{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:24:30Z","timestamp":1760235870821,"version":"build-2065373602"},"reference-count":47,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministerstwo Edukacji i Nauki","doi-asserted-by":"publisher","award":["PBZ-MEIN- 9\/2\/2006"],"award-info":[{"award-number":["PBZ-MEIN- 9\/2\/2006"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hyperuricemia accompanies many pathologies that contribute to overall death rate. The population-based multifaceted study of older adults in Poland made it possible to assess the effect of serum uric acid (SUA) on overall mortality. The PolSenior study performed between 2007\u20132011 included 3926 participants aged 65 years or above (mean age 79 \u00b1 9 years) not treated with xanthin oxidase inhibitors (XOI) who were stratified by sex and SUA concentration into six subgroups increasing by 1 mg\/dL. In 2019, survival data were retrieved from the population register. The crude risk of death was significantly higher in men and women with SUA \u2265 7 mg\/dL. After adjustment to statistically significant factors, SUA remained a risk factor of death in men with SUA \u2265 8 mg\/dL only, potentially due to the limited number of women with high SUA levels. Furthermore, age, heart failure, diabetes, and activities of daily living \u2264 4 pts were identified as factors increasing mortality risk regardless of sex. The risk of death increased also with smoking, past stroke, COPD\/asthma, and hs-CRP &gt; 3 mg\/dL for men; and eGFR &lt; 45 mL\/min\/1.73 m2, mini nutritional assessment \u2264 7 pts, and loop diuretics use for women. Mild hyperuricemia is a significant health status marker and an independent risk factor for overall mortality in older Caucasians not receiving XOI. Increased mortality is mostly limited to subjects with SUA levels \u2265 8 mg\/dL.<\/jats:p>","DOI":"10.3390\/jcm10194505","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T08:27:44Z","timestamp":1632904064000},"page":"4505","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Uric Acid Is a Weak Independent Predictor of Overall Survival in Older Adults"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3175-5660","authenticated-orcid":false,"given":"Mateusz","family":"Winder","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1179-6932","authenticated-orcid":false,"given":"Aleksander J.","family":"Owczarek","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Medical University of Silesia, 41-200 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Mossakowska","sequence":"additional","affiliation":[{"name":"International Institute of Molecular and Cell Biology, 02-109 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3289-1050","authenticated-orcid":false,"given":"Micha\u0142","family":"Holecki","sequence":"additional","affiliation":[{"name":"Department of Internal, Autoimmune and Metabolic Diseases, Medical University of Silesia, 40-752 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Broczek","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, Medical University of Warsaw, 02-007 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Grodzicki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, 31-531 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Zdrojewski","sequence":"additional","affiliation":[{"name":"Department of Hypertension and Diabetology, Department of Preventive Medicine and Education, Medical University of Gdansk, 80-211 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-7794","authenticated-orcid":false,"given":"Jerzy","family":"Chudek","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Oncological Chemotherapy, Medical University of Silesia, 40-029 Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-64587-z","article-title":"Sex- and age-specific variations, temporal trends and metabolic determinants of serum uric acid concentrations in a large population-based Austrian cohort","volume":"10","author":"Zitt","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_2","first-page":"2690","article-title":"Global prevalence of hyperuricemia: A systematic review of population-based epidemiological studies","volume":"67","author":"Smith","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.atherosclerosis.2018.10.007","article-title":"Hyperuricemia and endothelial function: From molecular background to clinical perspectives","volume":"278","author":"Maruhashi","year":"2018","journal-title":"Atherosclerosis"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1159\/000443769","article-title":"Hyperuricemia, cardiovascular disease, and hypertension","volume":"3","author":"Kuwabara","year":"2016","journal-title":"Pulse"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.amjcard.2011.12.018","article-title":"Prognostic value of uric acid in patients with acute coronary syndromes","volume":"109","author":"Ndrepepa","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/01.HYP.37.4.1069","article-title":"Prognostic significance of serum creatinine and uric acid in older chinese patients with isolated systolic hypertension","volume":"37","author":"Wang","year":"2001","journal-title":"Hypertension"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1253\/circj.CJ-08-0828","article-title":"The JCAD Study Investigators elevated serum uric acid is an independent predictor for cardiovascular events in patients with severe coronary artery stenosis: Subanalysis of the Japanese Coronary Artery Disease (JCAD) study","volume":"73","author":"Okura","year":"2009","journal-title":"Circ. J."},{"key":"ref_8","first-page":"483","article-title":"Association between low-grade inflammation and left ventricular diastolic dysfunction in patients with metabolic syndrome and hyperuricemia","volume":"36","author":"Liu","year":"2020","journal-title":"Acta. Cardiol. Sin."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"ehz872-102","DOI":"10.1093\/ehjci\/ehz872.102","article-title":"P282 elevated serum uric acid associated with both electrocardiographic and echocardiographic left ventricular hypertrophy independent of blood pressure in healthy individuals","volume":"41","author":"Liu","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.ajkd.2014.04.024","article-title":"Uric acid levels, kidney function, and cardiovascular mortality in US adults: National Health and Nutrition Examination Survey (NHANES) 1988\u20131994 and 1999\u20132002","volume":"64","author":"Odden","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1161\/01.HYP.36.6.1072","article-title":"Relation between serum uric acid and risk of cardiovascular disease in essential hypertension. The PIUMA study","volume":"36","author":"Verdecchia","year":"2000","journal-title":"Hypertension"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Winder, M., Owczarek, A.J., Mossakowska, M., Broczek, K., Grodzicki, T., Wierucki, \u0141., and Chudek, J. (2021). Prevalence of hyperuricemia and the use of allopurinol in older poles-results from a population-based PolSenior study. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18020387"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijcard.2015.08.109","article-title":"Regulation of uric acid metabolism and excretion","volume":"213","author":"Maiuolo","year":"2016","journal-title":"Int. J. Cardiol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1016\/S0140-6736(16)00346-9","article-title":"Gout","volume":"388","author":"Dalbeth","year":"2016","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fmed.2018.00160","article-title":"Physiology of hyperuricemia and urate-lowering treatments","volume":"5","author":"Benn","year":"2018","journal-title":"Front. Med."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Butler, F., Alghubayshi, A., and Roman, Y. (2021). The epidemiology and genetics of hyperuricemia and gout across major racial groups: A literature review and population genetics secondary database analysis. J. Pers. Med., 11.","DOI":"10.21203\/rs.3.rs-153295\/v1"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Piani, F., Cicero, A.F.G., and Borghi, C. (2021). Uric acid and hypertension: Prognostic role and guide for treatment. J. Clin. Med., 10.","DOI":"10.3390\/jcm10030448"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Kuhns, V.L.H., and Woodward, O.M. (2020). Sex differences in urate handling. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21124269"},{"key":"ref_19","first-page":"38","article-title":"Prevalence and factors of hyperuricemia in older adults","volume":"28","author":"Winder","year":"2020","journal-title":"Gerontol. Pol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1002\/acr.24205","article-title":"Mortality in patients with gout treated with allopurinol: A systematic review and meta-analysis","volume":"73","author":"Hay","year":"2020","journal-title":"Arthritis Care Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.amjcard.2011.09.042","article-title":"Prognostic value of uric acid in patients with ST-elevated myocardial infarction undergoing primary coronary intervention","volume":"109","author":"Kaya","year":"2012","journal-title":"Am. J. Cardiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijcard.2011.12.110","article-title":"Uric acid: A cardiovascular risk factor in patients with recent myocardial infarction","volume":"167","author":"Levantesi","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.numecd.2020.10.020","article-title":"Elevated serum uric acid is associated with a greater inflammatory response and with short- and long-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention","volume":"31","author":"Cornara","year":"2021","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7326\/0003-4819-131-1-199907060-00003","article-title":"Serum uric acid and risk for cardiovascular disease and death: The Framingham Heart Study","volume":"131","author":"Culleton","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Krishnan, E. (2012). Reduced glomerular function and prevalence of gout: NHANES 2009-10. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0050046"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"3192","DOI":"10.1093\/ndt\/gfn222","article-title":"Increased risk of mortality in the elderly population with late-stage chronic kidney disease: A cohort study in Taiwan","volume":"23","author":"Hwang","year":"2008","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_27","unstructured":"GBD 2015 Mortality and Causes of Death Collaborators (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: A systematic analysis for the Global Burden of Disease Study 2015 [published correction appears in Lancet. 2017; 389 (10064): e1]. Lancet, 388, 1459\u20131544."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e8491","DOI":"10.1097\/MD.0000000000008491","article-title":"Association of metabolic syndrome and its components with all-cause and cardiovascular mortality in the elderly: A meta-analysis of prospective cohort studies","volume":"96","author":"Ju","year":"2017","journal-title":"Medicine"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1001\/jama.1991.03470210076036","article-title":"Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration","volume":"266","author":"Facchini","year":"1991","journal-title":"JAMA"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000484283","article-title":"Uric acid as a cause of the metabolic syndrome","volume":"192","author":"King","year":"2018","journal-title":"Contrib. Nephrol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.exger.2011.09.006","article-title":"Medical, psychological and socioeconomic aspects of aging in Poland: Assumptions and objectives of the PolSenior project","volume":"46","author":"Bledowski","year":"2011","journal-title":"Exp. Gerontol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejim.2020.01.001","article-title":"Management of hyperuricemia in asymptomatic patients: A critical appraisal","volume":"74","author":"Brucato","year":"2020","journal-title":"Eur. J. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.2215\/CJN.05190420","article-title":"Effect of urate-lowering therapy on cardiovascular and kidney outcomes: A systematic review and meta-analysis","volume":"15","author":"Chen","year":"2020","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1093\/ndt\/gft029","article-title":"Uric acid and chronic kidney disease: Which is chasing which?","volume":"28","author":"Johnson","year":"2013","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.kint.2020.10.015","article-title":"Does gouty nephropathy exist, and is it more common than we think?","volume":"99","author":"Piani","year":"2021","journal-title":"Kidney Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/00000441-198412000-00003","article-title":"Urate nephropathy","volume":"288","author":"Foley","year":"1984","journal-title":"Am. J. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1681\/ASN.2008101115","article-title":"Posing the question again: Does chronic uric acid nephropathy exist?","volume":"21","author":"Moe","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_38","first-page":"608","article-title":"Kidney function, nutritional status, and the left ventricle dysfunction are associated with serum uric acid levels in patients with heart failure with reduced ejection fraction","volume":"48","author":"Owczarek","year":"2018","journal-title":"Ann. Clin. Lab. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"J\u00f8rgensen, P., Langhammer, A., Krokstad, S., and Forsmo, S. (2017). Mortality in persons with undetected and diagnosed hypertension, type 2 diabetes, and hypothyroidism, compared with persons without corresponding disease\u2014A prospective cohort study; The HUNT Study, Norway. BMC Fam. Pract., 18.","DOI":"10.1186\/s12875-017-0672-7"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1016\/j.jacc.2017.08.074","article-title":"Heart failure with preserved, borderline, and reduced ejection fraction: 5-year outcomes","volume":"70","author":"Shah","year":"2017","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s10157-016-1228-1","article-title":"Serum uric acid levels and mortality in the Japanese population: The Yamagata (Takahata) study","volume":"20","author":"Kamei","year":"2016","journal-title":"Clin. Exp. Nephrol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e007523","DOI":"10.1161\/JAHA.117.007523","article-title":"Taiwan Geriatric Kidney Disease (TGKD) Research Group. U-Shaped association between serum uric acid levels with cardiovascular and all-cause mortality in the elderly: The role of malnourishment","volume":"7","author":"Tseng","year":"2018","journal-title":"J. Am. Heart Assoc."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejim.2020.10.001","article-title":"Serum uric acid and mortality thresholds among men and women in the Irish health system: A cohort study","volume":"84","author":"Browne","year":"2021","journal-title":"Eur. J. Intern. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1023\/A:1013735717961","article-title":"NIPPON DATA 80 Research Group. Absence of an association between serum uric acid and mortality from cardiovascular disease: NIPPON DATA 80, 1980\u20131994. National integrated projects for prospective observation of non-communicable diseases and its trend in the Aged","volume":"17","author":"Sakata","year":"2001","journal-title":"Eur. J. Epidemiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3899\/jrheum.131159","article-title":"Effect of urate-lowering therapies on renal disease progression in patients with hyperuricemia","volume":"41","author":"Levy","year":"2014","journal-title":"J. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"e026677","DOI":"10.1136\/bmjopen-2018-026677","article-title":"Diagnosis and treatment for hyperuricemia and gout: A systematic review of clinical practice guidelines and consensus statements","volume":"9","author":"Li","year":"2019","journal-title":"BMJ Open"},{"key":"ref_47","first-page":"1295","article-title":"Is it time to revise the normal range of serum uric acid levels?","volume":"18","author":"Desideri","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4505\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:07:16Z","timestamp":1760166436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/19\/4505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":47,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcm10194505"],"URL":"https:\/\/doi.org\/10.3390\/jcm10194505","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,9,29]]}}}