{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:59:56Z","timestamp":1790816396135,"version":"4.1.0"},"reference-count":202,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Muscular Dystrophy UK","award":["#18-GROI-PG24-0140"],"award-info":[{"award-number":["#18-GROI-PG24-0140"]}]},{"DOI":"10.13039\/100007354","name":"Fondation Lefoulon-Delalande","doi-asserted-by":"publisher","award":["2021 awards"],"award-info":[{"award-number":["2021 awards"]}],"id":[{"id":"10.13039\/100007354","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Union's Horizon 2020 research and innovation programme","award":["n\u00b0779257"],"award-info":[{"award-number":["n\u00b0779257"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Laminopathies are a group of rare disorders due to mutation in LMNA gene. Depending on the mutation, they may affect striated muscles, adipose tissues, nerves or are multisystemic with various accelerated ageing syndromes. Although the diverse pathomechanisms responsible for laminopathies are not fully understood, several therapeutic approaches have been evaluated in patient cells or animal models, ranging from gene therapies to cell and drug therapies. This review is focused on these therapies with a strong focus on striated muscle laminopathies and premature ageing syndromes.<\/jats:p>","DOI":"10.3390\/jcm10214834","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:22:02Z","timestamp":1634862122000},"page":"4834","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preclinical Advances of Therapies for Laminopathies"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2805-9170","authenticated-orcid":false,"given":"Louise","family":"Benarroch","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Cohen","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Atalaia","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabah","family":"Ben Yaou","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2516-3258","authenticated-orcid":false,"given":"Gis\u00e8le","family":"Bonne","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-848X","authenticated-orcid":false,"given":"Anne T","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm, Institut de Myologie, Centre de Recherche en Myologie, 75013 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"a018242","DOI":"10.1101\/cshperspect.a018242","article-title":"Intermediate Filaments: Structure and Assembly","volume":"8","author":"Herrmann","year":"2016","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/319463a0","article-title":"Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins","volume":"319","author":"McKeon","year":"1986","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.semcdb.2013.12.012","article-title":"B-type lamins in health and disease","volume":"29","author":"Hutchison","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.sbi.2020.06.017","article-title":"Structure and unique mechanical aspects of nuclear lamin filaments","volume":"64","author":"Tenga","year":"2020","journal-title":"Curr. Opin. Struct. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature21382","article-title":"The molecular architecture of lamins in somatic cells","volume":"543","author":"Turgay","year":"2017","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1242\/jcs.203430","article-title":"Lamins in the nuclear interior\u2013Life outside the lamina","volume":"130","author":"Naetar","year":"2017","journal-title":"J. Cell Sci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/6799","article-title":"Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery-Dreifuss muscular dystrophy","volume":"21","author":"Bonne","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ana.21417","article-title":"De novo LMNA mutations cause a new form of congenital muscular dystrophy","volume":"64","author":"Mbieleu","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","article-title":"Identification of mutations in the gene encoding lamins A\/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)","volume":"9","author":"Muchir","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1080\/19491034.2018.1462635","article-title":"Clinical aspects of Emery-Dreifuss muscular dystrophy","volume":"9","year":"2018","journal-title":"Nucleus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","article-title":"Missense Mutations in the Rod Domain of the Lamin A\/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1046\/j.1460-9592.2000.01661.x","article-title":"High Incidence of Sudden Death with Conduction System and Myocardial Disease Due to Lamins A and C Gene Mutation","volume":"23","author":"Becane","year":"2000","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00109-007-0275-1","article-title":"Incomplete nonsense-mediated decay of mutant lamin A\/C mRNA provokes dilated cardiomyopathy and ventricular tachycardia","volume":"86","author":"Geiger","year":"2008","journal-title":"J. Mol. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/mus.20122","article-title":"Nuclear envelope alterations in fibroblasts from patients with muscular dystrophy, cardiomyopathy, and partial lipodystrophy carrying lamin A\/C gene mutations","volume":"30","author":"Muchir","year":"2004","journal-title":"Muscle Nerve"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1006\/excr.2002.5669","article-title":"Expression of Lamin A Mutated in the Carboxyl-Terminal Tail Generates an Aberrant Nuclear Phenotype Similar to That Observed in Cells from Patients with Dunnigan-Type Partial Lipodystrophy and Emery-Dreifuss Muscular Dystrophy","volume":"282","author":"Favreau","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1093\/hmg\/ddt079","article-title":"Myopathic lamin mutations impair nuclear stability in cells and tissue and disrupt nucleo-cytoskeletal coupling","volume":"22","author":"Zwerger","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1242\/jcs.114.24.4447","article-title":"Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy","volume":"114","author":"Raharjo","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yexcr.2005.10.011","article-title":"Laminopathy-inducing lamin A mutants can induce redistribution of lamin binding proteins into nuclear aggregates","volume":"312","author":"Hubner","year":"2006","journal-title":"Exp. Cell Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1016\/j.yexcr.2008.04.017","article-title":"Specific contribution of lamin A and lamin C in the development of laminopathies","volume":"314","author":"Sylvius","year":"2008","journal-title":"Exp. Cell Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.114.24.4435","article-title":"Properties of lamin A mutants found in Emery-Dreifuss muscular dystrophy, cardiomyopathy and Dunnigan-type partial lipodystrophy","volume":"114","author":"Bonne","year":"2001","journal-title":"J. Cell Sci."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Messner, M., Ghadge, S.K., Goetsch, V., Wimmer, A., D\u00f6rler, J., P\u00f6lzl, G., and Zaruba, M.-M. (2018). Upregulation of the aging related LMNA splice variant progerin in dilated cardiomyopathy. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196739"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00395-010-0085-4","article-title":"Genetic and ultrastructural studies in dilated cardiomyopathy patients: A large deletion in the lamin A\/C gene is associated with cardiomyocyte nuclear envelope disruption","volume":"105","author":"Gupta","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1083\/jcb.201902117","article-title":"Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy","volume":"218","author":"Bertero","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1128\/MCB.01676-12","article-title":"Lamin A\/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest","volume":"33","author":"Singh","year":"2013","journal-title":"Mol. Cell. Biol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.147.5.913","article-title":"Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy","volume":"147","author":"Sullivan","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.yjmcc.2007.11.008","article-title":"Lamin A\/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease","volume":"44","author":"Wolf","year":"2008","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3152","DOI":"10.1093\/hmg\/ddt172","article-title":"Heterozygous LmnadelK32 mice develop dilated cardiomyopathy through a combined pathomechanism of haploinsufficiency and peptide toxicity","volume":"22","author":"Cattin","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/01.wnl.0000261254.87181.80","article-title":"Phenotypic clustering of lamin A\/C mutations in neuromuscular patients","volume":"69","author":"Benedetti","year":"2007","journal-title":"Neurology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1093\/hmg\/ddh265","article-title":"Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy","volume":"13","author":"Navarro","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/095952878606900127","article-title":"Congenital Absence of Hair and Mammary Glands with Atrophic Condition of the Skin and its Appendages in a Boy Whose Mother Had Been Almost Wholly Bald from Alopecia Areata from the Age of Six","volume":"MCT-69","author":"Hutchinson","year":"1886","journal-title":"J. R. Soc. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1177\/095952879708000105","article-title":"On a Condition of Mixed Premature and Immature Development","volume":"MCT-80","author":"Gilford","year":"1897","journal-title":"J. R. Soc. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1086\/341908","article-title":"Mandibuloacral Dysplasia Is Caused by a Mutation in LMNA-Encoding Lamin A\/C","volume":"71","author":"Novelli","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S0140-6736(03)14069-X","article-title":"LMNA mutations in atypical Werner\u2019s syndrome","volume":"362","author":"Chen","year":"2003","journal-title":"The Lancet"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1056\/NEJMoa0706898","article-title":"Phenotype and Course of Hutchinson\u2013Gilford Progeria Syndrome","volume":"358","author":"Merideth","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/ajmg.a.31346","article-title":"Hutchinson\u2013Gilford progeria syndrome: Review of the phenotype","volume":"140A","author":"Hennekam","year":"2006","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1126\/science.1084125","article-title":"Lamin A Truncation in Hutchinson-Gilford Progeria","volume":"300","year":"2003","journal-title":"Science"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature01629","article-title":"Recurrent de novo point mutations in lamin A cause Hutchinson\u2013Gilford progeria syndrome","volume":"423","author":"Eriksson","year":"2003","journal-title":"Nature"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"8963","DOI":"10.1073\/pnas.0402943101","article-title":"Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson\u2013Gilford progeria syndrome","volume":"101","author":"Goldman","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/hmg\/9.1.109","article-title":"Nuclear lamin A\/C R482Q mutation in Canadian kindreds with Dunnigan-type familial partial lipodystrophy","volume":"9","author":"Cao","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/72807","article-title":"LMNA, encoding lamin A\/C, is mutated in partial lipodystrophy","volume":"24","author":"Shackleton","year":"2000","journal-title":"Nat. Genet."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/B978-0-444-59565-2.00007-1","article-title":"Emery\u2013Dreifuss muscular dystrophy, laminopathies, and other nuclear envelopathies","volume":"Volume 113","author":"Bonne","year":"2013","journal-title":"Handbook of Clinical Neurology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1093\/hmg\/ddu728","article-title":"The p.R482W substitution in A-type lamins deregulates SREBP1 activity in Dunnigan-type familial partial lipodystrophy","volume":"24","author":"Vadrot","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1086\/339274","article-title":"Homozygous Defects in LMNA, Encoding Lamin A\/C Nuclear-Envelope Proteins, Cause Autosomal Recessive Axonal Neuropathy in Human (Charcot-Marie-Tooth Disorder Type 2) and Mouse","volume":"70","author":"Chaouch","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0960-8966(02)00196-7","article-title":"The phenotypic manifestations of autosomal recessive axonalCharcot\u2013Marie\u2013Tooth due to a mutation in Lamin A\/C gene","volume":"13","author":"Chaouch","year":"2003","journal-title":"Neuromuscul. Disord."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/brain\/awh021","article-title":"Phenotypic variability in autosomal recessive axonal Charcot-Marie-Tooth disease due to the R298C mutation in lamin A\/C","volume":"127","author":"Tazir","year":"2004","journal-title":"Brain"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.semcdb.2014.01.001","article-title":"Striated muscle laminopathies","volume":"29","author":"Azibani","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4161\/nucl.21676","article-title":"A truncated lamin A in the Lmna \u2212\/\u2212 mouse line: Implications for the understanding of laminopathies","volume":"3","author":"Jahn","year":"2012","journal-title":"Nucleus"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1172\/JCI27125","article-title":"Prelamin A and lamin A appear to be dispensable in the nuclear lamina","volume":"116","author":"Fong","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1093\/hmg\/ddq158","article-title":"An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria","volume":"19","author":"Davies","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Frock, R.L., Chen, S.C., Da, D.-F., Frett, E., Lau, C., Brown, C., Pak, D.N., Wang, Y., Muchir, A., and Worman, H.J. (2012). Cardiomyocyte-Specific Expression of Lamin A Improves Cardiac Function in Lmna\u2212\/\u2212 Mice. PLoS ONE, 7.","DOI":"10.1371\/annotation\/92be6b32-d8e7-44c2-80a9-21097ad27965"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1093\/hmg\/ddl170","article-title":"Pathology and nuclear abnormalities in hearts of transgenic mice expressing M371K lamin A encoded by an LMNA mutation causing Emery-Dreifuss muscular dystrophy","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/gt.2015.8","article-title":"Ameliorating pathogenesis by removing an exon containing a missense mutation: A potential exon-skipping therapy for laminopathies","volume":"22","author":"Scharner","year":"2015","journal-title":"Gene Ther."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.omtn.2017.12.012","article-title":"Gene Therapy via Trans-Splicing for LMNA-Related Congenital Muscular Dystrophy","volume":"10","author":"Azibani","year":"2018","journal-title":"Mol. Ther.\u2014Nucleic Acids"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/hmg\/ddr534","article-title":"DelK32-lamin A\/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death","volume":"21","author":"Bertrand","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/s41467-019-09929-w","article-title":"The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy","volume":"10","author":"Salvarani","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/humu.20250","article-title":"Thymopoietin (lamina-associated polypeptide 2) gene mutation associated with dilated cardiomyopathy","volume":"26","author":"Taylor","year":"2005","journal-title":"Hum. Mutat."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1093\/hmg\/ddt135","article-title":"Defective skeletal muscle growth in lamin A\/C-deficient mice is rescued by loss of Lap2\u03b1","volume":"22","author":"Cohen","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Pilat, U., Dechat, T., Bertrand, A.T., Woisetschl\u00e4ger, N., Gotic, I., Spilka, R., Biadasiewicz, K., Bonne, G., and Foisner, R. (2013). Muscle dystrophy-causing \u0394K32 lamin A\/C mutant does not impair functions of nucleoplasmic LAP2\u03b1\u2014lamin A\/C complexes in mice. J. Cell Sci., jcs.115246.","DOI":"10.1242\/jcs.115246"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1001\/jamacardio.2016.2225","article-title":"Adult Stem Cell Therapy and Heart Failure, 2000 to 2016: A Systematic Review","volume":"1","author":"Nguyen","year":"2016","journal-title":"JAMA Cardiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/hmg\/ddi017","article-title":"Mouse model carrying H222P- Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies","volume":"14","author":"Arimura","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/mt.2013.15","article-title":"Myoblasts and Embryonic Stem Cells Differentially Engraft in a Mouse Model of Genetic Dilated Cardiomyopathy","volume":"21","author":"Catelain","year":"2013","journal-title":"Mol. Ther."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/jcb.26169","article-title":"Stem Cell Therapy: A New Therapeutic Option for Cardiovascular Diseases","volume":"119","author":"Goradel","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Lee, Y., Lau, Y., Cai, Z., Lai, W., Wong, L., Tse, H., Ng, K., and Siu, C. (2017). Modeling Treatment Response for Lamin A\/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells. J. Am. Heart Assoc., 6.","DOI":"10.1161\/JAHA.117.005677"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13059-020-02003-5","article-title":"Lamina-associated domains: Peripheral matters and internal affairs","volume":"21","author":"Briand","year":"2020","journal-title":"Genome Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13059-016-1146-2","article-title":"Chrom3D: Three-dimensional genome modeling from Hi-C and nuclear lamin-genome contacts","volume":"18","author":"Paulsen","year":"2017","journal-title":"Genome Biol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"335ra58","DOI":"10.1126\/scitranslmed.aad4991","article-title":"Laminopathies disrupt epigenomic developmental programs and cell fate","volume":"8","author":"Perovanovic","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.118.314177","article-title":"Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy","volume":"124","author":"Cheedipudi","year":"2019","journal-title":"Circ. Res."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/CIRCRESAHA.117.312052","article-title":"Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies","volume":"122","author":"Auguste","year":"2018","journal-title":"Circ. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI29042","article-title":"Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy","volume":"117","author":"Muchir","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"4740","DOI":"10.1172\/JCI135922","article-title":"BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A\/C\u2013deficient mice","volume":"130","author":"Auguste","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"e136488","DOI":"10.1172\/JCI136488","article-title":"Targeting the histone demethylase LSD1 prevents cardiomyopathy in a mouse model of laminopathy","volume":"131","author":"Jebeniani","year":"2021","journal-title":"J. Clin. Investig."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41563-019-0563-5","article-title":"Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells","volume":"19","author":"Earle","year":"2020","journal-title":"Nat. Mater."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.devcel.2019.04.020","article-title":"Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest","volume":"49","author":"Cho","year":"2019","journal-title":"Dev. Cell"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e12851","DOI":"10.1111\/acel.12851","article-title":"A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling","volume":"18","author":"Dworak","year":"2019","journal-title":"Aging Cell"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/978-1-4899-8032-8_19","article-title":"Nuclear Lamins and Oxidative Stress in Cell Proliferation and Longevity","volume":"Volume 773","author":"Schirmer","year":"2014","journal-title":"Cancer Biology and the Nuclear Envelope"},{"key":"ref_76","first-page":"11709","article-title":"Lamin A\/C promotes DNA base excision repair","volume":"4747","author":"Maynard","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/hmg\/ddy243","article-title":"N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nuclear A-type lamins gene","volume":"27","author":"Rodriguez","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1093\/hmg\/ddy215","article-title":"Cofilin-1 phosphorylation catalyzed by ERK1\/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A\/C gene mutation","volume":"27","author":"Chatzifrangkeskou","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1194\/jlr.M071381","article-title":"Extracellular matrix remodeling and transforming growth factor-\u03b2 signaling abnormalities induced by lamin A\/C variants that cause lipodystrophy","volume":"58","author":"Wu","year":"2017","journal-title":"J. Lipid Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/19491034.2018.1467722","article-title":"Elevated TGF \u03b22 serum levels in Emery-Dreifuss Muscular Dystrophy: Implications for myocyte and tenocyte differentiation and fibrogenic processes","volume":"9","author":"Bernasconi","year":"2018","journal-title":"Nucleus"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s11886-019-1224-7","article-title":"Lamin A\/C Cardiomyopathy: Implications for Treatment","volume":"21","author":"Chen","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1093\/hmg\/ddy278","article-title":"Rescue of biosynthesis of nicotinamide adenine dinucleotide protects the heart in cardiomyopathy caused by lamin A\/C gene mutation","volume":"27","author":"Vignier","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.200805049","article-title":"Fast regulation of AP-1 activity through interaction of lamin A\/C, ERK1\/2, and c-Fos at the nuclear envelope","volume":"183","author":"Casar","year":"2008","journal-title":"J. Cell Biol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1093\/hmg\/dds265","article-title":"Abnormal p38 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A\/C gene mutation","volume":"21","author":"Muchir","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/cvr\/cvr301","article-title":"Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A\/C gene","volume":"93","author":"Muchir","year":"2012","journal-title":"Cardiovasc. Res."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2044-5040-3-17","article-title":"Inhibition of extracellular signal-regulated kinase 1\/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A\/C gene mutation","volume":"3","author":"Muchir","year":"2013","journal-title":"Skelet. Muscle"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bmc.2016.12.014","article-title":"Macrocyclic MEK1\/2 inhibitor with efficacy in a mouse model of cardiomyopathy caused by lamin A\/C gene mutation","volume":"25","author":"Wu","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/hmg\/ddn343","article-title":"Inhibition of extracellular signal-regulated kinase signaling to prevent cardiomyopathy caused by mutation in the gene encoding A-type lamins","volume":"18","author":"Muchir","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.bbrc.2014.09.020","article-title":"Mitogen-activated protein kinase kinase 1\/2 inhibition and angiotensin II converting inhibition in mice with cardiomyopathy caused by lamin A\/C gene mutation","volume":"452","author":"Muchir","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1161\/CIRCULATIONAHA.110.970673","article-title":"Mitogen-Activated Protein Kinase Inhibitors Improve Heart Function and Prevent Fibrosis in Cardiomyopathy Caused by Mutation in Lamin A\/C Gene","volume":"123","author":"Wu","year":"2011","journal-title":"Circulation"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.bbadis.2010.04.001","article-title":"Pharmacological inhibition of c-Jun N-terminal kinase signaling prevents cardiomyopathy caused by mutation in LMNA gene","volume":"1802","author":"Wu","year":"2010","journal-title":"Biochim. Biophys. Acta BBA\u2014Mol. Basis Dis."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/hmg\/ddw090","article-title":"ERK1\/2 directly acts on CTGF\/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A\/C gene","volume":"25","author":"Chatzifrangkeskou","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1161\/CIRCRESAHA.119.314794","article-title":"Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf","volume":"125","author":"Tan","year":"2019","journal-title":"Circ. Res."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"109601","DOI":"10.1016\/j.celrep.2021.109601","article-title":"The non-muscle ADF\/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies","volume":"36","author":"Vignier","year":"2021","journal-title":"Cell Rep."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/hmg\/ddi221","article-title":"Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice","volume":"14","author":"Mounkes","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.yexcr.2012.12.014","article-title":"Phosphorylation of connexin43 on S279\/282 may contribute to laminopathy-associated conduction defects","volume":"319","author":"Chen","year":"2013","journal-title":"Exp. Cell Res."},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Macquart, C., J\u00fcttner, R., Morales Rodriguez, B., Le Dour, C., Lefebvre, F., Chatzifrangkeskou, M., Schmitt, A., Gotthardt, M., Bonne, G., and Muchir, A. (2018). Microtubule cytoskeleton regulates Connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene. Hum. Mol. Genet.","DOI":"10.1093\/hmg\/ddy227"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"e03175","DOI":"10.1016\/j.heliyon.2020.e03175","article-title":"Altered microtubule structure, hemichannel localization and beating activity in cardiomyocytes expressing pathologic nuclear lamin A\/C","volume":"6","author":"Borin","year":"2020","journal-title":"Heliyon"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI200419448","article-title":"Defects in nuclear structure and function promote dilated cardiomyopathy in lamin A\/C\u2013deficient mice","volume":"113","author":"Nikolova","year":"2004","journal-title":"J. Clin. Investig."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2018.10.017","article-title":"Amelioration of desmin network defects by \u03b1B-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation","volume":"125","author":"Galata","year":"2018","journal-title":"J. Mol. Cell. Cardiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and \u03b2-catenin signalling: Diseases and therapies","volume":"5","author":"Moon","year":"2004","journal-title":"Nat. Rev. Genet."},{"key":"ref_102","first-page":"333","article-title":"Decreased WNT\/\u03b2-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a\/C gene","volume":"26","author":"Macquart","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1159\/000485651","article-title":"Functional Characterization of a Novel Truncating Mutation in Lamin A\/C Gene in a Family with a Severe Cardiomyopathy with Conduction Defects","volume":"44","author":"Gerbino","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1161\/CIRCRESAHA.114.302022","article-title":"Mammalian Target of Rapamycin Signaling in Cardiac Physiology and Disease","volume":"114","author":"Sciarretta","year":"2014","journal-title":"Circ. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"144ra103","DOI":"10.1126\/scitranslmed.3003802","article-title":"Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A\/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival","volume":"4","author":"Ramos","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"144ra102","DOI":"10.1126\/scitranslmed.3003875","article-title":"Temsirolimus Activates Autophagy and Ameliorates Cardiomyopathy Caused by Lamin A\/C Gene Mutation","volume":"4","author":"Choi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1073\/pnas.1802811115","article-title":"Everolimus rescues multiple cellular defects in laminopathy-patient fibroblasts","volume":"115","author":"DuBose","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"803","DOI":"10.18632\/aging.100503","article-title":"Modeling of lamin A\/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells","volume":"4","author":"Siu","year":"2012","journal-title":"Aging"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/ddt387","article-title":"Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A\/C gene mutation partially prevents pathology before isoenzyme activation","volume":"23","author":"Wu","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"17039","DOI":"10.1038\/celldisc.2017.39","article-title":"Evidence that S6K1, but not 4E-BP1, mediates skeletal muscle pathology associated with loss of A-type lamins","volume":"3","author":"Liao","year":"2017","journal-title":"Cell Discov."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1093\/hmg\/ddy134","article-title":"Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A\/C gene mutation is primarily ERK1\/2-dependent and its depletion improves cardiac function and survival","volume":"27","author":"Choi","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nm1204","article-title":"Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome","volume":"11","author":"Scaffidi","year":"2005","journal-title":"Nat. Med."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1172\/JCI84164","article-title":"Interruption of progerin\u2013lamin A\/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype","volume":"126","author":"Lee","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1093\/hmg\/ddp184","article-title":"Activating the synthesis of progerin, the mutant prelamin A in Hutchinson\u2013Gilford progeria syndrome, with antisense oligonucleotides","volume":"18","author":"Fong","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"106ra107","DOI":"10.1126\/scitranslmed.3002847","article-title":"Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging","volume":"3","author":"Osorio","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Harhouri, K., Navarro, C., Baquerre, C., Da Silva, N., Bartoli, C., Casey, F., Mawuse, G., Doubaj, Y., L\u00e9vy, N., and De Sandre-Giovannoli, A. (2016). Antisense-Based Progerin Downregulation in HGPS-Like Patients\u2019 Cells. Cells, 5.","DOI":"10.3390\/cells5030031"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00439-005-0051-7","article-title":"Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference","volume":"118","author":"Huang","year":"2005","journal-title":"Hum. Genet."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1093\/hmg\/ddt537","article-title":"New Lmna knock-in mice provide a molecular mechanism for the \u2018segmental aging\u2019 in Hutchinson\u2013Gilford progeria syndrome","volume":"23","author":"Jung","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"E423","DOI":"10.1073\/pnas.1111780109","article-title":"Regulation of prelamin A but not lamin C by miR-9, a brain-specific microRNA","volume":"109","author":"Jung","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"e12766","DOI":"10.1111\/acel.12766","article-title":"MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies","volume":"17","author":"Frankel","year":"2018","journal-title":"Aging Cell"},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41591-018-0338-6","article-title":"Development of a CRISPR\/Cas9-based therapy for Hutchinson\u2013Gilford progeria syndrome","volume":"25","author":"Osorio","year":"2019","journal-title":"Nat. Med."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41591-019-0343-4","article-title":"Single-dose CRISPR\u2013Cas9 therapy extends lifespan of mice with Hutchinson\u2013Gilford progeria syndrome","volume":"25","author":"Beyret","year":"2019","journal-title":"Nat. Med."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/19491034.2018.1460045","article-title":"An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome","volume":"9","author":"Harhouri","year":"2018","journal-title":"Nucleus"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.stem.2011.04.019","article-title":"Targeted Gene Correction of Laminopathy-Associated LMNA Mutations in Patient-Specific iPSCs","volume":"8","author":"Liu","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1159\/000368856","article-title":"Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei","volume":"82","author":"Endisha","year":"2015","journal-title":"Pathobiology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41586-020-03086-7","article-title":"In vivo base editing rescues Hutchinson\u2013Gilford progeria syndrome in mice","volume":"589","author":"Koblan","year":"2021","journal-title":"Nature"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Gete, Y.G., Koblan, L.W., Mao, X., Trappio, M., Mahadik, B., Fisher, J.P., Liu, D.R., and Cao, K. (2021). Mechanisms of angiogenic incompetence in Hutchinson\u2013Gilford progeria via downregulation of endothelial NOS. Aging Cell, 20.","DOI":"10.1111\/acel.13388"},{"key":"ref_128","doi-asserted-by":"crossref","unstructured":"Mojiri, A., Walther, B.K., Jiang, C., Matrone, G., Holgate, R., Xu, Q., Morales, E., Wang, G., Gu, J., and Wang, R. (2021). Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice. Eur. Heart J., ehab547.","DOI":"10.1161\/circ.144.suppl_1.11821"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"12879","DOI":"10.1073\/pnas.0506001102","article-title":"Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome","volume":"102","author":"Capell","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1126\/science.1124875","article-title":"A Protein Farnesyltransferase Inhibitor Ameliorates Disease in a Mouse Model of Progeria","volume":"311","author":"Fong","year":"2006","journal-title":"Science"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/hmg\/ddi326","article-title":"Incomplete processing of mutant lamin A in Hutchinson\u2013Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition","volume":"14","author":"Glynn","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.18632\/aging.100709","article-title":"Progerin expression disrupts critical adult stem cell functions involved in tissue repair","volume":"6","author":"Pacheco","year":"2014","journal-title":"Aging"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.jprot.2013.08.008","article-title":"Identification of mitochondrial dysfunction in Hutchinson\u2013Gilford progeria syndrome through use of stable isotope labeling with amino acids in cell culture","volume":"91","author":"Osorio","year":"2013","journal-title":"J. Proteom."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"12873","DOI":"10.1073\/pnas.0505767102","article-title":"Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes","volume":"102","author":"Toth","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"10291","DOI":"10.1073\/pnas.0504641102","article-title":"Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation","volume":"102","author":"Yang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"15902","DOI":"10.1073\/pnas.0807840105","article-title":"A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model","volume":"105","author":"Capell","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1172\/JCI28968","article-title":"A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation","volume":"116","author":"Yang","year":"2006","journal-title":"J. Clin. Investig."},{"key":"ref_138","first-page":"36","article-title":"Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson\u2013Gilford progeria syndrome mutation","volume":"1781","author":"Yang","year":"2008","journal-title":"Biochim. Biophys. Acta BBA\u2014Mol. Cell Biol. Lipids"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nm1786","article-title":"Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging","volume":"14","author":"Varela","year":"2008","journal-title":"Nat. Med."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"e2105","DOI":"10.1038\/cddis.2015.374","article-title":"Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation","volume":"7","author":"Blondel","year":"2016","journal-title":"Cell Death Dis."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1126\/science.1238880","article-title":"Targeting Isoprenylcysteine Methylation Ameliorates Disease in a Mouse Model of Progeria","volume":"340","author":"Ibrahim","year":"2013","journal-title":"Science"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"510","DOI":"10.5966\/sctm.2013-0168","article-title":"Induced Pluripotent Stem Cells Reveal Functional Differences Between Drugs Currently Investigated in Patients With Hutchinson-Gilford Progeria Syndrome","volume":"3","author":"Blondel","year":"2014","journal-title":"STEM CELLS Transl. Med."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"16666","DOI":"10.1073\/pnas.1202529109","article-title":"Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome","volume":"109","author":"Gordon","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.0b013e31829d85c0","article-title":"Neurologic features of Hutchinson-Gilford progeria syndrome after lonafarnib treatment","volume":"81","author":"Ullrich","year":"2013","journal-title":"Neurology"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1001\/jama.2018.3264","article-title":"Association of Lonafarnib Treatment vs No Treatment with Mortality Rate in Patients with Hutchinson-Gilford Progeria Syndrome","volume":"319","author":"Gordon","year":"2018","journal-title":"JAMA"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1161\/CIRCULATIONAHA.116.022188","article-title":"Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome","volume":"134","author":"Gordon","year":"2016","journal-title":"Circulation"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"419","DOI":"10.3233\/JND-200596","article-title":"Laminopathies\u2019 Treatments Systematic Review: A Contribution Towards a \u2018Treatabolome\u2019","volume":"8","author":"Atalaia","year":"2021","journal-title":"J. Neuromuscul. Dis."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"89ra58","DOI":"10.1126\/scitranslmed.3002346","article-title":"Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells","volume":"3","author":"Cao","year":"2011","journal-title":"Sci. Transl. Med."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4081\/ejh.2011.e36","article-title":"Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria","volume":"55","author":"Cenni","year":"2011","journal-title":"Eur. J. Histochem."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.omtm.2019.05.011","article-title":"Rapamycin Rescues Age-Related Changes in Muscle-Derived Stem\/Progenitor Cells from Progeroid Mice","volume":"14","author":"Kawakami","year":"2019","journal-title":"Mol. Ther.\u2014Methods Clin. Dev."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"755","DOI":"10.18632\/aging.100680","article-title":"Rapamycin treatment of Mandibuloacral Dysplasia cells rescues localization of chromatin-associated proteins and cell cycle dynamics","volume":"6","author":"Cenni","year":"2014","journal-title":"Aging"},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/acel.12300","article-title":"Sulforaphane enhances progerin clearance in Hutchinson-Gilford progeria fibroblasts","volume":"14","author":"Gabriel","year":"2015","journal-title":"Aging Cell"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Gabriel, D., Gordon, L.B., and Djabali, K. (2016). Temsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0168988"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10522-018-9758-4","article-title":"Farnesyltransferase inhibitor and rapamycin correct aberrant genome organisation and decrease DNA damage respectively, in Hutchinson\u2013Gilford progeria syndrome fibroblasts","volume":"19","author":"Bikkul","year":"2018","journal-title":"Biogerontology"},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"64809","DOI":"10.18632\/oncotarget.19363","article-title":"Intermittent treatment with farnesyltransferase inhibitor and sulforaphane improves cellular homeostasis in Hutchinson-Gilford progeria fibroblasts","volume":"8","author":"Gabriel","year":"2017","journal-title":"Oncotarget"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"29914","DOI":"10.18632\/oncotarget.4939","article-title":"All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype","volume":"6","author":"Pellegrini","year":"2015","journal-title":"Oncotarget"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.15252\/emmm.201607315","article-title":"MG 132-induced progerin clearance is mediated by autophagy activation and splicing regulation","volume":"9","author":"Harhouri","year":"2017","journal-title":"EMBO Mol. Med."},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"16026","DOI":"10.1038\/npjamd.2016.26","article-title":"Metformin decreases progerin expression and alleviates pathological defects of Hutchinson\u2013Gilford progeria syndrome cells","volume":"2","author":"Egesipe","year":"2016","journal-title":"NPJ Aging Mech. Dis."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/exd.13323","article-title":"Metformin alleviates ageing cellular phenotypes in Hutchinson-Gilford progeria syndrome dermal fibroblasts","volume":"26","author":"Park","year":"2017","journal-title":"Exp. Dermatol."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s42003-020-01540-w","article-title":"Progerinin, an optimized progerin-lamin A binding inhibitor, ameliorates premature senescence phenotypes of Hutchinson-Gilford progeria syndrome","volume":"4","author":"Kang","year":"2021","journal-title":"Commun. Biol."},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1093\/hmg\/ddr327","article-title":"The accumulation of un-repairable DNA damage in laminopathy progeria fibroblasts is caused by ROS generation and is prevented by treatment with N-acetyl cysteine","volume":"20","author":"Richards","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/acel.12434","article-title":"Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria","volume":"15","author":"Xiong","year":"2016","journal-title":"Aging Cell"},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/acel.12584","article-title":"Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome","volume":"16","author":"Kang","year":"2017","journal-title":"Aging Cell"},{"key":"ref_164","first-page":"210","article-title":"Alleviation of Senescence via ATM Inhibition in Accelerated Aging Models","volume":"42","author":"Kuk","year":"2019","journal-title":"Mol. Cells"},{"key":"ref_165","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1161\/CIRCULATIONAHA.112.000571","article-title":"Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment","volume":"127","author":"Osorio","year":"2013","journal-title":"Circulation"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/j.cell.2016.05.017","article-title":"Repression of the Antioxidant NRF2 Pathway in Premature Aging","volume":"165","author":"Kubben","year":"2016","journal-title":"Cell"},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"306073","DOI":"10.1155\/2013\/306073","article-title":"Preventive and Therapeutic Effects of MG132 by Activating Nrf2-ARE Signaling Pathway on Oxidative Stress-Induced Cardiovascular and Renal Injury","volume":"2013","author":"Cui","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"726","DOI":"10.18632\/aging.100502","article-title":"NF-\u03baB in premature aging","volume":"4","author":"Osorio","year":"2012","journal-title":"Aging"},{"key":"ref_169","doi-asserted-by":"crossref","unstructured":"Liu, C., Arnold, R., Henriques, G., and Djabali, K. (2019). Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells. Cells, 8.","DOI":"10.3390\/cells8101276"},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1365-2567.2008.02806.x","article-title":"MG132 proteasome inhibitor modulates proinflammatory cytokines production and expression of their receptors in U937 cells: Involvement of nuclear factor-\u03baB and activator protein-1","volume":"124","year":"2008","journal-title":"Immunology"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/1756-185X.12353","article-title":"Proteasome inhibitor MG132 modulates inflammatory pain by central mechanisms in adjuvant arthritis","volume":"20","author":"Ahmed","year":"2017","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1126\/science.1252651","article-title":"Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells","volume":"344","author":"Larrieu","year":"2014","journal-title":"Science"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/s41467-018-03770-3","article-title":"Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome","volume":"9","author":"Balmus","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"5435","DOI":"10.1038\/s41467-018-07825-3","article-title":"Impaired immune surveillance accelerates accumulation of senescent cells and aging","volume":"9","author":"Ovadya","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s13238-018-0567-y","article-title":"Chemical screen identifies a geroprotective role of quercetin in premature aging","volume":"10","author":"Geng","year":"2019","journal-title":"Protein Cell"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Mateos, J., Fafi\u00e1n-Labora, J., Morente-L\u00f3pez, M., Lesende-Rodriguez, I., Monserrat, L., \u00d3dena, M.A., De Oliveira, E., De Toro, J., and Arufe, M.C. (2018). Next-Generation Sequencing and Quantitative Proteomics of Hutchinson-Gilford progeria syndrome-derived cells point to a role of nucleotide metabolism in premature aging. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0205878"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"eaav5078","DOI":"10.1126\/sciadv.aav5078","article-title":"Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model","volume":"5","author":"Ao","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_178","doi-asserted-by":"crossref","first-page":"e13002","DOI":"10.1111\/acel.13002","article-title":"Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity","volume":"18","year":"2019","journal-title":"Aging Cell"},{"key":"ref_179","doi-asserted-by":"crossref","first-page":"30018","DOI":"10.18632\/oncotarget.9065","article-title":"Vitamin D receptor signaling improves Hutchinson-Gilford progeria syndrome cellular phenotypes","volume":"7","author":"Kreienkamp","year":"2016","journal-title":"Oncotarget"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.cmet.2012.11.007","article-title":"Resveratrol Rescues SIRT1-Dependent Adult Stem Cell Decline and Alleviates Progeroid Features in Laminopathy-Based Progeria","volume":"16","author":"Liu","year":"2012","journal-title":"Cell Metab."},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"e34836","DOI":"10.7554\/eLife.34836","article-title":"Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria","volume":"7","author":"Qian","year":"2018","journal-title":"eLife"},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fcell.2019.00006","article-title":"Statins and Histone Deacetylase Inhibitors Affect Lamin A\/C\u2014Histone Deacetylase 2 Interaction in Human Cells","volume":"7","author":"Mattioli","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"16268","DOI":"10.1073\/pnas.1002696107","article-title":"Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function","volume":"107","author":"Marino","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_185","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0026-0495(97)90069-X","article-title":"Response to nutritional and growth hormone treatment in progeria","volume":"46","author":"Abdenur","year":"1997","journal-title":"Metabolism"},{"key":"ref_186","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.celrep.2018.07.089","article-title":"Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism","volume":"24","author":"Durand","year":"2018","journal-title":"Cell Rep."},{"key":"ref_187","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1080\/15548627.2018.1533059","article-title":"Methionine restriction for improving progeria: Another autophagy-inducing anti-aging strategy?","volume":"15","author":"Kroemer","year":"2019","journal-title":"Autophagy"},{"key":"ref_188","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/s41591-019-0504-5","article-title":"Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice","volume":"25","author":"Mayoral","year":"2019","journal-title":"Nat. Med."},{"key":"ref_189","doi-asserted-by":"crossref","first-page":"e12936","DOI":"10.1111\/acel.12936","article-title":"Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson\u2013Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite","volume":"18","author":"Salaices","year":"2019","journal-title":"Aging Cell"},{"key":"ref_190","doi-asserted-by":"crossref","unstructured":"Kreienkamp, R., Billon, C., Bedia-Diaz, G., Albert, C.J., Toth, Z., Butler, A.A., McBride-Gagyi, S., Ford, D.A., Baldan, A., and Burris, T.P. (2019). Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet. Aging Cell, 18.","DOI":"10.1111\/acel.12852"},{"key":"ref_191","doi-asserted-by":"crossref","first-page":"7094","DOI":"10.1074\/jbc.M708138200","article-title":"Eliminating the Synthesis of Mature Lamin A Reduces Disease Phenotypes in Mice Carrying a Hutchinson-Gilford Progeria Syndrome Allele","volume":"283","author":"Yang","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_192","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1172\/JCI85908","article-title":"Modulation of LMNA splicing as a strategy to treat prelamin A diseases","volume":"126","author":"Lee","year":"2016","journal-title":"J. Clin. Investig."},{"key":"ref_193","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.exger.2018.02.012","article-title":"A crucial role of ROCK for alleviation of senescence-associated phenotype","volume":"106","author":"Park","year":"2018","journal-title":"Exp. Gerontol."},{"key":"ref_194","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.2337\/db12-0004","article-title":"Alterations in Lipid Signaling Underlie Lipodystrophy Secondary to AGPAT2 Mutations","volume":"61","author":"Subauste","year":"2012","journal-title":"Diabetes"},{"key":"ref_195","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1080\/21623945.2017.1362510","article-title":"Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation","volume":"6","author":"Davies","year":"2017","journal-title":"Adipocyte"},{"key":"ref_196","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1161\/ATVBAHA.113.301933","article-title":"Lipodystrophy-Linked LMNA p.R482W Mutation Induces Clinical Early Atherosclerosis and In Vitro Endothelial Dysfunction","volume":"33","author":"Bidault","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_197","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1186\/s13023-019-1141-2","article-title":"Adherence with metreleptin therapy and health self-perception in patients with lipodystrophic syndromes","volume":"14","author":"Vatier","year":"2019","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_198","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1194\/jlr.M800491-JLR200","article-title":"The role of LMNA in adipose: A novel mouse model of lipodystrophy based on the Dunnigan-type familial partial lipodystrophy mutation","volume":"50","author":"Wojtanik","year":"2009","journal-title":"J. Lipid Res."},{"key":"ref_199","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1055\/s-0031-1301284","article-title":"Thiazolidinedione Response in Familial Lipodystrophy Patients with LMNA Mutations: A Case Series","volume":"44","author":"Luedtke","year":"2012","journal-title":"Horm. Metab. Res."},{"key":"ref_200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s12017-012-8168-z","article-title":"Behavioral and Molecular Exploration of the AR-CMT2A Mouse Model Lmna R298C\/R298C","volume":"14","author":"Poitelon","year":"2012","journal-title":"NeuroMol. Med."},{"key":"ref_201","doi-asserted-by":"crossref","first-page":"146683","DOI":"10.1016\/j.brainres.2020.146683","article-title":"Gene therapies for axonal neuropathies: Available strategies, successes to date, and what to target next","volume":"1732","author":"Morelli","year":"2020","journal-title":"Brain Res."},{"key":"ref_202","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/WCO.0000000000000373","article-title":"Recent advances in the genetic neuropathies","volume":"29","author":"Rossor","year":"2016","journal-title":"Curr. Opin. Neurol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/21\/4834\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:20:10Z","timestamp":1760167210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/21\/4834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":202,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["jcm10214834"],"URL":"https:\/\/doi.org\/10.3390\/jcm10214834","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]}}}