{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:49:48Z","timestamp":1791830988986,"version":"4.3.4"},"reference-count":49,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Aim: Medication-related osteonecrosis of the jaw (MRONJ) occurs after exposure to medication (antiresorptive or antiangiogenic agents) for bone-related complications. It is more common in the mandible than in the maxilla. The present study investigated maxillary MRONJ in elderly patients through a meta-analysis. Methods: Keywords, including \u201cMRONJ\u201d, \u201cmaxilla\u201d, and \u201csurgery\u201d, were entered into databases, including Embase, PubMed\/MEDLINE, Cochrane Library, and ProQuest, which were searched systematically. Results: Investigating 77 studies, we found that 18 (2 case reports and 16 case series) papers conformed to the standards. The results revealed a 2.6:1 female-to-male ratio of disease occurrence. The average age of patients was 70.6 \u00b1 5.5 years, and most patients were in the third stage (43.6%). The average time of medication usage was 50.0 \u00b1 20.1 months. The pooled proportion of clinical efficacy of surgery was 86%. Conclusion: To prevent and manage MRONJ, all elderly patients should maintain proper oral hygiene and receive dental examinations regularly. Risk assessment and safety management of MRONJ should be performed by medical teams.<\/jats:p>","DOI":"10.3390\/jcm10194480","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T08:27:44Z","timestamp":1632904064000},"page":"4480","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Investigation of the Effectiveness of Surgical Treatment on Maxillary Medication-Related Osteonecrosis of the Jaw: A Literature Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8995-3515","authenticated-orcid":false,"given":"Kun-Jung","family":"Hsu","sequence":"first","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szu-Yu","family":"Hsiao","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Division of Dentistry for Child and Special Needs, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0357-8081","authenticated-orcid":false,"given":"Ping-Ho","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Kaohsiung Municipal Siaogang Hospital, Kaohsiung 80812, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan"},{"name":"Division of Oral and Maxillofacial Surgery, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 80756, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1111\/bcp.12596","article-title":"Adverse drug reactions in special populations\u2013the elderly","volume":"80","author":"Davies","year":"2015","journal-title":"Br. J. Clin. Pharmaco."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1177\/2042098615615472","article-title":"Predicting risk of adverse drug reactions in older adults","volume":"7","author":"Lavan","year":"2016","journal-title":"Ther. Adv. Drug Saf."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","author":"Sozen","year":"2017","journal-title":"Eur. J. Rheumatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: Now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0278-2391(03)00720-1","article-title":"Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic","volume":"61","author":"Marx","year":"2003","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.joms.2004.02.004","article-title":"Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases","volume":"62","author":"Ruggiero","year":"2004","journal-title":"J. Oral Maxil. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/j.joms.2005.07.010","article-title":"Bisphosphonate-induced exposed bone (osteonecrosis\/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment","volume":"63","author":"Marx","year":"2005","journal-title":"J. Oral Maxil. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.oooo.2018.11.012","article-title":"Medication-related osteonecrosis of the jaw unrelated to bisphosphonates and denosumab-a review","volume":"127","author":"King","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1200\/JCO.2007.15.5424","article-title":"Osteonecrosis of the jaw related to bevacizumab","volume":"26","author":"Estilo","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00520-017-3903-5","article-title":"Incidence of medication-related osteonecrosis of the jaw in patients treated with both bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors","volume":"26","author":"Loyson","year":"2018","journal-title":"Support Care Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/jop.12516","article-title":"Use of new targeted cancer therapies in children: Effects on dental development and risk of jaw osteonecrosis: A review","volume":"46","author":"Hernandez","year":"2017","journal-title":"J. Oral Pathol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2014.04.031","article-title":"American Association of Oral and Maxillofacial Surgeons Position Paper on Medication-Related Osteonecrosis of the Jaw-2014 Update","volume":"72","author":"Ruggiero","year":"2014","journal-title":"J. Oral Maxil. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/j.jdent.2014.05.001","article-title":"The national-scale cohort study on bisphosphonate-related osteonecrosis of the jaw in Taiwan","volume":"42","author":"Yuh","year":"2014","journal-title":"J. Dent."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.11005\/jbm.2015.22.4.151","article-title":"Medication Related Osteonecrosis of the Jaw: 2015 Position Statement of the Korean Society for Bone and Mineral Research and the Korean Association of Oral and Maxillofacial Surgeons","volume":"22","author":"Kim","year":"2015","journal-title":"J. Bone Metab."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s10354-016-0437-2","article-title":"Position paper on medication-related osteonecrosis of the jaw (MRONJ)","volume":"166","author":"Svejda","year":"2016","journal-title":"Wien. Med. Wochenschr."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Japanese Allied Committee on Osteonecrosis of the Jaw, Yoneda, T., Hagino, H., Sugimoto, T., Ohta, H., Takahashi, S., Soen, S., Taguchi, A., Nagata, T., and Urade, M. (2017). Antiresorptive agent-related osteonecrosis of the jaw: Position Paper 2017 of the Japanese Allied Committee on Osteonecrosis of the Jaw. J. Bone Miner. Metab., 35, 6\u201319.","DOI":"10.1007\/s00774-016-0810-7"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/idj.12329","article-title":"Oral health for an ageing population: The importance of a natural dentition in older adults","volume":"67","author":"Muller","year":"2017","journal-title":"Int. Dent. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.jds.2020.12.007","article-title":"Surgical strategy for medication-related osteonecrosis of the jaw (MRONJ) on maxilla: A multicenter retrospective study","volume":"16","author":"Okuyama","year":"2021","journal-title":"J. Dent. Sci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1111\/odi.13615","article-title":"Medication-related osteonecrosis of the maxilla: Prognosis of oral surgery combined with endoscopic sinus surgery","volume":"27","author":"Park","year":"2020","journal-title":"Oral Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.amjms.2020.04.009","article-title":"Medication-Related Osteonecrosis of the Jaw","volume":"360","author":"Ohta","year":"2020","journal-title":"Am. J. Med. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1097\/SCS.0000000000004705","article-title":"Auto-Fluorescence and Histopathologic Evaluation of Medication-Related Osteonecrosis of the Jaws: Perspectives for Treatment","volume":"30","author":"Giovannacci","year":"2019","journal-title":"J. Craniofac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/odi.12992","article-title":"Surgical treatment of medication-related osteonecrosis of the upper jaw: Case series","volume":"25","author":"Aljohani","year":"2019","journal-title":"Oral Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/coa.12999","article-title":"Medication-related osteonecrosis of the posterior maxilla: Surgical treatment using a combined transnasal endoscopic and intraoral approach, our experience with seven consecutive patients","volume":"43","author":"Procacci","year":"2018","journal-title":"Clin. Otolaryngol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13005-015-0099-0","article-title":"Sinusitis and oroantral fistula in patients with bisphosphonate-associated necrosis of the maxilla","volume":"12","author":"Voss","year":"2016","journal-title":"Head Face Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.oooo.2016.03.015","article-title":"A technique for the treatment of oral-antral fistulas resulting from medication-related osteonecrosis of the maxilla: The combined buccal fat pad flap and radical sinusotomy","volume":"122","author":"Melville","year":"2016","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00198-015-3096-z","article-title":"Intraoperative detection of viable bone with fluorescence imaging using Visually Enhanced Lesion Scope in patients with bisphosphonate-related osteonecrosis of the jaw: Clinical and pathological evaluation","volume":"26","author":"Yoshiga","year":"2015","journal-title":"Osteoporos. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10006-013-0440-3","article-title":"Non-complex reconstructive techniques in the management of BRONJ: A case series of patient-related outcomes","volume":"18","author":"Sadiq","year":"2014","journal-title":"Oral Maxillofac. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"E6","DOI":"10.1002\/hed.21758","article-title":"Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases","volume":"35","author":"Lee","year":"2013","journal-title":"Head Neck J. Sci Spec."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1834-7819.2012.01675.x","article-title":"Radical surgical treatment of bisphosphonate related osteonecrosis of the jaw","volume":"57","author":"Hewson","year":"2012","journal-title":"Aust. Dent. J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tripleo.2010.04.015","article-title":"The role of surgical therapy in the management of intravenous bisphosphonates-related osteonecrosis of the jaw","volume":"111","author":"Wilde","year":"2011","journal-title":"Oral Surg. Oral Med. O"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ijom.2010.11.006","article-title":"Bisphosphonate-related osteonecrosis of the maxilla and sinusitis maxillaris","volume":"40","author":"Maurer","year":"2011","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/lsm.20730","article-title":"A Preliminary Report About Treatment of Bisphosphonate Related Osteonecrosis of the Jaw With Er:YAG Laser Ablation","volume":"41","author":"Stubinger","year":"2009","journal-title":"Laser Surg. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.joms.2009.01.006","article-title":"The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Carlson","year":"2009","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.mlg.0000187398.51857.3c","article-title":"Osteonecrosis of the mandible or maxilla associated with the use of new generation bisphosphonates","volume":"116","author":"Farrugia","year":"2006","journal-title":"Laryngoscope"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s00508-006-0644-8","article-title":"Osteonecrosis of the jaws and bisphosphonate treatment in cancer patients","volume":"118","author":"Wutzl","year":"2006","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.14219\/jada.archive.2011.0108","article-title":"Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis Executive summary of recommendations from the American Dental Association Council on Scientific Affairs","volume":"142","author":"Hellstein","year":"2011","journal-title":"J. Am. Dent. Assoc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"e03795","DOI":"10.1016\/j.heliyon.2020.e03795","article-title":"Efficacy of a high-dose antiresorptive drug holiday to reduce the risk of medication-related osteonecrosis of the jaw (MRONJ): A systematic review","volume":"6","author":"Ottesen","year":"2020","journal-title":"Heliyon"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00198-017-4063-7","article-title":"A multicenter retrospective study of the risk factors associated with medication-related osteonecrosis of the jaw after tooth extraction in patients receiving oral bisphosphonate therapy: Can primary wound closure and a drug holiday really prevent MRONJ?","volume":"28","author":"Hasegawa","year":"2017","journal-title":"Osteoporos Int."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/odi.12966","article-title":"Drug holiday patterns and bisphosphonate-related osteonecrosis of the jaw","volume":"25","author":"Jung","year":"2019","journal-title":"Oral Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"206","DOI":"10.5125\/jkaoms.2014.40.5.206","article-title":"Drug holiday as a prognostic factor of medication-related osteonecrosis of the jaw","volume":"40","author":"Kim","year":"2014","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5125\/jkaoms.2018.44.5.225","article-title":"Clinical characteristics and recurrence-related factors of medication-related osteonecrosis of the jaw","volume":"44","author":"Kang","year":"2018","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Di Fede, O., Panzarella, V., Mauceri, R., Fusco, V., Bedogni, A., Lo Muzio, L., Sipmo Onj, B., and Campisi, G. (2018). The Dental Management of Patients at Risk of Medication-Related Osteonecrosis of the Jaw: New Paradigm of Primary Prevention. Biomed. Res. Int.","DOI":"10.1155\/2018\/2684924"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Hasegawa, T., Ueda, N., Yamada, S.I., Kato, S., Iwata, E., Hayashida, S., Kojima, Y., Shinohara, M., Tojo, I., and Nakahara, H. (2021). Denosumab-related osteonecrosis of the jaw after tooth extraction and the effects of a short drug holiday in cancer patients: A multicenter retrospective study. Osteoporos Int.","DOI":"10.1007\/s00198-021-05995-3"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.oooo.2018.09.008","article-title":"Medication-related osteonecrosis of the jaw: Definition and best practice for prevention, diagnosis, and treatment","volume":"127","author":"Schiodt","year":"2019","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jcms.2014.11.014","article-title":"Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ)","volume":"43","author":"Ristow","year":"2015","journal-title":"J. Craniomaxillofac. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/SCS.0000000000001665","article-title":"Tooth extractions in high-risk patients under bisphosphonate therapy and previously affected with osteonecrosis of the jaws: Surgical protocol supported by low-level laser therapy","volume":"26","author":"Vescovi","year":"2015","journal-title":"J. Craniofac. Surg."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5125\/jkaoms.2020.46.3.191","article-title":"Regenerative effect of recombinant human bone morphogenetic protein-2\/absorbable collagen sponge (rhBMP-2\/ACS) after sequestrectomy of medication-related osteonecrosis of the jaw (MRONJ)","volume":"46","author":"Min","year":"2020","journal-title":"J. Korean Assoc. Oral Maxillofac. Surg."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1002\/hed.25944","article-title":"Adjuvant therapies in the management of medication-related osteonecrosis of the jaws: Systematic review","volume":"41","author":"Michellon","year":"2019","journal-title":"Head Neck"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s00774-019-00994-1","article-title":"Clinical significance of periosteal reaction as a predictive factor for treatment outcome of medication-related osteonecrosis of the jaw","volume":"37","author":"Kojima","year":"2019","journal-title":"J. Bone Minar. Metab."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4480\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:07:00Z","timestamp":1760166420000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":49,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcm10194480"],"URL":"https:\/\/doi.org\/10.3390\/jcm10194480","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]}}}