{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:05:41Z","timestamp":1779314741265,"version":"3.51.4"},"reference-count":24,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Closed incision negative pressure therapy (ciNPT) may reduce the rate of wound complications and promote healing of the incisional site. We report our experience with this dressing in breast reconstruction patients with abdominal free flap donor sites. Methods: A retrospective cohort study was conducted of all patients who underwent breast reconstruction using abdominal free flaps (DIEP, MS-TRAM) at a single institution (Royal Melbourne Hospital, Victoria) between 2016 and 2021. Results: 126 female patients (mean age: 50 \u00b1 10 years) were analysed, with 41 and 85 patients in the ciNPT (Prevena) and non-ciNPT (Comfeel) groups, respectively. There were reduced wound complications in almost all outcomes measured in the ciNPT group compared with the non-ciNPT group; however, none reached statistical significance. The ciNPT group demonstrated a lower prevalence of surgical site infections (9.8% vs. 11.8%), wound dehiscence (4.9% vs. 12.9%), wound necrosis (0% vs. 2.4%), and major complication requiring readmission (2.4% vs. 7.1%). Conclusion: The use of ciNPT for abdominal donor sites in breast reconstruction patients with risk factors for poor wound healing may reduce wound complications compared with standard adhesive dressings; however, large scale, randomised controlled trials are needed to confirm these observations. Investigation of the impact of ciNPT patients in comparison with conventional dressings, in cohorts with equivocal risk profiles, remains a focus for future research.<\/jats:p>","DOI":"10.3390\/jcm10215176","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T10:33:09Z","timestamp":1636108389000},"page":"5176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Use of Closed Incision Negative Pressure Therapy (ciNPT) in Breast Reconstruction Abdominal Free Flap Donor Sites"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1241-1371","authenticated-orcid":false,"given":"Jennifer","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zyg","family":"Chapman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC 3053, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Cole","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Koide","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldon","family":"Mah","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Overstall","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dean","family":"Trotter","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Royal Melbourne Hospital, Melbourne, VIC 3050, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/codi.14350","article-title":"Prophylactic closed-incision negative-pressure wound therapy is associated with decreased surgical site infection in high-risk colorectal surgery laparotomy wounds","volume":"21","author":"Curran","year":"2019","journal-title":"Colorectal Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/SAP.0b013e31824c9073","article-title":"Incisional Negative-Pressure Wound Therapy versus Conventional Dressings Following Abdominal Wall Reconstruction: A Comparative Study","volume":"71","author":"Chung","year":"2013","journal-title":"Ann. Plast. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00000637-199706000-00001","article-title":"Vacuum-Assisted Closure: A New Method for Wound Control and Treatment","volume":"38","author":"Morykwas","year":"1997","journal-title":"Ann. Plast. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1272\/jnms.78.68","article-title":"Clinical Applications of Basic Research that Shows Reducing Skin Tension Could Prevent and Treat Abnormal Scarring: The Importance of Fascial\/Subcutaneous Tensile Reduction Sutures and Flap Surgery for Keloid and Hypertrophic Scar Reconstruction","volume":"78","author":"Ogawa","year":"2011","journal-title":"J. Nippon. Med. Sch."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/SLA.0000000000003644","article-title":"Meta-analysis, Meta-regression, and GRADE Assessment of Randomized and Nonrandomized Studies of Incisional Negative Pressure Wound Therapy Versus Control Dressings for the Prevention of Postoperative Wound Complications","volume":"272","author":"Zwanenburg","year":"2020","journal-title":"Ann. Surg."},{"key":"ref_6","first-page":"CD009261","article-title":"Negative pressure wound therapy for surgical wounds healing by primary closure","volume":"6","author":"Norman","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00266-014-0333-3","article-title":"Meta-analysis of the Safety and Factors Contributing to Complications of MS-TRAM, DIEP, and SIEA Flaps for Breast Reconstruction","volume":"38","author":"Wang","year":"2014","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/PRS.0000000000004016","article-title":"Complications and Patient-Reported Outcomes after Abdominally Based Breast Reconstruction: Results of the Mastectomy Reconstruction Outcomes Consortium Study","volume":"141","author":"Wilkins","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/SLA.0000000000004310","article-title":"Prophylactic single-use negative pressure dressing in closed surgical wounds after incisional hernia repair: A randomized, controlled trial","volume":"273","author":"Bonafe","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jss.2019.03.033","article-title":"Closed-incision negative-pressure therapy efficacy in abdominal wall reconstruction in high-risk patients: A meta-analysis","volume":"241","author":"Tran","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.amjsurg.2012.10.004","article-title":"Negative pressure wound therapy in the prevention of wound infection in high risk abdominal wound closures","volume":"204","author":"Vargo","year":"2012","journal-title":"Am. J. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/PRS.0000000000001519","article-title":"Closed Incision Negative-Pressure Therapy Is Associated with Decreased Surgical-Site Infections: A Meta-Analysis","volume":"136","author":"Semsarzadeh","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00266-018-1301-0","article-title":"Continuous Negative Pressure Drain is associated with Better Outcome: A Randomized Prospective Trial in Plastic Surgery Patients","volume":"43","author":"Yu","year":"2019","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10353-020-00657-w","article-title":"Closed-incision negative-pressure wound management in surgery\u2014literature review and recommendations","volume":"52","author":"Smolle","year":"2020","journal-title":"Eur. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtv.2018.08.005","article-title":"The effect of postoperative closed incision negative pressure therapy on the incidence of donor site wound dehiscence in breast reconstruction patients: DEhiscence PREvention Study (DEPRES), pilot randomized controlled trial","volume":"27","author":"Hummelink","year":"2018","journal-title":"J. Tissue Viability"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/iwj.13273","article-title":"Closed incision negative pressure therapy following abdominoplasty after breast reconstruction with deep inferior epigastric perforator flaps","volume":"17","author":"Fang","year":"2019","journal-title":"Int. Wound J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00266-018-1095-0","article-title":"Randomized Controlled Study Comparing Disposable Negative-Pressure Wound Therapy with Standard Care in Bilateral Breast Reduction Mammoplasty Evaluating Surgical Site Complications and Scar Quality","volume":"42","author":"Tanaydin","year":"2018","journal-title":"Aesthetic Plast. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e1880","DOI":"10.1097\/GOX.0000000000001880","article-title":"The Impact of Closed Incision Negative Pressure Therapy on Postoperative Breast Reconstruction Outcomes","volume":"6","author":"Gabriel","year":"2018","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.bjps.2020.12.043","article-title":"Impact of body mass index on free DIEP flap breast reconstruction: A multicenter cohort study","volume":"74","author":"Heidekrueger","year":"2021","journal-title":"J. Plast. Reconstr. Aesthetic Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1461","DOI":"10.1097\/GOX.0000000000001461","article-title":"Defining the Association between Diabetes and Plastic Surgery Outcomes: An Analysis of Nearly 40,000 Patients","volume":"5","author":"Goltsman","year":"2017","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e1588","DOI":"10.1097\/GOX.0000000000001588","article-title":"Examining Length of Hospital Stay after Microsurgical Breast Reconstruction: Evaluation in a Case-Control Study","volume":"5","author":"Frey","year":"2017","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.2337\/dc10-0304","article-title":"Prevalence and clinical outcome of hyperglycemia in the perioperative period in noncardiac surgery","volume":"33","author":"Frisch","year":"2010","journal-title":"Diabetes Care"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jamcollsurg.2013.03.031","article-title":"Impact of obesity on outcomes in breast reconstruction: Analysis of 15,93& patients from the ACS-NSQIP datasets","volume":"217","author":"Fischer","year":"2013","journal-title":"J. Am. Coll. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.2105\/AJPH.94.9.1587","article-title":"Length of Hospital Stays among Obese Individuals","volume":"94","author":"Zizza","year":"2004","journal-title":"Am. J. 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