":"2015","journal-title":"Physiology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"e12662","DOI":"10.1111\/jne.12662","article-title":"The Osmoresponsiveness of Oxytocin and Vasopressin Neurones: Mechanisms, Allostasis and Evolution","volume":"31","author":"Leng","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"C916","DOI":"10.1152\/ajpcell.00100.2012","article-title":"Endogenous H 2 S Is Required for Hypoxic Sensing by Carotid Body Glomus Cells","volume":"303","author":"Makarenko","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1097\/00029330-200708010-00009","article-title":"Hydrogen Sulfide Facilitates Carotid Sinus Baroreceptor Activity in Anesthetized Male Rats","volume":"120","author":"Xiao","year":"2007","journal-title":"Chin. Med. J."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3484\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:41:55Z","timestamp":1760164915000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,6]]},"references-count":173,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163484"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163484","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,6]]}}}