{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T10:12:03Z","timestamp":1770459123732,"version":"3.49.0"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015773","name":"Instituto Nacional de Cardiolog\u00eda - Ignacio Ch\u00e1vez","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100015773","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Several easy-to-use risk scoring systems have been built to identify patients at risk of developing complications associated with COVID-19. However, information about the ability of each score to early predict major adverse outcomes during hospitalization of severe COVID-19 patients is still scarce. Methods: Eight risk scoring systems were rated upon arrival at the Emergency Department, and the occurrence of thrombosis, need for mechanical ventilation, death, and a composite that included all major adverse outcomes were assessed during the hospital stay. The clinical performance of each risk scoring system was evaluated to predict each major outcome. Finally, the diagnostic characteristics of the risk scoring system that showed the best performance for each major outcome were obtained. Results: One hundred and fifty-seven adult patients (55 \u00b1 12 years, 66% men) were assessed at admission to the Emergency Department and included in the study. A total of 96 patients (61%) had at least one major outcome during hospitalization; 32 had thrombosis (20%), 80 required mechanical ventilation (50%), and 52 eventually died (33%). Of all the scores, Obesity and Diabetes (based on a history of comorbid conditions) showed the best performance for predicting mechanical ventilation (area under the ROC curve (AUC), 0.96; positive likelihood ratio (LR+), 23.7), death (AUC, 0.86; LR+, 4.6), and the composite outcome (AUC, 0.89; LR+, 15.6). Meanwhile, the inflammation-based risk scoring system (including leukocyte count, albumin, and C-reactive protein levels) was the best at predicting thrombosis (AUC, 0.63; LR+, 2.0). Conclusions: Both the Obesity and Diabetes score and the inflammation-based risk scoring system appeared to be efficient enough to be integrated into the evaluation of COVID-19 patients upon arrival at the Emergency Department.<\/jats:p>","DOI":"10.3390\/jcm10163657","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T10:54:35Z","timestamp":1629284075000},"page":"3657","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of Easy-to-Use Risk Scoring Systems Rated in the Emergency Department to Predict Major Adverse Outcomes in Hospitalized COVID-19 Patients"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-3751","authenticated-orcid":false,"given":"Julieta","family":"Gonz\u00e1lez-Flores","sequence":"first","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"},{"name":"Programa de Maestr\u00eda en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3388-2006","authenticated-orcid":false,"given":"Carlos","family":"Garc\u00eda-\u00c1vila","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"},{"name":"Programa de Maestr\u00eda en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rashidi","family":"Springall","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malinalli","family":"Brianza-Padilla","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaneli","family":"Ju\u00e1rez-Vicu\u00f1a","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"M\u00e1rquez-Velasco","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-1632","authenticated-orcid":false,"given":"Fausto","family":"S\u00e1nchez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha A.","family":"Ballinas-Verdugo","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna","family":"Basilio-G\u00e1lvez","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"},{"name":"Programa de Maestr\u00eda en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Castillo-Salazar","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"},{"name":"Pharmacy Faculty, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca 62209, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"C\u00e1sarez-Alvarado","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"},{"name":"Programa de Maestr\u00eda en Ciencias Quimicobiol\u00f3gicas, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional, Miguel Hidalgo, Mexico City 11340, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6569-2851","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Hern\u00e1ndez-Diazcouder","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 L.","family":"S\u00e1nchez-Gloria","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6825-3600","authenticated-orcid":false,"given":"Julio","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Immunology Department, Instituto Nacional de Cardiolog\u00eda Ignacio Ch\u00e1vez, Tlalpan, Mexico City 14080, 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WHO Coronavirus Disease (COVID-19) Dashboard. Available online: https:\/\/covid19.who.int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1515\/cclm-2020-0369","article-title":"Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): A meta-analysis","volume":"58","author":"Henry","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: Development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J. Chronic Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1002\/emp2.12259","article-title":"The low-harm score for predicting mortality in patients diagnosed with COVID-19: A multicentric validation study","volume":"1","year":"2020","journal-title":"J. Am. Coll. Emerg. Physicians. Open"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1093\/cid\/ciaa414","article-title":"Prediction for Progression Risk in Patients with COVID-19 Pneumonia: The CALL Score","volume":"71","author":"Ji","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1210\/clinem\/dgaa346","article-title":"Predicting Mortality Due to SARS-CoV-2: A Mechanistic Score Relating Obesity and Diabetes to COVID-19 Outcomes in Mexico","volume":"105","author":"Naveja","year":"2020","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_7","first-page":"1","article-title":"Development and Validation of the Patient History COVID-19 (PH-Covid19) Scoring System: A Multivariable Prediction Model of Death in Mexican Patients with COVID-19","volume":"148","year":"2020","journal-title":"Epidemiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jjcc.2018.11.010","article-title":"Derivation and validation of a simple inflammation-based risk score system for predicting in-hospital mortality in acute coronary syndrome patients","volume":"73","author":"Bojalil","year":"2019","journal-title":"J. Cardiol."},{"key":"ref_10","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts--Rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl. Lek. Listy."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1002\/art.38690","article-title":"Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome","volume":"66","author":"Fardet","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"ref_12","unstructured":"World Health Organization (2021, April 10). COVID-19: Surveillance, Case Investigation and Epidemiological Protocols, 16 December 2020. World Health Organization. Available online: https:\/\/www.who.int\/publications\/i\/item\/WHO-2019-nCoV-Surveillance_Case_Definition-2020.2."},{"key":"ref_13","unstructured":"World Health Organization (2021, May 02). Clinical Management of Severe Acute Respiratory Infection (SARI) When COVID-19 Disease is Suspected: Interim Guidance, 13 March 2020. World Health Organization. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/331446."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1016\/j.dsx.2020.10.022","article-title":"Charlson comorbidity index and a composite of poor outcomes in COVID-19 patients: A systematic review and meta-analysis","volume":"14","author":"Henrina","year":"2020","journal-title":"Diabetes. Metab. Syndr."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00011-021-01466-x","article-title":"A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19","volume":"70","author":"Audelo","year":"2021","journal-title":"Inflamm. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12967-020-02374-0","article-title":"Neutrophil-to-lymphocyte ratio predicts critical illness patients with 2019 coronavirus disease in the early stage","volume":"18","author":"Liu","year":"2020","journal-title":"J. Transl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"HLH across speciality collaboration, UK. COVID-19: Consider cytokine storm syndromes and immunosuppres.sion","volume":"395","author":"Mehta","year":"2020","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.3389\/fimmu.2020.01582","article-title":"The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System","volume":"11","author":"Daryabor","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1001\/jamainternmed.2020.3539","article-title":"Risk Factors Associated with Mortality among Patients with COVID-19 in Intensive Care Units in Lombardy, Italy","volume":"180","author":"Grasselli","year":"2020","journal-title":"JAMA Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s00125-020-05180-x","article-title":"Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: The CORONADO study","volume":"63","author":"Cariou","year":"2020","journal-title":"Diabetologia"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/1753-0407.13084","article-title":"The impact of type 2 diabetes and its management on the prognosis of patients with severe COVID-19","volume":"12","author":"Xu","year":"2020","journal-title":"J. Diabetes"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e001343","DOI":"10.1136\/bmjdrc-2020-001343","article-title":"Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes","volume":"8","author":"Yan","year":"2020","journal-title":"BMJ Open. Diabetes Res. Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.2337\/dc20-0660","article-title":"Clinical Characteristics and Outcomes of Patients with Diabetes and COVID-19 in Association with Glucose-Lowering Medication","volume":"43","author":"Chen","year":"2020","journal-title":"Diabetes Care"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hui, Y., Li, Y., Tong, X., Wang, Z., Mao, X., Huang, L., and Zhang, D. (2020). The risk factors for mortality of diabetic patients with severe COVID-19: A retrospective study of 167 severe COVID-19 cases in Wuhan. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0243602"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1684\/ecn.2018.0415","article-title":"Obesity and inflammation","volume":"29","author":"Karczewski","year":"2018","journal-title":"Eur. Cytokine Netw."},{"key":"ref_26","first-page":"84","article-title":"Brief annotations on cytokine release syndrome and interleukin-6 therapeutic blockage in SARS-CoV-2\/COVID-19","volume":"90","year":"2020","journal-title":"Arch. Cardiol. Mex."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1002\/oby.22831","article-title":"High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation","volume":"28","author":"Simonnet","year":"2020","journal-title":"Obesity"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e13095","DOI":"10.1111\/obr.13095","article-title":"Obesity is a risk factor for developing critical condition in COVID-19 patients: A systematic review and meta-analysis","volume":"21","author":"Farkas","year":"2020","journal-title":"Obes. Rev."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"m1966","DOI":"10.1136\/bmj.m1966","article-title":"Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: Prospective cohort study","volume":"369","author":"Petrilli","year":"2020","journal-title":"BMJ"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e212536","DOI":"10.1001\/jamanetworkopen.2021.2536","article-title":"Body Weight Changes During Pandemic-Related Shelter-in-Place in a Longitudinal Cohort Study","volume":"4","author":"Lin","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"6660930","DOI":"10.1155\/2021\/6660930","article-title":"A Systematic Review and Meta-Analysis of Risk Factors Associated with Severity and Death in COVID-19 Patients","volume":"2021","author":"Du","year":"2021","journal-title":"Can. J. Infect. Dis. Med. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S2213-2600(20)30527-0","article-title":"Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: A nationwide, population-based retrospective cohort study","volume":"9","author":"Piroth","year":"2021","journal-title":"Lancet Respir. Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Savla, S.R., Prabhavalkar, K.S., and Bhatt, L.K. (2021). Cytokine storm associated coagulation complications in COVID-19 patients: Pathogenesis and Management. Expert. Rev. Anti. Infect. Ther., 1\u201317.","DOI":"10.1080\/14787210.2021.1915129"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s11547-020-01312-w","article-title":"Deep vein thrombosis in COVID-19 patients in general wards: Prevalence and association with clinical and laboratory variables","volume":"126","author":"Ierardi","year":"2021","journal-title":"Radiol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jinf.2021.01.003","article-title":"Incidence, risk factors, and thrombotic load of pulmonary embolism in patients hospitalized for COVID-19 infection","volume":"82","author":"Oscullo","year":"2021","journal-title":"J. Infect."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.thromres.2020.09.017","article-title":"Biomarkers for the prediction of venous thromboembolism in critically ill COVID-19 patients","volume":"196","author":"Dujardin","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.2020006520","article-title":"COVID-19 and coagulation: Bleeding and thrombotic manifestations of SARS-CoV-2 infection","volume":"136","author":"Dzik","year":"2020","journal-title":"Blood"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1161\/CIRCRESAHA.120.317173","article-title":"Hypoalbuminemia, coagulopathy, and vascular disease in COVID-19","volume":"127","author":"Violi","year":"2020","journal-title":"Circ. Res."},{"key":"ref_39","first-page":"102","article-title":"Albumin Supplementation Dampens Hypercoagulability in COVID-19: A Preliminary Report","volume":"1","author":"Violi","year":"2021","journal-title":"Thromb. Haemost."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/MBC.0000000000000974","article-title":"Factors associated with deep venous thrombosis in patients infected with coronavirus disease 2019: A meta-analysis","volume":"32","author":"Loomba","year":"2021","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1182\/blood.2020007008","article-title":"Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome","volume":"10","author":"Middleton","year":"2020","journal-title":"Blood"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1172\/JCI141374","article-title":"Complement and tissue factor-enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis","volume":"130","author":"Skendros","year":"2020","journal-title":"J. Clin. Invest."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1161\/ATVBAHA.120.315267","article-title":"Circulating Markers of Neutrophil Extracellular Traps Are of Prognostic Value in Patients With COVID-19","volume":"41","author":"Ng","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1136\/annrheumdis-2020-218100","article-title":"Presence of antiphospholipid antibodies in COVID-19: Case series study","volume":"80","author":"Springall","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"ref_45","first-page":"3015","article-title":"Are antiphospholipid antibodies just a common epiphenomenon or are they causative of immune-mediated coagulopathy in COVID-19?","volume":"7","author":"Torres","year":"2021","journal-title":"Clin. Rheumatol."},{"key":"ref_46","first-page":"247","article-title":"Hyperuricemia on Admission Predicts Short-Term Mortality due to Myocardial Infarction in a Population with High Prevalence of Cardiovascular Risk Factors","volume":"69","author":"Bojalil","year":"2017","journal-title":"Rev. Invest. Clin."},{"key":"ref_47","unstructured":"World Health Organization (2021, May 05). Noncommunicable Diseases, 13 April 2021. World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases."},{"key":"ref_48","unstructured":"Clark, K.E.N., Nevin, W.D., Mahungu, T., Lachmann, H., and Singh, A. (2020). Assessment of the Haemophagocytic lymphohistiocytosis HScore in patients with COVID-19. Clin. Infect. Dis., ciaa1463."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3657\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:46:48Z","timestamp":1760165208000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/16\/3657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,18]]},"references-count":48,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["jcm10163657"],"URL":"https:\/\/doi.org\/10.3390\/jcm10163657","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,18]]}}}