{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:35Z","timestamp":1792007615676,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Determining disease activity from clinical signs in patients with connective tissue panniculitis (CTP) is often challenging but is essential for therapeutic decision making, which largely relies on immunosuppressant treatment. High-frequency ultrasound (HFUS) may be useful in supporting such decisions by accurately determining CTP activity. This study aimed to investigate the accuracy of HFUS in identifying signs of CTP activity or inactivity and assess its usefulness in therapeutic decision making. A prospective cohort study of consecutive patients with biopsy-proven CTP receiving HFUS was conducted in a tertiary university hospital (2016\u20132020). HFUS was performed at inclusion and at each 3- or 6-month follow-up visit, depending on disease activity. Twenty-three patients with CTP were included, and 134 HFUSs were performed. In 59.7% (80) of the evaluations, the clinical presentation did not show whether CTP was active or not. In these cases, HFUS showed activity in 38.7% (31) and inactivity in 61.3% (49). In 71.25% (57) of the visits, HFUS was the determinant for therapeutic decisions. Further follow-up showed consistent clinical and HFUS responses in all unclear cases after treatment modification. HFUS appears to be a useful adjunct to the clinical examination for CTP to assess activity and make therapeutic decisions.<\/jats:p>","DOI":"10.3390\/jcm10194516","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:03:42Z","timestamp":1632960222000},"page":"4516","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High-Frequency Ultrasound to Assess Activity in Connective Tissue Panniculitis"],"prefix":"10.3390","volume":"10","author":[{"given":"Priscila","family":"Giavedoni","sequence":"first","affiliation":[{"name":"Department of Dermatology, Institut Cl\u00ednic de Medicina i Dermatologia, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Medical School, University of Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4150-0522","authenticated-orcid":false,"given":"Sebastian","family":"Podlipnik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Cl\u00ednic de Medicina i Dermatologia, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Medical School, University of Barcelona, 08036 Barcelona, Spain"},{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Fuertes de Vega","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Cl\u00ednic de Medicina i Dermatologia, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Medical School, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Iranzo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Cl\u00ednic de Medicina i Dermatologia, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9327-2555","authenticated-orcid":false,"suffix":"Jr.","given":"Jos\u00e9 Manuel","family":"Mascar\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Institut Cl\u00ednic de Medicina i Dermatologia, Hospital Cl\u00ednic de Barcelona, 08036 Barcelona, Spain"},{"name":"Medical School, University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"key":"ref_1","first-page":"444","article-title":"Lupus Panniculitis: Clinicopathological Features of a Series of 12 Patients","volume":"151","year":"2018","journal-title":"Med. 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