{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:44:29Z","timestamp":1760168669369,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Erectile dysfunction (ED) and coronary artery disease (CAD) share common risk factors, some of which have genetic backgrounds, while others may be stimulated by family lifestyle. We investigated the impact of the familial occurrence of CAD on the presence of ED and the presence of classic risk factors for ED in men with CAD. This cross-sectional observational study involved 751 men with CAD who were subjected to cardiac rehabilitation. Overall, 75.63% of the men had ED. CAD was diagnosed in 39.28% of the studied men\u2019s relatives. ED was less frequent in the men with familial CAD than in those without (71.53% vs. 78.29%). Similar relations were observed for the presence of CAD in parents (70.43% vs. 78.34%) and the father (69.95% vs. 77.46%). The International Index of Erectile Function 5 score was significantly higher in patients with familial CAD (median (interquartile range); 17 (12\u201322) vs. 16 (10\u201321); p = 0.0118), in parents (18 (12\u201322) vs. 16 (10\u201320); p = 0.021), and in the father (18 (12\u201322) vs. 16 (10\u201321); p = 0.0499). Age and education minimized the effect of familial CAD. Familial CAD increased the incidence of hypertension, dyslipidemia, and smoking but not sedentary lifestyle. Despite the higher prevalence of selected risk factors for ED in men with familial CAD, a higher incidence of ED was not observed.<\/jats:p>","DOI":"10.3390\/jcm10184046","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:24:25Z","timestamp":1631010265000},"page":"4046","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Erectile Dysfunction in Men Burdened with the Familial Occurrence of Coronary Artery Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Dariusz","family":"Ka\u0142ka","sequence":"first","affiliation":[{"name":"Cardiosexology Unit, Department of Physiology & Pathophysiology, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"},{"name":"Centre for Men\u2019s Health, 53-151 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Gebala","sequence":"additional","affiliation":[{"name":"Cardiosexology Students\u2019 Scientific Club, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2377-5290","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Biernikiewicz","sequence":"additional","affiliation":[{"name":"Studio S\u0142owa, 50-357 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aneta","family":"Mrozek-Szetela","sequence":"additional","affiliation":[{"name":"Doctoral School at Wroc\u0142aw of Environmental and Life Sciences, 50-375 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5589-4978","authenticated-orcid":false,"given":"Krystyna","family":"Ro\u017cek-Piechura","sequence":"additional","affiliation":[{"name":"Faculty of Physiotherapy, Wroc\u0142aw University of Health and Sport Sciences, 51-612 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Sobieszcza\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Wroc\u0142aw Medical University, 50-369 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1154-1606","authenticated-orcid":false,"given":"Ewa","family":"Szuster","sequence":"additional","affiliation":[{"name":"Cardiosexology Students\u2019 Scientific Club, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Majchrowska","sequence":"additional","affiliation":[{"name":"Cardiosexology Unit, Department of Physiology & Pathophysiology, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Mi\u0119tka","sequence":"additional","affiliation":[{"name":"Cardiosexology Unit, Department of Physiology & Pathophysiology, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2017-9688","authenticated-orcid":false,"given":"Agnieszka","family":"Rusiecka","sequence":"additional","affiliation":[{"name":"Cardiosexology Unit, Department of Physiology & Pathophysiology, Wroc\u0142aw Medical University, 50-368 Wroc\u0142aw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/CIRCULATIONAHA.111.065490","article-title":"Association Between Family History and Coronary Heart Disease Death Across Long-Term Follow-Up in Men","volume":"125","author":"Bachmann","year":"2012","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1001\/jamacardio.2016.0227","article-title":"Association of a Family History of Coronary Heart Disease with Initiation of Statin Therapy in Individuals at Intermediate Risk","volume":"1","author":"Safarova","year":"2016","journal-title":"JAMA Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.cell.2012.03.001","article-title":"Genetics of Human Cardiovascular Disease","volume":"148","author":"Kathiresan","year":"2012","journal-title":"Cell"},{"key":"ref_4","first-page":"287","article-title":"Genetic risk factors in myocardial infarction at young age","volume":"52","author":"Incalcaterra","year":"2004","journal-title":"Minerva Cardioangiol."},{"key":"ref_5","first-page":"14","article-title":"Modifiable risk factors for erectile dysfunction: An assessment of the awareness of such factors in patients suffering from ischaemic heart disease","volume":"28","author":"Domagala","year":"2015","journal-title":"Int. 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