{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:08:49Z","timestamp":1792080529198,"version":"4.4.0"},"reference-count":35,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T00:00:00Z","timestamp":1635292800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: The purpose of this prospective study was to evaluate the efficacy and safety of the Ultrasound Cyclo Plasty (UCP) procedure using high-intensity focused ultrasound in surgery-na\u00efve open-angle glaucoma patients. Methods: prospective, non-randomized, single-arm, multicenter clinical trial. Sixty-six eyes with primary open-angle glaucoma, intraocular pressure (IOP) \u226521 mmHg and with no history of filtering surgery were enrolled. Patients were treated by UCP with a therapy probe comprising six piezoelectric transducers, consecutively activated for 8 s each. Complete ophthalmic examination was performed before the procedure, 1 day after the procedure, and 1, 3, 6, 12, 18 and 24 months after the procedure. Primary outcomes were complete success (defined as IOP lowering from baseline \u226520% without additional glaucoma medications) and vision-threatening complications. Secondary outcomes were the presence of complications and the reduction of the number of medications used. Results: IOP was significantly reduced after one procedure (p &lt; 0.05), from a mean pre-operative value of 24.3 \u00b1 2.9 mmHg (n = 2.3 hypotensive medications) to a mean value of 15.9 \u00b1 3.6 mmHg (n = 2.2 hypotensive medications) at 2 years (mean IOP lowering of 33%). Surgical success was achieved in 74% of eyes. Notwithstanding side effects such as transient anterior chamber inflammation, refractive error changes, transient hypotony and macular edema, no major intra or post-operative complications such as phthisis, induced cataract, neovascularization or significant vision loss were observed. Conclusions: Ultrasound Cyclo Plasty is a valuable, effective and well-tolerated procedure to lower IOP in patients with open-angle glaucoma without previous filtering surgery.<\/jats:p>","DOI":"10.3390\/jcm10214982","type":"journal-article","created":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T23:24:42Z","timestamp":1635377082000},"page":"4982","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Ultrasound Cyclo Plasty for Treatment of Surgery-Na\u00efve Open-Angle Glaucoma Patients: A Prospective, Multicenter, 2-Year Follow-Up Trial"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2243-9033","authenticated-orcid":false,"given":"Michele","family":"Figus","sequence":"first","affiliation":[{"name":"Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0222-5177","authenticated-orcid":false,"given":"Chiara","family":"Posarelli","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Nardi","sequence":"additional","affiliation":[{"name":"Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, 56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Stalmans","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of UZ Leuven, 3001 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Vandewalle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of UZ Leuven, 3001 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Melamed","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Skaat","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-1659","authenticated-orcid":false,"given":"Ari","family":"Leshno","sequence":"additional","affiliation":[{"name":"The Sam Rothberg Glaucoma Center, Goldschleger Eye Institute, Sheba Medical Center, Tel-Aviv University, Tel-Hashomer 52621, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Cordeiro","family":"Sousa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Santa Maria Hospital, University of Lisbon, 1649-028 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Abeg\u00e3o","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Santa Maria Hospital, University of Lisbon, 1649-028 Lisbon, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,27]]},"reference":[{"key":"ref_1","first-page":"189","article-title":"Cryosurgery for the treatment of glaucoma","volume":"63","year":"1965","journal-title":"Trans. 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