{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:01:11Z","timestamp":1791212471519,"version":"4.1.0"},"reference-count":35,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background. Pain is one of the main aspects of hidradenitis suppurativa that strongly affects the quality of life of patients. We explored the relationship between pain and clinical severity as well as its role in defining the health status in patients with HS. Methods. Pain was defined by three measures: (a) question 1 (\u201cmy skin hurts\u201d) of the Skindex-17; (b) Bodily Pain (BP) scale of the SF-36; and (c) Visual Analog Scale (VAS). Clinical severity of HS was assessed by the Hurley staging, the Sartorius HS Score, and the International HS Severity Score System. Results. The study population included 341 HS patients with complete data for the VAS pain, 316 for question 1 of the Skindex-17, and 294 for BP. Clinical severity was positively associated with pain. This result was observed for all three severity scores and all three pain evaluation methods. In addition, the number of fistulae, abscesses, and nodules were significantly associated with the three severity measures of pain, while the association with scars was not observed for question 1 of the Skindex-17 and BP. Conclusions. Pain may be a good proxy of clinical severity and efficacy of a treatment in HS and therefore a crucial hallmark of patients\u2019 health status.<\/jats:p>","DOI":"10.3390\/jcm10163648","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:54:35Z","timestamp":1629284075000},"page":"3648","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Pain as Defining Feature of Health Status and Prominent Therapeutic Target in Patients with Hidradenitis Suppurativa"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-3290","authenticated-orcid":false,"given":"Francesca","family":"Sampogna","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Unit, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5585-9424","authenticated-orcid":false,"given":"Irene","family":"Campana","sequence":"additional","affiliation":[{"name":"Dermatology Department, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Fania","sequence":"additional","affiliation":[{"name":"Dermatology Department, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Mastroeni","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Fusari","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Ciccone","sequence":"additional","affiliation":[{"name":"Dermatology Department, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabatino","family":"Pallotta","sequence":"additional","affiliation":[{"name":"Dermatology Department, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-7617","authenticated-orcid":false,"given":"Damiano","family":"Abeni","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Unit, IDI-IRCCS, 00167 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e410","DOI":"10.1111\/jdv.14224","article-title":"Prevalence and incidence of hidradenitis suppurativa: An exercise on indirect estimation from psoriasis data","volume":"31","author":"Fania","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0190-9622(96)90321-7","article-title":"The prevalence of hidradenitis suppurativa and its potential precursor lesions","volume":"35","author":"Jemec","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","first-page":"3","article-title":"Update on pathogenesis of hidradenitis suppurativa","volume":"153","author":"Napolitano","year":"2018","journal-title":"G. Ital. Dermatol. Venereol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis Suppurativa\/Acne Inversa: Criteria for Diagnosis, Severity Assessment, Classification and Disease Evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/bjd.18656","article-title":"Pain perception in patients with hidradenitis suppurativa","volume":"182","author":"Nielsen","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_7","unstructured":"Merskey, H., and Bogduk, N. (1994). Classification of Chronic Pain, IASP Press. [2nd ed.]."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/AJP.0b013e3181ceb80c","article-title":"Painful hidradenitis suppurativa","volume":"26","author":"Smith","year":"2010","journal-title":"Clin. J. Pain"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2340\/00015555-1082","article-title":"Psychosocial impact of hidradenitis suppurativa: A qualitative study","volume":"91","author":"Esmann","year":"2011","journal-title":"Acta Derm. Venereol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1365-2133.2001.04137.x","article-title":"Morbidity in patients with hidradenitis suppurativa","volume":"144","author":"Jemec","year":"2001","journal-title":"Br. J. Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/bjd.14266","article-title":"Self-reported pain management in hidradenitis suppurativa","volume":"174","author":"Ring","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e171","DOI":"10.1111\/bjd.16603","article-title":"Profound consequences of hidradenitis suppurativa: A review","volume":"183","author":"Matusiak","year":"2020","journal-title":"Br. J. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"adv00120","DOI":"10.2340\/00015555-3477","article-title":"Exploring the EQ-5D Dimension of Pain\/Discomfort in Dermatology Outpatients from a Multicentre Study in 13 European Countries","volume":"100","author":"Sampogna","year":"2020","journal-title":"Acta Derm. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/bjd.15280","article-title":"The burden of common skin diseases assessed with the EQ5DTM: A European multicentre study in 13 countries","volume":"176","author":"Balieva","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e386","DOI":"10.1111\/jdv.16290","article-title":"The impact of hidradenitis suppurativa on general health is higher than that of hypertension, congestive heart failure, type 2 diabetes, myocardial infarction and depression","volume":"34","author":"Sampogna","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/bjd.16672","article-title":"A core domain set for hidradenitis suppurativa trial outcomes: An international Delphi process","volume":"179","author":"Thorlacius","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jaad.2015.07.046","article-title":"Pain management in patients with hidradenitis suppurativa","volume":"73","author":"Janse","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.12788\/j.sder.2017.016","article-title":"Quality of life considerations and pain management in hidradenitis suppurativa","volume":"36","author":"Jemec","year":"2017","journal-title":"Semin. Cutan. Med. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2340\/00015555-2815","article-title":"Clinical characteristics of pruritus and pain in patients with hidradenitis suppurativa","volume":"98","author":"Matusiak","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s11916-017-0647-3","article-title":"Pain, Psychological Comorbidities, Disability, and Impaired Qualify of Life in Hidradenitis Suppurativa","volume":"21","author":"Patel","year":"2017","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/sj.jid.5700212","article-title":"Testing and reducing skindex-29 using Rasch analysis: Skindex-17","volume":"126","author":"Nijsten","year":"2006","journal-title":"J. Investig. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection","volume":"30","author":"Ware","year":"1992","journal-title":"Med. Care"},{"key":"ref_23","unstructured":"Roenigk, R., and Roenigk, H.J. (1996). Axillary hyperhidrosis, apocrine bromhidrosis, hidradenitis suppurativa and familial benign pemphigus. Surgical approach. Roenigk and Roenigk\u2019s Dermatologic Surgery: Principles and Practice, Marcel Dekker."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2133.2009.09198.x","article-title":"Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity","volume":"161","author":"Sartorius","year":"2009","journal-title":"Br. J. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_26","first-page":"704","article-title":"Pain: Basics and relevance in dermatology: Academy CME","volume":"7","author":"Nashan","year":"2009","journal-title":"JDDG J. Ger. Soc. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Patel, Z.S., Hoffman, L.K., Sutton, L., Cohen, S.R., Lowes, M.A., and Seng, E.K. (2020). The patient experience of pain in hidradenitis suppurativa. Br. J. Dermatol.","DOI":"10.1111\/bjd.19016"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Scheinfeld, N. (2013). Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine. Dermatol. Online J., 19.","DOI":"10.5070\/D31911020616"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","article-title":"Neuropathic pain: Principles of diagnosis and treatment","volume":"90","author":"Gilron","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_30","first-page":"1","article-title":"Pain in Hidradenitis Suppurativa: A Cross-sectional Study of 1795 Patients","volume":"101","author":"Krajewski","year":"2021","journal-title":"Acta Derm. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Krajewski, P.K., Matusiak, \u0141., von Stebut, E., Schultheis, M., Kirschner, U., Nikolakis, G., and Szepietowski, J.C. (2021). Quality-of-Life Impairment among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study of 1795 Patients. Life, 11.","DOI":"10.3390\/life11010034"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/bjd.14038","article-title":"Diagnostic delay in hidradenitis suppurativa is a global problem","volume":"173","author":"Saunte","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2340\/00015555-2967","article-title":"Influence of itch and pain on sleep quality in patients with hidradenitis suppurativa","volume":"98","author":"Kaaz","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/bjd.14475","article-title":"Development of core outcome sets in hidradenitis suppurativa: Systematic review of outcome measure instruments to inform the process","volume":"175","author":"Ingram","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/jdv.12610","article-title":"Pain and inflammation in hidradenitis suppurativa correspond to morphological changes identified by high-frequency ultrasound","volume":"29","author":"Zarchi","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3648\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:46:26Z","timestamp":1760165186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":35,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163648"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163648","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]}}}