{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:48:42Z","timestamp":1781880522262,"version":"3.54.5"},"reference-count":16,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T00:00:00Z","timestamp":1631318400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/00083"],"award-info":[{"award-number":["PI17\/00083"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Inflammatory bowel disease (IBD) has been described as an independent risk factor for the development of cardiovascular (CV) disease. Since the QRESEARCH risk estimator version 3 (QRISK3) calculator was recently proposed to assess CV in the general population, our objective was to compare the predictive ability of QRISK3 with that of a well-established European CV risk calculator, the Systematic Coronary Risk Assessment (SCORE), to identify the presence of subclinical carotid atherosclerosis in patients with IBD. In all, 186 patients with IBD and 178 controls were recruited. The presence of subclinical atherosclerosis was evaluated by carotid ultrasound to identify carotid plaque and the thickness of the carotid intima-media (cIMT). QRISK3 and SCORE were calculated. The relationship of QRISK3 and SCORE with each other and with the presence of subclinical carotid atherosclerosis (both carotid plaque and cIMT) was studied in patients and controls. SCORE (0.2 (interquartile range 0.1\u20130.9) vs. 0.4 (0.1\u20131.4), p = 0.55) and QRISK3 1.7 ((0.6\u20134.6) vs. 3.0 (1.0\u20137.8), p = 0.16) absolute values did not differ between patients and controls. QRISK3 and SCORE correlated equally with cIMT within both populations. However, SCORE correlation with cIMT was found to be significantly lower in patients with IBD when compared to controls (Spearman\u2019s Rho 0.715 vs. 0.587, p = 0.034). Discrimination analysis of both calculators with carotid plaque was similar within both populations. Nevertheless, in patients with IBD, QRISK3 showed a trend toward a higher discrimination (QRISK3 area under the curve 0.812 (95%CI 0.748\u20130.875) vs. SCORE 0.790 (95%CI 0.723\u20130.856), p = 0.051). In conclusion, QRISK3 discrimination for subclinical atherosclerosis is optimal and equivalent to that of SCORE in IBD patients. However, our findings highlight the role of QRISK3 as an appropriate tool for the assessment of CV risk in patients with IBD.<\/jats:p>","DOI":"10.3390\/jcm10184102","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T21:45:57Z","timestamp":1631483157000},"page":"4102","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["QRISK3 Performance in the Assessment of Cardiovascular Risk in Patients with Inflammatory Bowel Disease"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1056-8711","authenticated-orcid":false,"given":"Marta","family":"Carrillo-Palau","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-207X","authenticated-orcid":false,"given":"Alejandro","family":"Hern\u00e1ndez-Camba","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Nuestra Se\u00f1ora de la Candelaria, 38010 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7015-1742","authenticated-orcid":false,"given":"Laura","family":"Ramos","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4537-9133","authenticated-orcid":false,"given":"Milagros","family":"Vela","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Nuestra Se\u00f1ora de la Candelaria, 38010 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Arranz","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Nuestra Se\u00f1ora de la Candelaria, 38010 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Hern\u00e1ndez Alvarez-Buylla","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0406-029X","authenticated-orcid":false,"given":"Inmaculada","family":"Alonso-Abreu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2548-6767","authenticated-orcid":false,"given":"Anjara","family":"Hern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Hern\u00e1ndez-Guerra","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilo","family":"Palazuelos","sequence":"additional","affiliation":[{"name":"Epidemiology and Public Health Group, IDIVAL, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Llorca","sequence":"additional","affiliation":[{"name":"Department of Medical Ciencies, University of Cantabria, CIBER Epidemiolog\u00eda y Salud P\u00fablica (CIBERESP), 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1.","family":"Gonz\u00e1lez-Gay","sequence":"additional","affiliation":[{"name":"Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, 39008 Santander, Spain"},{"name":"Division of Rheumatology, Hospital Universitario Marqu\u00e9s de Valdecilla, Universidad de Cantabria, 39008 Santander, Spain"},{"name":"Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health, Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0197-5267","authenticated-orcid":false,"given":"Iv\u00e1n","family":"Ferraz-Amaro","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital Universitario de Canarias, 38320 Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1093\/ecco-jcc\/jjy164","article-title":"Cardiovascular risk profile among patients with inflammatory bowel disease: A population-based study of more than 100,000 individuals","volume":"13","author":"Aarestrup","year":"2019","journal-title":"J. Crohn\u2019s Colitis"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1093\/eurheartj\/ehw106","article-title":"2016 European Guidelines on cardiovascular disease prevention in clinical practice","volume":"37","author":"Piepoli","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: The SCORE project","volume":"24","author":"Conroy","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Hippisley-Cox, J., Coupland, C., and Brindle, P. (2017). Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: Prospective cohort study. BMJ, 357.","DOI":"10.1136\/bmj.j2099"},{"key":"ref_5","first-page":"1956","article-title":"2018 ESC\/ESHGuidelines for themanagement of arterial hypertension","volume":"36","author":"Williams","year":"2018","journal-title":"J. Hypertens."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0140-6736(80)92767-1","article-title":"A simple index of crohn\u2019s-disease activity","volume":"315","author":"Harvey","year":"1980","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJM198712243172603","article-title":"Coated Oral 5-Aminosalicylic Acid Therapy for Mildly to Moderately Active Ulcerative Colitis","volume":"317","author":"Schroeder","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.12688\/f1000research.21679.3","article-title":"R package \u201cQRISK3\u201d: An unofficial research purposed implementation of ClinRisk\u2019s QRISK3 algorithm into R","volume":"8","author":"Li","year":"2020","journal-title":"F1000Research"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/annrheumdis-2012-203101","article-title":"Carotid ultrasound is useful for the cardiovascular risk stratification of patients with rheumatoid arthritis: Results of a population-based study","volume":"73","author":"Corrales","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000097034","article-title":"Mannheim carotid intima-media thickness consensus (2004\u20132006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006","volume":"23","author":"Touboul","year":"2007","journal-title":"Cerebrovasc. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"837","DOI":"10.2307\/2531595","article-title":"Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach","volume":"44","author":"DeLong","year":"1988","journal-title":"Biometrics"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.autrev.2016.07.026","article-title":"Cardiovascular risk assessment in patients with rheumatoid arthritis: The relevance of clinical, genetic and serological markers","volume":"15","author":"Corrales","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.semarthrit.2020.03.011","article-title":"Carotid plaques as predictors of cardiovascular events in patients with Rheumatoid Arthritis. Results from a 5-year-prospective follow-up study","volume":"50","author":"Corrales","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_14","first-page":"724","article-title":"Reclassification into very-high cardiovascular risk after carotid ultrasound in patients with axial spondyloarthritis","volume":"38","author":"Corrales","year":"2020","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.3899\/jrheum.180881","article-title":"Disease damage influences cardiovascular risk reclassification based on carotid ultrasound in patients with systemic lupus erythematosus","volume":"46","author":"Llorca","year":"2019","journal-title":"J. Rheumatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJMoa1012592","article-title":"Carotid-Wall Intima\u2013Media Thickness and Cardiovascular Events","volume":"365","author":"Polak","year":"2011","journal-title":"N. Engl. J. 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