{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:13:46Z","timestamp":1773872026203,"version":"3.50.1"},"reference-count":48,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["20-41-596005"],"award-info":[{"award-number":["20-41-596005"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["Program of activities of the Perm Scientific and Educational Center \"Rational Subsoil Use\""],"award-info":[{"award-number":["Program of activities of the Perm Scientific and Educational Center \"Rational Subsoil Use\""]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hemodynamically significant patent ductus arteriosus (hsPDA) in premature newborns is associated with a risk of PDA-related morbidities. Classification into risk groups may have a clinical utility in cases of suspected hsPDA to decrease the need for echocardiograms and unnecessary treatment. This prospective observational study included 99 premature newborns with extremely low body weight, who had an echocardiogram performed within the first three days of life. Discriminant analysis was utilized to find the best combination of prognostic factors for evaluation of hsPDA. We used binary logistic regression analysis to predict the relationship between parameters and hsPDA. The cohort\u2019s mean and standard deviation gestational age was 27.6 \u00b1 2.55 weeks, the mean birth weight was 1015 \u00b1 274 g. Forty-six (46.4%) infants had a PDA with a mean diameter of 2.78 mm. Median NT-pro-BNP levels were 17,600 pg\/mL for infants with a PDA and 2773 pg\/mL in the non-hsPDA group. The combination of prognostic factors of hsPDA in newborns of extremely low body weight on the third day of life was determined: NT-pro-BNP, Apgar score, Silverman\u2013Anderson score (Se = 82%, Sp = 88%). A cut-off value of NT-pro-BNP of more than 8500 pg\/mL can predict hsPDA (Se = 84%, Sp = 86%).<\/jats:p>","DOI":"10.3390\/jcm10163729","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T21:47:52Z","timestamp":1629668872000},"page":"3729","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Discriminant Analysis of Main Prognostic Factors Associated with Hemodynamically Significant PDA: Apgar Score, Silverman\u2013Anderson Score, and NT-Pro-BNP Level"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5189-0347","authenticated-orcid":false,"given":"Anna V.","family":"Permyakova","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Perm State Medical University, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artem","family":"Porodikov","sequence":"additional","affiliation":[{"name":"Federal Center of Cardiovascular Surgery, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0466-175X","authenticated-orcid":false,"given":"Alex G.","family":"Kuchumov","sequence":"additional","affiliation":[{"name":"Department of Computational Mathematics, Mechanics, and Biomechanics, Perm National Research Polytechnic University, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Biyanov","sequence":"additional","affiliation":[{"name":"Federal Center of Cardiovascular Surgery, 614990 Perm, Russia"},{"name":"Department of Pediatrics, Perm State Medical University, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vagram","family":"Arutunyan","sequence":"additional","affiliation":[{"name":"Federal Center of Cardiovascular Surgery, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgeniy G.","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of the Intermediate Level and Hospital Pediatrics, Perm State Medical University, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriy S.","family":"Sinelnkov","sequence":"additional","affiliation":[{"name":"Federal Center of Cardiovascular Surgery, 614990 Perm, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","article-title":"Patent Ductus Arteriosus: Are Current Neonatal Treatment Options Better or Worse Than No Treatment at All?","volume":"36","author":"Clyman","year":"2012","journal-title":"Semin. 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