{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:25:48Z","timestamp":1792805148590,"version":"4.5.0"},"reference-count":143,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds National de la Recherche Scientifique de Belgique","award":["7.4602.18F"],"award-info":[{"award-number":["7.4602.18F"]}]},{"name":"Fonds National de la Recherche Scientifique de Belgique","award":["5\/4\/150\/5"],"award-info":[{"award-number":["5\/4\/150\/5"]}]},{"name":"Fonds National de la Recherche Scientifique de Belgique - the Excellence of Science","award":["30443682"],"award-info":[{"award-number":["30443682"]}]},{"name":"Fonds National de la Recherche Scientifique de Belgique - Projet de Recherche","award":["T.0077.14"],"award-info":[{"award-number":["T.0077.14"]}]},{"DOI":"10.13039\/501100017653","name":"Fonds Sp\u00e9ciaux de Recherche","doi-asserted-by":"publisher","award":["\/"],"award-info":[{"award-number":["\/"]}],"id":[{"id":"10.13039\/501100017653","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Agence de la Biom\u00e9decine de France","award":["\/"],"award-info":[{"award-number":["\/"]}],"id":[{"id":"https:\/\/ror.org\/03tajza86","id-type":"ROR","asserted-by":"crossref"}]},{"name":"private donations","award":["\/"],"award-info":[{"award-number":["\/"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Chemotherapy, pelvic radiotherapy and ovarian surgery have known gonadotoxic effects that can lead to endocrine dysfunction, cessation of ovarian endocrine activity and early depletion of the ovarian reserve, causing a risk for future fertility problems, even in children. Important determinants of this risk are the patient\u2019s age and ovarian reserve, type of treatment and dose. When the risk of premature ovarian insufficiency is high, fertility preservation strategies must be offered to the patient. Furthermore, fertility preservation may sometimes be needed in conditions other than cancer, such as in non-malignant diseases or in patients seeking fertility preservation for personal reasons. Oocyte and\/or embryo vitrification and ovarian tissue cryopreservation are the two methods currently endorsed by the American Society for Reproductive Medicine, yielding encouraging results in terms of pregnancy and live birth rates. The choice of one technique above the other depends mostly on the age and pubertal status of the patient, and personal and medical circumstances. This review focuses on the available fertility preservation techniques, their appropriateness according to patient age and their efficacy in terms of pregnancy and live birth rates.<\/jats:p>","DOI":"10.3390\/jcm10225247","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T23:02:41Z","timestamp":1636671761000},"page":"5247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Fertility Preservation: How to Preserve Ovarian Function in Children, Adolescents and Adults"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6331-3026","authenticated-orcid":false,"given":"Marie-Madeleine","family":"Dolmans","sequence":"first","affiliation":[{"name":"Gynecology Research Unit, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Av. Mounier 52, 1200 Brussels, Belgium"},{"name":"Department of Gynecology, Cliniques Universitaires Saint-Luc, Av. Hippocrate 10, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-127X","authenticated-orcid":false,"given":"Camille","family":"Hossay","sequence":"additional","affiliation":[{"name":"Gynecology Research Unit, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Av. Mounier 52, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-8732","authenticated-orcid":false,"given":"Thu Yen Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Gynecology Research Unit, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain, Av. Mounier 52, 1200 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Poirot","sequence":"additional","affiliation":[{"name":"Department of Hematology, AYA Unit, Saint Louis Hospital AP-HP, 1 Avenue Claude Vellefaux, 75010 Paris, France"},{"name":"M\u00e9decine Sorbonne Universit\u00e9, Site Piti\u00e9 Salp\u00eatri\u00e8re, 91 Bd de l\u2019H\u00f4pital, 75013 Paris, France"},{"name":"Department of Reproductive Biology, Cochin Hospital AP-HP, 123 Bd de Port Royal, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1056\/NEJMra1614676","article-title":"Fertility preservation in women","volume":"377","author":"Donnez","year":"2017","journal-title":"N. Engl. J. 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