{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:08:58Z","timestamp":1780571338538,"version":"3.54.1"},"reference-count":55,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III and cofounded with the European Regional Development Fund \u201cA way to make Europe\u201d, within the \u201cPlan Estatal de Investigaci\u00f3n Cient\u00edfica y T\u00e9cnica y de Inno-vaci\u00f3n 2017\u20132020\u201d","award":["RD16\/0008\/0020; FIS\/PI18-00754"],"award-info":[{"award-number":["RD16\/0008\/0020; FIS\/PI18-00754"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Some discrepancies have been observed in the diagnostic efficacy of multifocal visual evoked potential (mfVEP) when evaluating visual field defects in glaucoma patients. Therefore, we evaluated the diagnostic precision of the mfVEP in glaucoma to find its best diagnostic indicator. A systematic review and meta-analysis of quantitative studies published up to 1 April 2021 was performed. The methodological quality of the included articles was assessed. Publication bias analysis and heterogeneity tests were performed. The sensitivity, specificity and diagnostic odds ratio were calculated. The area under the curve (AUC) was calculated using the summary of receiver operating characteristics curve. Six studies with a total of 241 patients were included according to the inclusion and exclusion criteria. The AUC was 0.98. There was no evidence of publication bias or threshold effect. The pooled sensitivity and pooled specificity of the mfVEP amplitude for detection of visual field defects in all studies was 0.93 and 0.89, respectively. The positive and negative likelihood ratios of mfVEP amplitude were 6.56 and 0.08, respectively. The amplitude of mfVEP showed a good diagnostic precision in the prediction of visual field defects. Interocular mfVEP amplitude analysis can be a good diagnostic indicator for visual field study.<\/jats:p>","DOI":"10.3390\/jcm10184165","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:00:44Z","timestamp":1631707244000},"page":"4165","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Multifocal Visual Evoked Potentials (mfVEP) for the Detection of Visual Field Defects in Glaucoma: Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"10","author":[{"given":"Haitao","family":"Liu","sequence":"first","affiliation":[{"name":"Physiology Unit, Department of Systems Biology, School of Medicine, University of Alcal\u00e1, 28005 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Liao","sequence":"additional","affiliation":[{"name":"Physiology Unit, Department of Systems Biology, School of Medicine, University of Alcal\u00e1, 28005 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e1n","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Surgery, School of Medicine, University of Alcal\u00e1, 28005 Madrid, Spain"},{"name":"Visual Neurophysiology Group-IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"de la Villa","sequence":"additional","affiliation":[{"name":"Physiology Unit, Department of Systems Biology, School of Medicine, University of Alcal\u00e1, 28005 Madrid, Spain"},{"name":"Visual Neurophysiology Group-IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global Prevalence of Glaucoma and Projections of Glaucoma Burden through 2040","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_2","first-page":"456","article-title":"Ueber die Iridectomie bei Glaucom und \u00fcber den glaucomatosen Process","volume":"3","year":"1857","journal-title":"Arch. 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