{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:51:22Z","timestamp":1788306682735,"version":"build-2803163510"},"reference-count":133,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Pili torti is a rare condition characterized by the presence of the hair shaft, which is flattened at irregular intervals and twisted 180\u00b0 along its long axis. It is a form of hair shaft disorder with increased fragility. The condition is classified into inherited and acquired. Inherited forms may be either isolated or associated with numerous genetic diseases or syndromes (e.g., Menkes disease, Bj\u00f6rnstad syndrome, Netherton syndrome, and Bazex-Dupr\u00e9-Christol syndrome). Moreover, pili torti may be a feature of various ectodermal dysplasias (such as Rapp-Hodgkin syndrome and Ankyloblepharon-ectodermal defects-cleft lip\/palate syndrome). Acquired pili torti was described in numerous forms of alopecia (e.g., lichen planopilaris, discoid lupus erythematosus, dissecting cellulitis, folliculitis decalvans, alopecia areata) as well as neoplastic and systemic diseases (such as cutaneous T-cell lymphoma, scalp metastasis of breast cancer, anorexia nervosa, malnutrition, cataracts, and chronic graft-vs.-host disease). The condition may also be induced by several drugs (epidermal growth factor receptor inhibitors, oral retinoids, sodium valproate, and carbamide perhydrate). The diagnosis of pili torti is based on trichoscopic or microscopic examination. As pili torti is a marker of numerous congenital and acquired disorders, in every case, the search for the signs of underlying conditions is recommended.<\/jats:p>","DOI":"10.3390\/jcm10173901","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:49:51Z","timestamp":1630363791000},"page":"3901","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pili Torti: A Feature of Numerous Congenital and Acquired Conditions"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2399-7638","authenticated-orcid":false,"given":"Aleksandra","family":"Hoffmann","sequence":"first","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wa\u015bkiel-Burnat","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2711-0579","authenticated-orcid":false,"given":"Jakub","family":"\u017b\u00f3\u0142kiewicz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leszek","family":"Blicharz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Rakowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Medical Center of the Johannes Gutenberg University, 55122 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Olszewska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Rudnicka","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, 02-008 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1001\/archderm.1932.01450030101015","article-title":"Twisted Hairs (Pili Torti)","volume":"26","author":"Ronchese","year":"1932","journal-title":"Arch. 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