{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:22:30Z","timestamp":1760235750312,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T00:00:00Z","timestamp":1632441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Primary thyroid tumours show different levels of aggressiveness, from indolent to rapidly growing infiltrating malignancies. The most effective therapeutic option is surgery when radical resection is feasible. Biomarkers of aggressiveness may help in scheduling extended resections such as airway infiltration, avoiding a non-radical approach. The aim of the study is to evaluate the prognostic role of E-cadherin, N-cadherin, Aryl hydrocarbon receptor (AhR), and CD147 in different biological behaviours. Fifty-five samples from three groups of thyroid carcinomas were stained: papillary thyroid carcinomas (PTCs) infiltrating the airway (PTC-A), papillary intra-thyroid carcinomas (PTC-B) and poorly differentiated or anaplastic thyroid carcinomas (PDTC\/ATC). High expressions of N-cadherin and AhR were associated with higher locoregional tumour aggressiveness (p = 0.005 and p &lt; 0.001 respectively); PDTC\/ATC more frequently showed a high expression of CD147 (p = 0.011), and a trend of lower expression of E-cadherin was registered in more aggressive neoplasms. Moreover, high levels of AhR were found with recurrent\/persistent diseases (p = 0.031), particularly when tumours showed a concomitant high N-cadherin expression (p = 0.043). The study suggests that knowing in advance onco-biological factors with a potential role to discriminate between different subsets of patients could help the decision-making process, providing a more solid therapeutic indication and an increased expectation for radical surgery.<\/jats:p>","DOI":"10.3390\/jcm10194351","type":"journal-article","created":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T20:15:32Z","timestamp":1632514532000},"page":"4351","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Epithelial\u2013Mesenchymal Immunophenotype on Local Aggressiveness in Papillary Thyroid Carcinoma Invading the Airway"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-4825","authenticated-orcid":false,"given":"Martina","family":"Mandarano","sequence":"first","affiliation":[{"name":"Section of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0399-7374","authenticated-orcid":false,"given":"Marco","family":"Andolfi","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, AOU Ospedali Riuniti di Ancona, 60126 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Colella","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Monacelli","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, University of Perugia Medical School, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1319-1147","authenticated-orcid":false,"given":"Andrea","family":"Polistena","sequence":"additional","affiliation":[{"name":"Department of Surgery \u201cPietro Valdoni\u201d, Policlinico Umberto I, University of Rome \u201cSapienza\u201d, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Moretti","sequence":"additional","affiliation":[{"name":"Internal Medicine and Endocrine and Metabolic Sciences Unit, University of Perugia Medical School, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6337-1701","authenticated-orcid":false,"given":"Guido","family":"Bellezza","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Efisio","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Internal Medicine and Endocrine and Metabolic Sciences Unit, University of Perugia Medical School, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sanguinetti","sequence":"additional","affiliation":[{"name":"General and Specialized Surgery, University of Perugia Medical School, Santa Maria Hospital, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Sidoni","sequence":"additional","affiliation":[{"name":"Section of Anatomic Pathology and Histology, Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Avenia","sequence":"additional","affiliation":[{"name":"General and Specialized Surgery, University of Perugia Medical School, Santa Maria Hospital, 05100 Terni, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Puma","sequence":"additional","affiliation":[{"name":"Thoracic Surgery Unit, University of Perugia Medical School, 06132 Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Vannucci","sequence":"additional","affiliation":[{"name":"Thoracic Surgery and Lung Transplantation Unit, Policlinico Umberto I, University of Rome \u201cSapienza\u201d, 00161 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3322\/caac.21254","article-title":"Cancer statistics, 2015","volume":"65","author":"Siegel","year":"2015","journal-title":"CA Cancer J. 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