{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:37:09Z","timestamp":1791481029942,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cardiac troponin I (cTnI) elevation is common in an acute episode of supraventricular tachycardia (SVT). However, there is limited evidence regarding the prognostic value of cTnI and the predictors of SVT recurrence in pediatric patients. We screened the electronic medical records of all pediatric patients presenting to the emergency departments at five Taiwanese hospitals from 1 January 2010 to 31 May 2021. Our primary outcomes were the occurrence of major adverse cardiac events (MACEs) during the follow-up period and 30-day SVT recurrence. A total of 112 patients were included in our study. Of these, 29 (25.9%) patients had positive cTnI values. Patients with cTnI elevation had significantly more complaints of dyspnea (27.6% vs. 7.2%, p = 0.008) and gastrointestinal discomfort (24.1% vs. 4.8%, p = 0.006). There were significantly more intensive care unit admissions (41.4% vs. 16.9%, p = 0.007) among the cTnI-positive group. One MACE was found in the cTnI-negative group. For 30-day SVT recurrence, the cTnI-positive group had a higher recurrence rate, without a statistically significant difference (20.7% vs. 7.2%, p = 0.075). Multivariable logistic regression analysis showed hypotension as an independent predictor of 30-day SVT recurrence (OR = 4.98; Cl 1.02\u201324.22; p = 0.047). Troponin had low value for predicting the outcomes of pediatric patients with SVT. The only significant predictor for recurrent SVT was initial hypotension.<\/jats:p>","DOI":"10.3390\/jcm10163638","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T21:27:40Z","timestamp":1629235660000},"page":"3638","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Prognostic Value of Cardiac Troponin and Risk Assessment in Pediatric Supraventricular Tachycardia"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4885-8175","authenticated-orcid":false,"given":"Chieh-Ching","family":"Yen","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"},{"name":"College of Medicine, National Yang Ming University, Taipei City 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3039-9644","authenticated-orcid":false,"given":"Shou-Yen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"},{"name":"Chang Gung Medical Education Research Center, Chang Gung Memorial Hospital, Taoyuan City 333, Taiwan"},{"name":"Division of Medical Education, Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3702-7499","authenticated-orcid":false,"given":"Chung-Hsien","family":"Chaou","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"},{"name":"Chang Gung Medical Education Research Center, Chang Gung Memorial Hospital, Taoyuan City 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Tzu","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0363-2938","authenticated-orcid":false,"given":"Chip-Jin","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan City 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan City 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.echo.2018.05.001","article-title":"Usefulness of Echocardiography in Children with New-Onset Supraventricular Tachycardia","volume":"31","author":"Conlon","year":"2018","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/joa3.12103","article-title":"Age makes a difference: Symptoms in pediatric supraventricular tachycardia","volume":"34","author":"Quattrocelli","year":"2018","journal-title":"J. Arrhythmia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/XCE.0000000000000208","article-title":"Clinical presentation of paroxysmal supraventricular tachycardia: Evaluation of usual and unusual symptoms","volume":"9","author":"Yetkin","year":"2020","journal-title":"Cardiovasc. Endocrinol. Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0002-9149(96)00701-1","article-title":"Frequency of Disabling Symptoms in Supraventricular Tachycardia","volume":"79","author":"Wood","year":"1997","journal-title":"Am. J. Cardiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00246-015-1289-z","article-title":"Characterization of Cardiac Troponin Elevation in the Setting of Pediatric Supraventricular Tachycardia","volume":"37","author":"Moore","year":"2015","journal-title":"Pediatr. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ahj.2017.04.016","article-title":"Use of troponin assay 99th percentile as the decision level for myocardial infarction diagnosis","volume":"190","author":"Bagai","year":"2017","journal-title":"Am. Heart J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa0706824","article-title":"Cardiac Troponin and Outcome in Acute Heart Failure","volume":"358","author":"Peacock","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1136\/hrt.2005.071282","article-title":"Differential diagnosis of elevated troponins","volume":"92","author":"Korff","year":"2006","journal-title":"Heart"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/jhm.2558","article-title":"Cardiac troponin in patients hospitalized with acute decompensated heart failure: A systematic review and meta-analysis","volume":"11","author":"Yousufuddin","year":"2016","journal-title":"J. Hosp. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jelectrocard.2020.09.001","article-title":"Prognostic value of cardiac troponin levels in patients presenting with supraventricular tachycardias","volume":"62","author":"Ghersin","year":"2020","journal-title":"J. Electrocardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/1742-6723.12971","article-title":"Review article: The utility of troponin and other investigations in patients presenting to the emergency department with supraventricular tachycardia","volume":"31","author":"Fernando","year":"2019","journal-title":"Emerg. Med. Australas."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.amjcard.2010.03.035","article-title":"Relationship of myocardial ischemia and injury to coronary artery disease in patients with supraventricular tachycardia","volume":"106","author":"Bukkapatnam","year":"2010","journal-title":"Am. J. Cardiol."},{"key":"ref_13","first-page":"008253","article-title":"Electrocardiogram Standards for Children and Young Adults Using Z -Scores","volume":"13","author":"Kimata","year":"2020","journal-title":"Circ. Arrhythmia Electrophysiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"642","DOI":"10.5603\/CJ.a2017.0058","article-title":"Elevated high-sensitivity troponin does not indicate the presence of coronary artery disease in patients presenting with supraventricular tachycardia","volume":"24","author":"Murer","year":"2017","journal-title":"Cardiol. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jemermed.2018.04.017","article-title":"Assessment of the Utility of Ordering a Troponin in Low- and Intermediate-Risk Patients Presenting to the Emergency Department with Supraventricular Tachycardia: A Retrospective Chart Review","volume":"55","author":"Noorvash","year":"2018","journal-title":"J. Emerg. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.14503\/THIJ-15-5338","article-title":"Predictors of High-Sensitivity Cardiac Troponin T Elevation in Patients with Acute Paroxysmal Supra-ventricular Tachycardia and Ischemic Heart Disease","volume":"44","author":"Sayadnik","year":"2017","journal-title":"Tex. Heart Inst. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jamainternmed.2021.0266","article-title":"Troponin Testing in Patients with Supraventricular Tachycardia\u2014Are We Overtesting? A Teachable Moment","volume":"181","author":"Allen","year":"2021","journal-title":"JAMA Intern. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s40620-019-00610-5","article-title":"Prognostic value of high-sensitive cardiac troponin I in asymptomatic chronic hemodialysis patients","volume":"33","author":"Maresca","year":"2019","journal-title":"J. Nephrol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/MD.0b013e3181dddb3b","article-title":"Prognostic Significance of Cardiac Troponin I Levels in Hospitalized Patients Presenting with Supraventricular Tachycardia","volume":"89","author":"Chow","year":"2010","journal-title":"Medicine"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cjca.2010.12.004","article-title":"Troponin Elevation in Supraventricular Tachycardia: Primary Dependence on Heart Rate","volume":"27","author":"Roux","year":"2011","journal-title":"Can. J. Cardiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.cjca.2010.12.003","article-title":"Troponin Elevation in Patients with Supraventricular Tachycardia: What Does It Mean?","volume":"27","author":"Healey","year":"2011","journal-title":"Can. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/08860220601098953","article-title":"Relationships between Brain Natriuretic Peptide, Troponin I and QT Dispersion in Asymptomatic Dialysis Patients","volume":"29","author":"Taskapan","year":"2007","journal-title":"Ren. Fail."},{"key":"ref_23","first-page":"133","article-title":"Elevation of cardiac troponin I indicates more than myocardial ischemia","volume":"26","author":"Higgins","year":"2003","journal-title":"Clin. Invest. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/S0002-9149(03)00285-6","article-title":"Usefulness of echocardiography in infants with supraventricular tachycardia","volume":"91","author":"Snyder","year":"2003","journal-title":"Am. J. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1161\/01.CIR.53.6.943","article-title":"Echocardiography in Wolff-Parkinson-White syndrome","volume":"53","author":"Chandra","year":"1976","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00246-014-1063-7","article-title":"Bias Related to Body Mass Index in Pediatric Echocardiographic Z Scores","volume":"36","author":"Dallaire","year":"2014","journal-title":"Pediatr. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/1742-6723.12766","article-title":"Usefulness of laboratory and radiological investigations in the management of supraventricular tachycardia","volume":"29","author":"Ashok","year":"2017","journal-title":"Emerg. Med. Australas."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"186","DOI":"10.5935\/0101-2800.20170033","article-title":"Ventricular arrhythmia in chronic kidney disease patients","volume":"39","author":"Bonato","year":"2017","journal-title":"Braz. J. Nephrol."},{"key":"ref_29","first-page":"349","article-title":"Severe hypothyroidism presenting with supraventricular tachycardia","volume":"73","author":"Mak","year":"2018","journal-title":"Med. J. Malays."},{"key":"ref_30","first-page":"463","article-title":"Neonatal thyrotoxicosis with severe supraventricular tachycardia: Case report and review of the literature","volume":"28","author":"Ecevit","year":"2015","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"ref_31","first-page":"71","article-title":"Study of thyroid function in patients with paroxysmal supraventricular tachycardia","volume":"29","author":"Vanin","year":"1989","journal-title":"Kardiologiia"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1159\/000006873","article-title":"Recurrence risk of supraventricular tachycardia in pediatric patients","volume":"91","author":"Riggs","year":"1999","journal-title":"Cardiology"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3638\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:45:50Z","timestamp":1760165150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":32,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163638"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163638","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]}}}