{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:17:53Z","timestamp":1777414673343,"version":"3.51.4"},"reference-count":23,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Purpose: The aim of this study is too correlate the sensitivity and thickness values of intraretinal layers at macula in healthy eyes and primary open-angle glaucoma (POAG) eyes. Methods: The thickness of different intraretinal segmentations was estimated by means of optical coherence tomography (OCT) Spectralis (Heidelberg, Engineering, Inc., Heidelberg, Germany) with the posterior pole analysis program 8 \u00d7 8 in 91 eyes from 91 patients (60 with glaucoma and 31 healthy patients). Macular sensitivity was also measured with an MP-1 microperimeter (Nidek Instruments, Inc Padova, Italy) with a customized, 36-stimulus pattern adjusted to an anatomical correspondence with the OCT grid. Correlations were calculated by using Spearman\u2019s rho and the results were represented in color maps. Results: Significant structure\u2013function correlations were much more frequent in the glaucoma group than in control group. In general terms, associations were positive for inner retinal layers but negative correlations were also found for the inner nuclear layer and outer retinal layer in glaucoma. Conclusions: In general terms, significant structure\u2013function correlations for different intraretinal layers are higher and wider in POAG eyes than in healthy eyes. Inner and outer retinal layers behave differently in terms of the structure\u2013function relationship in POAG as assessed by microperimetry and OCT.<\/jats:p>","DOI":"10.3390\/jcm10215009","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T23:51:36Z","timestamp":1635465096000},"page":"5009","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Macular Structure\u2013Function Relationships of All Retinal Layers in Primary Open-Angle Glaucoma Assessed by Microperimetry and 8 \u00d7 8 Posterior Pole Analysis of OCT"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6245-7271","authenticated-orcid":false,"given":"Jose Javier","family":"Garcia-Medina","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain"},{"name":"Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain"},{"name":"Department of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, Spain"},{"name":"Ophthalmic Research Unit Santiago Grisolia, 46017 Valencia, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Patolog\u00eda Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurilia","family":"Rotolo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Reina Sofia, 30003 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rubio-Velazquez","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, General University Hospital Morales Meseguer, 30007 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0118-7837","authenticated-orcid":false,"given":"Maria Dolores","family":"Pinazo-Duran","sequence":"additional","affiliation":[{"name":"Ophthalmic Research Unit Santiago Grisolia, 46017 Valencia, Spain"},{"name":"Red Tem\u00e1tica de Investigaci\u00f3n Cooperativa en Patolog\u00eda Ocular (OFTARED), Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Department of Ophthalmology, University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"del-Rio-Vellosillo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The Pathophysiology and Treatment of Glaucoma","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.oftal.2018.01.010","article-title":"Mapeo de los cambios de grosor en el glaucoma de las capas retinianas maculares segmentadas usando el programa de polo posterior de la tomograf\u00eda de coherencia \u00f3ptica de dominio espectral","volume":"93","year":"2018","journal-title":"Archivos de la Sociedad Espa\u00f1ola de Oftalmolog\u00eda"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Garcia-Medina, J.J., Del-Rio-Vellosillo, M., Palazon-Cabanes, A., Pinazo-Duran, M.D., Zanon-Moreno, V., and Villegas-Perez, M.P. 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