{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T05:08:13Z","timestamp":1785906493594,"version":"3.56.0"},"reference-count":50,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in Group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with a dietitian. Patients from Group 3 (G3-K) received nutrition advice from a gastroenterologist. Significant differences in the reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group (idiopathic abdominal pain, p &lt; 0.001; abdominal pain after a meal, p &lt; 0.001; abdominal pain during defecation, p = 0.008), while in the G1-FM group, some of the IBS symptoms significantly improved (mucus in stool, p = 0.031; bloating, p &lt; 0.001). In group G3-K no significant improvement was seen. Based on the results of this open-label study, it was concluded that various dietary interventions in the treatment of IBS-M patients do not uniformly affect the course and outcomes of disease management. Rotation diets based on IgG show significantly better results compared to other diets.<\/jats:p>","DOI":"10.3390\/jcm10194317","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T09:59:15Z","timestamp":1632391155000},"page":"4317","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Igg Food Antibody Guided Elimination-Rotation Diet Was More Effective than FODMAP Diet and Control Diet in the Treatment of Women with Mixed IBS\u2014Results from an Open Label Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0543-1817","authenticated-orcid":false,"given":"Lucyna","family":"Ostrowska","sequence":"first","affiliation":[{"name":"Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7188-6908","authenticated-orcid":false,"given":"Diana","family":"Wasiluk","sequence":"additional","affiliation":[{"name":"Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, ul. Mieszka I 4B, 15-054 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille F. J.","family":"Lieners","sequence":"additional","affiliation":[{"name":"Institute of Microecology, ul. Sielska 10, 60-129 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miros\u0142awa","family":"Ga\u0142\u0119cka","sequence":"additional","affiliation":[{"name":"Institute of Microecology, ul. Sielska 10, 60-129 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Bartnicka","sequence":"additional","affiliation":[{"name":"Institute of Microecology, ul. Sielska 10, 60-129 Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Tveiten","sequence":"additional","affiliation":[{"name":"Lab1 Medical Laboratory, Elias Smiths vei 10, 1337 Sandvika, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s00535-017-1428-9","article-title":"Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan","volume":"53","author":"Ono","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5056\/jnm16214","article-title":"What Is New in Rome IV","volume":"23","author":"Schmulson","year":"2017","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1053\/j.gastro.2016.02.014","article-title":"Development and validation of the Rome IV diagnostic questionnaire for adults","volume":"150","author":"Palsson","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12144","DOI":"10.3748\/wjg.v20.i34.12144","article-title":"Irritable bowel syndrome: A clinical review","volume":"20","author":"Soares","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/ajg.2013.105","article-title":"Self-reported food-related gastrointestinal symptoms in IBS are common and associated with more severe symptoms and reduced quality of life","volume":"108","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1053\/j.gastro.2013.09.046","article-title":"A diet low in FODMAPs reduces symptoms of irritable bowel syndrome","volume":"146","author":"Halmos","year":"2014","journal-title":"Gastroenerology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-277X.2011.01162.x","article-title":"Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome","volume":"24","author":"Staudacher","year":"2011","journal-title":"J. Hum. Nutr. Diet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/1756283X11436241","article-title":"Fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) and nonallergic food intolerance: FODMAPs or food chemicals?","volume":"5","author":"Barrett","year":"2012","journal-title":"Ther. Adv. Gastroenterol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1007\/s00394-019-02074-6","article-title":"Low FODMAP diet significantly improves IBS symptoms: An Irish retrospective cohort study","volume":"59","author":"Nawawi","year":"2020","journal-title":"Eur. J. Nutr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1111\/ijcp.12128","article-title":"The low FODMAP diet improves gastrointestinal symptoms in patients with irritable bowel syndrome: A prospective study","volume":"67","author":"Dobbs","year":"2013","journal-title":"Int. J. Clin. Pract."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1136\/gut.2003.037697","article-title":"Food elimination based on IgG antibodies in irritable bowel syndrome: A randomised controlled trial","volume":"53","author":"Atkinson","year":"2004","journal-title":"Gut"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1067\/mhn.2000.106402","article-title":"Treatment of delayed food allergy based on specific immunoglobulin G RAST testing","volume":"123","author":"Dixon","year":"2000","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_13","first-page":"641","article-title":"The therapeutic effects of eliminating allergic foods according to food specific IgG antibodies in irritable bowel syndrome","volume":"46","author":"Yang","year":"2007","journal-title":"Zhonghua Nei Ke Za Zhi"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/07315724.2006.10719567","article-title":"Treating irritable bowel syndrome with a food elimination diet followed by food challenge and probiotics","volume":"25","author":"Drisko","year":"2006","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_15","first-page":"237","article-title":"Deutschen Gesellschaft f\u00fcr Verdauungs- und Stoffwechselkrankheiten; Deutschen Gesellschaft f\u00fcr Neurogastroenterologie und Motilit\u00e4t (Irritable bowel syndrome: German consensus guidelines on definition, pathophysiology and management)","volume":"49","author":"Layer","year":"2011","journal-title":"Gastroenterol"},{"key":"ref_16","first-page":"7890461","article-title":"Effects of Diet Based on IgG Elimination Combined with Probiotics on Migraine Plus Irritable Bowel Syndrome","volume":"21","author":"Xie","year":"2019","journal-title":"Pain Res. Manag."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.1526-4610.2012.02296.x","article-title":"IgG-based elimination diet in migraine plus irritable bowel syndrome","volume":"53","author":"Aydinlar","year":"2013","journal-title":"Headache"},{"key":"ref_18","first-page":"1484","article-title":"Mouse and human neutrophils induce anaphylaxis","volume":"1","author":"Mancardi","year":"2011","journal-title":"J. Clin. Invest."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/j.1365-2222.2007.02727.x","article-title":"Alterations of food antigen-specific serum immunoglobulins G and E antibodies in patients with irritable bowel syndrome and functional dyspepsia","volume":"37","author":"Zuo","year":"2007","journal-title":"Clin. Exp. Allergy"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/01.mog.0000181712.81657.0a","article-title":"Food allergy and irritable bowel syndrome","volume":"21","author":"Kalliomaki","year":"2005","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000264649","article-title":"Clinical relevance of IgG antibodies against food antigen in Crohn\u2019s disease\u2014A double blind cross over diet intervention study","volume":"81","author":"Bentz","year":"2017","journal-title":"Digestion"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.4318\/tjg.2012.0332","article-title":"The effects of provocation by foods with raised IgG antibodies and additives on the course of Crohn\u2019s disease: A pilot study","volume":"23","author":"Uzun","year":"2012","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/0333102410361404","article-title":"Diet restriction in migraine, based on IgG against foods: A clinical double-blind, randomised, cross-over trial","volume":"30","author":"Alpay","year":"2010","journal-title":"Cephalalgia"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1007\/s11894-013-0370-0","article-title":"Dietary fructose intolerance and FODMAPs","volume":"16","author":"Fedewa","year":"2014","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/jgh.14051","article-title":"Low fermentable oligo-di-mono-saccharides and polyols diet versus general dietary advice in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial","volume":"33","author":"Zahedi","year":"2018","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1053\/j.gastro.2017.06.010","article-title":"A Diet Low in FODMAPs Reduces Symptoms in Patients With Irritable Bowel Syndrome and A Probiotic Restores Bifidobacterium Species: A Randomized Controlled Trial","volume":"153","author":"Staudacher","year":"2017","journal-title":"Gastroenterology"},{"key":"ref_27","first-page":"382","article-title":"Concentration of IgG antibodies against food allergens in patients with irritable bowel syndrome and healthy individuals","volume":"6","author":"Traczyk","year":"2011","journal-title":"Przegl\u0105d Gastroenterol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/apt.15120","article-title":"Population based study: Atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress","volume":"49","author":"Koloski","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1111\/apt.13738","article-title":"Evidence that independent gut-to-brain and brain-to-gutpathways operate in the irritable bowel syndrome and functionaldyspepsia: A 1-year population-based prospective study","volume":"44","author":"Koloski","year":"2016","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1136\/gut.51.suppl_1.i41","article-title":"A role for inflammation in irritable bowel syndrome?","volume":"51","author":"Barbara","year":"2002","journal-title":"Gut"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.3748\/wjg.v22.i7.2242","article-title":"Inflammation in irritable bowel syndrome: Myth or new treatment target?","volume":"22","author":"Sinagra","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4291\/wjgp.v1.i3.97","article-title":"Low-grade inflammation plays a pivotal role in gastrointestinal dysfunction in irritable bowel syndrome","volume":"1","author":"Akiho","year":"2010","journal-title":"World J. Gastrointest. Pathophysiol."},{"key":"ref_33","first-page":"11","article-title":"The role of indoleamine 2,3-dioxygenase (IDO) in the pathophysiology of interferon-alpha-induced depression","volume":"29","author":"Wichers","year":"2004","journal-title":"J. Psychiatry Neurosci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/ACI.0b013e3281667645","article-title":"IgG to foods: A test not ready for prime time","volume":"7","author":"Teuber","year":"2007","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: An odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin. Exp. Allergy"},{"key":"ref_36","first-page":"415","article-title":"Inhibition of complement activation by IgG4 antibodies","volume":"64","author":"Aalberse","year":"1986","journal-title":"Clin. Exp. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1111\/j.1398-9995.2008.01705.x","article-title":"Testing for IgG4 against foods is not recommended as a diagnostic tool: EAACI Task Force Report","volume":"63","author":"Stapel","year":"2008","journal-title":"Allergy"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-pathol-011110-130318","article-title":"The Th17 pathway and inflammatory diseases of the intestines, lungs, and skin","volume":"8","author":"Weaver","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"426","DOI":"10.3389\/fimmu.2019.00426","article-title":"Microbiome dependent regulation of Tregs and Th17 cells in mucosa","volume":"10","author":"Pandiyan","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaci.2007.07.033","article-title":"Anaphylaxis: Lessons from mouse models. Department of Medicine, Cincinnati Veterans Affairs Medical Center, Ohio, USA","volume":"120","author":"Finkelman","year":"2007","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.bbrc.2010.10.098","article-title":"IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen","volume":"26","author":"Ishikawa","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1067\/mai.2002.123302","article-title":"Pathways of anaphylaxis in the mouse","volume":"109","author":"Strait","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_43","first-page":"433","article-title":"Faecal calprotectin as an inflammatory marker in inflammatory bowel diseases","volume":"48","author":"Olender","year":"2012","journal-title":"J. Lab. Diagn."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.11613\/BM.2011.034","article-title":"Faecal calprotectin in the diagnosis of inflammatory bowel disease","volume":"21","author":"Burri","year":"2011","journal-title":"Biochem. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.dld.2009.07.002","article-title":"Diagnostic value of faecal calprotectin in unselected outpatients referred for colonoscopy: A multicenter prospective study","volume":"42","author":"Meucci","year":"2010","journal-title":"Dig. Liver Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/j.1572-0241.2007.01126.x","article-title":"Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy","volume":"102","author":"Karamountzos","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_47","first-page":"37","article-title":"Przydatno\u015b\u0107 diagnostyczna kopromarker\u00f3w w wybranych chorobach jelit","volume":"4","author":"Eder","year":"2014","journal-title":"Gastroenterol. Prakt."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/flgastro-2013-100420","article-title":"Utility of faecal calprotectin in inflammatory bowel disease (IBD): What cut-offs should we apply?","volume":"6","author":"Dhaliwal","year":"2015","journal-title":"Frontline Gastroenterol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Fengming, Y., and Jianbing, W. (2014). Biomarkers of inflammatory bowel disease. Dis. Markers, 710915.","DOI":"10.1155\/2014\/710915"},{"key":"ref_50","first-page":"363","article-title":"Diagnostic utility of faecal biomarkers in patients with irritable bowel syndrome","volume":"14","author":"Musci","year":"2014","journal-title":"World J. Gastroenterol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4317\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:03:37Z","timestamp":1760166217000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":50,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcm10194317"],"URL":"https:\/\/doi.org\/10.3390\/jcm10194317","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-145873\/v1","asserted-by":"object"}]},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,23]]}}}