{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:29:04Z","timestamp":1760236144071,"version":"build-2065373602"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T00:00:00Z","timestamp":1635033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Transcatheter aortic valve replacement (TAVR) offers a novel treatment option for patients with severe symptomatic aortic valve stenosis, particularly for patients who are unsuitable candidates for surgical intervention. However, high therapeutical costs, socio-economic considerations, and numerous comorbidities make it necessary to target and allocate available resources efficiently. In the present study, we aimed to identify risk factors associated with futile treatment following transfemoral (TF) and transapical (TA) TAVR. Five hundred and thirty-two consecutive patients (82 \u00b1 9 years, female 63%) who underwent TAVR between June 2009 and December 2016 at the Vienna Heart Center Hietzing were retrospectively analyzed to identify predictors of futility, defined as all-cause mortality at one year following the procedure for the overall patient cohort, as well as the TF and TA cohort. Out of 532 patients, 91 (17%) did not survive the first year after TAVR. A multivariate logistic model identified cerebrovascular disease, home oxygen dependency, wheelchair dependency, periinterventional myocardial infarction, and postinterventional renal replacement therapy as the factors independently associated with an increased one-year mortality. Our findings underscore the significance of a precise preinterventional evaluation, as well as illustrating the subtle differences in baseline characteristics in the TF and TA cohort and their impact on one-year mortality.<\/jats:p>","DOI":"10.3390\/jcm10214911","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T22:06:16Z","timestamp":1635113176000},"page":"4911","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identifying Patients without a Survival Benefit following Transfemoral and Transapical Transcatheter Aortic Valve Replacement"],"prefix":"10.3390","volume":"10","author":[{"given":"Daniela","family":"Geisler","sequence":"first","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Klinik Floridsdorf and Karl Landsteiner Institute for Cardio-Vascular Research, 1210 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr Nikodem","family":"Rudzi\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Coronary and Structural Heart Diseases, The Cardinal Stefan Wyszy\u0144ski Institute of Cardiology, 04-628 Warsaw, Poland"},{"name":"Department of Cardiac Surgery, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waseem","family":"Hasan","sequence":"additional","affiliation":[{"name":"Imperial College London, London SW7 2AZ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Andreas","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ena","family":"Hasimbegovic","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University Vienna, 1090 Vienna, Austria"},{"name":"Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Adlbrecht","sequence":"additional","affiliation":[{"name":"Imed19-Privat, Private Clinical Research Center, Chimanistrasse 1, 1190 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Klinik Floridsdorf and Karl Landsteiner Institute for Cardio-Vascular Research, 1210 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Klinik Ottakring, 1160 Vienna, Austria"},{"name":"Medical Faculty, Sigmund Freud University, 1020 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Strouhal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Klinik Floridsdorf and the Karl Landsteiner Institute for Cardiovascular & Intensive Care Research Vienna, 1210 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Delle-Karth","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Klinik Floridsdorf and the Karl Landsteiner Institute for Cardiovascular & Intensive Care Research Vienna, 1210 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Grabenw\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Cardio-Vascular Surgery, Klinik Floridsdorf and Karl Landsteiner Institute for Cardio-Vascular Research, 1210 Vienna, Austria"},{"name":"Medical Faculty, Sigmund Freud University, 1020 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3184-4914","authenticated-orcid":false,"given":"Markus","family":"Mach","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Medical University Vienna, 1090 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.21037\/cdt.2019.09.12","article-title":"Transcatheter aortic valve replacement in low risk patients: A review of PARTNER 3 and Evolut low risk trials","volume":"10","author":"Braghiroli","year":"2020","journal-title":"Cardiovasc. 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