{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:24:10Z","timestamp":1760235850105,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003358","name":"Gedeon Richter","doi-asserted-by":"publisher","award":["educational grant"],"award-info":[{"award-number":["educational grant"]}],"id":[{"id":"10.13039\/501100003358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>(1) Background: Ulipristal acetate (UPA) is a selective progesterone receptor modulator (SPRM) widely used for emergency contraception and mid- to long-term leiomyoma treatment. The aim of this study was to identify modifications of miRNA expression in superficial and basal layers of the human endometrium at the end of the UPA treatment for at least 3 months. (2) Methods: Microarray miRNA analysis of formalin-fixed, paraffin-embedded hysterectomy tissue samples was conducted, followed by an Ingenuity Pathway Analysis. Samples were divided into three groups: women having had 3 months of UPA treatment (n = 7); and two control groups of UPA-na\u00efve women in the proliferative (n = 8) or secretory (n = 6) phase. (3) Results: The UPA modified the expression of 59 miRNAs involved in the processes of cell cycle, carcinogenesis, and inflammation. Their expression profiles were different in the basal and superficial layers. Most of the processes influenced by the UPA in the basal layer were connected to the cell cycle and immune regulation. (4) Conclusion: Specific changes were observed in both layers of the endometrium in the UPA group. However, the miRNA expression in the basal layer was not consistent with that in the superficial layer. Other large studies analysing the long-term impact of SPRM on endometrial miRNA expression are necessary.<\/jats:p>","DOI":"10.3390\/jcm10194442","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T10:39:20Z","timestamp":1632739160000},"page":"4442","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ulipristal Acetate Modifies miRNA Expression in Both Superficial and Basal Layers of the Human Endometrium"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-5345","authenticated-orcid":false,"given":"Kamila","family":"Kolanska","sequence":"first","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"},{"name":"Service de Gyn\u00e9cologie Sestertius et M\u00e9decine de la Reproduction, AP-HP Sorbonne Universit\u00e9 Site Tenon, 4 rue de la Chine, 75020 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3991-0389","authenticated-orcid":false,"given":"Maria","family":"Sbeih","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffroy","family":"Canlorbe","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"},{"name":"Department of Gynecological and Breast Surgery and Oncology, Piti\u00e9-Salp\u00eatri\u00e8re University Hospital, Assistance Publique des H\u00f4pitaux de Paris (AP-HP), 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ars\u00e8ne","family":"Mekinian","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Interne, AP-HP Sorbonne Universit\u00e9 Site St Antoine, 184 rue du Faubourg Saint Antoine, 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Varinot","sequence":"additional","affiliation":[{"name":"Service d\u2019Anatomopathologie, AP HP Sorbonne Universit\u00e9 Site Tenon, 4 rue de la Chine, 75020 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perrine","family":"Capmas","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, University Paris Saclay, 78 rue du G\u00e9n\u00e9ral Leclerc, 94270 Le Kremlin-Bic\u00eatre, France"},{"name":"Inserm, Centre of Research in Epidemiology and Population Health (CESP), U1018, 94276 Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Koskas","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"},{"name":"Department of Obstetrics and Gynecology, AP-HP Bichat University Hospital, 75018 Paris, France"},{"name":"Institut de Recherche en Sant\u00e9 de la Femme, Equipe d\u2019accueil 7285, Universite de Versailles Saint-Quentin-en-Yvelines, 78180 Montigny-le-Bretonneux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selim","family":"Aractingi","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Dara\u00ef","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"},{"name":"Service de Gyn\u00e9cologie Sestertius et M\u00e9decine de la Reproduction, AP-HP Sorbonne Universit\u00e9 Site Tenon, 4 rue de la Chine, 75020 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Chabbert-Buffet","sequence":"additional","affiliation":[{"name":"INSERM UMRS 938, Sorbonne Universit\u00e9, Site Saint-Antoine, 27 rue Chaligny, CEDEX 12, 75571 Paris, France"},{"name":"Service de Gyn\u00e9cologie Sestertius et M\u00e9decine de la Reproduction, AP-HP Sorbonne Universit\u00e9 Site Tenon, 4 rue de la Chine, 75020 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.mce.2012.02.021","article-title":"The immninent dawn of SPRMs in obstetrics and gynecology","volume":"358","author":"Pintiaux","year":"2012","journal-title":"Mol. 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