{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:06:26Z","timestamp":1780085186741,"version":"3.54.0"},"reference-count":34,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2020-R1F1A1048529"],"award-info":[{"award-number":["NRF-2020-R1F1A1048529"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020-M3E5D9080787"],"award-info":[{"award-number":["2020-M3E5D9080787"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021M3E5D1A01015175"],"award-info":[{"award-number":["2021M3E5D1A01015175"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1G1A1013360"],"award-info":[{"award-number":["2021R1G1A1013360"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Korean Centers for Disease Control and Prevention","award":["2019-ER7103-02#"],"award-info":[{"award-number":["2019-ER7103-02#"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: To investigate hearing impairment and its association with retinopathy of prematurity (ROP) among children born with very low birth weight (VLBW, birth weight &lt; 1500 g). Methods: This prospective registry study included 7940 VLBW infants who underwent both ophthalmic (ROP) and hearing screening at the 70 participating centers of the Korean Neonatal Network. Hearing screening was performed using auditory brainstem response and\/or automated otoacoustic emission testing. Hearing impairment, defined as a unilateral or bilateral hearing threshold of \u226540 dB on the auditory brainstem response threshold (ABR-T) test, was evaluated and compared between children with and without ROP at the corrected ages of 18 months and 3 years. Results: The frequency of infants who did not undergo hearing screening at near-term ages was higher in the ROP group than in the no-ROP group (18.2% vs. 12.0%, p &lt; 0.001), and the prevalence of hearing impairment at 18 months was higher in the ROP group than in the no-ROP group (3.5% vs. 2.2%, p = 0.043). The prevalence of deafness was higher in children with ROP than those without ROP (0.4% vs. 0.1%, p = 0.049). There were significant differences in hearing impairment among the stages of ROP (p &lt; 0.001). However, multivariate analyses and propensity score matching showed no significant association between ROP and hearing impairment at 18 months and 3 years after adjusting for prematurity-related variables (all p &gt; 0.05). Conclusions: Among infants born with VLBW, hearing impairment was more common in those with ROP than in those without ROP at 18 months of age. However, there was no significant independent association between hearing impairment and ROP.<\/jats:p>","DOI":"10.3390\/jcm10204781","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T03:01:13Z","timestamp":1634698873000},"page":"4781","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retinopathy of Prematurity and Hearing Impairment in Infants Born with Very-Low-Birth-Weight: Analysis of a Korean Neonatal Network Database"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5267-0135","authenticated-orcid":false,"given":"Chang Myeon","family":"Song","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology-Head & Neck Surgery, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-3744","authenticated-orcid":false,"given":"Ja-Hye","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Developmental Medicine, Hanyang University Hospital, Seoul 04763, Korea"},{"name":"Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0312-567X","authenticated-orcid":false,"given":"Jae Kyoon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ryul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Jung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeong Mi","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Developmental Medicine, Hanyang University Hospital, Seoul 04763, Korea"},{"name":"Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Neonatology and Developmental Medicine, Hanyang University Hospital, Seoul 04763, Korea"},{"name":"Department of Pediatrics, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4545-8344","authenticated-orcid":false,"given":"Seong Joon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hanyang University Hospital, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1056\/NEJMra1208129","article-title":"Mechanisms and management of retinopathy of prematurity","volume":"367","author":"Hartnett","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","article-title":"Retinopathy of prematurity","volume":"382","author":"Hellstrom","year":"2013","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e20173888","DOI":"10.1542\/peds.2017-3888","article-title":"Visual and Hearing Impairments after Preterm Birth","volume":"142","author":"Hirvonen","year":"2018","journal-title":"Pediatrics"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/AUD.0b013e318157f07f","article-title":"Current state of knowledge: Language and literacy of children with hearing impairment","volume":"28","author":"Moeller","year":"2007","journal-title":"Ear Hear."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(03)14631-4","article-title":"Severe visual impairment and blindness in children in the UK","volume":"362","author":"Rahi","year":"2003","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1542\/peds.2012-2996","article-title":"Screening examination of premature infants for retinopathy of prematurity","volume":"131","author":"Fierson","year":"2013","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"International Committee for the Classification of Retinopathy of Prematurity (2005). The International Classification of Retinopathy of Prematurity revisited. Arch. Ophthalmol., 123, 991\u2013999.","DOI":"10.1001\/archopht.123.7.991"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"The International Committee for the Classification of the Late Stages of Retinopathy of Prematurity (1987). An International Classification of Retinopathy of Prematurity. II. The classification of retinal detachment. Arch. Ophthalmol., 105, 906\u2013912.","DOI":"10.1001\/archopht.1987.01060070042025"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"The Committee for the Classification of Retinopathy of Prematurity (1984). An international classification of retinopathy of prematurity. Arch. Ophthalmol., 102, 1130\u20131134.","DOI":"10.1001\/archopht.1984.01040030908011"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"American Academy of Pediatrics (1984). An international classification of retinopathy of prematurity. Pediatrics, 74, 127\u2013133.","DOI":"10.1542\/peds.74.1.127"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e251","DOI":"10.3346\/jkms.2020.35.e251","article-title":"Results of a Government-supported Newborn Hearing Screening Pilot Project in the 17 Cities and Provinces from 2014 to 2018 in Korea","volume":"35","author":"Chung","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1542\/peds.2004-0204","article-title":"Impact of a physiologic definition on bronchopulmonary dysplasia rates","volume":"114","author":"Walsh","year":"2004","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e20183537","DOI":"10.1542\/peds.2018-3537","article-title":"Neurodevelopmental Outcomes of Preterm Infants with Retinopathy of Prematurity by Treatment","volume":"144","author":"Natarajan","year":"2019","journal-title":"Pediatrics"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1053\/j.semperi.2016.09.002","article-title":"Early neurodevelopmental outcomes of extremely preterm infants","volume":"40","author":"Rogers","year":"2016","journal-title":"Semin. Perinatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.62.2.2","article-title":"Brain White Matter Maturation and Early Developmental Outcomes in Preterm Infants with Retinopathy of Prematurity","volume":"62","author":"Ahn","year":"2021","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1167\/iovs.18-25849","article-title":"Diffusion Tensor Imaging Analysis of White Matter Microstructural Integrity in Infants with Retinopathy of Prematurity","volume":"60","author":"Ahn","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.5935\/0946-5448.20190006","article-title":"Sensorineural Hearing Loss in Newborns Hospitalized in Neonatal Intensive Care Unit: An Observational Study","volume":"23","author":"Stadio","year":"2019","journal-title":"Int. Tinnitus J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jama.2013.282153","article-title":"Association between severe retinopathy of prematurity and nonvisual disabilities at age 5 years","volume":"311","author":"Schmidt","year":"2014","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/coa.12794","article-title":"Newborn hearing screening in prematurity: Fate of screening failures and auditory maturation","volume":"42","author":"Yang","year":"2017","journal-title":"Clin. Otolaryngol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ijporl.2010.05.024","article-title":"Risk factors for sensorineural hearing loss in NICU infants compared to normal hearing NICU controls","volume":"74","author":"Coenraad","year":"2010","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ijporl.2016.12.029","article-title":"Prevalence and independent risk factors for hearing impairment among very low birth weight infants","volume":"93","author":"Wang","year":"2017","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.pedneo.2011.08.004","article-title":"Analysis of incidence and risk factors of retinopathy of prematurity among very-low-birth-weight infants in North Taiwan","volume":"52","author":"Yang","year":"2011","journal-title":"Pediatr. Neonatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0161-6420(93)31665-9","article-title":"Prognostic factors in the natural course of retinopathy of prematurity","volume":"100","author":"Schaffer","year":"1993","journal-title":"Ophthalmology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"The ESHRE Capri Workshop Group (2000). Multiple gestation pregnancy. Hum. Reprod., 15, 1856\u20131864.","DOI":"10.1093\/humrep\/15.8.1856"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1542\/peds.2004-1309","article-title":"Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network","volume":"115","author":"Darlow","year":"2005","journal-title":"Pediatrics"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/archopht.1956.00930040489001","article-title":"Retrolental fibroplasia; cooperative study of retrolental fibroplasia and the use of oxygen","volume":"56","author":"Kinsey","year":"1956","journal-title":"AMA Arch. Ophthalmol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1001\/jamaophthalmol.2014.5185","article-title":"Predictors for the development of referral-warranted retinopathy of prematurity in the telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study","volume":"133","author":"Ying","year":"2015","journal-title":"JAMA Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0420.1998.760216.x","article-title":"Neonatal risk factors for retinopathy of prematurity\u2014A population-based study","volume":"76","author":"Holmstrom","year":"1998","journal-title":"Acta Ophthalmol. Scand."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1111\/apa.14019","article-title":"Retrospective cohort study shows that the risks for retinopathy of prematurity included birth age and weight, medical conditions and treatment","volume":"106","author":"Ali","year":"2017","journal-title":"Acta Paediatr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.ophtha.2003.10.030","article-title":"Incidence of retinopathy of prematurity from 1996 to 2000: Analysis of a comprehensive New York state patient database","volume":"111","author":"Chiang","year":"2004","journal-title":"Ophthalmology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1016\/j.ophtha.2015.05.036","article-title":"Frizzled-4 Variations Associated with Retinopathy and Intrauterine Growth Retardation: A Potential Marker for Prematurity and Retinopathy","volume":"122","author":"Dailey","year":"2015","journal-title":"Ophthalmology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.survophthal.2018.04.002","article-title":"Retinopathy of prematurity: A review of risk factors and their clinical significance","volume":"63","author":"Kim","year":"2018","journal-title":"Surv. Ophthalmol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"JCIH American Academy of Pediatrics (2007). Year 2007 position statement: Principles and guidelines for early hearing detection and intervention programs. Pediatrics, 120, 898\u2013921.","DOI":"10.1542\/peds.2007-2333"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3345\/cep.2019.00822","article-title":"Short- and long-term outcomes of very low birth weight infants in Korea: Korean Neonatal Network update in 2019","volume":"63","author":"Lee","year":"2020","journal-title":"Clin. Exp. Pediatr."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/20\/4781\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:17:42Z","timestamp":1760167062000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/20\/4781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":34,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jcm10204781"],"URL":"https:\/\/doi.org\/10.3390\/jcm10204781","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,19]]}}}