{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:28:27Z","timestamp":1760236107281,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Servier Polska","award":["No grant number."],"award-info":[{"award-number":["No grant number."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Sarcopenia is common in metastatic colorectal cancer (mCRC), increases the risk of treatment-related toxicity and reduces survival. Trifluridine\/tipiracil (TT) chemotherapy significantly improved survival in refractory mCRC patients, but the prognostic and predictive role of pretherapeutic sarcopenia and variation in the skeletal muscle index (SMI) during this treatment has not been investigated so far. In this retrospective, observational study, clinical data on mCRC patients treated with TT at six cancer centres in Poland were collected. Computed tomography (CT) scans acquired at the time of initiation of TT (CT1) and on the first restaging (CT2), were evaluated. SMI was assessed based on the skeletal muscle area (SMA) at the level of the third lumbar vertebra. Progression-free survival (PFS) and overall survival (OS) were calculated from the treatment start. Neither initial sarcopenia nor \u22655% skeletal mass loss (SML) between CT1 and CT2 had a significant effect on PFS in treated patients (p = 0.5526 and p = 0.1092, respectively). In the multivariate analysis, reduced OS was found in patients with \u22655% SML (HR: 2.03 (1.11\u20133.72), p = 0.0039). We describe the prognostic role of sarcopenia beyond second line treatment and analyze other factors, such as performance status, tumor histological differentiation or carcinoembryonic antigen level that could predict TT treatment response.<\/jats:p>","DOI":"10.3390\/jcm10215107","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"5107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prognostic Value of Sarcopenia in Metastatic Colorectal Cancer Patients Treated with Trifluridine\/Tipiracil"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0278-1985","authenticated-orcid":false,"given":"Mateusz","family":"Malik","sequence":"first","affiliation":[{"name":"Lower Silesian Oncology Centre, Clinical Oncology Department, Plac Ludwika Hirszfelda 12, 53-413 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"Michalak","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medicine, University of Warmia and Mazury in Olsztyn, Aleja Warszawska 30, 11-082 Olsztyn, Poland"},{"name":"Diagnostic Imaging Department, MSWiA Hospital, Warmia and Mazury Oncology Centre, Aleja Wojska Polskiego 37, 10-228 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7979-7523","authenticated-orcid":false,"given":"Barbara","family":"Radecka","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052 Opole, Poland"},{"name":"Tadeusz Koszarowski Cancer Center in Opole, Department of Clinical Oncology, Katowicka 66a, 45-061 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Ge\u0142ej","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Medical Sciences, University of Opole, Oleska 48, 45-052 Opole, Poland"},{"name":"Tadeusz Koszarowski Cancer Center in Opole, Department of Clinical Oncology, Katowicka 66a, 45-061 Opole, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Jackowska","sequence":"additional","affiliation":[{"name":"Oncology and Immunooncology Clinic, MSWiA Hospital, Warmia and Mazury Oncology Centre, Aleja Wojska Polskiego 37, 10-228 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Filipczyk-Cisar\u017c","sequence":"additional","affiliation":[{"name":"Lower Silesian Oncology Centre, Clinical Oncology Department, Plac Ludwika Hirszfelda 12, 53-413 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Hetman","sequence":"additional","affiliation":[{"name":"West Pomeranian Oncology Center in Szczecin, Department of Clinical Oncology, Strzalowska 22, 71-730 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Foszczy\u0144ska-K\u0142oda","sequence":"additional","affiliation":[{"name":"West Pomeranian Oncology Center in Szczecin, Department of Clinical Oncology, Strzalowska 22, 71-730 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beata","family":"Kania-Zembaczy\u0144ska","sequence":"additional","affiliation":[{"name":"Beskid Oncology Centre in Bielsko-Biala, Department of Oncology and Oncohematology, Wyzwolenia 18, 43-300 Bielsko-Biala, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danuta","family":"Ma\u0144ka","sequence":"additional","affiliation":[{"name":"Beskid Oncology Centre in Bielsko-Biala, Department of Oncology and Oncohematology, Wyzwolenia 18, 43-300 Bielsko-Biala, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlena","family":"Orlikowska","sequence":"additional","affiliation":[{"name":"Kociewie Health Centre, Oncology Department, Doktora Jozefa Balewskiego 1, 83-200 Starogard Gdanski, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna","family":"Rogowska-Dro\u015b","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department, MSWiA Hospital, Warmia and Mazury Oncology Centre, Aleja Wojska Polskiego 37, 10-228 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-8778","authenticated-orcid":false,"given":"Lubomir","family":"Bodnar","sequence":"additional","affiliation":[{"name":"Oncology and Immunooncology Clinic, MSWiA Hospital, Warmia and Mazury Oncology Centre, Aleja Wojska Polskiego 37, 10-228 Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.21037\/atm.2019.07.91","article-title":"Concise Update on Colorectal Cancer Epidemiology","volume":"7","author":"Mattiuzzi","year":"2019","journal-title":"Ann. 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