{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T06:55:44Z","timestamp":1789541744231,"version":"build-2803163510"},"reference-count":46,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T00:00:00Z","timestamp":1629417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Worldwide, the left ventricular assist device Impella\u00ae (Abiomed, Danvers, MA, USA) is increasingly implanted in patients with acute cardiogenic shock or undergoing high-risk cardiac interventions. Despite its long history of use, few studies have assessed its safety and possible complications associated with its use. All patients treated with a left-sided Impella\u00ae device at the University Hospital of Basel from 1 January 2011 to 31 December 2019 were enrolled. The primary endpoint was the composite rate of mortality and adverse events (bleeding, acute kidney injury, and limb ischemia). Out of 281 included patients, at least one adverse event was present in 262 patients (93%). Rates of in-hospital, 90-day, and one-year mortality were 48%, 47%, and 50%, respectively. BARC type 3 bleeding (62%) and hemolysis (41.6%) were the most common complications. AKI was observed in 50% of all patients. Renal replacement therapy was required in 97 (35%) of all patients. Limb ischemia occurred in 13% of cases. Bleeding and hemolysis are common Impella\u00ae-associated complications. Additionally, we found a high rate of AKI. A careful selection of patients receiving microaxial LV support and defining the indication for its use are essential measures to be taken for the benefits to outweigh potential complications.<\/jats:p>","DOI":"10.3390\/jcm10163710","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"3710","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Adverse Events of Percutaneous Microaxial Left Ventricular Assist Devices\u2014A Retrospective, Single-Centre Cohort Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Anna S.","family":"Zaiser","sequence":"first","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Fahrni","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6799-1652","authenticated-orcid":false,"given":"Alexa","family":"Hollinger","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demian T.","family":"Knobel","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Bovey","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3202-2365","authenticated-orcid":false,"given":"N\u00faria M.","family":"Zellweger","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-6746","authenticated-orcid":false,"given":"Andreas","family":"Buser","sequence":"additional","affiliation":[{"name":"Regional Blood Transfusion Center SRK Basel and Department of Hematology, Transfusion Medicine, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4493-4326","authenticated-orcid":false,"given":"David","family":"Santer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1234-7568","authenticated-orcid":false,"given":"Hans","family":"Pargger","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.","family":"Gebhard","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-4140","authenticated-orcid":false,"given":"Martin","family":"Siegemund","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital Basel, 4031 Basel, Switzerland"},{"name":"Department of Clinical Research, University of Basel, 4031 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1093\/eurheartj\/ehw128","article-title":"2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC","volume":"37","author":"Ponikowski","year":"2016","journal-title":"Eur. 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