{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:16:21Z","timestamp":1785784581354,"version":"3.56.0"},"reference-count":68,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease that has been associated with a greater risk of metabolic and cardiovascular comorbidities. The aim of this study is to assess cardiovascular risk by means of intima-media thickness (IMT), metabolic syndrome, and other potential biomarkers in patients with severe hidradenitis suppurativa who are candidates for biologic therapy and to explore potentially associated factors. A cross-sectional study was performed. Body mass index (BMI), carotid intima-media thickness (IMT), and blood tests, including glycemic and lipid profile, insulin, vitamin D, and inflammation markers were performed. Fifty patients were included in the study; the male\/female ratio was 3:2. The mean age was 38 years, and the mean disease duration was 21.8 years. The mean carotid IMT was 651.39 \u03bcm. A positive association of IMT with disease duration, tobacco consumption, and HbA1c levels was observed. HbA1c correlated with the age of onset, hypertension, metabolic syndrome, and glucose levels. Vitamin D levels inversely correlated with the number of areas affected. In conclusion, patients with severe HS present a higher cardiovascular risk, but it is not distributed equally within the patients: Tobacco consumption, inadequate glycemic control, and disease duration could be useful clinical and biochemical markers to identify patients at higher risk.<\/jats:p>","DOI":"10.3390\/jcm10225222","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T12:46:23Z","timestamp":1636461983000},"page":"5222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cumulative Inflammation and HbA1c Levels Correlate with Increased Intima-Media Thickness in Patients with Severe Hidradenitis Suppurativa"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3626-1558","authenticated-orcid":false,"given":"Manuel","family":"S\u00e1nchez-D\u00edaz","sequence":"first","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-0259","authenticated-orcid":false,"given":"Luis","family":"Salvador-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4035-7955","authenticated-orcid":false,"given":"Trinidad","family":"Montero-V\u00edlchez","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"},{"name":"Dermatology Department, School of Medicine, University of Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-2113","authenticated-orcid":false,"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[{"name":"Dermatology Unit, Hospital Universitario Virgen de las Nieves, IBS Granada, 18002 Granada, Spain"},{"name":"Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, 18002 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1056\/NEJMoa1406656","article-title":"Demographic and Epidemiologic Drivers of Global Cardiovascular Mortality","volume":"372","author":"Roth","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1161\/CIRCRESAHA.111.246876","article-title":"The Intersection between Aging and Cardiovascular Disease","volume":"110","author":"North","year":"2012","journal-title":"Circ. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.metabol.2018.10.011","article-title":"Obesity and cardiovascular disease: Revisiting an old relationship","volume":"92","author":"Koliaki","year":"2019","journal-title":"Metabolism"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.2174\/0929867324666170428103206","article-title":"Diet and Cardiovascular Disease: Effects of Foods and Nutrients in Classical and Emerging Cardiovascular Risk Factors","volume":"26","author":"Badimon","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3547","DOI":"10.1093\/eurheartj\/ehz564","article-title":"Mortality reduction with physical activity in patients with and without cardiovascular disease","volume":"40","author":"Jeong","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.7326\/0003-4819-141-6-200409210-00007","article-title":"Meta-Analysis: Glycosylated Hemoglobin and Cardiovascular Disease in Diabetes Mellitus","volume":"141","author":"Selvin","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/j.cjca.2017.07.015","article-title":"Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies","volume":"33","author":"Gao","year":"2017","journal-title":"Can. J. Cardiol."},{"key":"ref_8","first-page":"977","article-title":"Vitamin D in Cardiovascular Disease","volume":"32","author":"Nitsa","year":"2018","journal-title":"Circ. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.carpath.2006.04.006","article-title":"C-reactive protein: A nontraditional serum marker of cardiovascular risk","volume":"16","author":"Rifai","year":"2007","journal-title":"Cardiovasc. Pathol. Off. J. Soc. Cardiovasc. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Frosteg\u00e5rd, J. (2013). Immunity, atherosclerosis and cardiovascular disease. BMC Med., 11.","DOI":"10.1186\/1741-7015-11-117"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11883-014-0435-z","article-title":"Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target","volume":"16","author":"Golia","year":"2014","journal-title":"Curr. Atheroscler. Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clindermatol.2017.09.007","article-title":"Hidradenitis suppurativa and the metabolic syndrome","volume":"36","author":"Ergun","year":"2018","journal-title":"Clin. Dermatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaad.2017.08.042","article-title":"Hidradenitis suppurativa and diabetes mellitus: A systematic review and meta-analysis","volume":"78","author":"Bui","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1111\/ced.13922","article-title":"Hidradenitis suppurativa and diabetes mellitus: Updated systematic review and adjusted meta-analysis","volume":"44","author":"Phan","year":"2019","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11886-019-1107-y","article-title":"Epidemiology of Diabetes Mellitus and Cardiovascular Disease","volume":"21","author":"Glovaci","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/ijd.14691","article-title":"Dietary and metabolic factors in the pathogenesis of hidradenitis suppurativa: A systematic review","volume":"59","author":"Choi","year":"2019","journal-title":"Int. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jdermsci.2020.05.004","article-title":"Altered keratinization and vitamin D metabolism may be key pathogenetic pathways in syndromic hidradenitis suppurativa: A novel whole exome sequencing approach","volume":"99","author":"Brandao","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1017\/S0007114520001890","article-title":"Vitamin D3 reduces risk of cardiovascular and liver diseases by lowering homocysteine levels: Double-blinded, randomised, placebo-controlled trial","volume":"125","author":"Hailat","year":"2021","journal-title":"Br. J. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Zittermann, A., Trummer, C., Theiler-Schwetz, V., Lerchbaum, E., M\u00e4rz, W., and Pilz, S. (2021). Vitamin D and Cardiovascular Disease: An Updated Narrative Review. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22062896"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1684\/ejd.2013.2241","article-title":"Vitamin D insufficiency is associated with higher carotid intima-media thickness in psoriatic patients","volume":"24","year":"2014","journal-title":"Eur. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/1570161118666191227101636","article-title":"Cardiovascular Disease in Systemic Lupus Erythematosus: Recent data on epidemiology, risk factors and prevention","volume":"18","author":"Kostopoulou","year":"2020","journal-title":"Curr. Vasc. Pharmacol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1016\/j.jacc.2020.10.027","article-title":"Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease","volume":"76","author":"Glassner","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"k1036","DOI":"10.1136\/bmj.k1036","article-title":"Increased cardiovascular risk in rheumatoid arthritis: Mechanisms and implications","volume":"361","author":"England","year":"2018","journal-title":"BMJ"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s12325-020-01346-6","article-title":"Psoriasis and Cardiovascular Risk: A Comprehensive Review","volume":"37","author":"Masson","year":"2020","journal-title":"Adv. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1111\/jdv.14841","article-title":"Studying the effect of systemic and biological drugs on intima-media thickness in patients suffering from moderate and severe psoriasis","volume":"32","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1684\/ejd.2012.1714","article-title":"Atheroma plaque, metabolic syndrome and inflammation in patients with psoriasis","volume":"22","author":"Ruiz","year":"2012","journal-title":"Eur. J. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/bjd.14024","article-title":"Cardiovascular disease risk factors in patients with hidradenitis suppurativa: A systematic review and meta-analysis of observational studies","volume":"173","author":"Tzellos","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/1346-8138.15038","article-title":"Increased risk of cardiovascular comorbidities in hidradenitis suppurativa: A nationwide, population-based, cohort study in Taiwan","volume":"46","author":"Hung","year":"2019","journal-title":"J. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Emtestam","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1111\/bjd.15748","article-title":"Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS 4), a novel dynamic scoring system to assess HS severity","volume":"177","author":"Zouboulis","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/bjd.17588","article-title":"Inter- and intrarater reliability of Hurley staging for hidradenitis suppurativa","volume":"181","author":"Ovadja","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000431175","article-title":"Hidradenitis Suppurativa\/Acne Inversa: Criteria for Diagnosis, Severity Assessment, Classification and Disease Evaluation","volume":"231","author":"Zouboulis","year":"2015","journal-title":"Dermatology"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1464-5491.2004.01115.x","article-title":"WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes","volume":"21","author":"Marchesini","year":"2004","journal-title":"Diabet. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","article-title":"Carotid Intima-Media Thickness and Plaque in Cardiovascular Risk Assessment","volume":"7","author":"Naqvi","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1093\/ehjci\/jex239","article-title":"Carotid plaque thickness and carotid plaque burden predict future cardiovascular events in asymptomatic adult Americans","volume":"19","author":"Sillesen","year":"2018","journal-title":"Eur. Heart J. Cardiovasc. Imaging"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1016\/j.cjca.2014.06.026","article-title":"Common carotid intima-media thickness as a risk factor for outcomes in Asian patients with acute ST-elevation myocardial infarction","volume":"30","author":"Lee","year":"2014","journal-title":"Can. J. Cardiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s42358-019-0060-1","article-title":"Methotrexate use, not interleukin 33, is associated with lower carotid intima-media thickness in patients with rheumatoid arthritis","volume":"59","author":"Pinto","year":"2019","journal-title":"Adv. Rheumatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2174\/1573397116666191217122030","article-title":"Investigation of the Association Between Carotid Artery Intima-Media Thickness (IMT) and Cardiac Risk Factors in Patients with Systemic Lupus Erythematosus","volume":"16","author":"Rezaieyazdi","year":"2020","journal-title":"Curr. Rheumatol. Rev."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1365-2036.2005.02657.x","article-title":"Increased carotid intima-media thickness in patients with inflammatory bowel disease","volume":"22","author":"Papa","year":"2005","journal-title":"Aliment. Pharmacol. Ther."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/CIRCOUTCOMES.109.857771","article-title":"Arterial intima-media thickness, endothelial function, and apolipoproteins in adolescents frequently exposed to tobacco smoke","volume":"3","author":"Kallio","year":"2010","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3233\/CH-180486","article-title":"Correlations of carotid intima-media thickness with endothelial function and atherosclerosis degree in patients with type 2 diabetes mellitus","volume":"72","author":"Wang","year":"2019","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/rheumatology\/keu376","article-title":"Inflammatory burden interacts with conventional cardiovascular risk factors for carotid plaque formation in rheumatoid arthritis","volume":"54","author":"Im","year":"2014","journal-title":"Rheumatology"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"404","DOI":"10.5507\/bp.2013.054","article-title":"Intima media thickness measurement as a marker of subclinical atherosclerosis in SLE patient","volume":"158","author":"Smrzova","year":"2014","journal-title":"Biomed. Pap."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaad.2016.03.025","article-title":"Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa (HS)","volume":"75","author":"Lacalle","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/RUQ.0000000000000243","article-title":"Carotid Intima-Media Thickness Manual Measurements: Intraoperator and Interoperator Agreements under A Strict Protocol in a Large Sample","volume":"33","year":"2017","journal-title":"Ultrasound Q."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0300-8932(10)70014-2","article-title":"Carotid Intima-Media Thickness in Subjects with No Cardiovascular Risk Factors","volume":"63","author":"Jarauta","year":"2010","journal-title":"Rev. Espa\u00f1ola Cardiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/jch.13812","article-title":"Association of pulse wave velocity and intima-media thickness with cardiovascular risk factors in young adults","volume":"22","author":"Cecelja","year":"2020","journal-title":"J. Clin. Hypertens."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.5603\/KP.a2019.0028","article-title":"Association between carotid-femoral pulse wave velocity and overall cardiovascular risk score assessed by the SCORE system in urban Polish population","volume":"77","author":"Podolec","year":"2019","journal-title":"Kardiol. Pol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/HYPERTENSIONAHA.118.10930","article-title":"Pulse Wave Velocity and Prognosis in End-Stage Kidney Disease","volume":"71","author":"Tripepi","year":"2018","journal-title":"Hypertension"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1161\/HYPERTENSIONAHA.117.09023","article-title":"Ambulatory Pulse Wave Velocity Is a Stronger Predictor of Cardiovascular Events and All-Cause Mortality Than Office and Ambulatory Blood Pressure in Hemodialysis Patients","volume":"70","author":"Sarafidis","year":"2017","journal-title":"Hypertension"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/MOL.0b013e3280106b95","article-title":"Glycated hemoglobin as a marker of cardiovascular risk","volume":"17","author":"Khaw","year":"2006","journal-title":"Curr. Opin. Lipidol."},{"key":"ref_52","first-page":"315","article-title":"The correlation between the Glycated hemoglobin (HbA1c) in non-diabetics and cardiovascular risk factors","volume":"29","author":"Wu","year":"2016","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/jdv.14894","article-title":"Insulin resistance in hidradenitis suppurativa: A case-control study","volume":"32","author":"Vilanova","year":"2018","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1871530315666150316124019","article-title":"Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect","volume":"15","author":"Saisho","year":"2015","journal-title":"Endocr. Metab. Immune Disord.-Drug Targets"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/09546634.2019.1592100","article-title":"Metformin use in hidradenitis suppurativa","volume":"31","author":"Jennings","year":"2020","journal-title":"J. Dermatol. Treat."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11154-017-9423-2","article-title":"Vitamin D, sub-inflammation and insulin resistance. A window on a potential role for the interaction between bone and glucose metabolism","volume":"18","author":"Garbossa","year":"2017","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ejcn.2016.177","article-title":"Aging, low-grade systemic inflammation and vitamin D: A mini-review","volume":"71","author":"Ribeiro","year":"2017","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1097\/MOG.0000000000000449","article-title":"Vitamin D in inflammatory bowel disease: More than just a supplement","volume":"34","author":"Gubatan","year":"2018","journal-title":"Curr. Opin. Gastroenterol."},{"key":"ref_59","first-page":"153","article-title":"Vitamin D and systemic lupus erythematous: A review of immunological and clinical aspects","volume":"36","author":"Cutolo","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1080\/09546634.2020.1714538","article-title":"Vitamin D deficiency and hidradenitis suppurativa: The impact on clinical severity and therapeutic responsivity","volume":"32","author":"Fabbrocini","year":"2021","journal-title":"J. Dermatol. Treat."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000505184","article-title":"Deranged Iron Status Evidenced by Iron Deficiency Characterizes Patients with Hidradenitis Suppurativa","volume":"236","author":"Ponikowska","year":"2020","journal-title":"Dermatology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1161\/CIRCRESAHA.119.316453","article-title":"Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability","volume":"127","author":"Tang","year":"2020","journal-title":"Circ. Res."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000371877","article-title":"Decreased number of circulating endothelial progenitor cells in hidradenitis suppurativa patients","volume":"230","author":"Matusiak","year":"2015","journal-title":"Dermatology"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/cvr\/cvz009","article-title":"Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: Results from a prospective observational study","volume":"115","author":"Elnabawi","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.3389\/fimmu.2018.01668","article-title":"Psoriasis, Cardiovascular Events, and Biologics: Lights and Shadows","volume":"9","author":"Caiazzo","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ijcard.2018.06.099","article-title":"Anti-TNF modulation reduces myocardial inflammation and improves cardiovascular function in systemic rheumatic diseases","volume":"270","author":"Ntusi","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/ATVBAHA.119.311998","article-title":"Anticytokine Immune Therapy and Atherothrombotic Cardiovascular Risk","volume":"39","author":"Libby","year":"2019","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s00296-020-04666-6","article-title":"The effect of anti-TNF treatment on body composition and insulin resistance in patients with rheumatoid arthritis","volume":"41","author":"Baniaamam","year":"2021","journal-title":"Rheumatol. 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