{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:33:55Z","timestamp":1760236435362,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"23","license":[{"start":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T00:00:00Z","timestamp":1637884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Faculty of Medicine, University of Regensburg","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"Philips Respironics","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"name":"ResMed Germany","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/100003305","name":"ResMed Foundation","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100003305","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Boehringer-Ingelheim","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bresotec","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/100016919","name":"NRI","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100016919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WA 2539\/7-1, and 8-1; MA 1982\/7-1; SFB 1350 387509280"],"award-info":[{"award-number":["WA 2539\/7-1, and 8-1; MA 1982\/7-1; SFB 1350 387509280"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Else-Kroener Fresenius Foundation","award":["2018_A159"],"award-info":[{"award-number":["2018_A159"]}]},{"DOI":"10.13039\/501100005970","name":"German Heart Research Foundation","doi-asserted-by":"publisher","award":["F\/15\/20"],"award-info":[{"award-number":["F\/15\/20"]}],"id":[{"id":"10.13039\/501100005970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Sleep-disordered breathing (SDB) is highly prevalent in patients with cardiovascular disease. We have recently shown that an elevation of the electrocardiographic (ECG) parameter P wave terminal force in lead V1 (PTFV1) is linked to atrial proarrhythmic activity by stimulation of reactive oxygen species (ROS)-dependent pathways. Since SDB leads to increased ROS generation, we aimed to investigate the relationship between SDB-related hypoxia and PTFV1 in patients with first-time acute myocardial infarction (AMI). We examined 56 patients with first-time AMI. PTFV1 was analyzed in 12-lead ECGs and defined as abnormal when \u22654000 \u00b5V*ms. Polysomnography (PSG) to assess SDB was performed within 3\u20135 days after AMI. SDB was defined by an apnea-hypopnea-index (AHI) &gt;15\/h. The multivariable regression analysis showed a significant association between SDB-related hypoxia and the magnitude of PTFV1 independent from other relevant clinical co-factors. Interestingly, this association was mainly driven by central but not obstructive apnea events. Additionally, abnormal PTFV1 was associated with SDB severity (as measured by AHI, B 21.495; CI [10.872 to 32.118]; p &lt; 0.001), suggesting that ECG may help identify patients suitable for SDB screening. Hypoxia as a consequence of central sleep apnea may result in atrial electrical remodeling measured by abnormal PTFV1 in patients with first-time AMI independent of ventricular function. The PTFV1 may be used as a clinical marker for increased SDB risk in cardiovascular patients.<\/jats:p>","DOI":"10.3390\/jcm10235555","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T01:43:22Z","timestamp":1638323002000},"page":"5555","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Central Sleep Apnea Is Associated with an Abnormal P-Wave Terminal Force in Lead V1 in Patients with Acute Myocardial Infarction Independent from Ventricular Function"],"prefix":"10.3390","volume":"10","author":[{"given":"Jan","family":"Pec","sequence":"first","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-8363","authenticated-orcid":false,"given":"Michael","family":"Wester","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5833-1230","authenticated-orcid":false,"given":"Christoph","family":"Fisser","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Debl","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Okka","family":"Hamer","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Poschenrieder","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Buchner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Cham Hospital, 93413 Cham, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-4429","authenticated-orcid":false,"given":"Lars","family":"Maier","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Arzt","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9471-1166","authenticated-orcid":false,"given":"Stefan","family":"Wagner","sequence":"additional","affiliation":[{"name":"University Heart Center Regensburg, University Hospital Regensburg, 93053 Regensburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1378\/chest.14-2152","article-title":"Impact of OSA on cardiovascular events aft er coronary artery bypass surgery","volume":"147","author":"Nunes","year":"2015","journal-title":"Chest"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.ejheart.2006.08.003","article-title":"Sleep-disordered breathing in patients with symptomatic heart failure. 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