{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:44:58Z","timestamp":1790675098200,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,10,30]],"date-time":"2021-10-30T00:00:00Z","timestamp":1635552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is an autoimmune disease, associated with a high risk of lymphoma. Mounting evidence suggests that cardiovascular morbidity and mortality are higher in patients with pSS, although data are heterogeneous. The aim of this study was to assess whether pSS patients are at higher risk of hospitalisation for cardiovascular events (CVEs), venous thromboembolic events (VTEs), pulmonary hypertension (PH), and sleep apnoea syndrome (SAS). Through a nationwide population-based retrospective study using the French health insurance database, we selected new-onset pSS in-patients hospitalised between 2011 and 2018. We compared the incidence of CVEs (ischemic heart diseases (IHDs), strokes, and heart failure), SAS, VTEs, and PH with an age- and sex-matched (1:10) hospitalised control group. The calculations of adjusted hazard ratios (aHR) included available confounding factors. We studied 25,661 patients hospitalised for pSS compared with 252,543 matched patients. The incidence of hospitalisation for IHD, SAS, and PH was significantly higher in pSS patients (aHR: 1.20 (1.06\u20131.34); p = 0.003, aHR: 1.97 (1.70\u20132.28); p &lt; 0.001, and aHR: 3.32 (2.10\u20135.25); p &lt; 0.001, respectively), whereas the incidence of stroke, heart failure, and VTE was the same between groups. Further prospective studies are needed to confirm these results and to explore the pathophysiological mechanisms involved.<\/jats:p>","DOI":"10.3390\/jcm10215115","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T22:21:34Z","timestamp":1635805294000},"page":"5115","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiovascular Events, Sleep Apnoea, and Pulmonary Hypertension in Primary Sj\u00f6gren\u2019s Syndrome: Data from the French Health Insurance Database"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-4097","authenticated-orcid":false,"given":"Radjiv","family":"Goulabchand","sequence":"first","affiliation":[{"name":"Internal Medicine Department, CHU N\u00eemes, University Montpellier, 30029 N\u00eemes, France"},{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Inserm U1183, Institute for Regenerative Medicine and Biotherapy, St Eloi Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5268-1704","authenticated-orcid":false,"given":"Camille","family":"Roubille","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Department of Internal Medicine, Lapeyronie Hospital, Montpellier University Hospital, 34295 Montpellier, France"},{"name":"PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9358-6922","authenticated-orcid":false,"given":"David","family":"Montani","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et Soins Intensifs Respiratoires, INSERM UMR_S 999, H\u00f4pital Bic\u00eatre, Universit\u00e9 Paris-Saclay, 94270 Le Kremlin-Bic\u00eatre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7831-6545","authenticated-orcid":false,"given":"Pierre","family":"Fesler","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Department of Internal Medicine, Lapeyronie Hospital, Montpellier University Hospital, 34295 Montpellier, France"},{"name":"PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bourdin","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier, France"},{"name":"Department of Respiratory Diseases, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Malafaye","sequence":"additional","affiliation":[{"name":"Department of Medical Information, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7545-6385","authenticated-orcid":false,"given":"Jacques","family":"Morel","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214, 34295 Montpellier, France"},{"name":"Department of Rheumatology, Montpellier University Hospital, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Arnaud","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, CHU N\u00eemes, University Montpellier, 30029 N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-500X","authenticated-orcid":false,"given":"Benoit","family":"Lattuca","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Cardiology Department, CHU N\u00eemes, University Montpellier, 30029 N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-5127","authenticated-orcid":false,"given":"Lucie","family":"Barateau","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Sleep-Wake Disorders Unit, Department of Neurology, Gui-de-Chauliac Hospital, CHU Montpellier, 34295 Montpellier, France"},{"name":"National Reference Network for Narcolepsy, CHU Montpellier, 34295 Montpellier, France"},{"name":"Institute for Neurosciences of Montpellier INM, University Montpellier, INSERM, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-2561","authenticated-orcid":false,"given":"Philippe","family":"Guilpain","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Inserm U1183, Institute for Regenerative Medicine and Biotherapy, St Eloi Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier, France"},{"name":"Local Referral Center for Systemic and Autoimmune Diseases, Department of Internal Medicine and Multi-Organic Diseases, St Eloi Hospital, 80 Avenue Augustin Fliche, 34295 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Mura","sequence":"additional","affiliation":[{"name":"Montpellier School of Medicine, University of Montpellier, 34000 Montpellier, France"},{"name":"Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, CHU N\u00eemes, University Montpellier, 30029 N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0025-6196(11)62408-7","article-title":"Incidence of Physician-Diagnosed Primary Sj\u00f6gren Syndrome in Residents of Olmsted County, Minnesota","volume":"76","author":"Pillemer","year":"2001","journal-title":"Mayo Clin. 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