{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T18:22:15Z","timestamp":1776622935033,"version":"3.51.2"},"reference-count":36,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Peripheral parenteral nutrition allows repletion of acute nutrient deficiencies and could prevent further nutrition deficits before and after colorectal surgery. A randomized open study was performed to evaluate the effect of perioperative peripheral parenteral nutrition (PPN) support on postoperative morbidity after colorectal cancer surgery within an enhanced recovery program. Methods: Patients were randomized into two groups: peripheral parenteral nutrition (PPN) (with Peri-Olimel N4-E) versus conventional fluid therapy (FT). Ninety-day postoperative complications, laboratory parameters, length of hospital stay, and compliance with the ERAS protocol were assessed. Results: A total of 158 patients were analysed. The overall 90-day complication rate was 38.6% (61 patients), and 24 patients had major complications (Clavien\u2013Dindo III\u2013V) (15.2%). In the multivariate analysis, the intervention (PPN vs. FC) showed a protective effect against postoperative complications (p = 0.0031, OR = 0.2 (CI: 0.08\u20130.87)). Following ordinal regression, PPN and early oral tolerance showed a protective effect, being less likely to develop complications or to move from minor to major complications. In patients with low compliance to ERAS during the first postoperative day, PPN showed a protective effect, preventing 28% of morbidity. Conclusions: Perioperative peripheral parenteral nutrition (PPN) support with Peri-Olimel N4-E in colorectal cancer surgery associated with early oral intake could reduce postoperative complications.<\/jats:p>","DOI":"10.3390\/jcm10163647","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:54:35Z","timestamp":1629284075000},"page":"3647","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of Early Peripheral Parenteral Nutrition Support in an Enhanced Recovery Program for Colorectal Cancer Surgery: A Randomized Open Trial"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0623-9074","authenticated-orcid":false,"given":"Luis","family":"S\u00e1nchez-Guill\u00e9n","sequence":"first","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Soriano-Irigaray","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Elche University Hospital-FISABIO, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"L\u00f3pez-Rodr\u00edguez-Arias","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3079-5855","authenticated-orcid":false,"given":"Xavier","family":"Barber","sequence":"additional","affiliation":[{"name":"Center for Operations Research, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Murcia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Elche University Hospital-FISABIO, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-8974","authenticated-orcid":false,"given":"M Jos\u00e9","family":"Alcaide","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0386-4627","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Aranaz-Ost\u00e1riz","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5228-2746","authenticated-orcid":false,"given":"\u00c1lvaro","family":"Soler-Silva","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-280X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Navarro-Ruiz","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Elche University Hospital-FISABIO, 03203 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Colorectal Unit, Department of General Surgery, Elche University Hospital, Miguel Hernandez University, 03202 Elche, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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