{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:50:55Z","timestamp":1762098655298,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,6]],"date-time":"2021-11-06T00:00:00Z","timestamp":1636156800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["NMRC\/CSA\/024\/2010","NMRC\/CSA\/0049\/2013"],"award-info":[{"award-number":["NMRC\/CSA\/024\/2010","NMRC\/CSA\/0049\/2013"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001350","name":"Ministry of Health","doi-asserted-by":"publisher","award":["HSRG\/0021\/2012"],"award-info":[{"award-number":["HSRG\/0021\/2012"]}],"id":[{"id":"10.13039\/501100001350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We evaluated the association between early coronary angiography (CAG) and outcomes in resuscitated out-of-hospital cardiac arrest (OHCA) patients, by linking data from the Singapore Pan-Asian Resuscitation Outcomes Study, with a national registry of cardiac procedures. The 30-day survival and neurological outcome were compared between patients undergoing early CAG (within 1-calender day), versus patients not undergoing early CAG. Inverse probability weighted estimates (IPWE) adjusted for non-randomized CAG. Of 976 resuscitated OHCA patients of cardiac etiology between 2011\u20132015 (mean(SD) age 64(13) years, 73.7% males), 337 (34.5%) underwent early CAG, of whom, 230 (68.2%) underwent PCI. Those who underwent early CAG were significantly younger (60(12) vs. 66(14) years old), healthier (42% vs. 59% with heart disease; 29% vs. 44% with diabetes), more likely males (86% vs. 67%), and presented with shockable rhythms (69% vs. 36%), compared with those who did not. Early CAG with PCI was associated with better survival and neurological outcome (adjusted odds ratio 1.91 and 1.82 respectively), findings robust to IPWE adjustment. The rates of bleeding and stroke were similar. CAG with PCI within 24 h was associated with improved clinical outcomes after OHCA, without increasing complications. Further studies are required to identify the characteristics of patients who would benefit most from this invasive strategy.<\/jats:p>","DOI":"10.3390\/jcm10215191","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:41:14Z","timestamp":1636317674000},"page":"5191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early Coronary Angiography Is Associated with Improved 30-Day Outcomes among Patients with Out-of-Hospital Cardiac Arrest"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1151-2357","authenticated-orcid":false,"given":"Shir Lynn","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-9814","authenticated-orcid":false,"given":"Yee How","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre, Singapore 169609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark Y.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terrance","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre, Singapore 169609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huay Cheem","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National University Heart Centre, Singapore 119228, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Foo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tan Tock Seng Hospital, Singapore 308433, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhan Yun","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boon Wah","family":"Liew","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-5273","authenticated-orcid":false,"given":"Nur","family":"Shahidah","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Singapore General Hospital, Singapore 168753, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7615-4792","authenticated-orcid":false,"given":"Desmond R.","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Acute & Emergency Care, Khoo Teck Puat Hospital, Singapore 768828, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Oon","family":"Cheah","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department, Ng Teng Fong General Hospital, Singapore 609606, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6952-7439","authenticated-orcid":false,"given":"Michael Y. C.","family":"Chia","sequence":"additional","affiliation":[{"name":"Emergency Department, Tan Tock Seng Hospital, Singapore 308433, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Nee","family":"Gan","sequence":"additional","affiliation":[{"name":"Accident & Emergency, Changi General Hospital, Singapore 529889, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1403-8993","authenticated-orcid":false,"given":"Benjamin S. H.","family":"Leong","sequence":"additional","affiliation":[{"name":"Emergency Medicine Department, National University Hospital, Singapore 119074, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yih Yng","family":"Ng","sequence":"additional","affiliation":[{"name":"Emergency Department, Tan Tock Seng Hospital, Singapore 308433, Singapore"},{"name":"Ministry of Home Affairs, Singapore 329560, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khung Keong","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Heart Centre, Singapore 169609, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7874-7612","authenticated-orcid":false,"given":"Marcus E. H.","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Singapore General Hospital, Singapore 168753, Singapore"},{"name":"Health Services and Systems Research, Duke-NUS Medical School, Singapore 169857, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1016\/j.resuscitation.2010.08.006","article-title":"Global incidences of out-of-hospital cardiac arrest and survival rates: Systematic review of 67 prospective studies","volume":"81","author":"Berdowski","year":"2010","journal-title":"Resuscitation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e139","DOI":"10.1161\/CIR.0000000000000757","article-title":"Heart Disease and Stroke Statistics-2020 Update: A Report from the American Heart Association","volume":"141","author":"Virani","year":"2020","journal-title":"Circulation"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.resuscitation.2018.02.029","article-title":"Regional variation in the characteristics, incidence and outcomes of out-of-hospital cardiac arrest in Australia and New Zealand: Results from the Aus-ROC Epistry","volume":"126","author":"Beck","year":"2018","journal-title":"Resuscitation"},{"key":"ref_4","first-page":"188","article-title":"EuReCa ONE-27 Nations, ONE Europe, ONE Registry: A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe","volume":"105","author":"Lefering","year":"2016","journal-title":"Resuscitation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/CIRCINTERVENTIONS.109.913665","article-title":"Immediate percutaneous coronary intervention is associated with better survival after out-of-hospital cardiac arrest: Insights from the PROCAT (Parisian Region Out of hospital Cardiac ArresT) registry","volume":"3","author":"Dumas","year":"2010","journal-title":"Circ. 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Open"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/21\/5191\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:26:52Z","timestamp":1760167612000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/10\/21\/5191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,6]]},"references-count":33,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["jcm10215191"],"URL":"https:\/\/doi.org\/10.3390\/jcm10215191","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2021,11,6]]}}}