{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:50:20Z","timestamp":1787028620115,"version":"build-2736575974"},"reference-count":41,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Introduction: Fixing fractures of the base and neck of mandibular condyles is demanding due to the difficulties in surgical access and the various shapes of bone fragments. Classic fixation techniques assume the use of straight mini-plates, utilized for other craniofacial bone fractures. Three dimensional mini-plates may provide a reasonable alternative due to their ease of use and steadily improved mechanical properties. The multitude of different shapes of 3D mini-plates proves the need for their evaluation. Aim: This paper aims to summarize the clinical trials regarding the use of various types of 3D condylar mini-plates in terms of need for reoperation and the incidence of loosening and damage to the osteosynthetic material. Materials and Methods: A systematic review was conducted in accordance with PICOS criteria and PRISMA protocol. The risk of bias was assessed using ROBINS-I and RoB 2 Cochrane protocols. The obtained data series was analyzed for correlations (Pearson\u2019s r) respecting statistical significance (Student\u2019s t-test p &gt; 0.05) and visualized using OriginLab. Results: 13 clinical trials with low overall risk of bias regarding 6 shapes of 3D mini-plates were included in the synthesis. The number of reoperations correlates with the number of fixations (r = 0.53; p = 0.015) and the total number of screw holes in the mini-plate (r = \u22120.45; p = 0.006). There is a strong correlation between the number of loosened osteosynthetic screws and the total number of fractures treated with 3D mini-plates (r = 0.79; p = 0.001 for each study and r = 0.99; p = 0.015 for each mini-plate shape). A correlation between the percentage of lost screws and the number of distal screw holes is weak regarding individual studies (r = \u22120.27; p = 0.000) and strong regarding individual mini-plate shape (r = \u22120.82; p = 0.001). Three cases of 3D mini-plate fractures are noted, which account for 0.7% of all analyzed fixation cases. Discussion: The reasons for reoperations indicated by the authors of the analyzed articles were: mispositioning of the bone fragments, lack of bone fragment union, secondary dislocation, and hematoma. The known screw loosening factors were poor bone quality, bilateral condylar fractures, difficulties in the correct positioning of the osteosynthetic material due to the limitations of the surgical approach, fracture line pattern, including the presence of intermediate fragments, and mechanical overload. Fractures of the straight mini-plates fixing the mandibular condyles amounts for up to 16% of cases in the reference articles. Conclusions: There is no convincing data that the number of reoperations depends on the type of 3D mini-plate used. The frequency of osteosynthetic screw loosening does not seem to depend on the 3D mini-plate\u2019s shape. Clinical fractures of 3D mini-plates are extremely rare.<\/jats:p>","DOI":"10.3390\/jcm10163604","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T21:27:45Z","timestamp":1629149265000},"page":"3604","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The Use of Titanium 3D Mini-Plates in the Surgical Treatment of Fractures of the Mandibular Condyle: A Systematic Review and Meta-Analysis of Clinical Trials"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-1950","authenticated-orcid":false,"given":"Maciej","family":"Sikora","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery, Hospital of the Ministry of Interior, Wojska Polskiego 51, 25-375 Kielce, Poland"},{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4753","authenticated-orcid":false,"given":"Maciej","family":"Ch\u0119ci\u0144ski","sequence":"additional","affiliation":[{"name":"Preventive Medicine Center, Komorowskiego 12, 30-106 Krak\u00f3w, Poland"},{"name":"StomaDent Non-Public Healthcare Institution, Dental Clinic, Ko\u015bciuszki 32, 46-320 Praszka, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzanna","family":"Nowak","sequence":"additional","affiliation":[{"name":"StomaDent Non-Public Healthcare Institution, Dental Clinic, Ko\u015bciuszki 32, 46-320 Praszka, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Ch\u0119ci\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Glass Technology and Amorphous Coatings, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, ul. Mickiewicza 30, 30-059 Krak\u00f3w, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Olszowski","sequence":"additional","affiliation":[{"name":"Department of Hygiene and Epidemiology, Pomeranian Medical University, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4497-4395","authenticated-orcid":false,"given":"Dariusz","family":"Chlubek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sikora, M., Ch\u0119ci\u0144ski, M., Sielski, M., and Chlubek, D. (2020). Use of 3D Titanium Miniplates in Surgical Treatment of Patients with Condylar Fractures. J. Clin. Med., 9.","DOI":"10.3390\/jcm9092923"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.jcms.2014.03.005","article-title":"Position paper from the IBRA Symposium on Surgery of the Head\u2014The 2nd International Symposium for Condylar Fracture Osteosynthesis, Marseille, France 2012","volume":"42","author":"Neff","year":"2014","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jcms.2021.01.017","article-title":"Towards a consensus for classification of mandibular condyle fractures","volume":"49","author":"McLeod","year":"2021","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00784-018-2459-1","article-title":"Classification proposal for fractures of the processus condylaris mandibulae","volume":"23","author":"Kozakiewicz","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"151616","DOI":"10.1016\/j.aanat.2020.151616","article-title":"Clinico-anatomical classification of the processus condylaris mandibulae for traumatological purposes","volume":"234","author":"Kozakiewicz","year":"2021","journal-title":"Ann. Anat."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Kozakiewicz, M., Zieli\u0144ski, R., Krasowski, M., and Okulski, J. (2019). Forces Causing One-Millimeter Displacement of Bone Fragments of Condylar Base Fractures of the Mandible after Fixation by All Available Plate Designs. Materials, 12.","DOI":"10.3390\/ma12193122"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, R., Kozakiewicz, M., Konieczny, B., Krasowski, M., and Okulski, J. (2020). Mechanical Evaluation of Titanium Plates for Osteosynthesis High Neck Condylar Fracture of Mandible. Materials, 13.","DOI":"10.3390\/ma13030592"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.jcms.2013.11.003","article-title":"\u201cA\u201d shape plate for open rigid internal fixation of mandible condyle neck fracture","volume":"42","author":"Kozakiewicz","year":"2014","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jcms.2016.04.008","article-title":"Use of the Delta plate for surgical treatment of patients with condylar fractures","volume":"44","author":"Sikora","year":"2016","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Kozakiewicz, M., Zieli\u0144ski, R., Konieczny, B., Krasowski, M., and Okulski, J. (2020). Open Rigid Internal Fixation of Low-Neck Condylar Fractures of the Mandible: Mechanical Comparison of 16 Plate Designs. Materials, 13.","DOI":"10.3390\/ma13081953"},{"key":"ref_11","first-page":"14","article-title":"Current views on the treatment of condylar fractures","volume":"64","author":"Sikora","year":"2018","journal-title":"Pomeranian J. Life Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"101404","DOI":"10.1016\/j.tice.2020.101404","article-title":"In vitro effect of three-dimensional (3D) titanium mini-plate systems used for surgical treatment of condylar fractures on interleukin 1 (IL-1) and interleukin 6 (IL-6) concentration in THP-1 macrophages","volume":"67","author":"Sikora","year":"2020","journal-title":"Tissue Cell"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2522.e1","DOI":"10.1016\/j.joms.2019.07.012","article-title":"What Is the Most Stable Fixation Technique for Mandibular Condyle Fracture?","volume":"77","author":"Marwan","year":"2019","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1590\/S0102-86502012000600011","article-title":"Biomechanical analysis of titanium plate systems in mandibular condyle fractures: A systematized literature review","volume":"27","author":"Costa","year":"2012","journal-title":"Acta Cir. Bras."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zieli\u0144ski, R., Kozakiewicz, M., and \u015awiniarski, J. (2019). Comparison of Titanium and Bioresorbable Plates in \u201cA\u201d Shape Plate Properties-Finite Element Analysis. Materials, 12.","DOI":"10.3390\/ma12071110"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.ijom.2014.07.011","article-title":"Finite element evaluation of three methods of stable fixation of condyle base fractures","volume":"43","author":"Vaz","year":"2014","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1239.e1","DOI":"10.1016\/j.joms.2017.02.014","article-title":"Computed Tomography-Based 3-Dimensional Finite Element Analyses of Various Types of Plates Placed for a Virtually Reduced Unilateral Condylar Fracture of the Mandible of a Patient","volume":"75","author":"Murakami","year":"2017","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"794.e1","DOI":"10.1016\/j.joms.2015.11.021","article-title":"Assessment of the Biomechanical Performance of 5 Plating Techniques in Fixation of Mandibular Subcondylar Fracture Using Finite Element Analysis","volume":"74","author":"Darwich","year":"2016","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/emermed-2020-209567","article-title":"Population, Intervention, Comparison, Outcomes and Study (PICOS) design as a framework to formulate eligibility criteria in systematic reviews","volume":"37","author":"Janati","year":"2020","journal-title":"Emerg. Med. J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1055\/s-0034-1389559","article-title":"The Comprehensive AOCMF Classification System: Condylar Process Fractures\u2014Level 3 Tutorial","volume":"7","author":"Neff","year":"2014","journal-title":"Craniomaxillofacial Trauma Reconstr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","article-title":"Updating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomized studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref_23","first-page":"14898","article-title":"RoB 2: A revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.ijom.2020.10.009","article-title":"Fixation of subcondylar fractures of the mandible: A randomized clinical trial comparing one trapezoidal plate with two miniplates","volume":"50","author":"Adhikari","year":"2021","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.joms.2017.12.018","article-title":"Comparative Evaluation of Clinical Outcomes Using Delta Plates and Conventional Miniplates for Internal Fixation of Mandibular Condylar Fractures in Adults","volume":"76","author":"Ahuja","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.jcms.2020.06.001","article-title":"Clinical results of two different three-dimensional titanium plates in the treatment of condylar neck and base fractures: A retrospective study","volume":"48","author":"Burkhard","year":"2020","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1016\/j.joms.2018.01.020","article-title":"Open Reduction and Internal Fixation of Mandibular Condylar Base and Neck Fractures Using Strut Plates","volume":"76","author":"Lechler","year":"2018","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.bjoms.2019.09.016","article-title":"Clinical experience and results with a Rhombic Plate for transoral endoscopically-assisted osteosynthesis of fractures of the condylar neck","volume":"57","author":"Leonhardt","year":"2019","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1330.e1","DOI":"10.1016\/j.joms.2020.12.023","article-title":"Does Three-Dimensional Plate Offer Better Outcome and Reduce the Surgical Time Following Open Reduction and Internal Fixation of Adult Mandibular Unilateral Subcondylar Fractures. A Randomized Clinical Study","volume":"79","author":"Scott","year":"2021","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.joms.2020.01.035","article-title":"Open Reduction and Internal Fixation of Unilateral Mandibular Condylar Base and Neck Fractures Using a Lambda Plate: Selection Criteria for Application","volume":"78","author":"Smolka","year":"2020","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1097\/SCS.0000000000006486","article-title":"Evaluation of Complications After Open Reduction and Internal Fixation of Mandibular Condylar Base and Neck Fractures Using Trapezoidal Plates","volume":"31","author":"Smolka","year":"2020","journal-title":"J. Craniofacial Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.jcms.2014.01.002","article-title":"Epidemiology and treatment outcome of surgically treated mandibular condyle fractures. A five years retrospective study","volume":"42","author":"Zrounba","year":"2014","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Champy, M., H\u00e4rle, F., and Terry, B.C. (2009). Atlas of Craniomaxillofacial Osteosynthesis, Thieme Publication. [2nd ed.].","DOI":"10.1055\/b-002-72255"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1097\/SCS.0000000000006480","article-title":"Endoscopically Assisted Open Reduction and Internal Fixation of Sub-Condylar Fractures: Debunking Some of the Myths","volume":"31","author":"Frenkel","year":"2020","journal-title":"J. Craniofacial Surg."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Sikora, M., Ch\u0119ci\u0144ski, M., Nowak, Z., and Chlubek, D. (2021). Variants and Modifications of the Retroauricular Approach Using in Temporomandibular Joint Surgery: A Systematic Review. J. Clin. Med., 10.","DOI":"10.3390\/jcm10102049"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bjoms.2017.04.013","article-title":"Small-diameter compression screws completely embedded in bone for rigid internal fixation of the condylar head of the mandible","volume":"56","author":"Kozakiewicz","year":"2018","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1007\/s00784-019-02842-y","article-title":"Comparison of compression screws used for mandible head fracture treatment-experimental study","volume":"23","author":"Kozakiewicz","year":"2019","journal-title":"Clin. Oral Investig."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jcms.2019.01.033","article-title":"Which fixation methods are better between three-dimensional anatomical plate and two miniplates for the mandibular subcondylar fracture open treatment?","volume":"47","author":"Sukegawa","year":"2019","journal-title":"J. Cranio-Maxillofac. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jormas.2020.03.009","article-title":"The high sub-mandibular approach: Our experience about 496 procedures","volume":"121","author":"Louvrier","year":"2020","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"ref_40","first-page":"184","article-title":"Periangular transmasseteric infraparotid approach in the treatment of condylar-base and low condylar-neck fractures","volume":"122","author":"Hirjak","year":"2021","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.joms.2006.05.068","article-title":"A new 3-dimensional plate for transoral endoscopic-assisted osteosynthesis of condylar neck fractures","volume":"65","author":"Lauer","year":"2007","journal-title":"J. Oral Maxillofac. Surg."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3604\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:46:47Z","timestamp":1760165207000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,16]]},"references-count":41,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163604"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163604","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,16]]}}}