{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:26:10Z","timestamp":1780604770531,"version":"3.54.1"},"reference-count":59,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2021,9,18]],"date-time":"2021-09-18T00:00:00Z","timestamp":1631923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Both obstructive sleep apnea (OSA) and metabolic syndrome (MS) promote arterial stiffening. As a basis for this study, we presumed that arterial stiffness could be assessed using the Arteriograph (TensioMed, Budapest, Hungary) to detect early modifications induced by continuous positive airway therapy (CPAP) in reversing this detrimental vascular remodeling. Arterial stiffness is increasingly acknowledged as a major cardiovascular risk factor and a marker of subclinical hypertension-mediated organ damage. The aim of this pilot study was to evaluate the arterial stiffness changes in patients with moderate\u2013severe OSA and MS after short-term CPAP use. Methods: We performed a prospective study that included patients with moderate\u2013severe OSA and MS who had not undergone previous CPAP therapy. All subjects underwent clinical examination and arterial stiffness assessment using the oscillometric technique with Arteriograph (TensioMed, Budapest, Hungary) detection before and after 8-week CPAP therapy. Results: 39 patients with moderate\u2013severe OSA were included. Eight weeks of CPAP therapy significantly improved central systolic blood pressure (\u0394 = \u221211.4 mmHg, p = 0.009), aortic pulse wave velocity (aoPWV: \u0394 = \u22120.66 m\/s, p = 0.03), and aortic augmentation index (aoAix: \u0394 = \u22128.25%, p = 0.01) only in patients who used the device for a minimum of 4 h\/night (n = 20). Conclusions: Arterial stiffness was improved only among CPAP adherent patients and could be detected using the Arteriograph (TensioMed, Budapest, Hungary), which involves a noninvasive procedure that is easy to implement for the clinical evaluation of arterial stiffness.<\/jats:p>","DOI":"10.3390\/jcm10184238","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T08:04:23Z","timestamp":1632211463000},"page":"4238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Arterial Stiffness Assessment Using the Arteriograph in Patients with Moderate\u2013Severe OSA and Metabolic Syndrome\u2014A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4053-4130","authenticated-orcid":false,"given":"Ioana M\u0103d\u0103lina","family":"Zota","sequence":"first","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"St\u0103tescu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radu Andy","family":"Sasc\u0103u","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Roca","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9438-8565","authenticated-orcid":false,"given":"Ovidiu","family":"Mitu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1791-0425","authenticated-orcid":false,"given":"Cristina Mihaela","family":"Ghiciuc","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Boisteanu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (III), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan","family":"Anghel","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3768-6232","authenticated-orcid":false,"given":"Sebastian Romica","family":"Cozma","sequence":"additional","affiliation":[{"name":"Department of Surgery (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Corina","family":"Dima-Cozma","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florin","family":"Mitu","sequence":"additional","affiliation":[{"name":"Department of Medical Specialties (I), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy Ia\u0219i, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/792693","article-title":"Evaluation of arterial stiffness for predicting future cardiovascular events in patients with st segment elevation and non-st segment elevation myocardial infarction","volume":"2013","author":"Akkus","year":"2013","journal-title":"Sci. World J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1097\/HJH.0b013e32833f0e93","article-title":"Evaluating aortic stiffness through an arm cuff oscillometric device: Is validation against invasive measurements enough?","volume":"28","author":"Parati","year":"2010","journal-title":"J. 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