{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:04:31Z","timestamp":1785377071514,"version":"3.55.0"},"reference-count":21,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JST PRESTO","award":["JPMJPR17J4"],"award-info":[{"award-number":["JPMJPR17J4"]}]},{"name":"JST AIP-PRISM","award":["JPMJCR18Y2"],"award-info":[{"award-number":["JPMJCR18Y2"]}]},{"name":"JSPS KAKENHI","award":["JP21H03485"],"award-info":[{"award-number":["JP21H03485"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>When carpal tunnel syndrome (CTS), an entrapment neuropathy, becomes severe, thumb motion is reduced, which affects manual dexterity, such as causing difficulties in writing; therefore, early detection of CTS by screening is desirable. To develop a screening method for CTS, we developed a tablet app to measure the stylus trajectory and pressure of the stylus tip when drawing a spiral on a tablet screen using a stylus and, subsequently, used these data as training data to predict the classification of participants as non-CTS or CTS patients using a support vector machine. We recruited 33 patients with CTS and 31 healthy volunteers for this study. From our results, non-CTS and CTS were classified by our screening method with 82% sensitivity and 71% specificity. Our CTS screening method can facilitate the screening for potential patients with CTS and provide a quantitative assessment of CTS.<\/jats:p>","DOI":"10.3390\/jcm10194437","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:39:20Z","timestamp":1632739160000},"page":"4437","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Accuracy of a Screening System for Carpal Tunnel Syndrome Using Hand Drawing"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0559-500X","authenticated-orcid":false,"given":"Takuro","family":"Watanabe","sequence":"first","affiliation":[{"name":"School of Science for Open and Environmental Systems, Graduate School of Science and Technology, Keio University, Kanagawa 223-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1676-7578","authenticated-orcid":false,"given":"Takafumi","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Spinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriku","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Orthopedic and Spinal Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-0273","authenticated-orcid":false,"given":"Akimoto","family":"Nimura","sequence":"additional","affiliation":[{"name":"Department of Functional Joint Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-0188","authenticated-orcid":false,"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Functional Joint Anatomy, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Sugiura","sequence":"additional","affiliation":[{"name":"School of Science for Open and Environmental Systems, Graduate School of Science and Technology, Keio University, Kanagawa 223-8522, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: Clinical features, diagnosis, and management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s11552-012-9471-8","article-title":"Carpal tunnel syndrome with thenar atrophy: Evaluation of the pinch and grip strength in patients undergoing surgical treatment","volume":"8","author":"Fernandes","year":"2013","journal-title":"Hand"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00701-019-03839-y","article-title":"Long-term outcome after carpal tunnel release and identification of prognostic factors","volume":"161","author":"Meulstee","year":"2019","journal-title":"Acta Neurochir."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jhsa.2017.12.002","article-title":"Electrodiagnostic grade and carpal tunnel release outcomes: A prospective analysis","volume":"43","author":"Rivlin","year":"2018","journal-title":"J. Hand Surg. Am."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14172","DOI":"10.2196\/14172","article-title":"A tablet-based App for carpal tunnel syndrome screening: Diagnostic case-control study","volume":"7","author":"Fujita","year":"2019","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e26320","DOI":"10.2196\/26320","article-title":"A screening method using anomaly detection on a smartphone for patients with carpal tunnel syndrome: Diagnostic case-control study","volume":"9","author":"Koyama","year":"2021","journal-title":"JMIR Mhealth Uhealth"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0363-5023(99)70014-6","article-title":"Symptoms, disability, and quality of life in patients with carpal tunnel syndrome","volume":"24","author":"Atroshi","year":"1999","journal-title":"J. Hand Surg. Am."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.2522\/ptj.20140118","article-title":"Characteristics of handwriting of people with cerebellar ataxia: Three-dimensional movement analysis of the pen tip, finger, and wrist","volume":"95","author":"Fujisawa","year":"2015","journal-title":"Phys. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s10926-013-9471-8","article-title":"Impact of distal median neuropathy on handwriting performance for patients with carpal tunnel syndrome in office and administrative support occupations","volume":"24","author":"Kuo","year":"2014","journal-title":"J. Occup. Rehabil."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jneumeth.2016.11.004","article-title":"Computerized spiral analysis using the iPad","volume":"275","author":"Sisti","year":"2017","journal-title":"J. Neurosci. Methods"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-60011-8","article-title":"Extending the spectrum of dysgraphia: A data driven strategy to estimate handwriting quality","volume":"10","author":"Asselborn","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1109\/RBME.2018.2840679","article-title":"Dynamic handwriting analysis for the assessment of neurodegenerative diseases: A pattern recognition perspective","volume":"12","author":"Impedovo","year":"2018","journal-title":"IEEE Rev. Biomed. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41746-019-0136-7","article-title":"The use of photoplethysmography for assessing hypertension","volume":"2","author":"Elgendi","year":"2019","journal-title":"NPJ Digit. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1145\/1778765.1778814","article-title":"NETRA: Interactive display for estimating refractive errors and focal range","volume":"29","author":"Pamplona","year":"2010","journal-title":"ACM Trans. Graph."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1089\/dia.2008.0283","article-title":"WellDoc mobile diabetes management randomized controlled trial: Change in clinical and behavioral outcomes and patient and physician satisfaction","volume":"10","author":"Quinn","year":"2008","journal-title":"Diabetes Technol. Ther."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liang, Y., Fan, H., Fang, Z., Miao, L., Li, W., Zhang, Z., Sun, W., Wang, K., He, L., and Chen, A. (2020, January 25\u201330). OralCam: Enabling self-examination and awareness of oral health using a smartphone camera. Proceedings of the 2020 CHI Conference on Human Factors in Computing Systems, Honolulu, HI, USA.","DOI":"10.1145\/3313831.3376238"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y","article-title":"A neurophysiological grading scale for carpal tunnel syndrome","volume":"23","author":"Bland","year":"2000","journal-title":"Muscle Nerve"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/(SICI)1097-0274(199606)29:6<602::AID-AJIM4>3.0.CO;2-L","article-title":"Development of an upper extremity outcome measure: The DASH (disabilities of the arm, shoulder, and head)","volume":"29","author":"Hudak","year":"1996","journal-title":"Am. J. Ind. Med."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Boser, B.E., Guyon, I.M., and Vapnik, V.N. (1992, January 27\u201329). A training algorithm for optimal margin classifiers. Proceedings of the Fifth Annual Workshop on Computational Learning Theory, New York, NY, USA.","DOI":"10.1145\/130385.130401"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1090\/S0025-5718-1965-0178586-1","article-title":"An algorithm for the machine calculation of complex Fourier series","volume":"19","author":"Cooley","year":"1965","journal-title":"Math. Comput."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"San Luciano, M., Wang, C., Ortega, R.A., Yu, Q., Boschung, S., Soto-Valencia, J., Bressman, S.B., Lipton, R.B., Pullman, S., and Saunders-Pullman, R. (2016). Digitized spiral drawing: A possible biomarker for early parkinson\u2019s disease. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0162799"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4437\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:05:50Z","timestamp":1760166350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,27]]},"references-count":21,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcm10194437"],"URL":"https:\/\/doi.org\/10.3390\/jcm10194437","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,27]]}}}