{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:03:55Z","timestamp":1791237835521,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health","award":["PE-2016-02364619"],"award-info":[{"award-number":["PE-2016-02364619"]}]},{"name":"Italian Ministry of Health","award":["1M30"],"award-info":[{"award-number":["1M30"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The superiority of transcatheter (TAVR) over surgical aortic valve replacement (SAVR) for severe aortic stenosis (AS) has not been fully demonstrated in a real-world setting. This prospective study included 5706 AS patients who underwent SAVR from 2010 to 2012 and 2989 AS patients who underwent TAVR from 2017 to 2018 from the prospective multicenter observational studies OBSERVANT I and II. Early adverse events as well as all-cause mortality, major adverse cardiac and cerebrovascular events (MACCEs), and hospital readmission due to heart failure at 1-year were investigated. Among 1008 propensity score matched pairs, TAVR was associated with significantly lower 30-day mortality (1.8 vs. 3.5%, p = 0.020), stroke (0.8 vs. 2.3%, p = 0.005), and acute kidney injury (0.6 vs. 8.2%, p &lt; 0.001) compared to SAVR. Moderate-to-severe paravalvular regurgitation (5.9 vs. 2.0%, p &lt; 0.001) and permanent pacemaker implantation (13.8 vs. 3.3%, p &lt; 0.001) were more frequent after TAVR. At 1-year, TAVR was associated with lower risk of all-cause mortality (7.9 vs. 11.5%, p = 0.006), MACCE (12.0 vs. 15.8%, p = 0.011), readmission due to heart failure (10.8 vs. 15.9%, p &lt; 0.001), and stroke (3.2 vs. 5.1%, p = 0.033) compared to SAVR. TAVR reduced 1-year mortality in the subgroups of patients aged 80 years or older (HR 0.49, 95% CI 0.33\u20130.71), in females (HR 0.57, 0.38\u20130.85), and among patients with EuroSCORE II \u2265 4.0% (HR 0.48, 95% CI 0.32\u20130.71). In a real-world setting, TAVR using new-generation devices was associated with lower rates of adverse events up to 1-year follow-up compared to SAVR.<\/jats:p>","DOI":"10.3390\/jcm10163703","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"3703","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["One-Year Outcomes after Surgical versus Transcatheter Aortic Valve Replacement with Newer Generation Devices"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6690-5537","authenticated-orcid":false,"given":"Stefano","family":"Rosato","sequence":"first","affiliation":[{"name":"National Centre for Global Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5028-8186","authenticated-orcid":false,"given":"Fausto","family":"Biancari","sequence":"additional","affiliation":[{"name":"Clinica Montevergine, GVM Care and Research, 83013 Mercogliano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"D\u2019Errigo","sequence":"additional","affiliation":[{"name":"National Centre for Global Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4903-5437","authenticated-orcid":false,"given":"Marco","family":"Barbanti","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.U. Policlinico \u201cG. Rodolico\u2014San Marco\u201d, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tarantini","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Department of Clinical and Interventional Cardiology, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Anesthesia and ICU, IRCCS Policlinico San Donato, San Donato Milanese, 20097 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-8988","authenticated-orcid":false,"given":"Giuliano","family":"Costa","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.U. Policlinico \u201cG. Rodolico\u2014San Marco\u201d, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatu","family":"Juvonen","sequence":"additional","affiliation":[{"name":"Heart and Lung Center, Helsinki University Hospital, University of Helsinki, 00029 Helsinki, Finland"},{"name":"Research Unit of Surgery, Anesthesiology and Critical Care, University of Oulu, 90570 Oulu, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Paolo","family":"Ussia","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Campus Bio-Medico University of Rome, 00128 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marcellusi","sequence":"additional","affiliation":[{"name":"Economic Evaluation and HTA (EEHTA), CEIS Faculty of Economics, University of Rome \u201cTor Vergata\u201d, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Baglio","sequence":"additional","affiliation":[{"name":"Italian National Agency for Regional Healthcare Services, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano Domenico","family":"Cicala","sequence":"additional","affiliation":[{"name":"Italian National Agency for Regional Healthcare Services, 00187 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Badoni","sequence":"additional","affiliation":[{"name":"National Centre for Global Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvia","family":"Seccareccia","sequence":"additional","affiliation":[{"name":"National Centre for Global Health, Istituto Superiore di Sanit\u00e0, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corrado","family":"Tamburino","sequence":"additional","affiliation":[{"name":"Division of Cardiology, A.O.U. Policlinico \u201cG. Rodolico\u2014San Marco\u201d, University of Catania, 95124 Catania, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the OBSERVANT II Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.jacc.2020.12.052","article-title":"PARTNER 3 Investigators. Outcomes 2 years after transcatheter aortic valve replacement in patients at low surgical risk","volume":"77","author":"Leon","year":"2021","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa1816885","article-title":"Transcatheter aortic-valve replacement with a self-expanding valve in low-risk patients","volume":"380","author":"Popma","year":"2019","journal-title":"N. Engl. J. 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