{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:32:35Z","timestamp":1765233155407,"version":"build-2065373602"},"reference-count":26,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Basic Science Research Program, National Research Foundation of Korea","award":["2019R1F1A1062796","2019M3E5D1A02068088"],"award-info":[{"award-number":["2019R1F1A1062796","2019M3E5D1A02068088"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: To investigate the factors associated with an increase in the neuroretinal rim (NRR) thickness measured based on Bruch\u2019s membrane opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary open-angle glaucoma (POAG). Methods: We analyzed the BMO-MRW using spectral-domain optical coherence tomography (SD-OCT) of patients with POAG who underwent a trabeculectomy for uncontrolled intraocular pressure (IOP) despite maximal IOP reduction treatment. The BMO-MRW was measured before and after trabeculectomy in patients with POAG. Demographic and systemic factors, ocular factors, pre- and post-operative IOP, and visual field parameters were collected, together with SD-OCT measurements. A regression analysis was performed to investigate the factors that affected the change in the BMO-MRW after the trabeculectomy. Results: Forty-four eyes of 44 patients were included in the analysis. The IOP significantly decreased from a preoperative 27.0 mmHg to a postoperative 10.5 mmHg. The mean interval between the trabeculectomy and the date of post-operative SD-OCT measurement was 3.3 months. The global and sectoral BMO-MRW significantly increased after trabeculectomy, whereas the peripapillary retinal nerve fiber layer thickness did not show a difference between before and after the trabeculectomy. Younger age and a greater reduction in the IOP after the trabeculectomy were significantly associated with the increase in the BMO-MRW after trabeculectomy. Conclusions: The NRR thickness measured based on the BMO-MRW increased with decreasing IOP after trabeculectomy, and the increase in the BMO-MRW was associated with the young age of the patients and greater reduction in the IOP after trabeculectomy. Biomechanically, these suggest that the NRR comprises cells and substances that sensitively respond to changes in the IOP and age.<\/jats:p>","DOI":"10.3390\/jcm10163646","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:54:35Z","timestamp":1629284075000},"page":"3646","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Factors Associated with Increased Neuroretinal Rim Thickness Measured Based on Bruch\u2019s Membrane Opening-Minimum Rim Width after Trabeculectomy"],"prefix":"10.3390","volume":"10","author":[{"given":"Do-Young","family":"Park","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu 42415, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon-Cheol","family":"Cha","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Yeungnam University Hospital, Yeungnam University College of Medicine, Daegu 42415, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/S0161-6420(03)00493-7","article-title":"Optical coherence tomography assessment of retinal nerve fiber layer thickness changes after glaucoma surgery","volume":"110","author":"Aydin","year":"2003","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1016\/j.ophtha.2007.02.012","article-title":"Effect of Lowering Intraocular Pressure on Optical Coherence Tomography Measurement of Peripapillary Retinal Nerve Fiber Layer Thickness","volume":"114","author":"Chang","year":"2007","journal-title":"Ophthalmology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ajo.2018.07.016","article-title":"Structural Reversal of Disc Cupping After Trabeculectomy Alters Bruch Membrane Opening\u2013Based Parameters to Assess Neuroretinal Rim","volume":"194","author":"Gietzelt","year":"2018","journal-title":"Am. J. Ophthalmol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0161-6420(85)33937-4","article-title":"Change in Appearance of the Optic Disc Associated with Lowering of intraocular Pressure","volume":"92","author":"Greenidge","year":"1985","journal-title":"Ophthalmology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0002-9394(14)70488-X","article-title":"Change in Optic Disk Topography After Trabeculectomy","volume":"122","author":"Irak","year":"1996","journal-title":"Am. J. Ophthalmol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/0002-9394(89)90492-3","article-title":"Reversible Optic Disk Cupping and Visual Field Improvement in Adults with Glaucoma","volume":"107","author":"Katz","year":"1989","journal-title":"Am. J. Ophthalmol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00417-018-4187-2","article-title":"Impact of ab-interno trabeculectomy on Bruch\u2019s membrane opening-based morphometry of the optic nerve head for glaucoma progression analysis","volume":"257","author":"Kiessling","year":"2018","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.ophtha.2012.01.034","article-title":"Reversal of Lamina Cribrosa Displacement and Thickness after Trabeculectomy in Glaucoma","volume":"119","author":"Lee","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0161-6420(99)00526-6","article-title":"Reversal of optic disc cupping after glaucoma surgery analyzed with a scanning laser tomograph","volume":"106","author":"Lesk","year":"1999","journal-title":"Ophthalmology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/0002-9394(77)90680-8","article-title":"The Pathogenesis of Reversible Cupping in Congenital Glaucoma","volume":"84","author":"Quigley","year":"1977","journal-title":"Am. J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ogla.2019.09.003","article-title":"Effect of Trabeculectomy on OCT Measurements of the Optic Nerve Head Neuroretinal Rim Tissue","volume":"3","author":"Sanchez","year":"2020","journal-title":"Ophthalmol. Glaucoma"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/0002-9394(79)90518-X","article-title":"Transient Reversible Cupping in Juvenile-Onset Glaucoma","volume":"88","author":"Robin","year":"1979","journal-title":"Am. J. Ophthalmol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ophtha.2012.09.055","article-title":"Enhanced Detection of Open-angle Glaucoma with an Anatomically Accurate Optical Coherence Tomography\u2013Derived Neuroretinal Rim Parameter","volume":"120","author":"Chauhan","year":"2012","journal-title":"Ophthalmology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1167\/iovs.11-9309","article-title":"Influence of Clinically Invisible, but Optical Coherence Tomography Detected, Optic Disc Margin Anatomy on Neuroretinal Rim Evaluation","volume":"53","author":"Reis","year":"2012","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2147\/OPTH.S298045","article-title":"Changes of Neuroretinal Rim and Retinal Nerve Fiber Layer Thickness Assessed by Optical Coherence Tomography After Filtration Surgery in Glaucomatous Eyes","volume":"15","author":"Koenig","year":"2021","journal-title":"Clin. Ophthalmol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Lee, S.H., Lee, E.J., Kim, J.M., Girard, M.J.A., Mari, J.M., and Kim, T.-W. (2020). Lamina Cribrosa Moves Anteriorly After Trabeculectomy in Myopic Eyes. Investig. Opthalmol. Vis. Sci., 61.","DOI":"10.1167\/iovs.61.6.36"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1167\/iovs.15-18982","article-title":"Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma","volume":"57","author":"Lee","year":"2016","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/j.ophtha.2018.05.011","article-title":"Long-Term Shape, Curvature, and Depth Changes of the Lamina Cribrosa after Trabeculectomy","volume":"125","author":"Lesinskas","year":"2018","journal-title":"Ophthalmology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100840","DOI":"10.1016\/j.preteyeres.2020.100840","article-title":"A neuroglia-based interpretation of glaucomatous neuroretinal rim thinning in the optic nerve head","volume":"77","author":"Lee","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0002-9394(66)90758-6","article-title":"The Structure of the Head of the Optic Nerve in Rhesus Monkey","volume":"61","author":"Hayreh","year":"1966","journal-title":"Am. J. Ophthalmol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/0042-6989(95)00317-7","article-title":"Immunohistochemical Study of Human Optic Nerve Head Astroglia","volume":"36","author":"Salazar","year":"1996","journal-title":"Vis. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.1167\/iovs.14-14969","article-title":"Astrocyte Processes Label for Filamentous Actin and Reorient Early Within the Optic Nerve Head in a Rat Glaucoma Model","volume":"55","author":"Tehrani","year":"2014","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1167\/iovs.12-10109","article-title":"Morphology of Astrocytes in a Glaucomatous Optic Nerve","volume":"54","author":"Sun","year":"2013","journal-title":"Investig. Opthalmol. Vis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0012-1606(85)90432-4","article-title":"A quantitative immunohistochemical study of macroglial cell development in the rat optic nerve: In vivo evidence for two distinct astrocyte lineages","volume":"111","author":"Miller","year":"1985","journal-title":"Dev. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.exer.2015.11.016","article-title":"Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA\/2J mouse model of glaucoma","volume":"150","author":"Cooper","year":"2015","journal-title":"Exp. Eye Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s00417-020-04621-y","article-title":"Dynamics of structural reversal in Bruch\u2019s membrane opening-based morphometrics after glaucoma drainage device surgery","volume":"258","author":"Gietzelt","year":"2020","journal-title":"Graefe Arch. Clin. Exp. Ophthalmol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3646\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:46:23Z","timestamp":1760165183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3646"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":26,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163646"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163646","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,8,18]]}}}