{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:22:10Z","timestamp":1788780130246,"version":"build-2803163510"},"reference-count":72,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Anal fissures (AFs) are lesions located in the lower anal canal. They can be primary (chronic or acute) or secondary to a basic disease. There is high comorbidity of depression and anxiety in patients with chronic AF, with poorer quality of life (QoL) and sexual function. This is a case\u2013control study carried out in the San Juan Hospital (Alicante, Spain). Sixty-seven participants were included in the study, including 35 cases and 32 controls: 36 males and 31 females. This study aims to investigate the association of presenting AFs with sexuality, quality of life, anxiety, depression, and anger. The instruments used were the Spanish validated versions of the validated original selected questionnaires. These instruments were used to assess health-related quality of life, anxiety, anger, depression, and sexual function. Results show higher values in cases than in controls with statistical significance in anxiety state and trait; anxiety and depression; bodily pain, general health, and vitality; and 10 of the 12 anger factors. Higher values in controls than in cases with statistical significance in sexuality and many of the QoL factors were found. Addressing these issues in AF surgical patients would be beneficial for their clinical assessment and intervention.<\/jats:p>","DOI":"10.3390\/jcm10194401","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T04:55:33Z","timestamp":1632718533000},"page":"4401","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Sexuality, Quality of Life, Anxiety, Depression, and Anger in Patients with Anal Fissure. A Case\u2013Control Study"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3653-6088","authenticated-orcid":false,"given":"Antonio","family":"Navarro-S\u00e1nchez","sequence":"first","affiliation":[{"name":"Faculty of Psychology, Miguel Hern\u00e1ndez University, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Luri-Prieto","sequence":"additional","affiliation":[{"name":"Department of Surgery, San Juan University Hospital, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-396X","authenticated-orcid":false,"given":"Antonio","family":"Compa\u00f1-Rosique","sequence":"additional","affiliation":[{"name":"Department of Surgery, San Juan University Hospital, 03550 San Juan, Spain"},{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Navarro-Ortiz","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Traumatology Service, Torrevieja University Hospital, 03186 Torrevieja, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Berenguer-Soler","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Miguel Hern\u00e1ndez University, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente F.","family":"Gil-Guill\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-9587","authenticated-orcid":false,"given":"Ernesto","family":"Cort\u00e9s-Castell","sequence":"additional","affiliation":[{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0784-4540","authenticated-orcid":false,"given":"Felipe","family":"Navarro-Cremades","sequence":"additional","affiliation":[{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1396-0484","authenticated-orcid":false,"given":"Luis","family":"G\u00f3mez-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Surgery, San Juan University Hospital, 03550 San Juan, Spain"},{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"P\u00e9rez-Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Surgery, San Juan University Hospital, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Palaz\u00f3n-Bru","sequence":"additional","affiliation":[{"name":"Department of Pathology and Surgery, School of Medicine, Miguel Hern\u00e1ndez University, 03550 San Juan, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-1333","authenticated-orcid":false,"given":"Angel L.","family":"Montejo","sequence":"additional","affiliation":[{"name":"Psychiatry Service, Clinical Hospital of the University of Salamanca, 37007 Salamanca, Spain"},{"name":"Institute of Biomedical Research of Salamanca (IBSAL), Paseo San Vicente SN, 37007 Salamanca, Spain"},{"name":"Department of Psychiatry, Nursing School, University of Salamanca, Av. Donantes de Sangre SN, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9089-0497","authenticated-orcid":false,"given":"Virtudes","family":"P\u00e9rez-Jover","sequence":"additional","affiliation":[{"name":"Faculty of Psychology, Miguel Hern\u00e1ndez University, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wienert, V., Raulf, F., and Mlitz, H. (2017). Anal fissure disease: Prevention and quality of life. Anal Fissure, Springer.","DOI":"10.1007\/978-3-319-49244-5"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Steele, S.R., Maykel, J.A., and Wexner, S.D. (2020). Anal Conditions: Anal Fissure\/Recurrent Anal Fissure. Chapter 10. Clinical Decision Making in Colorectal Surgery, Springer. 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