{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:23:35Z","timestamp":1790396615284,"version":"4.1.0"},"reference-count":38,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,22]],"date-time":"2021-09-22T00:00:00Z","timestamp":1632268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: About 10% of patients with gallbladder (GB) stones also have concurrent common bile duct (CBD) stones. Laparoscopic cholecystectomy (LC) after removal of CBD stones using endoscopic retrograde cholangiopancreatography (ERCP) is the most widely used method for treating coexisting gallbladder and common bile duct stones. We evaluated the optimal timing of LC after ERCP according to clinical factors, focusing on preoperative relief of jaundice. Methods: A total of 281 patients who underwent elective LC after ERCP because of choledocholithiasis and cholecystolithiasis from January 2010 to April 2018 were retrospectively reviewed. We compared the hospital stay, perioperative morbidity, and rate of surgical conversion to open cholecystectomy according to the relief of jaundice before surgery. These enrolled patients were divided into two groups: relief of jaundice before surgery (group 1, n = 125) or not (group 2, n = 156). Results: The initial total bilirubin level was higher in group 1; however, there were no significant differences in the other baseline characteristics including age, sex, American Society of Anesthesiologists score, previous surgical history, white blood cell count, C-reactive protein, and operative time between the two groups. There was also no significant difference in postoperative hospital stay between the two groups (4.5 \u00b1 3.3 vs. 5.5 \u00b1 5.6 days, p = 0.087). However, after ERCP, the waiting time until LC was significantly longer in group 1 (5.0 \u00b1 4.9 vs. 3.5 \u00b1 2.4 days, p &lt; 0.001). There were no statistical differences in the conversion rate (3.2% vs. 3.8%, p = 0.518) or perioperative morbidity (4.0% vs. 5.8%, p = 0.348), either. Conclusions: LC would not be delayed until the relief of jaundice after ERCP since there were no significant differences in perioperative morbidity or surgical conversion rate to open cholecystectomy. Early LC after ERCP may be feasible and safe in patients with cholangitis and cholecystolithiasis.<\/jats:p>","DOI":"10.3390\/jcm10194297","type":"journal-article","created":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T22:24:13Z","timestamp":1632695053000},"page":"4297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Impact of Preoperative Relief of Jaundice Following Endoscopic Retrograde Cholangiopancreatography on Determining Optimal Timing of Laparoscopic Cholecystectomy in Patients with Cholangitis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3145-3497","authenticated-orcid":false,"given":"Kyu-Hyun","family":"Paik","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, St. Mary\u2019s Daejeon Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5835-9417","authenticated-orcid":false,"given":"Yoon Suk","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang 10380, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Suk","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, St. Mary\u2019s Daejeon Hospital, College of Medicine, The Catholic University of Korea, Daejeon 34943, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Chan","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Inje University Ilsan Paik Hospital, Goyang 10380, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-3280","authenticated-orcid":false,"given":"Woo Hyun","family":"Paik","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,22]]},"reference":[{"key":"ref_1","first-page":"203","article-title":"Endoscopic sphincterotomy prior to laparoscopic cholecystectomy for the treatment of cholelithiasis","volume":"43","author":"Chang","year":"1996","journal-title":"Hepatogastroenterology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s00268-001-0108-2","article-title":"Choledocholithiasis: New approach to an old problem","volume":"25","author":"Cervantes","year":"2001","journal-title":"World J. 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