{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:58:32Z","timestamp":1788562712347,"version":"build-2803163510"},"reference-count":145,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Although shunt overdrainage is a well-known complication in hydrocephalus management, the problem has been underestimated. Current literature suggests that the topic requires more examination. An insight into this condition is limited by a lack of universally agreed-upon diagnostic criteria, heterogeneity of published series, the multitude of different management options and misunderstanding of relationships among pathophysiological mechanisms involved. We carried out a review of the literature on clinical, radiological, intracranial pressure (ICP), pathophysiological and treatment concepts to finally propose an integrative model. Active prophylaxis and management are proposed according to this model based on determination of pathophysiological mechanisms and predisposing factors behind each individual case. As pathophysiology is progressively multifactorial, prevention of siphoning with gravitational valves or antisiphon devices is mandatory to avoid or minimize further complications. Shunt optimization or transferal and neuroendoscopy may be recommended when ventricular collapse and cerebrospinal fluid isolation appear. Cranial expansion may be useful in congenital or acquired craniocerebral disproportion and shunting the subarachnoid space in communicating venous hydrocephalus and idiopathic intracranial hypertension.<\/jats:p>","DOI":"10.3390\/jcm10163620","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T03:43:04Z","timestamp":1629171784000},"page":"3620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Shunt Overdrainage: Reappraisal of the Syndrome and Proposal for an Integrative Model"],"prefix":"10.3390","volume":"10","author":[{"given":"Bienvenido","family":"Ros","sequence":"first","affiliation":[{"name":"Pediatric Neurosurgery Division, Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery Division, Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Linares","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Cerro","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Casado","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Arr\u00e1ez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Regional University Hospital, Avda. Carlos Haya s\/n, 29010 Malaga, Spain"},{"name":"Department of Surgery, Malaga University, 29010 Malaga, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1055\/s-2007-991178","article-title":"Concept and treatment of hydrocephalus in the Greco-Roman and early Arabic Medicine","volume":"50","author":"Grunert","year":"2007","journal-title":"Minim. 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